Patents
US 12758589 B2: Compositions and methods for using transplanted microglia as a vehicle for widespread delivery of cells and other biologic agents to the brain
- Granted
- 2026-10-13
- Filed
- 2021-04-08 application 17922098
- Type
- Utility · 2 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method of replacing endogenous microglia of a subject's brain, e.g., an adult subject, with transplanted donor microglia includes depleting at least a portion of the endogenous microglia by administering to the subject a Colony Stimulating Factor 1 Receptor (CSFR1) inhibitor, wherein the CSFR1 inhibitor is blood-brain barrier permeable and pharmacologically ablates endogenous microglia; optionally stopping administration of the CSFR1 inhibitor for a time sufficient to prevent ablation of the transplanted donor microglia; and transplanting the donor microglia into the brain of the subject to provide the transplanted donor microglia.
Source: PTBLXML, file of 2026-10-13 (ipgb20261013.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| ALBERT EINSTEIN COLLEGE OF MEDICINE 218 patents | US company or organization | Bronx, NY | ALBERT EINSTEIN COLLEGE OF MEDICINE State business registration EXACT high confidence: identical full name and state Albert Einstein College of Medicine College or university EXACT high confidence: identical full name and state ALBERT EINSTEIN COLLEGE OF MEDICINE Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-10-13 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jean M. Hebert | Bronx, NY | PTBLXML, file of 2026-10-13 | ||
| Marta Gronska-Peski | Bronx, NY | PTBLXML, file of 2026-10-13 | ||
| Hiroko Nobuta | New Brunswick, NJ | PTBLXML, file of 2026-10-13 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K35/30 | PTBLXML, file of 2026-10-13 |
| C07K | Peptides | C07K14/7153 | PTBLXML, file of 2026-10-13 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.