SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE: Form 990, tax year 2022

View the entire original 990 at ProPublica ↗

Organization: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (EIN 51-0197108)
Tax period: 2022-07-01 to 2023-06-30
Filed: 2024-05-13
IRS object ID: 202441349349304654
Schema version: 2022v5.0
Source: Download XML · Original 990 at ProPublica

Every field in the e-filed return. Faint text is the IRS element name, for citing.

Return header
Form 990
Schedule A
Schedule B
Schedule C
Schedule D
Schedule F
Schedule J
Schedule K
Schedule M
Schedule O

Return header ReturnHeader

Field	Value	IRS element (for citing)
Return	2024-05-13T11:37:00+00:00	ReturnTs
Tax Period End	2023-06-30	TaxPeriodEndDt

Preparer Firm PreparerFirmGrp

Field	Value	IRS element (for citing)
Preparer Firm EIN	346565596	PreparerFirmEIN

Preparer Firm Name PreparerFirmName

Field	Value	IRS element (for citing)
Business Name Line1	ERNST & YOUNG US LLP	BusinessNameLine1Txt

Preparer US Address PreparerUSAddress

Field	Value	IRS element (for citing)
Address Line1	2323 VICTORY AVENUE	AddressLine1Txt
City	DALLAS	CityNm
State Abbreviation	TX	StateAbbreviationCd
ZIP	75219	ZIPCd

Field	Value	IRS element (for citing)
Return Type	990	ReturnTypeCd
Tax Period Begin	2022-07-01	TaxPeriodBeginDt

Filer Filer

Field	Value	IRS element (for citing)
EIN	510197108	EIN

Business Name BusinessName

Field	Value	IRS element (for citing)
Business Name Line1	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Business Name Control	SANF	BusinessNameControlTxt
Phone	8586463100	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Business Officer BusinessOfficerGrp

Field	Value	IRS element (for citing)
Person	Robin Ryan	PersonNm
Person Title	CFO & TREASURER	PersonTitleTxt
Phone	8587955244	PhoneNum
Signature	2024-05-13	SignatureDt
Discuss With Paid Preparer	Yes (true)	DiscussWithPaidPreparerInd

Signing Officer SigningOfficerGrp

Person Full Name PersonFullName

Field	Value	IRS element (for citing)
Person First	Robin	PersonFirstNm
Person Last	Ryan	PersonLastNm

Field	Value	IRS element (for citing)
SSN	999009999	SSN

Preparer Person PreparerPersonGrp

Field	Value	IRS element (for citing)
Preparer Person	Patrick Shields	PreparerPersonNm
PTIN	P01508556	PTIN
Phone	2149698000	PhoneNum

Field	Value	IRS element (for citing)
Tax	2022	TaxYr
Build TS	2023-04-26 12:10:37Z	BuildTS

Form 990 IRS990

Principal Ofcr Business Name PrincipalOfcrBusinessName

Field	Value	IRS element (for citing)
Business Name Line1	David Brenner	BusinessNameLine1Txt

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES ROAD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Field	Value	IRS element (for citing)
Gross Receipts	$164,318,347	GrossReceiptsAmt
Group Return For Affiliates	false	GroupReturnForAffiliatesInd
Organization501c3	Yes (X)	Organization501c3Ind
Website Address	WWW.SBPDISCOVERY.ORG	WebsiteAddressTxt
Type Of Organization Corp	Yes (X)	TypeOfOrganizationCorpInd
Formation	1976	FormationYr
Legal Domicile State	CA	LegalDomicileStateCd
Activity Or Mission	SEE SCHEDULE O	ActivityOrMissionDesc
Voting Members Governing Body	14	VotingMembersGoverningBodyCnt
Voting Members Independent	12	VotingMembersIndependentCnt
Total Employee	624	TotalEmployeeCnt
Total Volunteers	15	TotalVolunteersCnt
Total Gross UBI	$1,344,299	TotalGrossUBIAmt
Net Unrelated Bus Txbl Incm	$49,256	NetUnrelatedBusTxblIncmAmt
PY Contributions Grants	$82,047,252	PYContributionsGrantsAmt
CY Contributions Grants	$104,423,511	CYContributionsGrantsAmt
PY Program Service Revenue	$806,855	PYProgramServiceRevenueAmt
CY Program Service Revenue	$1,012,265	CYProgramServiceRevenueAmt
PY Investment Income	$19,247,469	PYInvestmentIncomeAmt
CY Investment Income	$5,926,237	CYInvestmentIncomeAmt
PY Other Revenue	$5,201,458	PYOtherRevenueAmt
CY Other Revenue	$5,857,091	CYOtherRevenueAmt
PY Total Revenue	$107,303,034	PYTotalRevenueAmt
CY Total Revenue	$117,219,104	CYTotalRevenueAmt
PY Grants And Similar Paid	$0	PYGrantsAndSimilarPaidAmt
CY Grants And Similar Paid	$0	CYGrantsAndSimilarPaidAmt
PY Benefits Paid To Members	$0	PYBenefitsPaidToMembersAmt
CY Benefits Paid To Members	$0	CYBenefitsPaidToMembersAmt
PY Salaries Comp Emp Bnft Paid	$59,973,447	PYSalariesCompEmpBnftPaidAmt
CY Salaries Comp Emp Bnft Paid	$58,193,349	CYSalariesCompEmpBnftPaidAmt
PY Total Prof Fndrsng Expns	$0	PYTotalProfFndrsngExpnsAmt
CY Total Prof Fndrsng Expns	$0	CYTotalProfFndrsngExpnsAmt
CY Total Fundraising Expense	$1,889,633	CYTotalFundraisingExpenseAmt
PY Other Expenses	$46,807,632	PYOtherExpensesAmt
CY Other Expenses	$45,204,369	CYOtherExpensesAmt
PY Total Expenses	$106,781,079	PYTotalExpensesAmt
CY Total Expenses	$103,397,718	CYTotalExpensesAmt
PY Revenues Less Expenses	$521,955	PYRevenuesLessExpensesAmt
CY Revenues Less Expenses	$13,821,386	CYRevenuesLessExpensesAmt
Total Assets BOY	$289,830,509	TotalAssetsBOYAmt
Total Assets EOY	$308,605,226	TotalAssetsEOYAmt
Total Liabilities BOY	$70,200,509	TotalLiabilitiesBOYAmt
Total Liabilities EOY	$65,071,238	TotalLiabilitiesEOYAmt
Net Assets Or Fund Balances BOY	$219,630,000	NetAssetsOrFundBalancesBOYAmt
Net Assets Or Fund Balances EOY	$243,533,988	NetAssetsOrFundBalancesEOYAmt
Mission	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE CONDUCTS WORLD-CLASS, COLLABORATIVE RESEARCH DEDICATED TO FINDING CURES FOR HUMAN DISEASE, IMPROVING THE QUALITY OF LIFE, AND THUS CREATING A LEGACY FOR ITS EMPLOYEES, PARTNERS, DONORS, AND COMMUNITY.	MissionDesc
Significant New Program Srvc	false	SignificantNewProgramSrvcInd
Significant Change	false	SignificantChangeInd
Expense	$84,954,108	ExpenseAmt
Grant	$0	GrantAmt
Revenue	$1,348,911	RevenueAmt
Desc	See Schedule O	Desc
Total Program Service Expenses	$84,954,108	TotalProgramServiceExpensesAmt
Described In Section501c3	Yes (true)	DescribedInSection501c3Ind
Schedule B Required	Yes (true)	ScheduleBRequiredInd
Political Campaign Acty	false	PoliticalCampaignActyInd
Lobbying Activities	Yes (true)	LobbyingActivitiesInd
Donor Advised Fund	false	DonorAdvisedFundInd
Conservation Easements	false	ConservationEasementsInd
Collections Of Art	false	CollectionsOfArtInd
Credit Counseling	false	CreditCounselingInd
Donor Rstr Or Quasi Endowments	Yes (true)	DonorRstrOrQuasiEndowmentsInd
Report Land Building Equipment	Yes (true)	ReportLandBuildingEquipmentInd
Report Investments Other Sec	Yes (true)	ReportInvestmentsOtherSecInd
Report Program Related Invst	false	ReportProgramRelatedInvstInd
Report Other Assets	false	ReportOtherAssetsInd
Report Other Liabilities	Yes (true)	ReportOtherLiabilitiesInd
Include FIN48 Footnote	Yes (true)	IncludeFIN48FootnoteInd
Independent Audit Fincl Stmt	Yes (true)	IndependentAuditFinclStmtInd
Consolidated Audit Fincl Stmt	false	ConsolidatedAuditFinclStmtInd
School Operating	false	SchoolOperatingInd
Foreign Office	Yes (true)	ForeignOfficeInd
Foreign Activities	Yes (true)	ForeignActivitiesInd
More Than5000 K To Org	false	MoreThan5000KToOrgInd
More Than5000 K To Individuals	false	MoreThan5000KToIndividualsInd
Professional Fundraising	false	ProfessionalFundraisingInd
Fundraising Activities	false	FundraisingActivitiesInd
Gaming Activities	false	GamingActivitiesInd
Operate Hospital	false	OperateHospitalInd
Grants To Organizations	false	GrantsToOrganizationsInd
Grants To Individuals	false	GrantsToIndividualsInd
Schedule J Required	Yes (true)	ScheduleJRequiredInd
Tax Exempt Bonds	Yes (true)	TaxExemptBondsInd
Invest Tax Exempt Bonds	false	InvestTaxExemptBondsInd
Escrow Account	false	EscrowAccountInd
On Behalf Of Issuer	false	OnBehalfOfIssuerInd
Engaged In Excess Benefit Trans	false	EngagedInExcessBenefitTransInd
PY Excess Benefit Trans	false	PYExcessBenefitTransInd
Loan Outstanding	false	LoanOutstandingInd
Grant To Related Person	false	GrantToRelatedPersonInd
Business Rln With Org Mem	false	BusinessRlnWithOrgMemInd
Business Rln With Fam Mem	false	BusinessRlnWithFamMemInd
Business Rln With35 Ctrl Ent	false	BusinessRlnWith35CtrlEntInd
Deductible Non Cash Contri	Yes (true)	DeductibleNonCashContriInd
Deductible Art Contribution	false	DeductibleArtContributionInd
Terminate Operations	false	TerminateOperationsInd
Partial Liquidation	false	PartialLiquidationInd
Disregarded Entity	false	DisregardedEntityInd
Related Entity	false	RelatedEntityInd
Related Organization Ctrl Ent	false	RelatedOrganizationCtrlEntInd
Trnsfr Exmpt Non Chrtbl Rltd Org	false	TrnsfrExmptNonChrtblRltdOrgInd
Activities Conducted Prtshp	false	ActivitiesConductedPrtshpInd
Schedule O Required	Yes (true)	ScheduleORequiredInd
IRP Document	193	IRPDocumentCnt
IRP Document W2 G	0	IRPDocumentW2GCnt
Backup Wthld Compliance	Yes (true)	BackupWthldComplianceInd
Employee	624	EmployeeCnt
Employment Tax Returns Filed	Yes (true)	EmploymentTaxReturnsFiledInd
Unrelated Bus Incm Over Limit	Yes (true)	UnrelatedBusIncmOverLimitInd
Form990 T Filed	Yes (true)	Form990TFiledInd
Foreign Financial Account	false	ForeignFinancialAccountInd
Prohibited Tax Shelter Trans	false	ProhibitedTaxShelterTransInd
Taxable Party Notification	false	TaxablePartyNotificationInd
Nondeductible Contributions	false	NondeductibleContributionsInd
Quid Pro Quo Contributions	false	QuidProQuoContributionsInd
Form8282 Property Disposed Of	false	Form8282PropertyDisposedOfInd
Rcv Fnds To Pay Prsnl Bnft Cntrct	false	RcvFndsToPayPrsnlBnftCntrctInd
Pay Premiums Prsnl Bnft Cntrct	false	PayPremiumsPrsnlBnftCntrctInd
Indoor Tanning Services	false	IndoorTanningServicesInd
Subj To Tax Rmnrtn Ex Prcht Pymt	Yes (true)	SubjToTaxRmnrtnExPrchtPymtInd
Subject To Excs Tax Net Invst Inc	false	SubjectToExcsTaxNetInvstIncInd
Info In Schedule O Part VI	Yes (X)	InfoInScheduleOPartVIInd
Governing Body Voting Members	14	GoverningBodyVotingMembersCnt
Independent Voting Member	12	IndependentVotingMemberCnt
Family Or Business Rln	false	FamilyOrBusinessRlnInd
Delegation Of Mgmt Duties	false	DelegationOfMgmtDutiesInd
Change To Org Documents	false	ChangeToOrgDocumentsInd
Material Diversion Or Misuse	false	MaterialDiversionOrMisuseInd
Members Or Stockholders	false	MembersOrStockholdersInd
Election Of Board Members	false	ElectionOfBoardMembersInd
Decisions Subject To Approva	false	DecisionsSubjectToApprovaInd
Minutes Of Governing Body	Yes (true)	MinutesOfGoverningBodyInd
Minutes Of Committees	Yes (true)	MinutesOfCommitteesInd
Officer Mailing Address	false	OfficerMailingAddressInd
Local Chapters	false	LocalChaptersInd
Form990 Provided To Gvrn Body	Yes (true)	Form990ProvidedToGvrnBodyInd
Conflict Of Interest Policy	Yes (true)	ConflictOfInterestPolicyInd
Annual Disclosure Covered Prsn	Yes (true)	AnnualDisclosureCoveredPrsnInd
Regular Monitoring Enfrc	Yes (true)	RegularMonitoringEnfrcInd
Whistleblower Policy	Yes (true)	WhistleblowerPolicyInd
Document Retention Policy	Yes (true)	DocumentRetentionPolicyInd
Compensation Process CEO	Yes (true)	CompensationProcessCEOInd
Compensation Process Other	Yes (true)	CompensationProcessOtherInd
Investment In Joint Venture	false	InvestmentInJointVentureInd
States Where Copy Of Return Is Fld	CA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CO	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	CT	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	DC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	FL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	GA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	AL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	HI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	IL	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	KS	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	KY	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	ME	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MD	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MN	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MS	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	MO	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NH	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NJ	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NM	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NY	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	NC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	ND	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OH	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	OR	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	PA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	RI	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	SC	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	TN	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	UT	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	VA	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	AR	StatesWhereCopyOfReturnIsFldCd
States Where Copy Of Return Is Fld	WI	StatesWhereCopyOfReturnIsFldCd
Upon Request	Yes (X)	UponRequestInd

