VAN ANDEL RESEARCH INSTITUTE: Form 990, tax year 2011
View the entire original 990 at ProPublica ↗
- Organization
- VAN ANDEL RESEARCH INSTITUTE (EIN 52-2000823)
- Tax period
- 2011-12-01 to 2012-11-30
- Filed
- 2013-10-11
- IRS object ID
- 201332849349300018
- Schema version
- 2011v1.5
- Source
- Download XML · Original 990 at ProPublica
Every field in the e-filed return. Faint text is the IRS element name, for citing.
- Return header
- Form 990
- Schedule A
- Schedule B
- Schedule C
- Schedule D
- Schedule F
- Schedule I
- Schedule J
- Schedule K
- Schedule O
- Schedule R
Return header ReturnHeader
| Field | Value | IRS element (for citing) |
|---|---|---|
| Timestamp | 2013-10-11T11:04:10-05:00 | Timestamp |
| Tax Period End Date | 2012-11-30 | TaxPeriodEndDate |
Preparer Firm PreparerFirm
| Field | Value | IRS element (for citing) |
|---|---|---|
| EIN | 861065772 | EIN |
Preparer Firm Business Name PreparerFirmBusinessName
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | DELOITTE TAX LLP | BusinessNameLine1 |
Preparer Firm US Address PreparerFirmUSAddress
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 200 RENAISSANCE CENTER STE 3900 | AddressLine1 |
| City | DETROIT | City |
| State | MI | State |
| ZIP Code | 48243 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Return Type | 990 | ReturnType |
| Tax Period Begin Date | 2011-12-01 | TaxPeriodBeginDate |
Filer Filer
| Field | Value | IRS element (for citing) |
|---|---|---|
| EIN | 522000823 | EIN |
Name Name
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | VAN ANDEL RESEARCH INSTITUTE | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name Control | VANA | NameControl |
| Phone | 6162345000 | Phone |
US Address USAddress
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 333 BOSTWICK AVENUE NE | AddressLine1 |
| City | GRAND RAPIDS | City |
| State | MI | State |
| ZIP Code | 49503 | ZIPCode |
Officer Officer
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name | TIMOTHY J MYERS | Name |
| Title | CFO | Title |
| Phone | 6162345368 | Phone |
| Date Signed | 2013-10-11 | DateSigned |
| Authorize Third Party | 1 | AuthorizeThirdParty |
Preparer Preparer
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name | LORI BOYCE | Name |
| PTIN | P00121981 | PTIN |
| Phone | 3133963000 | Phone |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Tax Year | 2011 | TaxYear |
| Build TS | 2016-02-25 16:41:14Z | BuildTS |
Form 990 IRS990
| Field | Value | IRS element (for citing) |
|---|---|---|
| Name Of Principal Officer Person | TIMOTHY J MYERS | NameOfPrincipalOfficerPerson |
Address Principal Officer US AddressPrincipalOfficerUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 333 BOSTWICK AVENUE NE | AddressLine1 |
| City | GRAND RAPIDS | City |
| State | MI | State |
| ZIP Code | 49503 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Gross Receipts | 72051806 | GrossReceipts |
| Group Return For Affiliates | 0 | GroupReturnForAffiliates |
| Organization501c3 | X | Organization501c3 |
| Web Site | WWW.VAI.ORG | WebSite |
| Type Of Organization Trust | X | TypeOfOrganizationTrust |
| Year Formation | 1996 | YearFormation |
| State Legal Domicile | MI | StateLegalDomicile |
| Activity Or Mission Description | MEDICAL RESEARCH ORGANIZATION | ActivityOrMissionDescription |
| Nbr Voting Members Governing Body | 5 | NbrVotingMembersGoverningBody |
| Nbr Independent Voting Members | 3 | NbrIndependentVotingMembers |
| Total Nbr Employees | 367 | TotalNbrEmployees |
| Total Nbr Volunteers | 0 | TotalNbrVolunteers |
| Total Gross UBI | 897673 | TotalGrossUBI |
| Net Unrelated Business Txbl Income | 80719 | NetUnrelatedBusinessTxblIncome |
| Contributions Grants Prior Year | 57012820 | ContributionsGrantsPriorYear |
| Contributions Grants Current Year | 57997024 | ContributionsGrantsCurrentYear |
| Program Service Revenue Prior Year | 1522584 | ProgramServiceRevenuePriorYear |
| Program Service Revenue CY | 1242591 | ProgramServiceRevenueCY |
| Investment Income Prior Year | 819423 | InvestmentIncomePriorYear |
| Investment Income Current Year | 333140 | InvestmentIncomeCurrentYear |
| Other Revenue Prior Year | 4334013 | OtherRevenuePriorYear |
| Other Revenue Current Year | 10471022 | OtherRevenueCurrentYear |
| Total Revenue Prior Year | 63688840 | TotalRevenuePriorYear |
| Total Revenue Current Year | 70043777 | TotalRevenueCurrentYear |
| Grants And Similar Amnts Prior Year | 340825 | GrantsAndSimilarAmntsPriorYear |
| Grants And Similar Amnts CY | 341390 | GrantsAndSimilarAmntsCY |
| Benefits Paid To Members Prior Year | 0 | BenefitsPaidToMembersPriorYear |
| Benefits Paid To Members CY | 0 | BenefitsPaidToMembersCY |
| Salaries Etc Prior Year | 26065382 | SalariesEtcPriorYear |
| Salaries Etc Current Year | 27658068 | SalariesEtcCurrentYear |
| Total Prof Fundrsng Exp Prior Year | 0 | TotalProfFundrsngExpPriorYear |
| Total Prof Fundrsng Exp CY | 0 | TotalProfFundrsngExpCY |
| Total Fundrsng Exp Current Year | 412173 | TotalFundrsngExpCurrentYear |
| Other Expense Prior Year | 39147197 | OtherExpensePriorYear |
| Other Expenses Current Year | 40558351 | OtherExpensesCurrentYear |
| Total Expenses Prior Year | 65553404 | TotalExpensesPriorYear |
| Total Expenses Current Year | 68557809 | TotalExpensesCurrentYear |
| Revenues Less Expenses Prior Year | -1864564 | RevenuesLessExpensesPriorYear |
| Revenues Less Expenses CY | 1485968 | RevenuesLessExpensesCY |
| Total Assets BOY | 270167888 | TotalAssetsBOY |
| Total Assets EOY | 267685668 | TotalAssetsEOY |
| Total Liabilities BOY | 358085475 | TotalLiabilitiesBOY |
| Total Liabilities EOY | 361102589 | TotalLiabilitiesEOY |
| Net Assets Or Fund Balances BOY | -87917587 | NetAssetsOrFundBalancesBOY |
| Net Assets Or Fund Balances EOY | -93416921 | NetAssetsOrFundBalancesEOY |
| Mission Description | MEDICAL RESEARCH ORGANIZATION | MissionDescription |
| Significant New Program Services | 0 | SignificantNewProgramServices |
| Significant Change | 0 | SignificantChange |
| Expense | 2140903 | Expense |
| Revenue | 0 | Revenue |
| Description | THE PROGRAM FOR BIOSPECIMEN SCIENCE HAS FOCUSED ON THE CHANGE IN BIOLOGICAL PARAMETERS AND QUALITY OF BIOSPECIMENS CAUSED BY COLLECTION, PROCESSING, AND STORAGE PROCEDURES. THIS RESEARCH IDENTIFIES EFFECTS ON THE CELL BIOLOGY THAT MAY BE UNRELATED TO THE DISEASE AND MORE SO CAUSED BY THE MANAGEMENT OF THE BIOSPECIMEN. THE RESULTS CAN BE USED TO DEVELOP BEST PRACTICES IN THE MANAGEMENT OF BIOSPECIMENS AND ULTIMATELY IMPROVE THE QUALITY OF RESEARCH FINDINGS. SCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. | Description |
Activity2 Activity2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Expense | 1731921 | Expense |
| Revenue | 500 | Revenue |
| Description | THE LABORATORY OF MOLECULAR ONCOLOGY HAS FOCUSED ON UNDERSTANDING THE NUMEROUS AND DIVERSE ROLES THAT MET PLAYS IN MALIGNANT PROGRESSION AND METASTASIS. SCHEDULE O PROVIDES FURTHER INFORMATION REGARDING THIS PROGRAM'S ACCOMPLISHMENTS. | Description |
Activity3 Activity3
| Field | Value | IRS element (for citing) |
|---|---|---|
| Expense | 1661508 | Expense |
| Description | THE LABORATORY OF STRUCTURAL SCIENCES IS FOCUSED ON STUDYING THE STRUCTURES AND FUNCTIONS OF PROTEIN/ LIGAND COMPLEXES THAT PLAY KEY ROLES IN MAJOR HORMONE SIGNALING PATHWAYS. SEE SCHEDULE O FOR FURTHER INFORMATION ABOUT THIS PROGRAM. | Description |
Activity Other ActivityOther
| Field | Value | IRS element (for citing) |
|---|---|---|
| Expense | 39181071 | Expense |
| Grants | 341390 | Grants |
| Revenue | 2455766 | Revenue |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Of Other Program Service Exp | 39181071 | TotalOfOtherProgramServiceExp |
| Total Of Other Program Service Grnt | 341390 | TotalOfOtherProgramServiceGrnt |
| Total Of Other Program Service Rev | 2455766 | TotalOfOtherProgramServiceRev |
| Total Program Service Expense | 44715403 | TotalProgramServiceExpense |
| Described In501 C3 | 1 | DescribedIn501C3 |
| Schedule B Required | 1 | ScheduleBRequired |
| Political Activities | 0 | PoliticalActivities |
| Lobbying Activities | 1 | LobbyingActivities |
| Subject To Proxy Tax | 0 | SubjectToProxyTax |
| Donor Advised Funds | 0 | DonorAdvisedFunds |
| Conservation Easements | 0 | ConservationEasements |
| Collections Of Art | 0 | CollectionsOfArt |
| Credit Counseling | 0 | CreditCounseling |
| Term Or Permanent Endowments | 0 | TermOrPermanentEndowments |
| Report Land Bldg Equip | 1 | ReportLandBldgEquip |
| Report Invest Oth Securities | 0 | ReportInvestOthSecurities |
| Report Prog Rel Invest | 0 | ReportProgRelInvest |
