Patents
US 9533993 B2: Process for the preparation of morphine analogs via metal catalyzed N-demethylation/functionalization and intramolecular group transfer
- Granted
- 2017-01-03
- Filed
- 2015-07-30 application 14813602
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present application is directed to an efficient conversion of C-14 hydroxylated morphine alkaloids to various morphine analogs, such as naltrexone, naloxone and nalbuphone. One feature of this process is an intramolecular functional group transfer from the C-14 hydroxyl to the N-17 nitrogen atom following a palladium-catalyzed N-demethylation.
Source: PVGPATDIS, file of 2026-04-10 (ipg170103.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Brock University 27 patents | Foreign company or organization | Charlottetown, CA | Brock University College or university EXACT medium confidence: identical full name, one of each nationally BROCK UNIVERSITY Nonprofit EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Tomas Hudlicky | St. Catharines, CA | 17 | PVGPATDIS, file of 2026-04-10 | |
| Ales Machara | Praha, CZ | 10 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D489/02 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P25/04 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2015-08-06 | Assignment Assignment of assignor's interest | MACHARA, ALES signed 2011-06-08 HUDLICKY, TOMAS signed 2011-08-02 | BROCK UNIVERSITY ONTARIO | 36266/1 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.