Patents
US 12504423 B2: Human in vitro cardiotoxicity model
- Granted
- 2025-12-23
- Filed
- 2021-10-15 application 17502800
- Type
- Utility · 11 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The Cardiac Tissue Engineered Model (TEEM) invention provides a robust in vitro model for cardiotoxicity evaluation using three-dimensional (3D) human heart microtissues to quantify dose-dependent changes in electromechanical activity, resulting in a comprehensive cardiotoxicity and arrhythmia risk assessment of test compounds. The invention also provides a predictive in vitro screening platform for pro-arrhythmic toxicity testing using human three-dimensional cardiac microtissues. The invention enables the screening of environmental and pharmaceutical compounds, chemicals, and toxicants to establish safe human exposure levels.
Source: PVGPATDIS, file of 2026-04-10 (ipg251223.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Brown University 276 patents | US company or organization | Providence, RI | Brown University College or university EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Rhode Island Hospital 73 patents | US company or organization | Providence, RI | RHODE ISLAND HOSPITAL Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Bum-Rak CHOI | Apponaug, RI | 2 | PVGPATDIS, file of 2026-04-10 | |
| Kareen L. K. COULOMBE | Central Falls, RI | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/5014 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-10-28 | Assignment Assignment of assignor's interest | COULOMBE, KAREEN L.K. signed 2020-12-02 | BROWN UNIVERSITY PROVIDENCE, RI | 57942/13 | PASDL, file of 2026-10-15 |
| 2021-10-28 | Assignment Assignment of assignor's interest | CHOI, BUM-RAK signed 2020-12-02 | RHODE ISLAND HOSPIAL PROVIDENCE, RI | 57942/9 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.