Patents
US 12544348 B2: Methods for treating APOE4/4-associated disorders
- Granted
- 2026-02-10
- Filed
- 2019-04-12 application 17046950
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides methods of treating Alzheimer's Disease (AD) and rescuing cognitive deficits associated with AD in a subject having an apoE4/4 genotype, by administering a therapeutically effective amount of the loop-diuretic bumetanide to the subject. Also disclosed are kits for performing the method, including one or more doses of a bumetanide formulation; and which may also include instructions for treating a patient having an apoE4/4 genotype by administering bumetanide, and/or instructions and reagents for testing/identifying a subject having an apoE4/4 genotype.
Source: PTBLXML, file of 2026-02-10 (ipgb20260210.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The J. David Gladstone Institutes 72 patents | US company or organization | San Francisco, CA | J. DAVID GLADSTONE INSTITUTES State business registration FUZZY medium confidence: same name (legal endings aside) and state J DAVID GLADSTONE INSTITUTES Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-02-10 |
| The Regents of the University of California 8,781 patents | US company or organization | Oakland, CA | REGENTS OF THE UNIVERSITY OF CALIFORNIA State business registration FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-02-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yadong Huang | Daville, CA | 14 | PTBLXML, file of 2026-02-10 | |
| Alice Taubes | San Francisco, CA | PTBLXML, file of 2026-02-10 | ||
| Phil Nova | San Francisco, CA | PTBLXML, file of 2026-02-10 | ||
| Marina Sirota | San Francisco, CA | 9 | PTBLXML, file of 2026-02-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/196 | PTBLXML, file of 2026-02-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P25/28 | PTBLXML, file of 2026-02-10 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6883 | PTBLXML, file of 2026-02-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.