Patents
US 11786507 B2: Methods of treating HIV-associated neurological disorders (HAND)
- Granted
- 2023-10-17
- Filed
- 2021-12-10 application 17547472
- Type
- Utility · 10 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
In the present disclosure, doxycycline-inducible astrocyte-specific HIV Tat transgenic mice (iTat), a surrogate HAND model, were treated with PNU-125096, a positive allosteric modulator of α7 nicotinic acetylcholine receptor (α7 nAChR) and effects on Tat-induced behavioral impairments and neuropathologies were observed. This disclosure shows that PNU-125096 treatment significantly improved locomotor, learning and memory deficits of iTat mice while inhibited glial activation and increased PSD-95 expression in the cortex and hippocampus of iTat mice. α7 nAChR knockout eliminated the protective effects of PNU-125096 on iTat mice. In addition, inhibition of p38 phosphorylation by SB239063, a p38 MAPK-specific inhibitor, exacerbated Tat neurotoxicity in iTat mice. These findings demonstrated for the first time that α7 nAChR activation led to protection against HAND and suggest that α7 nAChR and PNU-125096 hold significant promise for development of therapeutics for HAND.
Source: PVGPATDIS, file of 2026-04-10 (ipg231017.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Rosalind Franklin University of Medicine and Science 42 patents | US company or organization | North Chicago, IL | Rosalind Franklin University of Medicine and Science State business registration EXACT high confidence: identical full name and state Rosalind Franklin University of Medicine and Science College or university EXACT high confidence: identical full name and state ROSALIND FRANKLIN UNIVERSITY OF MEDICINE & SCIENCE Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Johnny HE | North Chicago, IL | 1 | PVGPATDIS, file of 2026-04-10 | |
| Xiaojie Zhao | North Chicago, IL | 8 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/41 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P25/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-01-05 | Government interest Confirmatory license | ROSALIND FRANKLIN UNIV OF MEDICINE & SCI signed 2022-11-10 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 66033/855 | ECORSEXC, file of 2026-09-25 |
| 2022-01-04 | Assignment Assignment of assignor's interest | ZHAO, XIAOJIE signed 2021-12-22 HE, JOHNNY signed 2022-01-04 | ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE NORTH CHICAGO, IL | 58648/481 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.