Patents
US 11452737 B2: Compositions and methods for treating vascular malformation and related conditions
- Granted
- 2022-09-27
- Filed
- 2016-07-28 application 15750674
- Type
- Utility · 6 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
In one aspect, the present invention features a method of inhibiting proliferation and/or reducing survival of a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation, comprising contacting the cell with puromycin or a puromycin analog, thereby inhibiting proliferation and/or reducing survival of the cell. In another aspect, a method of treating a vascular malformation or related condition in a subject, comprising administering to the subject an effective amount of puromycin or a puromycin analog is featured. In another aspect, the present invention features a method of identifying a candidate agent that modulates a GNAQ R183Q or Q209L mutation-associated disease, comprising contacting a cell comprising a GNAQ polynucleotide or polypeptide having a R183Q or Q209L mutation with puromycin and a candidate agent and comparing viability of the contacted cell with a reference level of viability, wherein an alteration in viability indicates that the candidate agent modulates the GNAQ R183Q or Q209L mutation-associated disease.
Source: PVGPATDIS, file of 2026-04-10 (ipg220927.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Johns Hopkins University 2,182 patents | US company or organization | Baltimore, MD | Johns Hopkins University College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| Duke University 1,375 patents | US company or organization | Durham, NC | Duke University College or university EXACT high confidence: identical full name and state DUKE UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Kennedy Krieger Institute, Inc. 20 patents | US company or organization | Baltimore, MD | KENNEDY KRIEGER INSTITUTE, INC. State business registration EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE INC Nonprofit EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Anne Comi | Baltimore, MD | 3 | PVGPATDIS, file of 2026-04-10 | |
| Jonathan Pevsner | Baltimore, MD | 2 | PVGPATDIS, file of 2026-04-10 | |
| Zhenhua Huang | Ellicott City, MD | 35 | PVGPATDIS, file of 2026-04-10 | |
| Doug Marchuk | Chapel Hill, NC | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/7076 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P17/00 | PVGPATDIS, file of 2026-04-10 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/68 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-12-15 | Assignment Assignment of assignor's interest | MARCHUK, DOUGLAS signed 2021-12-06 | DUKE UNIVERSITY OFFICE FOR TRANSLATION & COMMERCIALIZATION DURHAM, NC | 58392/777 | ECORSEXC, file of 2026-09-25 |
| 2021-12-15 | Assignment Assignment of assignor's interest | COMI, ANNE signed 2021-12-08 PEVSNER, JONATHAN signed 2021-12-14 | THE JOHNS HOPKINS UNIVERSITY BALTIMORE, MD | 58392/712 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.