Patents

US 12405333 B2: Magnetic resonance imaging of glycogen and other polysaccharides by magnetic coupling with water

Granted: 2025-09-02
Filed: 2021-11-19 application 18037726
Type: Utility · 30 claims
Elsewhere: Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗

Abstract

Some embodiments provide a method for magnetic resonance imaging of polysaccharide molecules, that includes providing a magnetic field that is sufficiently homogeneous over an imaging volume, generating a spatial encoding in the magnetic field, and acquiring one or more water proton signal intensity measurements at each of multiple voxels within the imaging volume. The signal intensity measurements are acquired at one or more irradiation frequencies at lower parts-per-million (ppm) than a baseline frequency associated with free water protons. The method includes generating, based on the water proton signal intensity measurements in each voxel, a water proton signal intensity map of the relayed Nuclear Overhauser Effect (rNOE) exchange process of aliphatic protons in the polysaccharide molecules to free water protons in the imaging volume, and generating, using a calibration of the water proton signal intensity measurements for the rNOE exchange process, a concentration map of the polysaccharide molecules in the imaging volume.

Source: PVGPATDIS, file of 2026-04-10 (ipg250902.xml).

Assignees

Assignee	Type	Place	Also on furp.org	Source
The Johns Hopkins University 2,182 patents	US company or organization	Baltimore, MD	Johns Hopkins University College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state	PVGPATDIS, file of 2026-04-10
Kennedy Krieger Institute, Inc. 20 patents	US company or organization	Baltimore, MD	KENNEDY KRIEGER INSTITUTE, INC. State business registration EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE INC Nonprofit EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state	PVGPATDIS, file of 2026-04-10

Inventors

Inventor	Place	Patents	Source
Peter Van Zijl	Baltimore, MD	12	PVGPATDIS, file of 2026-04-10
Yang Zhou	Baltimore, MD	268	PVGPATDIS, file of 2026-04-10
Nirbhay Yadav	Baltimore, MD	3	PVGPATDIS, file of 2026-04-10

CPC categories

Subclass	Category	First group	Source
A61B	Diagnosis; surgery; identification	A61B5/055	PVGPATDIS, file of 2026-04-10
G01R	Measuring electric variables; measuring magnetic variables	G01R33/4828	PVGPATDIS, file of 2026-04-10
G01N	Investigating or analysing materials by determining their chemical or physical properties	G01N33/487	PVGPATDIS, file of 2026-04-10
Y02A	Technologies for adaptation to climate change	Y02A90/30	PVGPATDIS, file of 2026-04-10

Cooperative Patent Classification, as currently assigned (one row per subclass).

Assignments and security interests

Recorded	What	From	To	Reel/frame	Source
2023-10-25	Assignment Assignment of assignor's interest	YADAV, NIRBHAY N. signed 2021-09-17	KENNEDY KRIEGER INSTITUTE, INC. BALTIMORE, MD	65341/985	ECORSEXC, file of 2026-09-25
2023-10-25	Assignment Assignment of assignor's interest	VAN ZIJL, PETER signed 2023-06-04 ZHOU, YANG signed 2023-07-23	THE JOHNS HOPKINS UNIVERSITY BALTIMORE, MD	65341/939	ECORSEXC, file of 2026-09-25

Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.

USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.