Patents
US 11747352 B2: Eplerenone for phenotyping of CYP3A5 enzyme activity in saliva samples
- Granted
- 2023-09-05
- Filed
- 2018-08-07 application 16637153
- Type
- Utility · 8 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed are methods and compositions which may be used in human cytochrome P450 (CYP450) enzyme phenotyping. The methods and compositions typically utilize substrate for CYP3A5 comprising eplerenone which may be administered orally to a subject. Subsequently, metabolites of eplereone may be detected in the subject's saliva as well as any non- metabolized eplerenone to calculate a metabolic ratio for CYP3A5 enzyme in order to generate a phenytopic CYP3A5 enzyme profile for the subject.
Source: PVGPATDIS, file of 2026-04-10 (ipg230905.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Concordia University 17 patents | US company or organization | Mequon, WI | Concordia University-Wisconsin College or university FUZZY medium confidence: through the nonprofit with the college's EIN (same name (governing-board words and legal endings aside) and state) CONCORDIA UNIVERSITY INC Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Joseph McGraw | Germantown, WI | 2 | PVGPATDIS, file of 2026-04-10 | |
| Armin Henry Gerhardt | Mettawa, IL | 6 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/26 | PVGPATDIS, file of 2026-04-10 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/9453 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/4439 | PVGPATDIS, file of 2026-04-10 |
| C12Y | Enzymes | C12Y114/14001 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-04-04 | Assignment Assignment of assignor's interest | CONCORDIA UNIVERSITY, INC. signed 2025-03-25 | CU VENTURES, INC. MEQUON, WI | 70741/569 | ECORSEXC, file of 2026-09-25 |
| 2023-02-09 | Assignment Assignment of assignor's interest | GERHARDT, ARMIN signed 2018-08-07 MCGRAW, JOSEPH signed 2018-08-07 | CONCORDIA UNIVERSITY, INC. MEQUON, WI | 62646/314 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.