Patents
US 8470552 B2: Strategy to reduce lactic acid production and control PH in animal cell culture
- Granted
- 2013-06-25
- Filed
- 2010-10-12 application 12903046
- Type
- Utility · 16 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides a method for culturing cells in exogenous lactic acid. Certain aspects of the present disclosure include the production of recombinant proteins, such as antibodies and fragments thereof. Certain aspects of the present disclosure also relate to methods of controlling lactic acid production, pH stability and osmolality in cell culture.
Source: PVGPATDIS, file of 2026-04-10 (ipg130625.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| KECK GRADUATE INSTITUTE 13 patents | US company or organization | Claremont, CA | Keck Graduate Institute College or university EXACT high confidence: identical full name and state KECK GRADUATE INSTITUTE Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Matthew S. Croughan | Claremont, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Nathaniel W. Freund | Camarillo, CA | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0018 | PVGPATDIS, file of 2026-04-10 |
| C12P | Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture | C12P21/02 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2017-11-29 | Assignment Assignment of assignor's interest | KECK GRADUATE INSTITUTE signed 2017-11-28 | CROUGHAN, MATTHEW S. CLAREMONT, CA | 44246/526 | ECORSEXC, file of 2026-09-25 |
| 2011-01-19 | Assignment Assignment of assignor's interest | CROUGHAN, MATTHEW S. signed 2010-12-11 FREUND, NATHANIEL W. signed 2010-12-27 | KECK GRADUATE INSTITUTE CLAREMONT, CA | 25661/274 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.