Books In Care Of Detail BooksInCareOfDetail

Business Name BusinessName

Field	Value	IRS element (for citing)
Business Name Line1	ROBIN RYAN	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Phone	8586463100	PhoneNum

US Address USAddress

Field	Value	IRS element (for citing)
Address Line1	10901 NORTH TORREY PINES RD	AddressLine1Txt
City	LA JOLLA	CityNm
State Abbreviation	CA	StateAbbreviationCd
ZIP	92037	ZIPCd

Form990 Part VII Section A Form990PartVIISectionAGrp (27 entries)

TitleTitleTxt	Average Hours Per WeekAverageHoursPerWeekRt	Average Hours Per Week Rltd OrgAverageHoursPerWeekRltdOrgRt	Individual Trustee Or DirectorIndividualTrusteeOrDirectorInd	OfficerOfficerInd	Reportable Comp From OrgReportableCompFromOrgAmt	Reportable Comp From Rltd OrgReportableCompFromRltdOrgAmt	Other CompensationOtherCompensationAmt	Highest Compensated EmployeeHighestCompensatedEmployeeInd	Former Ofcr Director TrusteeFormerOfcrDirectorTrusteeInd
DAVID BRENNER MD
CEO AND PRESIDENT (AS OF 09/2022)	50.0	0.0	Yes (X)	Yes (X)	$252,575	$0	$91,847
DONALD B KEARNS PHD
VICE CHAIRMAN	1.0	0.0	Yes (X)	Yes (X)	$0	$0	$0
WILLIAM GERHART
CHAIRMAN	1.0	0.0	Yes (X)	Yes (X)	$0	$0	$0
DANIEL J EPSTEIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DAVID L SZEKERES
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DAVID W DOWN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
DOUGLAS H OBENSHAIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
JAMES C BLAIR PHD
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
JAMES E JARDON II
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
JAMES M MYERS
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
KAREN S HAYNES
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
KATHERINE CHAPIN
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
KAZUMI SHIOSAKI PHD
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
MATTHEW BROWNE
TRUSTEE (PART YEAR)	1.0	0.0	Yes (X)		$0	$0	$0
NICHOLAS COSFORD
PROFESSOR & TRUSTEE	50.0	0.0	Yes (X)		$243,409	$0	$65,028
STUART A TANZ
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
WILLIAM A ROPER
TRUSTEE	1.0	0.0	Yes (X)		$0	$0	$0
ADRIENNE CROWN
GENERAL COUNSEL & SECRETARY	50.0	0.0		Yes (X)	$213,256	$0	$31,665
AMAR DUVVUR
CFO (THRU 08/22)	50.0	0.0		Yes (X)	$463,528	$0	$29,585
ROBIN RYAN
CFO & TREASURER	50.0	0.0		Yes (X)	$272,541	$0	$39,563
SCOTT TOCHER
CORPORATE SECRETARY (PART YEAR)	50.0	0.0		Yes (X)	$236,687	$0	$9,983
CARL WARE PHD
CENTER DIRECTOR, IIDC	50.0	0.0			$445,990	$0	$58,835	Yes (X)
CHRISTINE DITTMER
CHIEF DEVELOPMENT OFFICER	50.0	0.0			$500,215	$0	$32,612	Yes (X)
JAMEY MARTH PHD
PROGRAM DIRECTOR	50.0	0.0			$494,296	$0	$58,042	Yes (X)
KRISTIINA VUORI MD PHD
PROFESSOR & FORMER PRESIDENT	50.0	0.0			$710,798	$0	$55,967	Yes (X)
ZE'EV RONAI PHD
CENTER DIRECTOR	50.0	0.0			$440,033	$0	$67,963	Yes (X)
C RANDAL MILLS PHD
FORMER CEO	0.0	0.0			$4,979,417	$0	$46,642		Yes (X)

Field	Value	IRS element (for citing)
Total Reportable Comp From Org	$9,252,745	TotalReportableCompFromOrgAmt
Tot Reportable Comp Rltd Org	$0	TotReportableCompRltdOrgAmt
Total Other Compensation	$587,732	TotalOtherCompensationAmt
Indiv Rcvd Greater Than100 K	114	IndivRcvdGreaterThan100KCnt
Former Ofcr Employees Listed	Yes (true)	FormerOfcrEmployeesListedInd
Total Comp Greater Than150 K	Yes (true)	TotalCompGreaterThan150KInd
Compensation From Other Srcs	false	CompensationFromOtherSrcsInd

