Patents
US 12548733 B2: Automating cryo-electron microscopy data collection
- Granted
- 2026-02-10
- Filed
- 2024-08-06 application 18795867
- Type
- Utility · 1 claim
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method of automated control of a microscope in cryogenic electron microscopy (cryo-EM), wherein the microscope is configured to collect high-magnification micrographs of particles suspended in vitreous ice. Such particles are found in grid squares, and a square contains holes from which high-magnification micrographs are imaged. The method is carried out during an active data collection session, leveraging a pipeline that comprises a set of models. The pipeline evaluates a set of collection locations to determine whether to continue collection at a current grid/square or instead at a new grid/square. The evaluation is based on a set of one or more quality scores derived from one or more pretrained models and machine learning-based active learning. Based on the determination, control information is provided to automatically control the microscope to move to a next target for data collection.
Source: PTBLXML, file of 2026-02-10 (ipgb20260210.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| New York Structural Biology Center 5 patents | US company or organization | New York, NY | THE NEW YORK STRUCTURAL BIOLOGY CENTER, INC. State business registration FUZZY medium confidence: same name (legal endings aside) and state NEW YORK STRUCTURAL BIOLOGY CENTER INC Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-02-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Paul T. Kim | San Francisco, CA | PTBLXML, file of 2026-02-10 | ||
| Tristan Bepler | Hillsborough, NY | 3 | PTBLXML, file of 2026-02-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| H01J | Electric discharge tubes or discharge lamps | H01J37/265 | PTBLXML, file of 2026-02-10 |
| G06N | Computing arrangements based on specific computational models | G06N7/01 | PTBLXML, file of 2026-02-10 |
| G06T | Image data processing or generation, in general | G06T7/0002 | PTBLXML, file of 2026-02-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.