Patents
US 11249161 B2: Magnetic resonance method for detecting molecular binding with enhanced sensitivity
- Granted
- 2022-02-15
- Filed
- 2018-03-02 application 16490219
- Type
- Utility · 37 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method to detect transient binding of a substrate molecule of interest in solution to a molecular target includes selecting the substrate molecule of interest and the molecular target such that the substrate molecule of interest can transiently bind to the molecular target; placing one of a sample or a subject of interest in a magnetic resonance (MR) apparatus, the sample or the subject of interest containing the substrate molecule of interest so as to be in contact with the molecular target; providing magnetic labelling of non-exchangeable or slowly exchangeable MR sensitive nuclei of the substrate molecule of interest; receiving an MR signal from the MR sensitive nuclei of the solvent molecules using the MR apparatus; and analyzing the MR signal to obtain a quantity associated with the transient binding of the substrate molecule of interest to the molecular target.
Source: PVGPATDIS, file of 2026-04-10 (ipg220215.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Johns Hopkins University 2,182 patents | US company or organization | Baltimore, MD | Johns Hopkins University College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| Kennedy Krieger Institute, Inc. 20 patents | US company or organization | Baltimore, MD | KENNEDY KRIEGER INSTITUTE, INC. State business registration EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE INC Nonprofit EXACT high confidence: identical full name and state KENNEDY KRIEGER INSTITUTE Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Peter Van Zijl | Hanover, MD | 12 | PVGPATDIS, file of 2026-04-10 | |
| Nirbhay Yadav | Baltimore, MD | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G01R | Measuring electric variables; measuring magnetic variables | G01R33/5605 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2019-08-30 | Assignment Assignment of assignor's interest | VAN ZIJL, PETER signed 2017-07-28 | THE JOHNS HOPKINS UNIVERSITY BALTIMORE, MD | 50222/565 | ECORSEXC, file of 2026-09-25 |
| 2019-08-30 | Assignment Assignment of assignor's interest | YADAV, NIRBHAY signed 2017-07-05 | KENNEDY KRIEGER INSTITUTE BALTIMORE, MD | 50222/552 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.