Patents
US 12510548 B2: Method of determining toxicity of an immunomodulatory drug for use in humans
- Granted
- 2025-12-30
- Filed
- 2024-03-13 application 18603889
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Humanized mouse models and methods are provided for determining whether administration of an immunomodulatory drug likely elicits a severe cytokine release syndrome in a human. Humanized mouse models and methods are also provided for determining the immunotoxicity in a human of a drug candidate or of drug combinations.
Source: PVGPATDIS, file of 2026-04-10 (ipg251230.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Jackson Laboratory 76 patents | US company or organization | Bar Harbor, ME | JACKSON LABORATORY Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| James Keck | Bar Harbor, ME | 9 | PVGPATDIS, file of 2026-04-10 | |
| Chunting Ye | Bar Harbor, ME | 4 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/6863 | PVGPATDIS, file of 2026-04-10 |
| A01K | Animal husbandry; aviculture; apiculture; pisciculture; fishing; rearing or breeding animals, not otherwise provided for; new breeds of animals | A01K67/0278 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K16/2809 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-06-13 | Assignment Assignment of assignor's interest | KECK, JAMES signed 2021-12-06 YE, CHUNTING signed 2021-12-21 | THE JACKSON LABORATORY BAR HARBOR, ME | 67716/270 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.