Patents
US 11744896 B2: Compositions, use, and method for CDK2-PROTACs for cancer therapy and hearing loss
- Granted
- 2023-09-05
- Filed
- 2021-09-28 application 17488080
- Type
- Utility · 7 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided are CDK2-PROTAC compounds and pharmaceutical compositions thereof that can be used for specific degradation of the cyclin-dependent kinase 2 (CDK2) protein, for treatment of cancers and other CDK2 related diseases as well as for prevention and treatment of hearing loss.
Source: PVGPATDIS, file of 2026-04-10 (ipg230905.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| CREIGHTON UNIVERSITY 41 patents | US company or organization | Omaha, NE | Creighton University College or university EXACT high confidence: identical full name and state CREIGHTON UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (TENNESSEE NOT FOR PROFIT CORPORATION) 1 patents | US company or organization | Memphis, TN | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jian Zuo | Omaha, NE | 30 | PVGPATDIS, file of 2026-04-10 | |
| Santanu Hati | Omaha, NE | 2 | PVGPATDIS, file of 2026-04-10 | |
| Marisa Laura Zallocchi | Omaha, NE | 3 | PVGPATDIS, file of 2026-04-10 | |
| Robert Alan HAZLITT | Boulder, CO | 3 | PVGPATDIS, file of 2026-04-10 | |
| Jaeki Min | Memphis, TN | 27 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/55 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P27/16 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-06-21 | Government interest Government interest agreement | CREIGHTON UNIVERSITY signed 2023-06-22 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY ARLINGTON, VA | 67802/203 | ECORSEXC, file of 2026-09-25 |
| 2024-01-30 | Government interest Confirmatory license | CREIGHTON UNIVERSITY signed 2023-07-25 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 66378/851 | ECORSEXC, file of 2026-09-25 |
| 2023-04-11 | Assignment Assignment of assignor's interest | MIN, JAEKI signed 2023-03-09 HAZLITT, ROBERT signed 2023-03-22 | ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC. (TENNESSEE NOT FOR PROFIT CORPORATION) MEMPHIS, TN | 63292/241 | ECORSEXC, file of 2026-09-25 |
| 2023-04-11 | Assignment Assignment of assignor's interest | ZALLOCCHI, MARISA LAURA signed 2023-03-13 ZUO, JIAN signed 2023-03-14 HATI, SANTANU signed 2023-03-24 | CREIGHTON UNIVERSITY OMAHA, NE | 63292/17 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.