| Report Other Assets | 1 | ReportOtherAssets |
| Report Other Liabilities | 1 | ReportOtherLiabilities |
| Report Fin48 Footnote | 1 | ReportFin48Footnote |
| Independent Audit Financial Stmt | 0 | IndependentAuditFinancialStmt |
| Consolidated Audit Financial Stmt | 1 | ConsolidatedAuditFinancialStmt |
| School | 0 | School |
| Foreign Office | 1 | ForeignOffice |
| Foreign Activities | 1 | ForeignActivities |
| More Than5000 K To Organizations | 0 | MoreThan5000KToOrganizations |
| More Than5000 K To Individuals | 0 | MoreThan5000KToIndividuals |
| Professional Fundraising | 0 | ProfessionalFundraising |
| Fundraising Activities | 0 | FundraisingActivities |
| Gaming | 0 | Gaming |
| Hospital | 0 | Hospital |
| Grants To Organizations | 0 | GrantsToOrganizations |
| Grants To Individuals | 1 | GrantsToIndividuals |
| Schedule J Required | 1 | ScheduleJRequired |
| Tax Exempt Bonds | 1 | TaxExemptBonds |
| Invest Tax Exempt Bonds | 0 | InvestTaxExemptBonds |
| Escrow Account | 0 | EscrowAccount |
| On Behalf Of Issuer | 0 | OnBehalfOfIssuer |
| Excess Benefit Transaction | 0 | ExcessBenefitTransaction |
| Prior Excess Benefit Transaction | 0 | PriorExcessBenefitTransaction |
| Loan To Officer Or DQP | 0 | LoanToOfficerOrDQP |
| Grant To Related Person | 0 | GrantToRelatedPerson |
| Bsnss Rltnshp With Organization | 0 | BsnssRltnshpWithOrganization |
| Bsnss Rltnshp Thru Family Member | 0 | BsnssRltnshpThruFamilyMember |
| Officer Entity With Bsnss Rltnshp | 0 | OfficerEntityWithBsnssRltnshp |
| Deductible Non Cash Contributions | 0 | DeductibleNonCashContributions |
| Deductible Contributions Of Art | 0 | DeductibleContributionsOfArt |
| Terminated | 0 | Terminated |
| Partial Liquidation | 0 | PartialLiquidation |
| Disregarded Entity | 1 | DisregardedEntity |
| Related Entity | 1 | RelatedEntity |
| Related Org Controlled Entity | 1 | RelatedOrgControlledEntity |
| Transaction Related Entity | 1 | TransactionRelatedEntity |
| Transfers To Exempt Non Chrtbl Org | 0 | TransfersToExemptNonChrtblOrg |
| Activities Conducted Partnership | 0 | ActivitiesConductedPartnership |
| Schedule O Required | 1 | ScheduleORequired |
| Number Forms Transmitted With1096 | 113 | NumberFormsTransmittedWith1096 |
| Number W2 G Included | 0 | NumberW2GIncluded |
| Number Of Employees | 367 | NumberOfEmployees |
| Employment Tax Returns Filed | 1 | EmploymentTaxReturnsFiled |
| Unrelated Business Income | 1 | UnrelatedBusinessIncome |
| Form990-T Filed | 1 | Form990-TFiled |
| Foreign Financial Account | 0 | ForeignFinancialAccount |
| Prohibited Tax Shelter Trans | 0 | ProhibitedTaxShelterTrans |
| Taxable Party Notification | 0 | TaxablePartyNotification |
| Non Deductible Contributions | 0 | NonDeductibleContributions |
| Quid Pro Quo Contributions | 0 | QuidProQuoContributions |
| Form8282 Property Disposed Of | 0 | Form8282PropertyDisposedOf |
| Funds To Pay Premiums | 0 | FundsToPayPremiums |
| Premiums Paid | 0 | PremiumsPaid |
| Indoor Tanning Services | 0 | IndoorTanningServices |
| Info In Schedule O Part VI | X | InfoInScheduleOPartVI |
| Nbr Voting Governing Body Members | 5 | NbrVotingGoverningBodyMembers |
| Number Independent Voting Members | 3 | NumberIndependentVotingMembers |
| Family Or Business Relationship | 1 | FamilyOrBusinessRelationship |
| Delegation Of Management Duties | 1 | DelegationOfManagementDuties |
| Changes To Organizing Docs | 0 | ChangesToOrganizingDocs |
| Material Diversion Or Misuse | 0 | MaterialDiversionOrMisuse |
| Members Or Stockholders | 0 | MembersOrStockholders |
| Election Of Board Members | 1 | ElectionOfBoardMembers |
| Decisions Subject To Approval | 0 | DecisionsSubjectToApproval |
| Minutes Of Governing Body | 1 | MinutesOfGoverningBody |
| Minutes Of Committees | 1 | MinutesOfCommittees |
| Officer Mailing Address | 0 | OfficerMailingAddress |
| Local Chapters | 0 | LocalChapters |
| Form990 Provided To Governing Body | 1 | Form990ProvidedToGoverningBody |
| Conflict Of Interest Policy | 1 | ConflictOfInterestPolicy |
| Annual Disclosure Covered Persons | 1 | AnnualDisclosureCoveredPersons |
| Regular Monitoring Enforcement | 1 | RegularMonitoringEnforcement |
| Whistleblower Policy | 1 | WhistleblowerPolicy |
| Document Retention Policy | 1 | DocumentRetentionPolicy |
| Compensation Process CEO | 1 | CompensationProcessCEO |
| Compensation Process Other | 1 | CompensationProcessOther |
| Investment In Joint Venture | 0 | InvestmentInJointVenture |
| States Where Copy Of Return Is Filed | MI | StatesWhereCopyOfReturnIsFiled |
| Upon Request | X | UponRequest |
The Books Are In Care Of TheBooksAreInCareOf
Name Business NameBusiness
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | TIMOTHY J MYERS CFO | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Telephone Number | 6162345368 | TelephoneNumber |
Address US AddressUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 333 BOSTWICK AVENUE NE | AddressLine1 |
| City | GRAND RAPIDS | City |
| State | MI | State |
| ZIP Code | 495032518 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Info In Schedule O Part VII | X | InfoInScheduleOPartVII |
Form990 Part VII Section A Form990PartVIISectionA (16 entries)
| TitleTitle | Average Hours Per WeekAverageHoursPerWeek | Individual Trustee Or DirectorIndividualTrusteeOrDirector | OfficerOfficer | Reportable Comp From OrganizationReportableCompFromOrganization | Reportable Comp From Related OrgsReportableCompFromRelatedOrgs | Other CompensationOtherCompensation | Highest Compensated EmployeeHighestCompensatedEmployee |
|---|---|---|---|---|---|---|---|
| DAVID VAN ANDEL | |||||||
| CHAIRMAN / CEO | 28.00 | X | X | 411467 | 0 | 122461 | |
| DR GEORGE VANDE WOUDE | |||||||
| TRUSTEE/ DIST INVESTIGATOR | 50.00 | X | 299763 | 0 | 25940 | ||
| DR JAMES FAHNER | |||||||
| TRUSTEE | 1.00 | X | 10000 | 0 | 0 | ||
| DR FRITZ ROTTMAN PHD | |||||||
| TRUSTEE | 1.00 | X | 10000 | 2000 | 0 | ||
| DR JEFFREY TRENTTHROUGH 312 | |||||||
| PRESIDENT & RESEARCH DIRECTOR | 50.00 | X | X | 1180739 | 0 | 243940 | |
| WILLIAM POST THROUGH 312 | |||||||
| TRUSTEE | 1.00 | X | 2000 | 0 | 0 | ||
| DR GARY TARPLEY | |||||||
| TRUSTEE | 1.00 | X | 0 | 0 | 0 | ||
| R JACK FRICK THROUGH 1211 | |||||||
| CHIEF ADMINISTRATIVE OFFICER | 50.00 | X | 275769 | 0 | 95458 | ||
| TIMOTHY MYERS | |||||||
| CHIEF FINANCIAL OFFICER | 50.00 | X | 237174 | 0 | 78801 | ||
| DAVID WHITESCARVER | |||||||
| SECRETARY/ CHIEF LEGAL OFFICER | 50.00 | X | 197281 | 0 | 49962 | ||
| DR JANA HALL | |||||||
| CHIEF OPERATIONS OFFICER | 50.00 | X | 0 | 0 | 0 | ||
| DR H ERIC XU | |||||||
| DIST INVESTIGATOR | 45.00 | 294385 | 0 | 49433 | X | ||
| JOHN BENDER | |||||||
| CLINICAL OPERATIONS DIRECTOR | 45.00 | 235889 | 0 | 49192 | X | ||
| BRYON CAMPBELL | |||||||
| CHIEF INFORMATION OFFICER | 45.00 | 191590 | 0 | 35484 | X | ||
| DR GISELLE SAULNIER SHOLLER | |||||||
| DIST INVESTIGATOR | 45.00 | 222748 | 0 | 34912 | X | ||
| DR SCOTT JEWELL | |||||||
| DIST INVESTIGATOR | 45.00 | 296776 | 0 | 65194 | X | ||
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Reportable Comp From Org | 3865581 | TotalReportableCompFromOrg |
| Total Reportable Comp Frm Rltd Orgs | 2000 | TotalReportableCompFrmRltdOrgs |
| Total Other Compensation | 850777 | TotalOtherCompensation |
| Number Individuals GT100 K | 43 | NumberIndividualsGT100K |
| Formers Listed | 0 | FormersListed |
| Total Comp GT150 K | 1 | TotalCompGT150K |
| Compensation From Other Sources | 0 | CompensationFromOtherSources |
Contractor Compensation ContractorCompensation (5 entries)
| Address Line1AddressOfContractor/AddressUS/AddressLine1 | CityAddressOfContractor/AddressUS/City | StateAddressOfContractor/AddressUS/State | ZIP CodeAddressOfContractor/AddressUS/ZIPCode | Description Of ServicesDescriptionOfServices | CompensationCompensation |
|---|---|---|---|---|---|
| BANK OF AMERICAMERRILL LYNCH | |||||
| 100 N TRYON ST | CHARLOTTE | NC | 28202 | CREDIT ENHANCEMENT FEES | 3384333 |
| AON RISK SERVICES CENTER INC | |||||
| 75 REMITTANCE DR STE 1943 | CHICAGO | IL | 606751943 | INSURANCE | 551182 |
| WARNER NORCROSS & JUDD | |||||
| 111 LYON ST 900 OLD KENT | GRAND RAPIDS | MI | 495032487 | LEGAL/ CONSULTING | 547737 |
| PRIORITY HEALTH | |||||
| 1686 RELIABLE PARKWAY | CHICAGO | IL | 60686 | HEALTH INSURANCE ADMIN | 464179 |
| DK SECURITY | |||||
| 5160 FALCONVIEW AVE SE KENTWOOD | KENTWOOD | MI | 49512 | SECURITY SERVICES | 370952 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Number Of Contractors GT100 K | 19 | NumberOfContractorsGT100K |
| Related Organizations | 47258660 | RelatedOrganizations |
