Patents
US 12150750 B2: D-glucose and its analogs as tracers to assess the glucose transporter function on blood-cerebrospinal fluid barrier and the functioning of the brain lymphatic system
- Granted
- 2024-11-26
- Filed
- 2021-04-07 application 17918031
- Type
- Utility · 16 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method of assessing the brain lymphatic or glymphatic system and the glucose transporter function on blood-cerebrospinal fluid barrier (BCSFB) of a subject using D-glucose or a D-glucose analog. A spatial map is generated of water MR signals that are sensitized to changes in D-glucose or a D-glucose analog in cerebrospinal fluid (CSF) of the subject. The spatial map is observed at one or more time points before, one or more time points during, and one or more time points after, raising the blood level of the D-glucose or a D-glucose analog in the subject CSF. A difference is detected between the MR signals of the spatial map before, during, and after raising the blood level of D-glucose or a D-glucose analog. A physiological parameter associated with the brain lymphatic or glymphatic system and the glucose transporter function on BCSFB of the subject is ascertained based on the detected difference.
Source: PVGPATDIS, file of 2026-04-10 (ipg241126.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Johns Hopkins University 2,182 patents | US company or organization | Baltimore, MD | Johns Hopkins University College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| Kennedy Krieger Institute, Inc. 20 patents | US company or organization | Baltimore, MD | KENNEDY KRIEGER INSTITUTE, INC. State business registration EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE INC Nonprofit EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| CITY UNIVERSITY OF HONG KONG 758 patents | Foreign company or organization | Not reported | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jiadi Xu | Timonium, MD | 4 | PVGPATDIS, file of 2026-04-10 | |
| Peter Van Zijl | Hanover, MD | 12 | PVGPATDIS, file of 2026-04-10 | |
| Lin Chen | Baltimore, MD | 32 | PVGPATDIS, file of 2026-04-10 | |
| Kannie Wai Yan Chan | Hong Kong, CN | 6 | PVGPATDIS, file of 2026-04-10 | |
| Jianpan HUANG | Hong Kong, CN | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61B | Diagnosis; surgery; identification | A61B5/055 | PVGPATDIS, file of 2026-04-10 |
| G01R | Measuring electric variables; measuring magnetic variables | G01R33/565 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-10-23 | Assignment Assignment of assignor's interest | HUANG, JIANPAN signed 2023-07-28 WAI YAN CHAN, KANNIE signed 2023-07-28 | CITY UNIVERSITY OF HONG KONG KOWLOON TONG, KOWLOON, HONG KONG SAR | 65311/783 | ECORSEXC, file of 2026-09-25 |
| 2023-10-23 | Assignment Assignment of assignor's interest | XU, JIADI signed 2022-12-20 | THE JOHNS HOPKINS UNIVERSITY BALTIMORE, MD KENNEDY KRIEGER INSTITUTE, INC. BALTIMORE, MD | 65311/772 | ECORSEXC, file of 2026-09-25 |
| 2023-10-23 | Assignment Assignment of assignor's interest | CHEN, LIN signed 2022-12-22 VAN ZIJL, PETER signed 2022-12-22 | THE JOHNS HOPKINS UNIVERSITY BALTIMORE, MD | 65311/748 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.