Contractor Compensation ContractorCompensationGrp (5 entries)

Address Line1ContractorAddress/USAddress/AddressLine1Txt	CityContractorAddress/USAddress/CityNm	State AbbreviationContractorAddress/USAddress/StateAbbreviationCd	ZIPContractorAddress/USAddress/ZIPCd	ServicesServicesDesc	CompensationCompensationAmt
Universal Protection Service LP
PO Box 31001-2374	Pasadena	CA	921102374	Building security services	$374,203
Deloitte & Touche LLP
PO Box 844708	Dallas	TX	75284	Audit services	$373,337
Wilson Sonsini Goodrich & Rosati
PO Box 742866	Los Angeles	CA	900742866	Legal services	$372,919
JAGGAER LLC
PO BOX 952218	DALLAS	TX	753952218	Digital procurement services	$224,706
Divigard & Associates LLC
PO Box 881	Northampton	MA	010610881	Consulting services	$185,088

Field	Value	IRS element (for citing)
Cntrct Rcvd Greater Than100 K	11	CntrctRcvdGreaterThan100KCnt
Government Grants	$68,831,594	GovernmentGrantsAmt
All Other Contributions	$35,591,917	AllOtherContributionsAmt
Noncash Contributions	$42,857	NoncashContributionsAmt
Total Contributions	$104,423,511	TotalContributionsAmt

Program Service Revenue ProgramServiceRevenueGrp

Field	Value	IRS element (for citing)
Desc	Shared Services Revenue	Desc
Business	541990	BusinessCd
Total Revenue Column	$1,012,265	TotalRevenueColumnAmt
Related Or Exempt Func Income	$1,012,265	RelatedOrExemptFuncIncomeAmt

Total Oth Program Service Rev TotalOthProgramServiceRevGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$0	TotalRevenueColumnAmt
Related Or Exempt Func Income	$0	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$0	UnrelatedBusinessRevenueAmt
Exclusion	$0	ExclusionAmt

Field	Value	IRS element (for citing)
Total Program Service Revenue	$1,012,265	TotalProgramServiceRevenueAmt

Investment Income InvestmentIncomeGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$5,285,480	TotalRevenueColumnAmt
Unrelated Business Revenue	$54,014	UnrelatedBusinessRevenueAmt
Exclusion	$5,231,466	ExclusionAmt

Royalties Revenue RoyaltiesRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$3,774,742	TotalRevenueColumnAmt
Exclusion	$3,774,742	ExclusionAmt

Gross Rents GrossRentsGrp

Field	Value	IRS element (for citing)
Real	$455,418	RealAmt

Less Rental Expenses LessRentalExpensesGrp

Field	Value	IRS element (for citing)
Real	$0	RealAmt

Rental Income Or Loss RentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Real	$455,418	RealAmt
Personal	$0	PersonalAmt

Net Rental Income Or Loss NetRentalIncomeOrLossGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$455,418	TotalRevenueColumnAmt
Exclusion	$455,418	ExclusionAmt

Gross Amount Sales Assets GrossAmountSalesAssetsGrp

Field	Value	IRS element (for citing)
Securities	$47,740,000	SecuritiesAmt

Less Cost Oth Basis Sales Expnss LessCostOthBasisSalesExpnssGrp

Field	Value	IRS element (for citing)
Securities	$47,099,243	SecuritiesAmt

Gain Or Loss GainOrLossGrp

Field	Value	IRS element (for citing)
Securities	$640,757	SecuritiesAmt
Other	$0	OtherAmt

Net Gain Or Loss Investments NetGainOrLossInvestmentsGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$640,757	TotalRevenueColumnAmt
Exclusion	$640,757	ExclusionAmt

Other Revenue Misc OtherRevenueMiscGrp (3 entries)

DescDesc	BusinessBusinessCd	Total Revenue ColumnTotalRevenueColumnAmt	Unrelated Business RevenueUnrelatedBusinessRevenueAmt	Related Or Exempt Func IncomeRelatedOrExemptFuncIncomeAmt
Research	541700	$1,290,285	$1,290,285
Equipment Proceeds	541990	$283,000		$283,000
Sale of Reagents	541990	$40,961		$40,961

Miscellaneous Revenue MiscellaneousRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$12,685	TotalRevenueColumnAmt
Related Or Exempt Func Income	$12,685	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$0	UnrelatedBusinessRevenueAmt
Exclusion	$0	ExclusionAmt

Field	Value	IRS element (for citing)
Other Revenue Total	$1,626,931	OtherRevenueTotalAmt

Total Revenue TotalRevenueGrp

Field	Value	IRS element (for citing)
Total Revenue Column	$117,219,104	TotalRevenueColumnAmt
Related Or Exempt Func Income	$1,348,911	RelatedOrExemptFuncIncomeAmt
Unrelated Business Revenue	$1,344,299	UnrelatedBusinessRevenueAmt
Exclusion	$10,102,383	ExclusionAmt

Grants To Domestic Orgs GrantsToDomesticOrgsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Grants To Domestic Individuals GrantsToDomesticIndividualsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Foreign Grants ForeignGrantsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Benefits To Members BenefitsToMembersGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt

Comp Current Ofcr Directors CompCurrentOfcrDirectorsGrp

Field	Value	IRS element (for citing)
Total	$1,054,509	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$937,603	ManagementAndGeneralAmt
Fundraising	$116,906	FundraisingAmt

Comp Disqual Persons CompDisqualPersonsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Other Salaries And Wages OtherSalariesAndWagesGrp

Field	Value	IRS element (for citing)
Total	$44,095,826	TotalAmt
Program Services	$34,324,157	ProgramServicesAmt
Management And General	$8,614,372	ManagementAndGeneralAmt
Fundraising	$1,157,297	FundraisingAmt

Pension Plan Contributions PensionPlanContributionsGrp

Field	Value	IRS element (for citing)
Total	$2,808,206	TotalAmt
Program Services	$2,186,957	ProgramServicesAmt
Management And General	$574,808	ManagementAndGeneralAmt
Fundraising	$46,441	FundraisingAmt

Other Employee Benefits OtherEmployeeBenefitsGrp

Field	Value	IRS element (for citing)
Total	$7,401,327	TotalAmt
Program Services	$5,628,997	ProgramServicesAmt
Management And General	$1,597,200	ManagementAndGeneralAmt
Fundraising	$175,130	FundraisingAmt

Payroll Taxes PayrollTaxesGrp

Field	Value	IRS element (for citing)
Total	$2,833,481	TotalAmt
Program Services	$2,134,035	ProgramServicesAmt
Management And General	$634,473	ManagementAndGeneralAmt
Fundraising	$64,973	FundraisingAmt

Fees For Services Management FeesForServicesManagementGrp

Field	Value	IRS element (for citing)
Total	$531,870	TotalAmt
Program Services	$174,399	ProgramServicesAmt
Management And General	$300,165	ManagementAndGeneralAmt
Fundraising	$57,306	FundraisingAmt

Fees For Services Legal FeesForServicesLegalGrp

Field	Value	IRS element (for citing)
Total	$100,052	TotalAmt
Program Services	$58,449	ProgramServicesAmt
Management And General	$41,603	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Accounting FeesForServicesAccountingGrp

Field	Value	IRS element (for citing)
Total	$440,906	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$440,906	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Lobbying FeesForServicesLobbyingGrp

Field	Value	IRS element (for citing)
Total	$1,500	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$1,500	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Prof Fundraising FeesForServicesProfFundraising

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Fundraising	$0	FundraisingAmt

Fees For Srvc Invst Mgmnt Fees FeesForSrvcInvstMgmntFeesGrp

Field	Value	IRS element (for citing)
Total	$553,900	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$553,900	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Fees For Services Other FeesForServicesOtherGrp

Field	Value	IRS element (for citing)
Total	$904,348	TotalAmt
Program Services	$721,866	ProgramServicesAmt
Management And General	$149,758	ManagementAndGeneralAmt
Fundraising	$32,724	FundraisingAmt

Advertising AdvertisingGrp

Field	Value	IRS element (for citing)
Total	$15	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$15	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Office Expenses OfficeExpensesGrp

Field	Value	IRS element (for citing)
Total	$5,365,932	TotalAmt
Program Services	$4,919,280	ProgramServicesAmt
Management And General	$385,735	ManagementAndGeneralAmt
Fundraising	$60,917	FundraisingAmt

Information Technology InformationTechnologyGrp

Field	Value	IRS element (for citing)
Total	$1,494,399	TotalAmt
Program Services	$1,053,828	ProgramServicesAmt
Management And General	$407,175	ManagementAndGeneralAmt
Fundraising	$33,396	FundraisingAmt

Royalties RoyaltiesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Occupancy OccupancyGrp

Field	Value	IRS element (for citing)
Total	$6,742,030	TotalAmt
Program Services	$6,300,154	ProgramServicesAmt
Management And General	$415,040	ManagementAndGeneralAmt
Fundraising	$26,836	FundraisingAmt

Travel TravelGrp

Field	Value	IRS element (for citing)
Total	$275,140	TotalAmt
Program Services	$243,583	ProgramServicesAmt
Management And General	$28,472	ManagementAndGeneralAmt
Fundraising	$3,085	FundraisingAmt

Pymt Travel Entrtnmnt Pub Ofcl PymtTravelEntrtnmntPubOfclGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Conferences Meetings ConferencesMeetingsGrp

Field	Value	IRS element (for citing)
Total	$1,277,926	TotalAmt
Program Services	$665,430	ProgramServicesAmt
Management And General	$605,750	ManagementAndGeneralAmt
Fundraising	$6,746	FundraisingAmt