| Government Grants | 6031998 | GovernmentGrants |
| All Other Contributions | 4706366 | AllOtherContributions |
| Noncash Contributions | 12000 | NoncashContributions |
| Total Contributions | 57997024 | TotalContributions |
Program Service Revenue ProgramServiceRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Description | RESEARCH BILLED REV | Description |
| Business Code | 541700 | BusinessCode |
| Total Revenue Column | 1242591 | TotalRevenueColumn |
| Related Or Exempt Function Income | 345420 | RelatedOrExemptFunctionIncome |
| Unrelated Business Revenue | 897171 | UnrelatedBusinessRevenue |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Program Service Revenue | 1242591 | TotalProgramServiceRevenue |
Investment Income InvestmentIncome
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 214931 | TotalRevenueColumn |
| Exclusion | $214,931 | ExclusionAmount |
Royalties Revenue RoyaltiesRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 253826 | TotalRevenueColumn |
| Exclusion | $253,826 | ExclusionAmount |
Gross Rents GrossRents
| Field | Value | IRS element (for citing) |
|---|---|---|
| Real | 2602254 | Real |
| Personal | 1308 | Personal |
Less Rental Expenses LessRentalExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Real | 1506788 | Real |
| Personal | 806 | Personal |
Rental Income Or Loss RentalIncomeOrLoss
| Field | Value | IRS element (for citing) |
|---|---|---|
| Real | 1095466 | Real |
| Personal | 502 | Personal |
Net Rental Income Or Loss NetRentalIncomeOrLoss
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 1095968 | TotalRevenueColumn |
| Related Or Exempt Function Income | 1095466 | RelatedOrExemptFunctionIncome |
| Unrelated Business Revenue | 502 | UnrelatedBusinessRevenue |
Gross Amount Sales Assets GrossAmountSalesAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other | 618644 | Other |
Less Cost Oth Basis Sales Expenses LessCostOthBasisSalesExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other | 500435 | Other |
Gain Or Loss GainOrLoss
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other | 118209 | Other |
Net Gain Or Loss Investments NetGainOrLossInvestments
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 118209 | TotalRevenueColumn |
| Related Or Exempt Function Income | 118209 | RelatedOrExemptFunctionIncome |
Other Revenue Misc OtherRevenueMisc (2 entries)
| DescriptionDescription | Business CodeBusinessCode | Total Revenue ColumnTotalRevenueColumn | ExclusionExclusionAmount |
|---|---|---|---|
| REL. PARTY ADMIN SUPPO | 561000 | 5425172 | $5,425,172 |
| REIMBURSED EXPENSES | 900099 | 3654325 | $3,654,325 |
Miscellaneous Revenue MiscellaneousRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 41731 | TotalRevenueColumn |
| Exclusion | $41,731 | ExclusionAmount |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Other Revenue | 9121228 | TotalOtherRevenue |
Total Revenue TotalRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Revenue Column | 70043777 | TotalRevenueColumn |
| Related Or Exempt Function Income | 1559095 | RelatedOrExemptFunctionIncome |
| Unrelated Business Revenue | 897673 | UnrelatedBusinessRevenue |
| Exclusion | $9,589,985 | ExclusionAmount |
Grants To Domestic Individuals GrantsToDomesticIndividuals
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 341390 | Total |
| Program Services | 341390 | ProgramServices |
Comp Current Officers Directors CompCurrentOfficersDirectors
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2248987 | Total |
| Program Services | 1128006 | ProgramServices |
| Management And General | 1120981 | ManagementAndGeneral |
Other Salaries And Wages OtherSalariesAndWages
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 19866298 | Total |
| Program Services | 10781536 | ProgramServices |
| Management And General | 8793980 | ManagementAndGeneral |
| Fundraising | 290782 | Fundraising |
Pension Plan Contributions PensionPlanContributions
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 1515029 | Total |
| Program Services | 841171 | ProgramServices |
| Management And General | 651804 | ManagementAndGeneral |
| Fundraising | 22054 | Fundraising |
Other Employee Benefits OtherEmployeeBenefits
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2549100 | Total |
| Program Services | 1413005 | ProgramServices |
| Management And General | 1098522 | ManagementAndGeneral |
| Fundraising | 37573 | Fundraising |
Payroll Taxes PayrollTaxes
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 1478654 | Total |
| Program Services | 818280 | ProgramServices |
| Management And General | 638320 | ManagementAndGeneral |
| Fundraising | 22054 | Fundraising |
Fees For Services Legal FeesForServicesLegal
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 926115 | Total |
| Program Services | 55923 | ProgramServices |
| Management And General | 870192 | ManagementAndGeneral |
Fees For Services Accounting FeesForServicesAccounting
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 132611 | Total |
| Program Services | 15194 | ProgramServices |
| Management And General | 117417 | ManagementAndGeneral |
Fees For Services Lobbying FeesForServicesLobbying
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 68133 | Total |
| Management And General | 68133 | ManagementAndGeneral |
Fees For Services Other FeesForServicesOther
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2245213 | Total |
| Program Services | 1495233 | ProgramServices |
| Management And General | 749980 | ManagementAndGeneral |
Advertising Advertising
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 709562 | Total |
| Program Services | 10046 | ProgramServices |
| Management And General | 699516 | ManagementAndGeneral |
Office Expenses OfficeExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 136899 | Total |
| Program Services | 77504 | ProgramServices |
| Management And General | 59395 | ManagementAndGeneral |
Information Technology InformationTechnology
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 366110 | Total |
| Program Services | 155278 | ProgramServices |
| Management And General | 210832 | ManagementAndGeneral |
Occupancy Occupancy
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 2448990 | Total |
| Program Services | 1904532 | ProgramServices |
| Management And General | 544458 | ManagementAndGeneral |
Travel Travel
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 695945 | Total |
| Program Services | 445065 | ProgramServices |
| Management And General | 250880 | ManagementAndGeneral |
Conferences Meetings ConferencesMeetings
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 164918 | Total |
| Program Services | 91507 | ProgramServices |
| Management And General | 73411 | ManagementAndGeneral |
Interest Interest
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 11375530 | Total |
| Program Services | 8869107 | ProgramServices |
| Management And General | 2506423 | ManagementAndGeneral |
Depreciation Depletion DepreciationDepletion
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 9970658 | Total |
| Program Services | 8061216 | ProgramServices |
| Management And General | 1909442 | ManagementAndGeneral |
Insurance Insurance
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 440991 | Total |
| Program Services | 289362 | ProgramServices |
| Management And General | 151629 | ManagementAndGeneral |
Other Expenses OtherExpenses (4 entries)
| DescriptionDescription | TotalTotal | Program ServicesProgramServices | Management And GeneralManagementAndGeneral |
|---|---|---|---|
| LAB SUPPLIES & SERVICES | 3248873 | 3248873 | |
| EQUIPMENT & SOFTWARE | 2033196 | 1077077 | 956119 |
| OTHER SCIENTIFIC | 1143154 | 1143154 | |
| SCIENTIFIC PURCH. SVC. | 663483 | 663483 |
All Other Expenses AllOtherExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 3787970 | Total |
| Program Services | 1789461 | ProgramServices |
| Management And General | 1958799 | ManagementAndGeneral |
| Fundraising | 39710 | Fundraising |
Total Functional Expenses TotalFunctionalExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total | 68557809 | Total |
| Program Services | 44715403 | ProgramServices |
| Management And General | 23430233 | ManagementAndGeneral |
| Fundraising | 412173 | Fundraising |
Savings And Temp Cash Investments SavingsAndTempCashInvestments
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 954773 | BOY |
| EOY | 1687416 | EOY |
Pledges And Grants Receivable PledgesAndGrantsReceivable
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1194099 | BOY |
| EOY | 2507373 | EOY |
