Patents
US 11518784 B2: 14-3-3 targeting peptides for cancer treatment
- Granted
- 2022-12-06
- Filed
- 2020-05-08 application 16870253
- Type
- Utility · 6 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Systems and methods for treatment of squamous cell carcinoma or other cancer utilizing targeting peptides are described. The targeting peptides interact with SCC cells or other cancerous cells to block or interfere with 14-3-3ε heterodimerization or CDC25A binding to 14-3-3ε. A peptide composition embodiment includes, but is not limited to, at least one of a first targeting peptide comprising a structure of Trp-Tyr-Trp-Lys-NH2 (SEQ ID NO: 1), a second targeting peptide comprising a structure of phospho-Ser178; Ac-Thr-Gln-Arg-Gln-Asn-Ser-(PO32−)-Ala-Pro-Arg-Met-Leu-Ser-Ser-Asn-NH2 (SEQ ID NO: 2), and a third targeting peptide comprising a structure of phospho-Thr507 residue; Ac-Arg-Thr-Lys-Ser-Arg-Thr(PO32−)-Trp-Ala-Gly-Glu-Lys-Ser-Lys-Arg-NH2 (SEQ ID NO: 3).
Source: PVGPATDIS, file of 2026-04-10 (ipg221206.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| CREIGHTON UNIVERSITY 41 patents | US company or organization | Omaha, NE | Creighton University College or university EXACT high confidence: identical full name and state CREIGHTON UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| NUtech Ventures 204 patents | US company or organization | Lincoln, NE | NUTECH VENTURES Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Laura Hansen | Bellevue, NE | 3 | PVGPATDIS, file of 2026-04-10 | |
| Sandor Lovas | Omaha, NE | 3 | PVGPATDIS, file of 2026-04-10 | |
| Nicholas Palermo | Omaha, NE | 4 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K5/1024 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K9/06 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-11-18 | Assignment Assignment of assignor's interest | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA signed 2021-11-04 | NUTECH VENTURES LINCOLN, NE | 58154/449 | ECORSEXC, file of 2026-09-25 |
| 2021-06-07 | Assignment Assignment of assignor's interest | PALERMO, NICHOLAS signed 2021-05-18 | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA LINCOLN, NE | 56456/808 | ECORSEXC, file of 2026-09-25 |
| 2021-05-26 | Assignment Assignment of assignor's interest | LOVAS, SANDOR signed 2020-09-29 HANSEN, LAURA signed 2020-09-30 | CREIGHTON UNIVERSITY OMAHA, NE | 56354/507 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.