Interest InterestGrp

Field	Value	IRS element (for citing)
Total	$1,319,092	TotalAmt
Program Services	$1,233,879	ProgramServicesAmt
Management And General	$79,937	ManagementAndGeneralAmt
Fundraising	$5,276	FundraisingAmt

Payments To Affiliates PaymentsToAffiliatesGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Depreciation Depletion DepreciationDepletionGrp

Field	Value	IRS element (for citing)
Total	$5,180,844	TotalAmt
Program Services	$4,846,162	ProgramServicesAmt
Management And General	$313,959	ManagementAndGeneralAmt
Fundraising	$20,723	FundraisingAmt

Insurance InsuranceGrp

Field	Value	IRS element (for citing)
Total	$220,382	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$220,382	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Other Expenses OtherExpensesGrp (4 entries)

DescDesc	TotalTotalAmt	Program ServicesProgramServicesAmt	Management And GeneralManagementAndGeneralAmt	FundraisingFundraisingAmt
RESEARCH SUPPLIES & SVCS	$9,633,741	$9,631,881	$1,860
SCIENTIFIC COLLABORATIONS	$10,383,161	$10,383,161	$0	$0
RECRUITMENT	$262,717	$174,340	$49,521	$38,856
TUITION FEES	$126,457	$126,457	$0	$0

All Other Expenses AllOtherExpensesGrp

Field	Value	IRS element (for citing)
Total	$389,957	TotalAmt
Program Services	$147,093	ProgramServicesAmt
Management And General	$199,843	ManagementAndGeneralAmt
Fundraising	$43,021	FundraisingAmt

Total Functional Expenses TotalFunctionalExpensesGrp

Field	Value	IRS element (for citing)
Total	$103,397,718	TotalAmt
Program Services	$84,954,108	ProgramServicesAmt
Management And General	$16,553,977	ManagementAndGeneralAmt
Fundraising	$1,889,633	FundraisingAmt

Total Joint Costs TotalJointCostsGrp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt
Program Services	$0	ProgramServicesAmt
Management And General	$0	ManagementAndGeneralAmt
Fundraising	$0	FundraisingAmt

Cash Non Interest Bearing CashNonInterestBearingGrp

Field	Value	IRS element (for citing)
BOY	$9,217,022	BOYAmt
EOY	$3,884,263	EOYAmt

Savings And Temp Cash Invst SavingsAndTempCashInvstGrp

Field	Value	IRS element (for citing)
BOY	$5,520	BOYAmt
EOY	$3,005	EOYAmt

Pledges And Grants Receivable PledgesAndGrantsReceivableGrp

Field	Value	IRS element (for citing)
BOY	$6,105,380	BOYAmt
EOY	$8,358,514	EOYAmt

Accounts Receivable AccountsReceivableGrp

Field	Value	IRS element (for citing)
BOY	$2,229,543	BOYAmt
EOY	$728,432	EOYAmt

Receivables From Officers Etc ReceivablesFromOfficersEtcGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Rcvbl From Disqualified Prsn RcvblFromDisqualifiedPrsnGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Oth Notes Loans Receivable Net OthNotesLoansReceivableNetGrp

Field	Value	IRS element (for citing)
BOY	$2,482,064	BOYAmt
EOY	$3,332,786	EOYAmt

Inventories For Sale Or Use InventoriesForSaleOrUseGrp

Field	Value	IRS element (for citing)
BOY	$59,562	BOYAmt
EOY	$318,694	EOYAmt

Prepaid Expenses Defrd Charges PrepaidExpensesDefrdChargesGrp

Field	Value	IRS element (for citing)
BOY	$8,294,257	BOYAmt
EOY	$9,710,993	EOYAmt

Field	Value	IRS element (for citing)
Land Bldg Equip Cost Or Other Bss	$165,322,233	LandBldgEquipCostOrOtherBssAmt
Land Bldg Equip Accum Deprec	$113,214,928	LandBldgEquipAccumDeprecAmt

Land Bldg Equip Basis Net LandBldgEquipBasisNetGrp

Field	Value	IRS element (for citing)
BOY	$52,186,438	BOYAmt
EOY	$52,107,305	EOYAmt

Investments Pub Traded Sec InvestmentsPubTradedSecGrp

Field	Value	IRS element (for citing)
BOY	$174,605,755	BOYAmt
EOY	$193,702,694	EOYAmt

Investments Other Securities InvestmentsOtherSecuritiesGrp

Field	Value	IRS element (for citing)
BOY	$33,340,626	BOYAmt
EOY	$35,094,304	EOYAmt

Investments Program Related InvestmentsProgramRelatedGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt

Other Assets Total OtherAssetsTotalGrp

Field	Value	IRS element (for citing)
BOY	$1,304,342	BOYAmt
EOY	$1,364,236	EOYAmt

Total Assets TotalAssetsGrp

Field	Value	IRS element (for citing)
BOY	$289,830,509	BOYAmt
EOY	$308,605,226	EOYAmt

Accounts Payable Accr Expnss AccountsPayableAccrExpnssGrp

Field	Value	IRS element (for citing)
BOY	$15,387,946	BOYAmt
EOY	$14,782,361	EOYAmt

Deferred Revenue DeferredRevenueGrp

Field	Value	IRS element (for citing)
BOY	$7,819,616	BOYAmt
EOY	$7,432,976	EOYAmt

Tax Exempt Bond Liabilities TaxExemptBondLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$43,306,541	BOYAmt
EOY	$39,230,617	EOYAmt

Loans From Officers Directors LoansFromOfficersDirectorsGrp

Field	Value	IRS element (for citing)
BOY	$0	BOYAmt
EOY	$0	EOYAmt

Other Liabilities OtherLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$3,686,406	BOYAmt
EOY	$3,625,284	EOYAmt

Total Liabilities TotalLiabilitiesGrp

Field	Value	IRS element (for citing)
BOY	$70,200,509	BOYAmt
EOY	$65,071,238	EOYAmt

Field	Value	IRS element (for citing)
Organization Follows FASB117	Yes (X)	OrganizationFollowsFASB117Ind

No Donor Restriction Net Assets NoDonorRestrictionNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$179,779,759	BOYAmt
EOY	$183,976,210	EOYAmt

Donor Restriction Net Assets DonorRestrictionNetAssetsGrp

Field	Value	IRS element (for citing)
BOY	$39,850,241	BOYAmt
EOY	$59,557,778	EOYAmt

Total Net Assets Fund Balance TotalNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$219,630,000	BOYAmt
EOY	$243,533,988	EOYAmt

Tot Liab Net Assets Fund Balance TotLiabNetAssetsFundBalanceGrp

Field	Value	IRS element (for citing)
BOY	$289,830,509	BOYAmt
EOY	$308,605,226	EOYAmt

Field	Value	IRS element (for citing)
Reconcilation Revenue Expnss	$13,821,386	ReconcilationRevenueExpnssAmt
Net Unrlzd Gains Losses Invst	$10,082,602	NetUnrlzdGainsLossesInvstAmt
Other Changes In Net Assets	$0	OtherChangesInNetAssetsAmt
Method Of Accounting Accrual	Yes (X)	MethodOfAccountingAccrualInd
Accountant Compile Or Review	false	AccountantCompileOrReviewInd
FS Audited	Yes (true)	FSAuditedInd

FS Audited Basis FSAuditedBasisGrp

Field	Value	IRS element (for citing)
Separate Basis Fincl Stmt	Yes (X)	SeparateBasisFinclStmtInd

Field	Value	IRS element (for citing)
Audit Committee	Yes (true)	AuditCommitteeInd
Federal Grant Audit Required	Yes (true)	FederalGrantAuditRequiredInd
Federal Grant Audit Performed	Yes (true)	FederalGrantAuditPerformedInd

Schedule A IRS990ScheduleA

Field	Value	IRS element (for citing)
Public Organization170	Yes (X)	PublicOrganization170Ind

Gifts Grants Contri Rcvd170 GiftsGrantsContriRcvd170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$108,300,329	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$100,963,692	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$111,444,313	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$82,047,252	CurrentTaxYearMinus1YearAmt
Current Tax Year	$104,423,511	CurrentTaxYearAmt
Total	$507,179,097	TotalAmt

Tax Rev Levied Orgnztnl Bnft170 TaxRevLeviedOrgnztnlBnft170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Govt Furn Srvc Fclts Vl170 GovtFurnSrvcFcltsVl170Grp

Field	Value	IRS element (for citing)
Total	$0	TotalAmt

Total Calendar Year170 TotalCalendarYear170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$108,300,329	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$100,963,692	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$111,444,313	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$82,047,252	CurrentTaxYearMinus1YearAmt
Current Tax Year	$104,423,511	CurrentTaxYearAmt
Total	$507,179,097	TotalAmt

Field	Value	IRS element (for citing)
Substantial Contributors Tot	$29,223,216	SubstantialContributorsTotAmt
Public Support Total170	$477,955,881	PublicSupportTotal170Amt

Gross Investment Income170 GrossInvestmentIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$5,942,288	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$3,455,907	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$5,237,546	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$7,508,720	CurrentTaxYearMinus1YearAmt
Current Tax Year	$9,515,640	CurrentTaxYearAmt
Total	$31,660,101	TotalAmt

Unrelated Business Net Incm170 UnrelatedBusinessNetIncm170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$0	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$0	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$0	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$0	CurrentTaxYearMinus1YearAmt
Total	$0	TotalAmt