Accounts Receivable AccountsReceivable
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 2551038 | BOY |
| EOY | 1262403 | EOY |
Other Notes Loans Receivable Net OtherNotesLoansReceivableNet
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1664455 | BOY |
| EOY | 1647915 | EOY |
Prepaid Expenses Deferred Charges PrepaidExpensesDeferredCharges
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1271897 | BOY |
| EOY | 1153469 | EOY |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Land Buildings Equipment Basis | 266334661 | LandBuildingsEquipmentBasis |
| Land Bldg Equipment Accum Deprec | 62385484 | LandBldgEquipmentAccumDeprec |
Land Buildings Equipment Basis Net LandBuildingsEquipmentBasisNet
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 210880670 | BOY |
| EOY | 203949177 | EOY |
Investments Other Securities InvestmentsOtherSecurities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1367061 | BOY |
| EOY | 1431848 | EOY |
Investments Program Related InvestmentsProgramRelated
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 97917 | BOY |
| EOY | 0 | EOY |
Other Assets Total OtherAssetsTotal
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 50185978 | BOY |
| EOY | 54046067 | EOY |
Total Assets TotalAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 270167888 | BOY |
| EOY | 267685668 | EOY |
Accounts Payable Accrued Expenses AccountsPayableAccruedExpenses
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 55926177 | BOY |
| EOY | 61769366 | EOY |
Deferred Revenue DeferredRevenue
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 1756331 | BOY |
| EOY | 388625 | EOY |
Tax Exempt Bond Liabilities TaxExemptBondLiabilities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 220385000 | BOY |
| EOY | 221189000 | EOY |
Other Liabilities OtherLiabilities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 80017967 | BOY |
| EOY | 77755598 | EOY |
Total Liabilities TotalLiabilities
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 358085475 | BOY |
| EOY | 361102589 | EOY |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Follow SFAS117 | X | FollowSFAS117 |
Unrestricted Net Assets UnrestrictedNetAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | -80494164 | BOY |
| EOY | -95108778 | EOY |
Temporarily Restricted Net Assets TemporarilyRestrictedNetAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | -7425523 | BOY |
| EOY | 1689257 | EOY |
Permanently Restricted Net Assets PermanentlyRestrictedNetAssets
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 2100 | BOY |
| EOY | 2600 | EOY |
Total Net Assets Fund Balances TotalNetAssetsFundBalances
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | -87917587 | BOY |
| EOY | -93416921 | EOY |
Total Liab Net Assets Fund Balances TotalLiabNetAssetsFundBalances
| Field | Value | IRS element (for citing) |
|---|---|---|
| BOY | 270167888 | BOY |
| EOY | 267685668 | EOY |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Info In Schedule O Part XI | X | InfoInScheduleOPartXI |
| Reconcilation Revenue Expenses | 1485968 | ReconcilationRevenueExpenses |
| Reconcilation Other Changes | -6985302 | ReconcilationOtherChanges |
| Info In Schedule O Part XII | X | InfoInScheduleOPartXII |
| Method Of Accounting Accrual | X | MethodOfAccountingAccrual |
| Accountant Compile Or Review | 0 | AccountantCompileOrReview |
| FS Audited | 1 | FSAudited |
| Audit Committee | 1 | AuditCommittee |
| Financial Statement Consolidated | X | FinancialStatementConsolidated |
| Federal Grant Audit Required | 1 | FederalGrantAuditRequired |
| Federal Grant Audit Performed | 1 | FederalGrantAuditPerformed |
Schedule A IRS990ScheduleA
| Field | Value | IRS element (for citing) |
|---|---|---|
| Medical Research Org170b1 Aiii | X | MedicalResearchOrg170b1Aiii |
Hospital Name And Address HospitalNameAndAddress
Name Name
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | SPECTRUM HEALTH | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| City | GRAND RAPIDS | City |
| State | MI | State |
Schedule B IRS990ScheduleB
Contributor Info ContributorInfo
| Field | Value | IRS element (for citing) |
|---|---|---|
| Contributor Number | RESTRICTED | ContributorNumber |
Contributor Name Business ContributorNameBusiness
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | RESTRICTED | BusinessNameLine1 |
Contributor Address US ContributorAddressUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | RESTRICTED | AddressLine1 |
| Address Line2 | RESTRICTED | AddressLine2 |
| City | RESTRICTED | City |
| State | RESTRICTED | State |
| ZIP Code | RESTRICTED | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Aggregate Contributions | RESTRICTED | AggregateContributions |
Schedule C IRS990ScheduleC
Total Grassroots Lobbying TotalGrassrootsLobbying
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 0 | FilingOrganizationsTotals |
Total Direct Lobbying TotalDirectLobbying
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 68133 | FilingOrganizationsTotals |
Total Lobbying Expenditures TotalLobbyingExpenditures
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 68133 | FilingOrganizationsTotals |
Other Exempt Purpose Expenditures OtherExemptPurposeExpenditures
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 68489676 | FilingOrganizationsTotals |
Total Exempt Purpose Expenditures TotalExemptPurposeExpenditures
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 68557809 | FilingOrganizationsTotals |
Lobbying Nontaxable LobbyingNontaxableAmount
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 1000000 | FilingOrganizationsTotals |
Grassroots Nontaxable GrassrootsNontaxableAmount
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 250000 | FilingOrganizationsTotals |
Tot Lobbying Grassroot Minus Non Tx TotLobbyingGrassrootMinusNonTx
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 0 | FilingOrganizationsTotals |
Tot Lobby Expend Mns Lobbying Nontx TotLobbyExpendMnsLobbyingNontx
| Field | Value | IRS element (for citing) |
|---|---|---|
| Filing Organizations Totals | 0 | FilingOrganizationsTotals |
Lobbying Nontaxable Amount2 LobbyingNontaxableAmount2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Current Year | 1000000 | CurrentYear |
| Total | 1000000 | Total |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Lobbying Ceiling | $1,500,000 | LobbyingCeilingAmount |
Total Lobbying Expenditures2 TotalLobbyingExpenditures2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Current Year | 68133 | CurrentYear |
| Total | 68133 | Total |
Grassroots Nontaxable Amount2 GrassrootsNontaxableAmount2
| Field | Value | IRS element (for citing) |
|---|---|---|
| Current Year | 250000 | CurrentYear |
| Total | 250000 | Total |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Grassroots Ceiling | $375,000 | GrassrootsCeilingAmount |
Form990 Schedule C Part IV Form990ScheduleCPartIV
| Field | Value | IRS element (for citing) |
|---|---|---|
| Identifier | PART IV, SUPPLEMENTAL INFORMATION: | Identifier |
| Explanation | VARI EMPLOYEES MANAGE RELATIONSHIPS WITH OUTSIDE CONSULTANTS AND DID NOT PARTICIPATE IN DIRECT LOBBYING. THEREFORE, NO COMPENSATION EXPENSE HAS BEEN ALLOCATED TO LOBBYING EXPENSE. | Explanation |
Schedule D IRS990ScheduleD
| Field | Value | IRS element (for citing) |
|---|---|---|
| Collect Used For Public Exhibition | X | CollectUsedForPublicExhibition |
| Endowments Held By Related Orgs | 1 | EndowmentsHeldByRelatedOrgs |
| Are Related Orgs Listed Schedule R | 1 | AreRelatedOrgsListedScheduleR |
Land Land
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 5288315 | OtherCostOrOtherBasis |
| Book Value | 5288315 | BookValue |
Buildings Buildings
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 218645316 | OtherCostOrOtherBasis |
| Depreciation | 32192644 | Depreciation |
| Book Value | 186452672 | BookValue |
Equipment Equipment
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 40708927 | OtherCostOrOtherBasis |
| Depreciation | 30154521 | Depreciation |
| Book Value | 10554406 | BookValue |
Other Land Buildings OtherLandBuildings
| Field | Value | IRS element (for citing) |
|---|---|---|
| Other Cost Or Other Basis | 1692103 | OtherCostOrOtherBasis |
| Depreciation | 38319 | Depreciation |
| Book Value | 1653784 | BookValue |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Of Book Value Land Buildings | 203949177 | TotalOfBookValueLandBuildings |
Other Assets OtherAssets (2 entries)
| DescriptionDescription | Book ValueBookValue |
|---|---|
| BOND ISSUANCE COSTS NET OF ACCUMULATED AMORTIZATION | 1516067 |
