Patents
US 12559789 B2: Method of targeting patient-specific oncogenes in extrachromosomal DNA to treat glioblastoma
- Granted
- 2026-02-24
- Filed
- 2018-01-19 application 16479427
- Type
- Utility · 8 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided are methods of targeting patient-specific oncogenes in extrachromosomal DNA (ecDNA) to treat glioma in a human. The present methods include identifying a drug that targets against an oncogene present in ecDNA of a human suffering from glioma, such as glioblastoma. The identified oncogenes present in ecDNA include MET, MET/CAPZA2, MDM2, CDK4, SOX2, PIK3CA, MECOM, PDGFRA, EGFR, MYCN, MYC, TERT, SMARCA4, RP56, FBXW7, CDK6, CCND2, ERBB2, BRCA1, and BAP1. The present methods include identifying a drug targeted against the ecDNA oncogene, which drug inhibits the function of the identified oncogene, so as to inhibit tumor growth or progression of the glioma in the human. Also provided are PDX mouse models to further identify and/or confirm patient-specific drugs that target the identified oncogene(s) present in ecDNA. Also provided are methods of diagnosing gliomas or recurrent gliomas and methods of screening or monitoring for recurrence of gliomas. Further provided are methods of validating a predicted presence of ecDNA in a brain tumor using fluorescence in situ hybridization (FISH). Also provided are methods of screening drug candidates for a patient by implanting different identified drugs that target an identified oncogene into PDX mouse models.
Source: PTBLXML, file of 2026-02-24 (ipgb20260224.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Jackson Laboratory 76 patents | US company or organization | Bar Harbor, ME | JACKSON LABORATORY Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-02-24 |
| Henry Ford Health System 66 patents | US company or organization | Detroit, MI | HENRY FORD HEALTH SYSTEM State business registration EXACT high confidence: identical full name and state HENRY FORD HEALTH SYSTEM Federal lobbying client EXACT high confidence: identical full name and state HENRY FORD HEALTH SYSTEM Nonprofit EXACT high confidence: identical full name and state | PTBLXML, file of 2026-02-24 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Roel Verhaak | West Hartford, CT | PTBLXML, file of 2026-02-24 | ||
| Hoon Kim | West Hartford, CT | PTBLXML, file of 2026-02-24 | ||
| Ana Decarvalho | Detroit, MI | PTBLXML, file of 2026-02-24 | ||
| Tom Mikkelsen | Detroit, MI | 8 | PTBLXML, file of 2026-02-24 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6841 | PTBLXML, file of 2026-02-24 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/4545 | PTBLXML, file of 2026-02-24 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PTBLXML, file of 2026-02-24 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.