Other Income170 OtherIncome170Grp

Field	Value	IRS element (for citing)
Current Tax Year Minus4 Years	$0	CurrentTaxYearMinus4YearsAmt
Current Tax Year Minus3 Years	$0	CurrentTaxYearMinus3YearsAmt
Current Tax Year Minus2 Years	$0	CurrentTaxYearMinus2YearsAmt
Current Tax Year Minus1 Year	$0	CurrentTaxYearMinus1YearAmt
Current Tax Year	$0	CurrentTaxYearAmt
Total	$0	TotalAmt

Field	Value	IRS element (for citing)
Total Support	$538,839,198	TotalSupportAmt
Gross Receipts Rltd Activities	$5,081,916	GrossReceiptsRltdActivitiesAmt
Public Support CY170	0.8870	PublicSupportCY170Pct
Public Support PY170	0.9418	PublicSupportPY170Pct
Thirty Thr Pct Suprt Tests CY170	Yes (X)	ThirtyThrPctSuprtTestsCY170Ind

Schedule B IRS990ScheduleB

Contributor Information ContributorInformationGrp

Field	Value	IRS element (for citing)
Contributor	RESTRICTED	ContributorNum

Contributor Business Name ContributorBusinessName

Field	Value	IRS element (for citing)
Business Name Line1	RESTRICTED	BusinessNameLine1

Contributor US Address ContributorUSAddress

Field	Value	IRS element (for citing)
Address Line1	RESTRICTED	AddressLine1
Address Line2	RESTRICTED	AddressLine2
City	RESTRICTED	City
State	RESTRICTED	State
ZIP Code	RESTRICTED	ZIPCode

Field	Value	IRS element (for citing)
Total Contributions	RESTRICTED	TotalContributionsAmt

Schedule C IRS990ScheduleC

Field	Value	IRS element (for citing)
Volunteers	false	VolunteersInd
Paid Staff Or Management	false	PaidStaffOrManagementInd
Media Advertisements	false	MediaAdvertisementsInd
Mailings Members	false	MailingsMembersInd
Publications Or Broadcast	false	PublicationsOrBroadcastInd
Grants Other Organizations	false	GrantsOtherOrganizationsInd
Direct Contact Legislators	false	DirectContactLegislatorsInd
Rallies Demonstrations	false	RalliesDemonstrationsInd
Other Activities	Yes (true)	OtherActivitiesInd
Other Activities	$1,500	OtherActivitiesAmt
Total Lobbying Expenditures	$1,500	TotalLobbyingExpendituresAmt
Not Described Section501c3	false	NotDescribedSection501c3Ind

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule C, Part II-B, Line 1 DETAILED DESCRIPTION OF THE LOBBYING ACTIVITY	FormAndLineReferenceDesc
Explanation	DUES TO A RESEARCH AND BIOMEDICAL ORGANIZATION, A PORTION OF WHICH IS CONSIDERED LOBBYING.	ExplanationTxt

Schedule D IRS990ScheduleD

CY Endwmt Fund CYEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$20,548,272	BeginningYearBalanceAmt
Contributions	$2,825	ContributionsAmt
Investment Earnings Or Losses	$1,615,074	InvestmentEarningsOrLossesAmt
Other Expenditures	$953,749	OtherExpendituresAmt
End Year Balance	$21,212,422	EndYearBalanceAmt

CY Minus1 Yr Endwmt Fund CYMinus1YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$23,536,441	BeginningYearBalanceAmt
Contributions	$1,805	ContributionsAmt
Investment Earnings Or Losses	-$2,492,894	InvestmentEarningsOrLossesAmt
Other Expenditures	$497,080	OtherExpendituresAmt
End Year Balance	$20,548,272	EndYearBalanceAmt

CY Minus2 Yr Endwmt Fund CYMinus2YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$19,914,852	BeginningYearBalanceAmt
Contributions	$3,687	ContributionsAmt
Investment Earnings Or Losses	$4,470,604	InvestmentEarningsOrLossesAmt
Other Expenditures	$852,702	OtherExpendituresAmt
End Year Balance	$23,536,441	EndYearBalanceAmt

CY Minus3 Yr Endwmt Fund CYMinus3YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$29,814,541	BeginningYearBalanceAmt
Contributions	$1,005	ContributionsAmt
Investment Earnings Or Losses	$724,999	InvestmentEarningsOrLossesAmt
Other Expenditures	$10,625,693	OtherExpendituresAmt
End Year Balance	$19,914,852	EndYearBalanceAmt

CY Minus4 Yr Endwmt Fund CYMinus4YrEndwmtFundGrp

Field	Value	IRS element (for citing)
Beginning Year Balance	$29,799,743	BeginningYearBalanceAmt
Contributions	$4,000	ContributionsAmt
Investment Earnings Or Losses	$1,337,873	InvestmentEarningsOrLossesAmt
Other Expenditures	$1,327,075	OtherExpendituresAmt
End Year Balance	$29,814,541	EndYearBalanceAmt

Field	Value	IRS element (for citing)
Board Designated Balance EOY	0.0	BoardDesignatedBalanceEOYPct
Prmnnt Endowment Balance EOY	0.66	PrmnntEndowmentBalanceEOYPct
Term Endowment Balance EOY	0.34	TermEndowmentBalanceEOYPct
Endowments Held Unrelated Org	false	EndowmentsHeldUnrelatedOrgInd
Endowments Held Related Org	false	EndowmentsHeldRelatedOrgInd

Land LandGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$12,758,161	OtherCostOrOtherBasisAmt
Book Value	$12,758,161	BookValueAmt

Buildings BuildingsGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$92,177,238	OtherCostOrOtherBasisAmt
Depreciation	$61,309,090	DepreciationAmt
Book Value	$30,868,148	BookValueAmt

Equipment EquipmentGrp

Field	Value	IRS element (for citing)
Other Cost Or Other Basis	$60,386,834	OtherCostOrOtherBasisAmt
Depreciation	$51,905,838	DepreciationAmt
Book Value	$8,480,996	BookValueAmt

Field	Value	IRS element (for citing)
Total Book Value Land Buildings	$52,107,305	TotalBookValueLandBuildingsAmt

Other Securities OtherSecuritiesGrp (3 entries)

DescDesc	Book ValueBookValueAmt	Method ValuationMethodValuationCd
PRIVATE EQUITY LPS	$11,306,585	F
TOTAL RETURN HEDGE FUNDS	$1,792,263	F
SELECT EQUITY FUNDS	$21,995,456	F

Field	Value	IRS element (for citing)
Total Book Value Securities	$35,094,304	TotalBookValueSecuritiesAmt

Other Liabilities Org OtherLiabilitiesOrgGrp (2 entries)

DescDesc	AmtAmt
OPERATING LEASE LIABILITIES	$1,364,236
FINANCE LEASE LIABILITIES	$2,261,048

Field	Value	IRS element (for citing)
Total Liability	$3,625,284	TotalLiabilityAmt
Footnote Text	Yes (X)	FootnoteTextInd
Total Rev Etc Audited Fincl Stmt	$127,499,000	TotalRevEtcAuditedFinclStmtAmt
Net Unrealized Gains Invst	$10,082,602	NetUnrealizedGainsInvstAmt
Donated Services And Use Fclts	$751,308	DonatedServicesAndUseFcltsAmt
Other Revenue	$0	OtherRevenueAmt
Revenue Not Reported	$10,833,910	RevenueNotReportedAmt
Revenue Subtotal	$116,665,090	RevenueSubtotalAmt
Investment Expenses Not Incld	$553,900	InvestmentExpensesNotIncldAmt
Other Revenues Not Included	$114	OtherRevenuesNotIncludedAmt
Revenue Not Reported Fincl Stmt	$554,014	RevenueNotReportedFinclStmtAmt
Total Revenue Per Form990	$117,219,104	TotalRevenuePerForm990Amt
Tot Expns Etc Audited Fincl Stmt	$103,595,000	TotExpnsEtcAuditedFinclStmtAmt
Donated Services Use Fclts	$751,308	DonatedServicesUseFcltsAmt
Other Expenses Included	$0	OtherExpensesIncludedAmt
Expenses Not Reported	$751,308	ExpensesNotReportedAmt
Expenses Subtotal	$102,843,692	ExpensesSubtotalAmt
Investment Expenses Not Incld2	$553,900	InvestmentExpensesNotIncld2Amt
Other Expenses Not Included	$126	OtherExpensesNotIncludedAmt
Expenses Not Rpt Fincl Stmt	$554,026	ExpensesNotRptFinclStmtAmt
Total Expenses Per Form990	$103,397,718	TotalExpensesPerForm990Amt

Supplemental Information Detail SupplementalInformationDetail (4 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Schedule D, Part V, Line 4 Intended uses of endowment funds	INTENDED USES OF THE ORGANIZATION'S ENDOWMENT FUNDS: THE INSTITUTE'S ENDOWMENT FUNDS ARE ESTABLISHED FOR VARIOUS PURPOSES: SCIENTIFIC RESEARCH, CEO CHAIR, PRESIDENTIAL CHAIR, CANCER AND NEUROSCIENCE LEADERSHIP CHAIRS, AND UNRESTRICTED AS TO INCOME.
Schedule D, Part X, Line 2 FIN 48 (ASC 740) footnote	THE INSTITUTE HAS NO MATERIAL DEFERRED TAX ASSETS OR DEFERRED TAX LIABILITIES RECORDED AS OF JUNE 30, 2023 AND 2022. THE INSTITUTE DID NOT RECOGNIZE A CHANGE IN LIABILITY FOR UNRECOGNIZED TAX BENEFITS (THE DIFFERENCE BETWEEN A TAX POSITION TAKEN, OR EXPECTED TO BE TAKEN, IN A TAX RETURN AND THE BENEFIT RECOGNIZED AND MEASURED IN THE FINANCIAL STATEMENTS). THERE WERE NO LIABILITIES FOR UNRECOGNIZED TAX BENEFITS AT JUNE 30, 2023 AND 2022.
Schedule D, Part XI, Line 4(b) Other revenues in form 990 not in audited financial statements	ROUNDING - 114
Schedule D, Part XII, Line 4(b) Other expenses in form 990 not in audited financial statements	ROUNDING - 126