| PLEDGED SECURITIES | 52530000 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Book Value Other Assets | 54046067 | TotalBookValueOtherAssets |
Other Liabilities OtherLiabilities (4 entries)
| DescriptionDescription | AmountAmount |
|---|---|
| ACCRUED POSTRETIREMENT BENEFIT OBLIGATION | $1,524,181 |
| UNREALIZED LOSS ON BOND SWAP | $69,959,449 |
| MSU COLLEGE OF HUMAN MEDICINE- CONTRIBUTION PAYABLE | $6,205,908 |
| CAPITAL LEASE | $66,060 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Of Amounts | 77755598 | TotalOfAmounts |
| Total Revenue | 70043777 | TotalRevenue |
| Total Expenses | 68557809 | TotalExpenses |
| Excess Or Deficit For Year | 1485968 | ExcessOrDeficitForYear |
| Net Unrealized GL On Investments | 64787 | NetUnrealizedGLOnInvestments |
| Other | -$7,050,089 | OtherAmount |
| Total Adjustments | -6985302 | TotalAdjustments |
| Excess Or Deficit Per FS | -5499334 | ExcessOrDeficitPerFS |
| Tot Revenue Etc Audited Fincl Stmt | 64297349 | TotRevenueEtcAuditedFinclStmt |
| Net Unrealized Gains Investments | 64787 | NetUnrealizedGainsInvestments |
| Other Revenues | 100790 | OtherRevenues |
| Revenue Not Rptd F990 | 165577 | RevenueNotRptdF990 |
| Revenue Subtotal | 64131772 | RevenueSubtotal |
| Other Revenues Not Included | 5912006 | OtherRevenuesNotIncluded |
| Revenue Not Rptd On Fin Stmt | 5912006 | RevenueNotRptdOnFinStmt |
| Total Revenue Per Form990 | 70043778 | TotalRevenuePerForm990 |
| Tot Expenses Etc Audited Fincl Stmt | 69796683 | TotExpensesEtcAuditedFinclStmt |
| Other Expenses Included | 7150879 | OtherExpensesIncluded |
| Expenses Not Rptd F990 | 7150879 | ExpensesNotRptdF990 |
| Expenses Subtotal | 62645804 | ExpensesSubtotal |
| Other Expenses Not Included | 5912006 | OtherExpensesNotIncluded |
| Expenses Not Rptd On Fin Stmt | 5912006 | ExpensesNotRptdOnFinStmt |
| Total Expenses Per Form990 | 68557810 | TotalExpensesPerForm990 |
Form990 Schedule D Part XIV Form990ScheduleDPartXIV (5 entries)
| IdentifierIdentifier | Return ReferenceReturnReference | ExplanationExplanation |
|---|---|---|
| DESCRIPTION OF INTENDED USE OF ENDOWMENT FUNDS: | PART V, LINE 4: | TO SUPPORT THE CORE RESEARCH OF VARI BY SUPPLYING A STEADY SOURCE OF INCOME FOR ITS OPERATING EXPENDITURES. |
| PART XI, LINE 8 - OTHER ADJUSTMENTS: | LOSS ON INTEREST RATE SWAP -7,050,089. | |
| PART X, LINE 1(1) AND LINE 2: MANAGEMENT BELIEVES THE LIKELIHOOD VARI, OR ANY RELATED ORGANIZATION, WILL BE REQUIRED TO MAKE ANY ADDITIONAL PAYMENTS IS REMOTE. PART XI, LINE 8: NET LOSS RELATED TO THE INTEREST RATE SWAP. PART XII, LINE 2D: RECLASS OF TRANSMED SYSTEMS (A RELATED PARTY) COST OF GOODS SOLD TO PRESENT ON STATEMENT OF REVENUE RATHER THAN STATEMENT OF FUNCTIONAL EXPENSES. PART XIII, LINE 2D: INCLUDES BOTH THE NET LOSS RELATED TO THE INTEREST RATE SWAP AND RECLASS OF TRANSMED SYSTEMS COST OF GOODS SOLD TO PRESENT ON STATEMENT OF REVENUE RATHER THAN STATEMENT OF FUNCTIONAL EXPENSES. | ||
| PART XII AND XIII, LINE 4B: EXPENSE ALLOCATIONS PRESENTED WITHIN REVENUE. | ||
| PART V - ALL ENDOWMENT FUNDS ARE HELD AT THE VAN ANDEL INSTITUTE (A RELATED ORGANIZATION). |
Schedule F IRS990ScheduleF
| Field | Value | IRS element (for citing) |
|---|---|---|
| Grant Records Maintained | 1 | GrantRecordsMaintained |
Accts Actvs Out US Table AcctsActvsOutUSTable
| Field | Value | IRS element (for citing) |
|---|---|---|
| Region | EAST ASIA & THE PACIFIC | Region |
| Number Of Offices | 0 | NumberOfOffices |
| Number Of Employees | 2 | NumberOfEmployees |
| Type Of Activities Conducted | PROGRAM SERVICES | TypeOfActivitiesConducted |
| Specific Services Provided | RESEARCH COLLABORATION - RESEARCH SERVICES | SpecificServicesProvided |
| Total Expenditures | 455219 | TotalExpenditures |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Subtotal Number Of Offices | 0 | SubtotalNumberOfOffices |
| Subtotal Number Of Employees | 2 | SubtotalNumberOfEmployees |
| Cont Number Of Offices | 0 | ContNumberOfOffices |
| Cont Number Of Employees | 0 | ContNumberOfEmployees |
| Total Number Of Offices | 0 | TotalNumberOfOffices |
| Total Number Of Employees | 2 | TotalNumberOfEmployees |
| Subtotal Amount Spent | 455219 | SubtotalAmountSpent |
| Cont Amount Spent | 0 | ContAmountSpent |
| Total Amount Spent | 455219 | TotalAmountSpent |
| Transfer To Foreign Corp | 0 | TransferToForeignCorp |
| Interest In Foreign Trust | 0 | InterestInForeignTrust |
| Own Foreign Corp | 0 | OwnForeignCorp |
| Passive Foreign Invest Co | 0 | PassiveForeignInvestCo |
| Foreign Partnership | 0 | ForeignPartnership |
| Boycott Countries | 0 | BoycottCountries |
Schedule I IRS990ScheduleI
| Field | Value | IRS element (for citing) |
|---|---|---|
| Records Maintained | 1 | RecordsMaintained |
Form990 Schedule I Part III Form990ScheduleIPartIII (2 entries)
| Type Of GrantTypeOfGrant | Number Of RecipientsNumberOfRecipients | Amount Of Cash GrantAmountOfCashGrant | Amount Of Non Cash AssistanceAmountOfNonCashAssistance | Method Of ValuationMethodOfValuation |
|---|---|---|---|---|
| GRADUATE STUDENT STIPENDS FOR VAN ANDEL GRADUATE SCHOOL AND MICHIGAN STATE UNIVERSITY STUDENTS | 8 | 198410 | 12000 | TUITION PAID |
| FOREIGN NATIONAL STUDENT STIPENDS | 13 | 105980 |
Form990 Schedule I Part IV Form990ScheduleIPartIV
| Field | Value | IRS element (for citing) |
|---|---|---|
| Explanation | SCHEDULE I, PART I, LINE 2: STIPENDS ARE PROVIDED TO THE RESEARCH STUDENTS FOR LIVING AND INSURANCE ASSISTANCE. | Explanation |
Schedule J IRS990ScheduleJ
| Field | Value | IRS element (for citing) |
|---|---|---|
| First Class Or Charter Travel | X | FirstClassOrCharterTravel |
| Housing Allowance Or Residence | X | HousingAllowanceOrResidence |
| Written Policy Re T And E Expenses | 0 | WrittenPolicyReTAndEExpenses |
| Substantiation Required | 1 | SubstantiationRequired |
| Compensation Committee | X | CompensationCommittee |
| Independent Consultant | X | IndependentConsultant |
| Written Employment Contract | X | WrittenEmploymentContract |
| Compensation Survey | X | CompensationSurvey |
| Board Or Committee Approval | X | BoardOrCommitteeApproval |
| Severance Payment | 0 | SeverancePayment |
| Supplemental Nonqual Retire Plan | 0 | SupplementalNonqualRetirePlan |
| Equity Based Comp Arrangement | 0 | EquityBasedCompArrangement |
| Comp Based On Revenue Of Filing Org | 0 | CompBasedOnRevenueOfFilingOrg |
| Comp Based On Revenue Related Orgs | 0 | CompBasedOnRevenueRelatedOrgs |
| Comp Based Net Earnings Filing Org | 0 | CompBasedNetEarningsFilingOrg |
| Comp Based Net Earnings Relate Orgs | 0 | CompBasedNetEarningsRelateOrgs |
| Any Non Fixed Payments | 1 | AnyNonFixedPayments |
| Initial Contract Exception | 0 | InitialContractException |
Form990 Schedule J Part II Form990ScheduleJPartII (11 entries)
| Base Compensation Filing OrgBaseCompensationFilingOrg | Comp Based On Related OrgsCompBasedOnRelatedOrgs | Bonus Filing OrgBonusFilingOrg | Bonus Related OrgsBonusRelatedOrgs | Other Compensation Filing OrgOtherCompensationFilingOrg | Other Compensation Related OrgsOtherCompensationRelatedOrgs | Deferred Comp Filing OrgDeferredCompFilingOrg | Deferred Comp Related OrgsDeferredCompRelatedOrgs | Nontaxable Benefits Filing OrgNontaxableBenefitsFilingOrg | Nontaxable Benefits Related OrgsNontaxableBenefitsRelatedOrgs | Total Compensation Filing OrgTotalCompensationFilingOrg | Total Compensation Related OrgsTotalCompensationRelatedOrgs | Comp Report Prior990 Filing OrgCompReportPrior990FilingOrg | Comp Report Prior990 Related OrgsCompReportPrior990RelatedOrgs |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DAVID VAN ANDEL | |||||||||||||
| 300014 | 0 | 86404 | 0 | 25049 | 0 | 121954 | 0 | 507 | 0 | 533928 | 0 | 86404 | 0 |
| DR GEORGE VANDE WOUDE | |||||||||||||
| 258791 | 0 | 22000 | 0 | 18972 | 0 | 24500 | 0 | 1440 | 0 | 325703 | 0 | 0 | 0 |
| DR JEFFREY TRENTTHROUGH 312 | |||||||||||||
| 837136 | 0 | 248256 | 0 | 95347 | 0 | 242500 | 0 | 1440 | 0 | 1424679 | 0 | 248256 | 0 |
| R JACK FRICK THROUGH 1211 | |||||||||||||
| 219566 | 0 | 54223 | 0 | 1980 | 0 | 86320 | 0 | 9138 | 0 | 371227 | 0 | 54223 | 0 |
| TIMOTHY MYERS | |||||||||||||
| 180247 | 0 | 56627 | 0 | 300 | 0 | 69663 | 0 | 9138 | 0 | 315975 | 0 | 56627 | 0 |
| DAVID WHITESCARVER | |||||||||||||
| 101372 | 0 | 0 | 0 | 95909 | 0 | 46154 | 0 | 3808 | 0 | 247243 | 0 | 0 | 0 |
| DR H ERIC XU | |||||||||||||
| 258778 | 0 | 35157 | 0 | 450 | 0 | 40295 | 0 | 9138 | 0 | 343818 | 0 | 22251 | 0 |
| JOHN BENDER | |||||||||||||
| 207680 | 0 | 7590 | 0 | 20619 | 0 | 40055 | 0 | 9137 | 0 | 285081 | 0 | 7590 | 0 |
| BRYON CAMPBELL | |||||||||||||
