Patents
US 12128015 B2: APE/REF1 inhibitors for the treatment of cancer
- Granted
- 2024-10-29
- Filed
- 2022-11-18 application 17990401
- Type
- Utility · 16 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Apurinic/apuyrimidinic endonuclease 1/Redox Factor-1 (APE/Ref-1) inhibitors are provided along with methods of using the same. The inhibitor has the structure of Formula I: or a pharmaceutically acceptable salt thereof. n is an integer from 4 to 14, X and X′ are each independently H or OH, and Y and Y′ are each independently H or OH.
Source: PVGPATDIS, file of 2026-04-10 (ipg241029.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Chapman University 10 patents | US company or organization | Orange, CA | Chapman University State business registration EXACT high confidence: identical full name and state Chapman University College or university EXACT high confidence: identical full name and state CHAPMAN UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 8,781 patents | US company or organization | Oakland, CA | REGENTS OF THE UNIVERSITY OF CALIFORNIA State business registration FUZZY medium confidence: same name (legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Sun Yang | Orange, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Keykavous Parang | Orange, CA | 9 | PVGPATDIS, file of 2026-04-10 | |
| Richard Chamberlin | Irvine, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Frank L. Meyskens, Jr. | Orange, CA | 7 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/165 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-09-11 | Assignment Assignment of assignor's interest | YANG, SUN signed 2023-01-20 PARANG, KEYKAVOUS signed 2024-09-10 | CHAPMAN UNIVERSITY ORANGE, CA | 68560/935 | ECORSEXC, file of 2026-09-25 |
| 2024-09-11 | Assignment Assignment of assignor's interest | CHAMBERLIN, RICHARD signed 2022-01-07 MEYSKENS, FRANK L. signed 2022-01-07 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA OAKLAND, CA | 68560/903 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.