Schedule F IRS990ScheduleF

Account Activities Outside US AccountActivitiesOutsideUSGrp (7 entries)

RegionRegionTxt	EmployeeEmployeeCnt	Type Of Activities ConductedTypeOfActivitiesConductedTxt	Specific Services ProvidedSpecificServicesProvidedTxt	Region Total ExpendituresRegionTotalExpendituresAmt
Europe (Including Iceland and Greenland)	20	Program Services	SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$75,212
East Asia and the Pacific	2	Program Services	SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$3,319
Central America and the Caribbean	1	Program Services	SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$1,726
South America	1	Program Services	SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$1,057
North America (Canada & Mexico only)	2	Program Services	SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$4,367
Central America and the Caribbean	0	Investments		$13,098,848
Middle East and North Africa	1	Program Services	SPECIFIC PROGRAM SERVICE ACTIVITY IN ALL REGIONS IS AGENTS ATTENDING AND/OR SPEAKING AT SCIENTIFIC CONFERENCES AND COLLABORATIONS.	$1,535

Field	Value	IRS element (for citing)
Subtotal Offices	0	SubtotalOfficesCnt
Subtotal Employees	27	SubtotalEmployeesCnt
Continuation Total Office	0	ContinuationTotalOfficeCnt
Continuation Total Employee	0	ContinuationTotalEmployeeCnt
Total Office	0	TotalOfficeCnt
Total Employee	27	TotalEmployeeCnt
Subtotal Spent	$13,186,064	SubtotalSpentAmt
Continuation Spent	$0	ContinuationSpentAmt
Total Spent	$13,186,064	TotalSpentAmt
Transfer To Foreign Corp	Yes (true)	TransferToForeignCorpInd
Interest In Foreign Trust	false	InterestInForeignTrustInd
Foreign Corp Ownership	Yes (true)	ForeignCorpOwnershipInd
Passive Foreign Investmest Co	Yes (true)	PassiveForeignInvestmestCoInd
Foreign Partnership	Yes (true)	ForeignPartnershipInd
Boycott Countries	false	BoycottCountriesInd

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule F, Part I, Line 3 Method used to account for expenditures on org's financial statements	FormAndLineReferenceDesc
Explanation	CENTRAL AMERICA AND THE CARIBBEAN-Accrual,; EAST ASIA AND THE PACIFIC-Accrual; EUROPE (INCLUDING ICELAND AND GREENLAND)-Accrual; MIDDLE EAST AND NORTH AFRICA-Accrual; NORTH AMERICA (CANADA & MEXICO ONLY)-Accrual; SOUTH AMERICA-Accrual	ExplanationTxt

Schedule J IRS990ScheduleJ

Field	Value	IRS element (for citing)
First Class Or Charter Travel	Yes (X)	FirstClassOrCharterTravelInd
Idemnification Gross Up Pmts	Yes (X)	IdemnificationGrossUpPmtsInd
Club Dues Or Fees	Yes (X)	ClubDuesOrFeesInd
Written Policy Ref T And E Expnss	Yes (true)	WrittenPolicyRefTAndEExpnssInd
Substantiation Required	Yes (true)	SubstantiationRequiredInd
Compensation Committee	Yes (X)	CompensationCommitteeInd
Independent Consultant	Yes (X)	IndependentConsultantInd
Form990 Of Other Organizations	Yes (X)	Form990OfOtherOrganizationsInd
Written Employment Contract	Yes (X)	WrittenEmploymentContractInd
Compensation Survey	Yes (X)	CompensationSurveyInd
Board Or Committee Approval	Yes (X)	BoardOrCommitteeApprovalInd
Severance Payment	Yes (true)	SeverancePaymentInd
Supplemental Nonqual Rtr Plan	Yes (true)	SupplementalNonqualRtrPlanInd
Equity Based Comp Arrngm	false	EquityBasedCompArrngmInd
Comp Based On Revenue Of Flng Org	false	CompBasedOnRevenueOfFlngOrgInd
Comp Bsd On Rev Related Orgs	false	CompBsdOnRevRelatedOrgsInd
Comp Bsd Net Earns Flng Org	false	CompBsdNetEarnsFlngOrgInd
Comp Bsd Net Earns Rltd Orgs	false	CompBsdNetEarnsRltdOrgsInd
Any Non Fixed Payments	Yes (true)	AnyNonFixedPaymentsInd
Initial Contract Exception	false	InitialContractExceptionInd

Rltd Org Officer Trst Key Empl RltdOrgOfficerTrstKeyEmplGrp (12 entries)

TitleTitleTxt	Base Compensation Filing OrgBaseCompensationFilingOrgAmt	Compensation Based On Rltd OrgsCompensationBasedOnRltdOrgsAmt	Bonus Filing OrganizationBonusFilingOrganizationAmount	Bonus Related OrganizationsBonusRelatedOrganizationsAmt	Other Compensation Filing OrgOtherCompensationFilingOrgAmt	Other Compensation Rltd OrgsOtherCompensationRltdOrgsAmt	Deferred Compensation Flng OrgDeferredCompensationFlngOrgAmt	Deferred Comp Rltd OrgsDeferredCompRltdOrgsAmt	Nontaxable Benefits Filing OrgNontaxableBenefitsFilingOrgAmt	Nontaxable Benefits Rltd OrgsNontaxableBenefitsRltdOrgsAmt	Total Compensation Filing OrgTotalCompensationFilingOrgAmt	Total Compensation Rltd OrgsTotalCompensationRltdOrgsAmt	Comp Report Prior990 Filing OrgCompReportPrior990FilingOrgAmt	Comp Report Prior990 Rltd OrgsCompReportPrior990RltdOrgsAmt
DAVID BRENNER MD
CEO AND PRESIDENT (AS OF 09/2022)	$251,098	$0	$0	$0	$1,477	$0	$89,167	$0	$2,680	$0	$344,422	$0	$0	$0
NICHOLAS COSFORD
PROFESSOR & TRUSTEE	$240,624	$0	$0	$0	$2,785	$0	$24,270	$0	$40,758	$0	$308,437	$0	$0	$0
SCOTT TOCHER
CORPORATE SECRETARY (PART YEAR)	$228,094	$0	$7,291	$0	$1,302	$0	$0	$0	$9,983	$0	$246,670	$0	$0	$0
AMAR DUVVUR
CFO (THRU 08/22)	$358,275	$0	$103,840	$0	$1,413	$0	$0	$0	$29,585	$0	$493,113	$0	$0	$0
ROBIN RYAN
CFO & TREASURER	$268,084	$0	$0	$0	$4,457	$0	$25,900	$0	$13,663	$0	$312,104	$0	$0	$0
ADRIENNE CROWN
GENERAL COUNSEL & SECRETARY	$211,463	$0	$0	$0	$1,793	$0	$21,340	$0	$10,325	$0	$244,921	$0	$0	$0
CARL WARE PHD
CENTER DIRECTOR, IIDC	$417,296	$0	$0	$0	$28,694	$0	$30,500	$0	$28,335	$0	$504,825	$0	$0	$0
ZE'EV RONAI PHD
CENTER DIRECTOR	$430,192	$0	$0	$0	$9,841	$0	$30,500	$0	$37,463	$0	$507,996	$0	$0	$0
KRISTIINA VUORI MD PHD
PROFESSOR & FORMER PRESIDENT	$707,813	$0	$0	$0	$2,985	$0	$30,500	$0	$25,467	$0	$766,765	$0	$0	$0
JAMEY MARTH PHD
PROGRAM DIRECTOR	$451,816	$0	$35,006	$0	$7,474	$0	$30,500	$0	$27,542	$0	$552,338	$0	$0	$0
CHRISTINE DITTMER
CHIEF DEVELOPMENT OFFICER	$382,585	$0	$114,400	$0	$3,230	$0	$4,313	$0	$28,299	$0	$532,827	$0	$0	$0
C RANDAL MILLS PHD
FORMER CEO	$469,912	$0	$0	$0	$4,509,505	$0	$30,500	$0	$16,142	$0	$5,026,059	$0	$0	$0