| 176668 | 0 | 14232 | 0 | 690 | 0 | 26347 | 0 | 9137 | 0 | 227074 | 0 | 14232 | 0 |
| DR GISELLE SAULNIER SHOLLER | |||||||||||||
| 145942 | 0 | 20000 | 0 | 56806 | 0 | 28821 | 0 | 6091 | 0 | 257660 | 0 | 20000 | 0 |
| DR SCOTT JEWELL | |||||||||||||
| 254861 | 0 | 40625 | 0 | 1290 | 0 | 56057 | 0 | 9137 | 0 | 361970 | 0 | 40625 | 0 |
Form990 Schedule J Part III Form990ScheduleJPartIII (3 entries)
| Return ReferenceReturnReference | ExplanationExplanation |
|---|---|
| PART I, LINE 1A | VARI ALLOWS FOR FIRST-CLASS OR CHARTER TRAVEL FOR OFFICERS AND TRUSTEES. PART I, LINE 1B: HOUSING ALLOWANCE AND RESIDENCE FOR PERSONAL USE ARE MANAGED BY HUMAN RESOURCES ON A CASE BY CASE BASIS, BOTH OF WHICH EXCLUSIVELY OCCUR IN CONNECTION WITH RELOCATION TO GRAND RAPIDS. |
| PART I, LINE 1B | A WRITTEN POLICY IS IN PLACE FOR FIRST CLASS/ CHARTER TRAVEL. |
| PART I, LINE 7 | ALL OFFICERS AND OTHER HIGHLY COMPENSATED EMPLOYEES ARE INCLUDED IN A VARIABLE PAY PLAN BASED ON ACHIEVEMENTS OF THE ORGANIZATION AS WELL AS RESPECTIVE INDIVIDUAL PREDETERMINED GOALS AND OBJECTIVES. |
Schedule K IRS990ScheduleK
Form990 Schedule K Part I Form990ScheduleKPartI
Issuer Name IssuerName
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | MICHIGAN STRATEGIC FUND LIMITED OBLIGATION REVENUE | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Issuer EIN | 521417332 | IssuerEIN |
| CUSIP Number | 594698EG3 | CUSIPNumber |
| Date Issued | 2008-04-10 | DateIssued |
| Issue Price | 220000000 | IssuePrice |
| Description Of Purpose | BUILD, EQUIP & FURNISH PHASE II RESEARCH FACILITY, & REFUND $50M PRIOR LTD | DescriptionOfPurpose |
| Defeased | 0 | Defeased |
| On Behalf Of Issuer | 0 | OnBehalfOfIssuer |
| Pool Financing | 0 | PoolFinancing |
Form990 Schedule K Part II Form990ScheduleKPartII
| Field | Value | IRS element (for citing) |
|---|---|---|
| Total Proceeds | 223154512 | TotalProceeds |
| Capital Expenditures | 113036720 | CapitalExpenditures |
| Other Spent Proceeds | 110117792 | OtherSpentProceeds |
| Year Of Subst Completion | 2009 | YearOfSubstCompletion |
| Current Refunding | 1 | CurrentRefunding |
| Advance Refunding | 0 | AdvanceRefunding |
| Final Allocation Made | 1 | FinalAllocationMade |
| Adequate Books And Recds Maintaind | 1 | AdequateBooksAndRecdsMaintaind |
Form990 Schedule K Part III Form990ScheduleKPartIII
| Field | Value | IRS element (for citing) |
|---|---|---|
| Owning Bond Financed Property | 0 | OwningBondFinancedProperty |
| Any Lease Arrangements | 1 | AnyLeaseArrangements |
| Mngment Cntrct Bond Financd Prprty | 1 | MngmentCntrctBondFinancdPrprty |
| Engage Bond Counsel Contracts | 1 | EngageBondCounselContracts |
| Any Research Agreements | 1 | AnyResearchAgreements |
| Engage Bond Counsel Research | 1 | EngageBondCounselResearch |
| Percentage Of Prvt Business Re UBI | 0.01090 | PercentageOfPrvtBusinessReUBI |
| Total Private Business Use | 0.01090 | TotalPrivateBusinessUse |
| Post Issuance Compliance Procdrs | 1 | PostIssuanceComplianceProcdrs |
Form990 Schedule K Part IV Form990ScheduleKPartIV
| Field | Value | IRS element (for citing) |
|---|---|---|
| Form8038 T Filed | 1 | Form8038TFiled |
| Variable Rate Issue | 1 | VariableRateIssue |
| Hedge Identified In Books And Recds | 0 | HedgeIdentifiedInBooksAndRecds |
| Gross Proceeds Invested In GIC | 0 | GrossProceedsInvestedInGIC |
| Gross Proceeds Invested | 0 | GrossProceedsInvested |
| Exception To Rebate | 0 | ExceptionToRebate |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Fed Tax Requirements Compliance | X | FedTaxRequirementsCompliance |
Schedule O IRS990ScheduleO
General Explanation GeneralExplanation (16 entries)
| Return ReferenceReturnReference | ExplanationExplanation | IdentifierIdentifier |
|---|---|---|
| FORM 990, PART VI, SECTION A, LINE 2 | VARI AND VAEI SHARE COMMON MANAGEMENT. AS OFFICERS OF VARI, DAVID VAN ANDEL, R. JACK FRICK, DR. JANA HALL, TIMOTHY MYERS AND DAVID WHITESCARVER INTERACT AND WORK TOGETHER WITH STEVE TRIEZENBERG, AN OFFICER OF VAEI. | |
| FORM 990, PART VI, SECTION A, LINE 2 | VARI AND THE TRANSLATIONAL GENOMICS INSTITUTE (TGEN) SHARED COMMON GOVERNANCE. DR. WILLIAM J. POST, DR. JOSE CARDENAS, AND DR. JEFF TRENT ALL SERVED AS DIRECTORS FOR BOTH VARI AND TGEN (A RELATED ORGANIZATION). AS OF MARCH 12, 2012, VARI AND TGEN TERMINATED THEIR ALLIANCE AND AFFILIATION AGREEMENT. | |
| FORM 990, PART VI, SECTION A, LINE 3 | DURING THE FISCAL YEAR, JERRY CALLAHAN, AN INDEPENDENT CONTRACTOR, SERVED AS THE VICE PRESIDENT OF BUSINESS DEVELOPMENT AND EXTRAMURAL ADMINISTRATION. AS OF JANUARY 2013, MR. CALLAHAN BECAME A FULL TIME EMPLOYEE. | |
| FORM 990, PART VI, SECTION A, LINE 7A | THE TRUSTEES OF VAN ANDEL INSTITUTE HAVE THE AUTHORITY TO ELECT ONE OR MORE MEMBERS OF VARI'S GOVERNING BODY. | |
| FORM 990, PART VI, SECTION B, LINE 11 | FOLLOWING COMPLETION OF THE FINANCIAL STATEMENT AUDIT, THE FORM 990 IS PREPARED AND REVIEWED BY MANAGEMENT. IT IS THEN CIRCULATED TO THE FULL BOARD FOR REVIEW AND FINAL APPROVAL PRIOR TO FILING WITH THE IRS. | |
| FORM 990, PART VI, SECTION B, LINE 12C | VARI HAS A WRITTEN CONFLICT OF INTEREST POLICY FOR WHICH THE ORGANIZATION ENFORCES A PROCESS TO IDENTIFY, EVALUATE, AND CORRECT OR REMOVE POTENTIAL CONFLICTS OF INTEREST. THIS POLICY HAS BEEN BOARD APPROVED. THE VAN ANDEL INSTITUTE ADMINISTERS THE CONFLICT OF INTEREST (COI) POLICY, ON BEHALF OF VARI, THROUGH TWO COMMITTEES: THE CONFLICTS COMMITTEE ("CC") AND THE INSTITUTIONAL COI COMMITTEE ("ICOIC"). THE COI POLICY SERVES AS GUIDE FOR ALL STAFF MEMBERS OF THE ORGANIZATION. THE POLICY IS INTENDED TO 1) PROVIDE STAFF WITH A USEFUL RESOURCE WHEN DEVELOPING ACTIVITIES WITH OUTSIDE INDUSTRY AND 2) PROVIDE ASSURANCE TO STAFF THAT THERE IS A COMMITTEE TO REVIEW AND RESOLVE POTENTIAL CONFLICTS OF INTEREST IF / WHEN THEY ARISE. THE CC, CHAIRED BY THE DIRECTOR OF COMPLIANCE, GENERATES AN ANNUAL DISCLOSURE QUESTIONNAIRE DISTRIBUTED TO ALL STAFF TO ENFORCE THE POLICY. THE CC IS RESPONSIBLE FOR MAKING RECOMMENDATIONS TO THE DIRECTOR. RESOLUTIONS ARE IMPLEMENTED WITH APPROVAL OF THE COMMITTEE AND IN DISCUSSION WITH THE CHAIRMAN. THE COI POLICY ALSO SERVES AS A GUIDE FOR ALL MEMBERS OF THE BOARD OF TRUSTEES AND SENIOR EXECUTIVES. THE ICOIC REQUIRES TRUSTEES TO COMPLETE AN ANNUAL DISCLOSURE STATEMENT. THIS STATEMENT AFFIRMS THEIR UNDERSTANDING OF THE POLICY, REQUIRES THEIR ACKNOWLEDGEMENT OF THE ORGANIZATION'S NONPROFIT STATUS, AND REQUESTS DISCLOSURE IF / WHEN POTENTIAL CONFLICTS ARISE. IN THE EVENT A POTENTIAL CONFLICT ARISES AT THE BOARD OR SENIOR OFFICER LEVEL, THE CHIEF LEGAL OFFICE REVIEWS AND MEETS WITH THE BOARD OF TRUSTEES TO RESOLVE POTENTIAL CONFLICTS. | |
| FORM 990, PART VI, SECTION B, LINE 15 | COMPARABILITY DATA FROM EXPERT, THIRD PARTY IS OBTAINED AND REVIEWED BY VAN ANDEL INSTITUTE'S INDEPENDENT COMPENSATION COMMITTEE TO DETERMINE APPROPRIATE COMPENSATION FOR THE CEO, EXECUTIVE MANAGEMENT OFFICIALS, EXECUTIVE DIRECTOR, OFFICERS, AND KEY EMPLOYEES, ON BEHALF OF VAN ANDEL RESEARCH INSTITUTE. | |
| FORM 990, PART VI, SECTION C, LINE 19 | THE CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. | |
| FORM 990, PART VII, PAGE 7 | DAVID VAN ANDEL, R. JACK FRICK, DR. JANA HALL, TIMOTHY MYERS, AND DAVID WHITESCARVER ALSO PERFORMED WORK FOR VAN ANDEL INSTITUTE, VAN ANDEL EDUCATION INSTITUTE, AND VAN ANDEL INSTITUTE GRADUATE SCHOOL (RELATED ENTITIES). | |
| FORM 990, PART XI, LINE 5: | NET UNREALIZED GAINS ON INVESTMENTS: 64,787. LOSS ON INTEREST RATE SWAP -7,050,089. TOTAL TO FORM 990, PART XI, LINE 5: -6,985,302. | CHANGES IN NET ASSETS OR FUND BALANCES: |
| FORM 990, PART XII, LINE 2C | THE PROCESS FOR SELECTING THE AUDITOR FOR VAN ANDEL RESEARCH INSTITUTE'S FINANCIAL STATEMENTS DID NOT CHANGE DURING 2012. | |
| PART III, LINE 3 | EFFECTIVE MARCH 12, 2012, VARI AND TGEN TERMINATED THEIR ALLIANCE AND AFFILIATION AGREEMENT AND TGEN CONVERTED FROM A MEMBER-BASED ARIZONA NOT-FOR-PROFIT CORPORATION TO A DIRECTOR-BASED ARIZONA NOT-FOR-PROFIT CORPORATION, WHEREBY VARI IS NO LONGER THE SOLE MEMBER OF TGEN. THE RESULTS OF OPERATIONS OF TGEN THROUGH THE EFFECTIVE TERMINATION DATE, ARE REFLECTED AS DISCONTINUED OPERATIONS WITHIN THE VAN ANDEL INSTITUTE AND AFFILIATES CONSOLIDATED AND CONSOLIDATING STATEMENTS OF ACTIVITIES AND CHANGES IN NET ASSETS (WHICH VARI IS PART OF). TGEN ASSETS, LIABILITIES AND NET ASSETS TRANSFERRED TOTALED $57,577,000, $21,348,000 AND $36,229,000, RESPECTIVELY. TGEN REVENUE AND SUPPORT EARNED BEFORE THE AGREEMENT TERMINATION, DURING FISCAL YEAR 2012 TOTALED $9,012,000. TGEN EXPENSES INCURRED BEFORE THE AGREEMENT TENNINATION, DURING FISCAL YEAR 2012 TOTALED $13,193,000. TGEN REVENUE AND SUPPORT EARNED FOR FISCAL YEAR ENDED NOVEMBER 30, 2011 TOTALED $54,670,000. TGEN EXPENSES INCURRED FOR FISCAL YEAR ENDED NOVEMBER 30, 2011 TOTALED $68,855,000. | |
