Patents
US 11617804 B2: Hyaluronic acid-based nanoparticles as biosensors for imaging-guided surgery and drug delivery vehicles and methods associated therewith
- Granted
- 2023-04-04
- Filed
- 2015-07-18 application 15326694
- Type
- Utility · 11 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention relates to intraoperative fluorescent imaging (IFI) used both pre-clinically using in-vivo models, as well as clinically to map sentinel lymph nodes in breast cancer, skin cancer, GI cancer, lung cancer, prostate cancer and several other cancers. IFI can be used to image solid tumors both non-specifically in hepatobiliary and breast cancers as well as in prostate and ovarian cancer. In one embodiment, two-dimensional resolution to 10 μm2 is possible with optical imaging, significantly higher than other imaging modalities.In one embodiment, the present invention relates to a series of self-assembled nanoparticles using HLA (hyaluronic acid) as both a polymeric backbone as well as targeting ligand. In some embodiments, the present invention relates to the synthesis of HLA conjugates, and the effect of variation of the hydrophobic ligand structure and conjugation level on nanoparticle self-assembly, size, ICG loading efficiency, and ICG fluorescence quenching and reactivation.
Source: PVGPATDIS, file of 2026-04-10 (ipg230404_r1.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| WAKE FOREST UNIVERSITY 60 patents | US company or organization | Winston-Salem, NC | WAKE FOREST UNIVERSITY State business registration EXACT high confidence: identical full name and state Wake Forest University College or university EXACT high confidence: identical full name and state WAKE FOREST UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Aaron M. Mohs | Omaha, NE | 4 | PVGPATDIS, file of 2026-04-10 | |
| Tanner K. Hill | Omaha, NE | 2 | PVGPATDIS, file of 2026-04-10 | |
| Sneha Sanjay Kelkar | York, PA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Steve Kridel | Clemmons, NC | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K49/0093 | PVGPATDIS, file of 2026-04-10 |
| A61B | Diagnosis; surgery; identification | A61B5/0075 | PVGPATDIS, file of 2026-04-10 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/54346 | PVGPATDIS, file of 2026-04-10 |
| B82Y | Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | B82Y5/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2019-10-25 | Assignment Assignment of assignor's interest | KELKAR, SNEHA SANJAY signed 2019-10-09 HILL, TANNER KINKADE signed 2019-10-10 MOHS, AARON MICHAEL signed 2019-10-10 | WAKE FOREST UNIVERSITY WINSTON-SALEM, NC | 50829/661 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.