Patents
US 11999697 B2: Methods and compositions for inhibition of dihydroorotate dehydrogenase
- Granted
- 2024-06-04
- Filed
- 2021-11-10 application 17523675
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are compounds, 3,4,6,8-substituted-2-([1,1′-biphenyl]-4-yl)quinoline analogs, that are inhibitors of dihydroorotate dehydrogenase (DHODH) with improved pharmacokinetic properties. The disclosed compounds can be used in the treatment of a variety of disorders and diseases in which inhibition of DHODH can be clinically useful, including cancer, such as a hematological cancer, including acute myeloid leukemia (AML); graft-versus-host-diseases; autoimmune disorders; and disorders associated with T-cell proliferation. The disclosed compounds can demonstrate flip-flop kinetics when administered orally, i.e., pharmacokinetics in which the rate of absorption, rather than the rate of elimination, dominates the pharmacokinetics. The disclosed compounds can demonstrate a sustained pharmacokinetic profile instead of an immediate release profile. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
Source: PVGPATDIS, file of 2026-04-10 (ipg240604.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Ohio State Innovation Foundation 733 patents | US company or organization | Columbus, OH | OHIO STATE INNOVATION FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| HENDRIX COLLEGE 3 patents | US company or organization | Conway, AR | HENDRIX COLLEGE State business registration EXACT high confidence: identical full name and state Hendrix College College or university EXACT high confidence: identical full name and state HENDRIX COLLEGE Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| John C. Byrd | Columbus, OH | 15 | PVGPATDIS, file of 2026-04-10 | |
| Thomas E. Goodwin | Conway, AR | 4 | PVGPATDIS, file of 2026-04-10 | |
| Ola ELGAMAL | Columbus, OH | 2 | PVGPATDIS, file of 2026-04-10 | |
| Erin HERTLEIN | Columbus, OH | 3 | PVGPATDIS, file of 2026-04-10 | |
| Mouad ABDULRAHIM | Conway, AR | 2 | PVGPATDIS, file of 2026-04-10 | |
| Chad E. Bennett | Powell, OH | 13 | PVGPATDIS, file of 2026-04-10 | |
| Sandip Madhukar VIBHUTE | Columbus, OH | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/436 | PVGPATDIS, file of 2026-04-10 |
| C07D | Heterocyclic compounds | C07D215/52 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P17/06 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-11-12 | Assignment Assignment of assignor's interest | GOODWIN, THOMAS E. signed 2021-10-08 ABDULRAHIM, MOUAD signed 2021-10-11 | HENDRIX COLLEGE CONWAY, AR | 58098/217 | PASDL, file of 2026-10-15 |
| 2021-11-12 | Assignment Assignment of assignor's interest | BYRD, JOHN C. signed 2021-09-27 ELGAMAL, OLA signed 2021-09-27 HERTLEIN, ERIN signed 2021-10-19 BENNETT, CHAD E. signed 2021-10-07 VIBHUTE, SANDIP MADHUKAR signed 2021-09-27 | OHIO STATE INNOVATION FOUNDATION COLUMBUS, OH | 58098/162 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.