| FORM 990, PART III, LINES 4A-4C | LINE 4A - PROGRAM SERVICE ACTIVITY #1 THE PROGRAM FOR BIOSPECIMEN SCIENCE HAS FOCUSED ON THE CHANGE IN BIOLOGICAL PARAMETERS AND QUALITY OF BIOSPECIMENS CAUSED BY COLLECTION, PROCESSING, AND STORAGE PROCEDURES. THE BIOREPOSITORY WITHIN THE PROGRAM FOR BIOSPECIMEN SCIENCE INCLUDES SCIENTIFIC EVALUATION ON THE PATTERNS OF DEGRADATION IN BIOSPECIMENS, DATABASE TRACKING AND MANAGEMENT OF BIOSPECIMEN INVENTORY; BIOSPECIMEN KIT DEVELOPMENT AND MANUFACTURING; SHIPPING AND TRACKING SERVICES; PROCUREMENT OF SURGICAL TISSUE AND BIOSPECIMENS FROM PATIENT POPULATIONS; QUALITY CONTROL ASSESSMENT OF OPERATIONS FOR THE COLLECTION AND BANKING OF BIOSPECIMENS; AND BIOSPECIMEN PROJECT MANAGEMENT. THE VARI BIOREPOSITORY CONTAINS APPROXIMATELY 10,000 FROZEN HUMAN TISSUES AND THEIR DERIVATIVES AND A PARAFFIN BLOCK ARCHIVE OF HUMAN DIAGNOSTIC TISSUES CURRENTLY EXCEEDING 900,000 BLOCKS. TISSUE ACQUISITION IS IN COLLABORATION WITH WEST MICHIGAN HOSPITALS, PROVIDING FRESH-FROZEN AND PARAFFIN-EMBEDDED SURGICAL TISSUES AND BLOOD FROM CONSENTING PATIENTS. THE BIOREPOSITORY IS DESIGNED TO PROVIDE HUMAN TUMORS TO INVESTIGATORS WITH IRB-APPROVED BASIC AND TRANSLATIONAL RESEARCH PROJECTS. ACCOMPLISHMENTS INCLUDE; MANAGING BIOREPOSITORY SERVICES FOR THE MULTIPLE MYELOMA RESEARCH FOUNDATION, THE NATIONAL CANCER INSTITUTE'S CANCER HUMAN BIOBANK (CAHUB), MULTIPLE BIOSPECIMEN ACQUISITION AND BIOREPOSITORY MANAGEMENT PROJECTS FOR VARI INVESTIGATORS, BIOREPOSITORY ACCREDITATION FROM THE COLLEGE OF AMERICAN PATHOLOGIST (CAP), AND A FOUNDING MEMBER OF THE GREAT LAKES BIOREPOSITORY RESEARCH NETWORK (GLBRN). LINE 4B - PROGRAM SERVICE ACTIVITY #2 SINCE DISCOVERING THE C-MET RECEPTOR AND ITS LIGAND HEPATOCYTE GROWTH FACTOR (HGF/SF) IN THE MID-1980S, THE LABORATORY OF MOLECULAR ONCOLOGY HAS FOCUSED ON INVESTIGATING THE PARAMOUNT ROLE THESE PROTEINS PLAY IN MALIGNANT PROGRESSION AND METASTASIS. MET IS OVEREXPRESSED IN MANY TYPES OF HUMAN CANCER, AND ITS EXPRESSION CORRELATES WITH AN AGGRESSIVE DISEASE AND POOR PROGNOSIS (HTTP://WWW.VAI.ORG/MET/). THE ABERRANT EXPRESSION OF MET IN MANY HUMAN TUMORS ALSO NECESSITATED THE DEVELOPMENT OF COMPANION DIAGNOSTICS TO IDENTIFY THOSE PATIENTS WHO COULD BENEFIT FROM MET TARGETED THERAPIES. AS PART OF THE ONGOING EFFORT TO FURTHER ENHANCE OUR UNDERSTANDING OF THE HGF/SF-MET SIGNALING PATHWAY, OUR LAB CURRENTLY FOCUSES ON THE PROJECTS DESCRIBED BELOW: - CONTINUING TO DEVELOP AND CHARACTERIZE NOVEL RESEARCH MODELS FOR A VARIETY OF HUMAN CANCERS (LIVER, BRAIN, BREAST, LUNG AND OTHERS) AND USING THEM FOR PRE-CLINICAL EVALUATION OF NEW C-MET INHIBITORS AS WELL AS OTHER THERAPEUTIC STRATEGIES - EVALUATING HGF AUTOCRINE AS A THERAPEUTIC MARKER PREDICTING SENSITIVITY TO C-MET INHIBITION USING VARIOUS GLIOBLASTOMA AND HEPATOCELLULAR CARCINOMA MODELS - STUDYING THE MECHANISMS RESPONSIBLE FOR PHENOTYPIC SWITCHING (E-MT/M-ET) AND EVALUATING THE ROLE OF CHROMOSOME INSTABILITY IN TUMOR PROGRESSION - INVESTIGATING THE ROLES OF MIG-6 AND THE MECHANISMS OF ITS ACTION IN CANCER DEVELOPMENT AND IN THE MAINTENANCE OF JOINT HOMEOSTASIS - PLANNING FURTHER IN VIVO DRUG COMBINATION STUDIES FOR DEVELOPING BETTER THERAPEUTIC STRATEGIES THAT WILL BE MORE EFFECTIVE THAN C-MET INHIBITOR AS A SINGLE AGENT IN TREATING MET-EXPRESSING TUMORS - INVESTIGATING HOW MET SIGNALING INTERACTS WITH THE ERBB FAMILY OF RECEPTORS IN THE PROGRESSION AND THERAPEUTIC RESISTANCE OF ERBB2-POSITIVE AND TRIPLE-NEGATIVE BREAST CANCERS - USING OUR UNIQUE HUMAN-HGF TRANSGENIC SCID MOUSE MODEL TO EXPLORE THE EFFECTIVENESS OF MET TARGETED THERAPY IN TREATING HUMAN CANCERS SUCH AS NON-SMALL CELL LUNG CANCER AND THE POTENTIAL MET DRUG RESISTANCE MECHANISM LINE 4C - PROGRAM SERVICE ACTIVITY #3 THE LABORATORY OF STRUCTURAL SCIENCES IS FOCUSED ON STUDYING THE STRUCTURES AND FUNCTIONS OF PROTEIN/ LIGAND COMPLEXES THAT PLAY KEY ROLES IN MAJOR HORMONE SIGNALING PATHWAYS. THE LABORATORY ALSO WORKS ON EXPLORING THE STRUCTURAL INFORMATION TO DEVELOP THERAPEUTIC AGENTS FOR TREATING HUMAN DISEASE, INCLUDING CANCER AND DIABETES. LAB STUDIES USE MULTIDISCIPLINARY APPROACHES, INCLUDING MOLECULAR AND CELLULAR BIOLOGY, BIOCHEMISTRY, ANIMAL PHYSIOLOGY, AND X-RAY CRYSTALLOGRAPHY. RESEARCH IN THIS GROUP CURRENTLY FOCUSES ON THREE AREAS: NUCLEAR HORMONE RECEPTORS, THE MET TYROSINE KINASE RECEPTOR, AND G PROTEIN-COUPLED RECEPTORS. THESE PROTEINS, BEYOND THEIR FUNDAMENTAL ROLES IN BIOLOGY, ARE IMPORTANT DRUG TARGETS. RECENT DISCOVERIES INCLUDE: THE CRYSTAL STRUCTURES OF EACH PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS (PPAR) LIGAND-BINDING DOMAIN (LBD) BOUND TO MANY DIVERSE LIGANDS IN ORDER TO UNDERSTAND THE MOLECULAR BASIS OF LIGAND-MEDIATED SIGNALING BY PPAR'S; THE CRYSTAL STRUCTURES OF THE RECEPTORS BOUND TO COACTIVATORS OR CO-REPRESSORS, WHICH PROVIDES A FRAMEWORK FOR UNDERSTANDING THE MECHANISMS OF PPAR AGONISTS AND ANTAGONIST AND THE RECRUITMENT OF COACTIVATORS AND CO-REPRESSORS; ANDROGEN RECEPTOR (AR) MUTATION IN PROSTATE CANCERS OFTEN RESULTS IN ENHANCED BINDING TO A PARTICULAR COACTIVATOR, SRC-3 (WHICH IS ALSO CALLED "AMPLIFIED IN BREAST CANCER1", OR AIB1); AND RETINOIC ACID IS A LOW-AFFINITY LIGAND FOR COUP-TF, WHICH IS ONE OF THE MOST CONSERVED NUCLEAR RECEPTORS AND HAS ESSENTIAL ROLES IN ANGIOGENESIS, HEART DEVELOPMENT, CNS ACTIVITY, AND METABOLIC HOMEOSTASIS. FOR THE MET TYROSINE KINASE RECEPTOR, THE LAB HAS DETERMINED THE CRYSTAL STRUCTURE OF THE C-MET LIGAND, HEPATOCYTE GROWTH FACTOR, NK1 AND NK2 VARIANTS, AND FOR G PROTEIN-COUPLED RECEPTORS (GPCRS) WE HAVE DETERMINED CRYSTAL STRUCTURES OF THE LIGAND BINDING DOMAIN OF THE PTH RECEPTOR AND THE CRF RECEPTOR, AND WE ARE DEVELOPING HORMONE ANALOGS FOR TREATING OSTEOPOROSIS, DEPRESSION, AND DIABETES. IN ADDITION, WE ARE DEVELOPING A MAMMALIAN OVEREXPRESSION SYSTEM AND PLAN TO USE IT TO EXPRESS FULL-LENGTH GPCRS FOR CRYSTALLIZATION AND STRUCTURAL STUDIES. THE LAB ALSO STUDIES THE PLANT HORMONE ABSCISIC ACID (ABA) SIGNALING PATHWAYS, WITH THEIR STRUCTURES OF ABA RECEPTORS BEING HIGHLIGHTED AS ONE OF TOP 10 SCIENTIFIC BREAKTHROUGHS BY SCIENCE IN 2009. | |
| FORM 990, PART III, LINE 4D | IN 2012, VARI RESEARCHERS FOUND WAYS TO POTENTIALLY DIAGNOSE AND FIGHT SEVERAL DIFFERENT TYPES OF CANCER AND NEURODEGENERATIVE DISEASES. BELOW ARE EXAMPLES OF SIGNIFICANT RESEARCH FINDINGS: - VARI RESEARCHERS PROVIDED A MORE COMPLETE UNDERSTANDING OF THE BIOLOGY OF TYPE 2 PAPILLARY RENAL CELL CARCINOMA (PRCC2), AN AGGRESSIVE TYPE OF KIDNEY CANCER WITH NO EFFECTIVE TREATMENT, WHICH WILL HELP DEVELOP EFFECTIVE TREATMENT STRATEGIES. - VARI RESEARCHERS INTEGRATED GENE EXPRESSION PROFILING AND RNAI SCREENING DATA TO IDENTIFY GENES INVOLVED IN THE DEVELOPMENT AND PROGRESSION OF CLEAR CELL RENAL CELL CARCINOMA (CCRCC), A SUB TYPE THAT ACCOUNTS FOR 75 PERCENT OF ALL KIDNEY CANCERS AND THAT, UNLIKE PRCC2, RESPONDS FAVORABLY TO DRUGS TARGETING VASCULAR ENDOTHELIAL GROWTH FACTOR. THE STUDY INDICATED THAT CELL-CYCLE-RELATED GENES, IN PARTICULAR PLK1, WERE ASSOCIATED WITH DISEASE AGGRESSIVENESS AND HIGHLIGHT PLK1 AS A PROMISING POTENTIAL THERAPEUTIC TARGET. - VARI RESEARCHERS DETERMINED THAT COMBINATION DRUG THERAPY MAY BE NEEDED TO COMBAT NON-SMALL CELL LUNG CANCER (NSCLC). THEY FOUND THAT PROTEIN SIGNALING PLAYS A CRITICAL ROLE IN TUMOR CELL DEVELOPMENT, ACTIVATING THE STAT3 GENE, AN OVERACTIVE GENE IN SEVERAL TYPES OF CANCER, IN SOME NSCLC CELL LINES. THIS TYPE OF PROTEIN-GENE SIGNALING PLAYS A CRUCIAL ROLE IN TUMOR CELL BEHAVIOR THAT MAY NOT BE IMPACTED BY DRUGS THAT SELECTIVELY TARGET THESE MUTATIONS. - AN INTERNATIONAL TEAM LED BY THE NCCS-VARI TRANSLATIONAL RESEARCH LABORATORY REPORTED THE FIRST COMPREHENSIVE GENOMIC STUDY OF BILE DUCT CANCER, DISCOVERING CRITICAL GENES RESPONSIBLE FOR THE ONSET OF THE DISEASE. IDENTIFYING NEW GENES FREQUENTLY MUTATED IN BILE DUCT CANCERS WILL LEAD TO A BETTER UNDERSTANDING OF HOW BILE DUCT CANCERS DEVELOP. - VARI BECAME PART OF A NATIONAL RESEARCH EFFORT TO HELP PATIENTS WITH MULTIPLE MYELOMA BY EXTRACTING AND STORING DNA AND RNA FROM TISSUE SAMPLES FOR NEXT-GENERATION SEQUENCING ANALYSIS. RESEARCHERS HOPE TO SHED NEW LIGHT ON THE RELATIONSHIP BETWEEN MOLECULAR VARIATION AND PATIENTS' RESPONSE OR RESISTANCE TO THERAPY. - VARI RESEARCHERS AND COLLEAGUES IN CHINA DEMONSTRATED THAT AN ELEVATED PERCENTAGE OF TH17 CELLS IN THE TUMOR MICROENVIRONMENT PLAY A CRUCIAL ROLE IN THE PRODUCTION AND ACCUMULATION OF A CELL CORRELATED TO SURVIVAL OF PATIENTS WITH NASOPHARYNGEAL CARCINOMA (NPC), A CANCER OF THE HEAD AND NECK. - RESEARCHERS FROM LUND UNIVERSITY IN SWEDEN, UNDER THE DIRECTION OF DR. PATRIK BRUNDIN, DIRECTOR OF THE VARI CENTER FOR NEURODEGENERATIVE SCIENCE ANNOUNCED A BREAKTHROUGH IN RESTORING NEURON FUNCTION TO PARTS OF THE BRAIN DAMAGED BY HUNTINGTON'S DISEASE BY SUCCESSFULLY TRANSPLANTING INDUCED PLURIPOTENT STEM (IPS) CELLS INTO ANIMAL MODELS. THEY ALSO PUBLISHED A STUDY DETAILING HOW PARKINSON'S DISEASE SPREADS THROUGH THE BRAIN. - VARI RESEARCHERS IDENTIFIED PLASMA-BASED MOLECULAR BIOMARKERS. MOLECULAR BIOMARKERS WOULD BE HIGHLY USEFUL CLINICAL TOOLS TO DETECT PARKINSON'S PRIOR TO THE DEVELOPMENT OF THE DISEASE'S MOTOR SYMPTOMS. - VARI SCIENTISTS MAPPING THE STRUCTURE OF THE RECEPTOR FOR ABSCISIC ACID (ABA), A PLANT HORMONE THAT CONTROLS GROWTH, DEVELOPMENT AND RESPONSES TO ENVIRONMENTAL STRESS, DISCOVERED THAT ABA REGULATES THE STRESS-RESPONSE PATHWAY BY AFFECTING AN ENZYME BELONGING TO THE PHOSPHATASE FAMILY. | |