Supplemental Information Detail SupplementalInformationDetail (7 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Schedule J, Part I, Line 1a First-class or charter travel	FIRST CLASS TRAVEL IS GENERALLY NOT PERMITTED, EXCEPT UNDER VERY LIMITED AND RARE CIRCUMSTANCES AND CONDITIONS, SUCH AS A MEDICAL CONDITION REQUIREMENT AND URGENT CIRCUMSTANCES. THIS WAS NOT TREATED AS TAXABLE COMPENSATION.
Schedule J, Part I, Line 1a Tax indemnification and gross-up payments	RELOCATION COSTS WERE GROSSED UP FOR CHIEF DEVELOPMENT OFFICER.
Schedule J, Part I, Line 1a Health or social club dues or initiation fees	HEALTH OR SOCIAL CLUB DUES ARE NEGOTIATED IN THE HIRING PROCESS FOR CERTAIN EMPLOYEES. THE AMOUNTS WERE TREATED AS TAXABLE COMPENSATION.
Schedule J, Part I, Line 4a Severance or change-of-control payment	C. Randal Mills, PHD received $4,508,750 in severance as part of his separation agreement.
Schedule J, Part I, Line 4b Supplemental nonqualified retirement plan	THE PARTICIPANT OF THE 457(F) DEFERRED COMPENSATION PLAN IS C. RANDAL MILLS. VESTING FOR C. RANDAL MILLS OCCURS THE EARLIEST OF 07/13/25, OR INVOLUNTARY TERMINATION WITHOUT CAUSE, OR PARTICIPANT'S RESIGNATION FOR GOOD CAUSE, OR THE DATE OF TERMINATION OF THE PLAN. DISTRIBUTION IS A ONE-TIME LUMP SUM PAYMENT UPON VESTING OF 100% OF THE VALUE OF THE PARTICIPANT'S INVESTMENT (COMPRISED OF INSTITUTE CONTRIBUTIONS TO THE CORPUS PLUS ANY INVESTMENT GAINS OR LOSSES THEREON). RANDALL MILLS RESIGNED FROM THE INSTITUTE PRIOR TO VESTING, FORFEITING THE BALANCE ATTRIBUTED TO HIS PLAN. A RETENTION BONUS WAS SET UP FOR THE NEW PRESIDENT AND CEO, DR. DAVID BRENNER, WHERE VESTING WILL OCCUR THE EARLIEST OF 09/14/27. DISTRIBUTION IS A ONE-TIME LUMP SUM PAYMENT UPON VESTING.
Schedule J, Part I, Line 7 Non-fixed payments	SOME SENIOR EXECUTIVES HAVE EMPLOYMENT AGREEMENTS STIPULATING A BONUS WILL BE PAID TO THEM PROVIDED CERTAIN GOALS OR ACCOMPLISHMENTS ARE ACHIEVED.
Schedule J, Part II, Column (C) RETIREMENT AND OTHER DEFERRED COMPENSATION	THE AMOUNT REPORTED IN SCHEDULE J, PART II, COLUMN C INCLUDES THE ACCRUAL OF $89,167 FOR THE PRESIDENT & CEO, DR. DAVID BRENNER FOR A RETENTION BONUS DESCRIBED IN PART I. THE AMOUNT IS NOT VESTED AND IS SUBJECT TO SUBSTANTIAL RISK OF FORFEITURE.

Schedule K IRS990ScheduleK

Tax Exempt Bonds Issues TaxExemptBondsIssuesGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd

Issuer Name IssuerName

Field	Value	IRS element (for citing)
Business Name Line1	COUNTY OF SAN DIEGO	BusinessNameLine1Txt

Field	Value	IRS element (for citing)
Bond Issuer EIN	956000934	BondIssuerEIN
CUSIP	79742YAQ5	CUSIPNum
Bond Issued	2015-11-12	BondIssuedDt
Issue Price	$61,963,256	IssuePriceAmt
Purpose	REFINANCE 2006 AND 2012 BONDS WITH ISSUE DATES OF 02/01/2006 AND 11/15/2012 , RESPECTIVELY.	PurposeDesc
Defeased	false	DefeasedInd
On Behalf Of Issuer	false	OnBehalfOfIssuerInd
Pool Financing	false	PoolFinancingInd

Tax Exempt Bonds Proceeds TaxExemptBondsProceedsGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Retired	$19,365,000	RetiredAmt
Bond Defeased	$0	BondDefeasedAmt
Total Proceeds	$61,963,256	TotalProceedsAmt
In Reserve Fund	$0	InReserveFundAmt
Capitalized Interest	$0	CapitalizedInterestAmt
Refunding Escrow	$0	RefundingEscrowAmt
Issuance Costs From Proceeds	$289,386	IssuanceCostsFromProceedsAmt
Credit Enhancement	$0	CreditEnhancementAmt
Working Capital Expenditures	$0	WorkingCapitalExpendituresAmt
Capital Expenditures	$0	CapitalExpendituresAmt
Other Spent Proceeds	$61,673,870	OtherSpentProceedsAmt
Unspent	$0	UnspentAmt
Substantial Completion	2015	SubstantialCompletionYr
Refunding Tax Exempt Bonds	Yes (true)	RefundingTaxExemptBondsInd
Refunding Taxable Bonds	false	RefundingTaxableBondsInd
Final Allocation Made	Yes (true)	FinalAllocationMadeInd
Adequate Books And Rec Maint	Yes (true)	AdequateBooksAndRecMaintInd

Tax Exempt Bonds Private Bus Use TaxExemptBondsPrivateBusUseGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Owning Bond Financed Property	false	OwningBondFinancedPropertyInd
Any Lease Arrangements	Yes (true)	AnyLeaseArrangementsInd
Mgmt Contract Bond Fincd Prop	Yes (true)	MgmtContractBondFincdPropInd
Engage Bond Counsel Contracts	Yes (true)	EngageBondCounselContractsInd
Any Research Agreements	Yes (true)	AnyResearchAgreementsInd
Engage Bond Counsel Research	Yes (true)	EngageBondCounselResearchInd
Private Bus Use By Others	0.0128	PrivateBusUseByOthersPct
Private Bus Concerning UBI	0.0	PrivateBusConcerningUBIPct
Total Private Business Use	0.0128	TotalPrivateBusinessUsePct
Bond Iss Meet Prvt Sec Pymt Test	false	BondIssMeetPrvtSecPymtTestInd
Change In Use Bond Financed Prop	false	ChangeInUseBondFinancedPropInd
Procs Nonqualified Bond Remdtd	Yes (true)	ProcsNonqualifiedBondRemdtdInd

Tax Exempt Bonds Arbitrage TaxExemptBondsArbitrageGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Form8038 T Filed	false	Form8038TFiledInd
Rebate Not Due Yet	false	RebateNotDueYetInd
Exception To Rebate	Yes (true)	ExceptionToRebateInd
No Rebate Due	false	NoRebateDueInd
Variable Rate Issue	Yes (true)	VariableRateIssueInd
Hedge Identified In Bks And Rec	false	HedgeIdentifiedInBksAndRecInd
Gross Proceeds Invested In GIC	false	GrossProceedsInvestedInGICInd
Gross Proceeds Invested	false	GrossProceedsInvestedInd
Written Proc To Monitor Reqs	Yes (true)	WrittenProcToMonitorReqsInd

Procedures Corrective Action ProceduresCorrectiveActionGrp

Field	Value	IRS element (for citing)
Bond Reference	A	BondReferenceCd
Procedures Corrective Action	Yes (true)	ProceduresCorrectiveActionInd

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule K, Part V Different Procedures to Undertake Corrective Action	FormAndLineReferenceDesc
Explanation	Issuer name: COUNTY OF SAN DIEGO FOR THE BOND ISSUES LISTED IN PART I, THE ALTERNATIVE PERIOD USED FOR THE REPORTING REQUIREMENTS IN THIS SECTION IS THE TWELVE MONTHS ENDED DECEMBER 31, 2022.	ExplanationTxt

Schedule M IRS990ScheduleM

Other Non Cash Contri Table OtherNonCashContriTableGrp (3 entries)

Non Cash CheckboxNonCashCheckboxInd	DescDesc	ContributionContributionCnt	Noncash Contributions Rpt F990NoncashContributionsRptF990Amt	Method Of Determining RevenuesMethodOfDeterminingRevenuesTxt
Yes (X)	LAB EQUIPMENT	4	$35,857	Market value
Yes (X)	FURNITURE	1	$5,000	Market value
Yes (X)	WINE FOR EVENTS	1	$2,000	Market value

Field	Value	IRS element (for citing)
Any Property That Must Be Held	false	AnyPropertyThatMustBeHeldInd
Review Process Unusual NC Gifts	Yes (true)	ReviewProcessUnusualNCGiftsInd
Third Parties Used	false	ThirdPartiesUsedInd

Supplemental Information Detail SupplementalInformationDetail

Field	Value	IRS element (for citing)
Form And Line Reference	Schedule M, Part I Explanations of reporting method for number of contributions	FormAndLineReferenceDesc
Explanation	Other - LAB EQUIPMENT reporting the contributions Other - FURNITURE reporting the contributions Other - WINE FOR EVENTS reporting the contributions	ExplanationTxt

Schedule O IRS990ScheduleO

Supplemental Information Detail SupplementalInformationDetail (12 entries)

