Patents
US 12709745 B2: Tethering cysteine residues using cyclic disulfides
- Granted
- 2026-08-18
- Filed
- 2024-05-16 application 18665737
- Type
- Utility · 18 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.
Source: PTBLXML, file of 2026-08-18 (ipgb20260818.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Brandeis University 165 patents | US company or organization | Waltham, MA | Brandeis University College or university EXACT high confidence: identical full name and state BRANDEIS UNIVERSITY Federal lobbying client EXACT high confidence: identical full name and state BRANDEIS UNIVERSITY Nonprofit EXACT high confidence: identical full name and state BRANDEIS UNIVERSITY INC. State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-08-18 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jeffrey N. Agar | Newton, MA | 11 | PTBLXML, file of 2026-08-18 | |
| Joseph Salisbury | Cranston, RI | 7 | PTBLXML, file of 2026-08-18 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/96 | PTBLXML, file of 2026-08-18 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/095 | PTBLXML, file of 2026-08-18 |
| C07K | Peptides | C07K19/00 | PTBLXML, file of 2026-08-18 |
| C12Y | Enzymes | C12Y115/01001 | PTBLXML, file of 2026-08-18 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-11-14 | Other License | BRANDEIS UNIVERSITY signed 2024-07-23 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 69383/488 | PASDL, file of 2026-08-13 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.