| FORM 990, PART X, LINE 33 | VARI NET ASSETS SHOULD BE CONSIDERED ON A CONSOLIDATED BASIS WITH VAN ANDEL INSTITUTE (VAI), VAN ANDEL EDUCATION INSTITUTE (VAEI), AND THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE (TGEN), RELATED PARTIES. ON A CONSOLIDATED BASIS, NET ASSETS ARE $1,024,607,000 PER AUDITED FINANCIAL STATEMENTS. THE NEGATIVE NET ASSET BALANCE AT VARI IS DUE TO VAI FUNDING EXPENSES ON A CASH BASIS AND THE UNREALIZED LOSS RECORDED IN ASSOCIATION WITH THE INTEREST RATE SWAP. | |
| FORM 990, PART IX, COLUMN D | FUNDRAISING EXPENSES AT VARI WERE INCURRED TO SUPPORT THE MISSION OF THE RESEARCH INSTITUTE THROUGH GRANT SOLICITATION AND EXTRAMURAL PROPOSAL PREPARATION. |
Schedule R IRS990ScheduleR
Form990 Schedule R Part I Form990ScheduleRPartI (4 entries)
| Address Line1AddressUS/AddressLine1 | CityAddressUS/City | StateAddressUS/State | ZIP CodeAddressUS/ZIPCode | EINEIN | Primary ActivitiesPrimaryActivities | Legal Domicile StateLegalDomicileState | Total IncomeTotalIncome | EOY AssetsEOYAssets | Business Name Line1DirectControllingEntityName/BusinessNameLine1 |
|---|---|---|---|---|---|---|---|---|---|
| VAI INNOVATIONS LLC | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000823 | LICENSING INTELLECTUAL PROPERTY OF VARI | MI | -551461 | 10174 | VAN ANDEL RESEARCH INSTITUTE |
| VARI INTERNATIONAL | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 262615936 | BIOMEDICAL RESEARCH | MI | 147 | 172379 | VAN ANDEL RESEARCH INSTITUTE |
| BOSTWICK EVENT MANAGEMENT | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000823 | EVENT MANAGEMENT | MI | 1659 | 117458 | VAN ANDEL RESEARCH INSTITUTE |
| VARI-CLINXUS LLC | |||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 274015168 | CLINICAL TRIALS | MI | -95413 | 45834 | VAN ANDEL RESEARCH INSTITUTE |
Form990 Schedule R Part II Form990ScheduleRPartII (5 entries)
| Address Line1AddressUS/AddressLine1 | CityAddressUS/City | StateAddressUS/State | ZIP CodeAddressUS/ZIPCode | EINEIN | Primary ActivitiesPrimaryActivities | Legal Domicile StateLegalDomicileState | Exempt Code SectionExemptCodeSection | Public Charity StatusPublicCharityStatus | Direct Controlling Entity NADirectControllingEntityNA | Controlled OrgControlledOrg | Business Name Line1DirectControllingEntityName/BusinessNameLine1 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| VAN ANDEL INSTITUTE | |||||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000820 | SUPPORTING ORGANIZATION FOR VARI AND VAEI | MI | 501(C)(3) | 11C | N/A | 0 | |
| VAN ANDEL EDUCATION INSTITUTE | |||||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | MI | 495032518 | 522000824 | OPERATING A SCHOOL | MI | 501(C)(3) | 2 | 1 | VAN ANDEL INSTITUTE | |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | |||||||||||
| 333 BOSTWICK AVENUE NE | GRAND RAPIDS | ME | 495032518 | 203340886 | OPERATING A SCHOOL | MI | 501(C)(3) | 2 | 1 | VAN ANDEL EDUCATION INSTITUTE | |
| THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | |||||||||||
| 445 N 5TH STREET SUITE 600 | PHOENIX | AZ | 85004 | 753065445 | MEDICAL RESEARCH | AZ | 501(C)(3) | 7 | 1 | VAN ANDEL RESEARCH INSTITUTE | |
| TGEN RESEARCH INSTITUTE FOUNDATION | |||||||||||
| 400 E VAN BUREN SUITE 850 | PHOENIX | AZ | 85004 | 331092191 | FUNDRAISING | AZ | 501(C)(3) | 7 | 1 | THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | |
Form990 Schedule R Part IV Form990ScheduleRPartIV
Name Of Related Org NameOfRelatedOrg
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | TRANSMED SYSTEMS INC | BusinessNameLine1 |
Address US AddressUS
| Field | Value | IRS element (for citing) |
|---|---|---|
| Address Line1 | 21170 CANYON OAK WAY | AddressLine1 |
| City | CUPERTINO | City |
| State | CA | State |
| ZIP Code | 95014 | ZIPCode |
| Field | Value | IRS element (for citing) |
|---|---|---|
| EIN | 272358859 | EIN |
| Primary Activity | PERSONALIZED MEDICINE SOFTWARE AND SERVICES | PrimaryActivity |
| Legal Domicile State | DE | LegalDomicileState |
Direct Controlling Entity Name DirectControllingEntityName
| Field | Value | IRS element (for citing) |
|---|---|---|
| Business Name Line1 | VAI INNOVATIONS LLC | BusinessNameLine1 |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Type Of Entity | C | TypeOfEntity |
| Share Of Total Income | -1355136 | ShareOfTotalIncome |
| Share Of EOY Assets | 776718 | ShareOfEOYAssets |
| Percentage Ownership | 0.53370 | PercentageOwnership |
| Field | Value | IRS element (for citing) |
|---|---|---|
| Receipt Of Int Ann Rents Royalties | 1 | ReceiptOfIntAnnRentsRoyalties |
| Gift Grant Or Cap Contr To Other Org | 1 | GiftGrantOrCapContrToOtherOrg |
| Gift Grant Or Cap Contr Fr Other Org | 1 | GiftGrantOrCapContrFrOtherOrg |
| Loans Or Guarantees To Other Org | 0 | LoansOrGuaranteesToOtherOrg |
| Loans Or Guarantees From Other Org | 1 | LoansOrGuaranteesFromOtherOrg |
| Sale Of Assets To Other Org | 0 | SaleOfAssetsToOtherOrg |
| Purchase Of Assets From Other Org | 0 | PurchaseOfAssetsFromOtherOrg |
| Exchange Of Assets | 0 | ExchangeOfAssets |
| Rental Of Facilities To Other Orgs | 0 | RentalOfFacilitiesToOtherOrgs |
| Rental Of Facilities Fr Other Orgs | 0 | RentalOfFacilitiesFrOtherOrgs |
| Perform Of Services For Other Orgs | 1 | PerformOfServicesForOtherOrgs |
| Perform Of Services By Other Orgs | 0 | PerformOfServicesByOtherOrgs |
| Sharing Of Facilities | 1 | SharingOfFacilities |
| Sharing Of Paid Employees | 1 | SharingOfPaidEmployees |
| Reimbursement Paid To Other Org | 1 | ReimbursementPaidToOtherOrg |
| Reimbursement Paid By Other Org | 1 | ReimbursementPaidByOtherOrg |
| Other Transfer To Other Org | 1 | OtherTransferToOtherOrg |
| Other Transfer From Other Org | 0 | OtherTransferFromOtherOrg |
Transactions Related Orgs Table TransactionsRelatedOrgsTable (21 entries)
| Transaction TypeTransactionType | Amount InvolvedAmountInvolved | Method Of Amt DeterminationMethodOfAmtDetermination |
|---|---|---|
| VAN ANDEL INSTITUTE | ||
| C | 47258660 | ACTUAL AMOUNT PAID |
| VAN ANDEL INSTITUTE | ||
| E | 52530000 | TOTAL RECORDED |
| VAN ANDEL INSTITUTE | ||
| M | 297514 | ALLOCATION BASED ON SQ. FOOTAGE |
| VAN ANDEL INSTITUTE | ||
| O | 122179 | ACTUAL AMOUNT PAID |
| VAN ANDEL INSTITUTE | ||
| N | 150926 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL EDUCATION INSTITUTE | ||
| O | 113347 | ACTUAL AMOUNT PAID |
| VAN ANDEL EDUCATION INSTITUTE | ||
| P | 1185642 | ACTUAL AMOUNT RECEIVED |
| VAN ANDEL EDUCATION INSTITUTE | ||
| N | 64648 | APPORTIONED SALARY AND BENEFITS |
| VAN ANDEL EDUCATION INSTITUTE | ||
| N | 35015 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| N | 16904 | ALLOCATION BASED ON EFFORT |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| M | 178508 | ALLOCATION BASED ON SQ. FOOTAGE |
| VAN ANDEL INSTITUTE GRADUATE SCHOOL | ||
| P | 421046 | ACTUAL AMOUNT RECEIVED |
| THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE | ||
| Q | 8000000 | ACTUAL AMOUNT PAID |
| THE TRANSLATIONAL GENOMIC RESEARCH INSTITUTE | ||
| N | 392174 | NET AMOUNT INVOICED |
| THE TRANSLATIONAL GENOMIC RESEARCH INSTITUTE | ||
| C | 767513 | ACTUAL GRANT TOTAL |
| THE TRANSLATIONAL GENOMIC RESEARCH INSTITUTE | ||
| K | 87486 | ACTUAL AMOUNT PAID |
| THE TRANSLATIONAL GENOMIC RESEARCH INSTITUTE | ||
| B | 25237 | ACCRUED PER CONTRACT |
| THE TRANSLATIONAL GENOMIC RESEARCH INSTITUTE | ||
| O | 136 | ACTUAL AMOUNT PAID |
| TRANSMED SYSTEMS INC | ||
| A | 291667 | ACCRUED PER CONTRACT |
| TRANSMED SYSTEMS INC | ||
| B | 712941 | ACTUAL AMOUNT PAID |
| VAN ANDEL INSTITUTE | ||
| P | 3518531 | ACTUAL AMOUNT PAID |
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