Form And Line ReferenceFormAndLineReferenceDesc	ExplanationExplanationTxt
Form 990, Part I, Line 1 MISSION STATEMENT	SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE CONDUCTS WORLD-CLASS, COLLABORATIVE RESEARCH DEDICATED TO FINDING CURES FOR HUMAN DISEASE, IMPROVING THE QUALITY OF LIFE, AND THUS CREATING A LEGACY FOR ITS EMPLOYEES, PARTNERS, DONORS, AND COMMUNITY.
Form 990, Part III, Line 4a	Form 990 - Part III, line 4 Program Service Accomplishments Sanford Burnham Prebys is an independent nonprofit medical research organization dedicated to uncovering the origins of disease and launching bold new strategies that lay the foundation for cures. Our Institute has deep expertise in fundamental biology and is one of the most comprehensive drug discovery centers in the nonprofit world. Addiction Sanford Burnham Prebys researchers awarded $6.4M to advance treatment for substance use disorders. Nicholas Cosford, Ph.D., has been awarded $6.4 million from the National Institute on Drug Abuse to test new potential drugs to treat opioid and methamphetamine use disorders. The three-year project will be completed with partners from Wake Forest University School of Medicine and Camino Pharma, LLC. Cancer Computational biology superstar Sanju Sinha joins Sanford Burnham Prebys Sanju Sinha, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Cancer Molecular Therapeutics Program to continue his research on cancer development and drug discovery. Cells need more than an accumulation of mutations to become cancerous-they must be triggered into becoming cancerous by changes in their environment. One of the goals of Sinha's research is to identify these triggers and develop interventions against them. Reviving exhausted T cells to tackle immunotherapy-resistant cancers When the cells of our immune system are under constant stress due to cancer or other chronic diseases, the T cells of the immune system shut down in a process called T-cell exhaustion. Without active T cells, which kill tumor cells, it's impossible for our bodies to fight back against cancer. Researchers at Sanford Burnham Prebys, including Linda Bradley, Ph.D. and Jennifer Hope, Ph.D., described a new approach in Cell Reports that can reduce T-cell exhaustion even in melanoma tumors that are resistant to clinically approved immunotherapies. It can also help T cells from becoming exhausted. Taking a 3D view of the genome may help treat pediatric brain cancers Researchers at Sanford Burnham Prebys, led by Lukas Chavez, Ph.D., are leveraging the latest technology to take a never-before-seen look at ependymoma, one of the deadliest pediatric brain tumors. By visualizing how the genome is organized and arranged within tumor cells, they were able to reveal genes in tumors that may be future targets for therapy. The results appear in Nature Communications. Charles Spruck awarded $1.7M to advance "ancient virus" treatment for prostate cancer With the help of a grant from the U.S. Department of Defense for more than $1.7 million, Charles Spruck, Ph.D., will advance an innovative therapeutic approach for metastatic prostate cancer. Known as viral mimicry, the approach tricks the body into thinking that it has a viral infection, stimulating an immune response that can help the body fight cancer. Sanford Burnham Prebys researchers awarded $2.6M to discover pancreatic cancer drugs Cosimo Commisso, Ph.D., and Susanne Heynen-Genel, Ph.D., earned $2.6 million from the National Cancer Institute to advance a new treatment approach for pancreatic cancer. project will identify potential drugs that can manipulate the pH of cells to stop pancreatic tumors from growing. The promising approach would selectively kill pancreatic cancer cells without affecting surrounding healthy cells. New treatment approach for prostate cancer could stop resistance in its tracks For the first time, researchers have discovered that prostate cancer can be killed by targeting a single enzyme, called PI5P4K. The findings, published recently in Science Advances, could help address the growing threat of treatment resistance in prostate cancer and could also lead to improved treatments for other cancers, such as those affecting the breast, skin and pancreas. Brooke Emerling, Ph.D. is principal investigator. Childhood cancer trailblazer Lukas Chavez joins Sanford Burnham Prebys Lukas Chavez, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Tumor Initiation and Maintenance Program to continue his research on chromatin and gene regulation in childhood brain cancers. His research focuses on circular DNA fragments called ecDNA that are detached from normal chromosomes. These DNA circles allow cancer cells to produce and transcribe many copies of cancer-causing genes. Liver cancer study encourages caution with certain gene therapies Research led by Randal J. Kaufman, Ph.D., has found that misfolded proteins in liver cells contribute to the development of liver cancer, shedding new light on the mysterious origins of one of the world's deadliest diseases. The findings, published in the journal Molecular Therapy, could also help improve the safety of certain gene therapies for hemophilia. Zhouji Chen, Ph.D., was co-first author on the study. Sanford Burnham Prebys selected for participation in National Cancer Institute Chemical Biology Consortium For the third time, Sanford Burnham Prebys has been selected by the Frederick National Laboratory for Cancer Research, currently operated by Leidos Biomedical Research, Inc., supporting the National Cancer Institute Experimental Therapeutics (NExT) Program as a Center for the Chemical Biology Consortium. NExT works to bring life-changing therapies to people with cancer by supporting the most promising drug discovery and development research. Sanford Burnham Prebys was first selected for the consortium in 2009, and the selection was renewed for the first time in 2016. The current selection continues that designation for the next five years. Sanford Burnham Prebys Partners with nation's top cancer organizations to endorse initiative to increase lung cancer screening in the United States Lung cancer is the leading cause of cancer death in the United States, accounting for almost 25% of all cancer deaths. Sanford Burnham Prebys has partnered with more than 50 cancer organizations to issue a call to action urging individuals, providers and insurers to increase access to and utilization of low-dose computed tomography (CT) scans for those at high risk for lung cancer. Inhibiting key metabolic enzyme shows promise against melanoma Researchers at Sanford Burnham Prebys, led by Ze'ev Ronai, Ph.D., have shown for the first time that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth. Published in Nature Cell Biology, these findings could lead to a new class of drugs to selectively treat melanoma, the most severe form of skin cancer. Jianhua Zhao awarded $2.4M to reveal cancer targets through atomic-resolution imaging Jianhua Zhao, Ph.D., has been awarded a unique and competitive grant from the National Institute of General Medical Sciences, part of the National Institutes of Health. The five-year, $2.4 million grant aims to give researchers greater research flexibility to work on fundamental questions in biology. Zhao's research focuses on proteolysis, the process cells use to break down and recycle unused proteins. Proteolysis is essential for normal cell replication because our cells use the by-products of this process to know when it's time to replicate. Because cancer occurs when cellular replication spirals out of control, proteolysis is also an important process for cancer cells. Degenerative Diseases Randal J. Kaufman among the world's most highly cited researchers Sanford Burnham Prebys professor Randal J. Kaufman, Ph.D. was included on Clarivate's 2022 Highly Cited Researchers list, a global ranking of influential researchers based on the number of times their work has been cited in peer-reviewed publication over the last decade. Launched in 2014 by Clarivate, a global research analytics company, the list identifies scientists who have demonstrated exceptional influence in their respective fields. Timothy Huang awarded $2.8M to study well-known gene linked to Alzheimer's disease Timothy Huang, Ph.D., was awarded $2.8 million by the National Institute on Aging (NIA) to continue his work on Alzheimer's disease. One of the defining characteristics of Alzheimer's disease is the accumulation of proteins in the brain called amyloid proteins. Huang and his team will be studying a gene called SORLA, which helps regulate how much amyloid protein is able to accumulate. Development, Aging and Regeneration Program New algorithm can predict diabetic kidney disease Researchers from Sanford Burnham Prebys developed a computational approach to predict whether a person with type 2 diabetes will develop kidney disease, a frequent and dangerous complication of diabetes. Their results, published in Nature Communications, could help doctors prevent or better manage kidney disease in people with type 2 diabetes. Kevin Yip, Ph.D. was co-senior author of the study.
Form 990, Part III, Line 4a	(Continue) Heart attack study could change the game in regenerative medicine Sanford Burnham Prebys researchers, including Alexandre Colas, Ph.D., reported in Nature Communications that they have identified a group of proteins that could be the secret to cellular reprogramming, an emerging approach in regenerative medicine in which scientists transform cells to repair damaged or injured body tissues. The scientists were able to reprogram damaged heart cells to repair heart injuries in mice following a heart attack. Yu Xin (Will) Wang joins Sanford Burnham Prebys to advance regenerative medicine Molecular biologist Yu Xin (Will) Wang, Ph.D., has joined Sanford Burnham Prebys as an assistant professor in the Development, Aging, and Regeneration Program to uncover the ways muscle, nerve and immune cells work together to overcome disease. Wang studies the cell-cell interactions that mediate the function of tissue-specific stem cells during regeneration and disease. When these cell-to-cell interactions go awry, it can result in debilitating neuromuscular diseases, such as muscular dystrophy and myasthenia gravis. Research unlocks the circuitry of diabetes Research led by Pamela Itkin-Ansari, Ph.D., and Randal Kaufman Ph.D., has mapped out a network of biochemical interactions that help special cells in the pancreas called islet cells create insulin, shedding light on the origins of diabetes and revealing new targets for future treatments. The study, recently published in the journal JCEM, found that inflammation disrupts these interactions, triggering a snowball effect of cellular stress that damages pancreatic islets and makes it harder for the body to produce insulin. These findings open up a new world of potential targets to treat and possibly even cure diabetes. Erkki Ruoslahti wins America's top biomedical research award Distinguished Professor Emeritus Erkki Ruoslahti, M.D., Ph.D., has been announced as one of three winners of the Albert Lasker Basic Medical Research Award, the most prestigious American award for biomedical research, for his transformational research leading to the discovery of the cell adhesion receptors now known as integrins. Ruoslahti is the first Institute researcher to ever win the Lasker Award, known as "America's Nobel." Peter Adams and Bing Ren awarded $10.6M to create atlas of aging cells Sanford Burnham Prebys professor Peter Adams, Ph.D., and Bing Ren, Ph.D., from UC San Diego, were awarded a new grant from the National Institutes of Health to join a multi-institution initiative studying the process of aging. The $10.6 million grant was awarded as part of the Cellular Senescence Network program, which aims to create a comprehensive atlas of how and where aging cells accumulate in our tissues and open new avenues for treating age-related diseases. The goal is to create an invaluable resource for the aging research community that, over the long term, could significantly change the way scientists approach senescence-related diseases. Human Genetics Incurable liver disease may prove curable Research has shown for the first time that the effects of Alagille syndrome, an incurable genetic disorder that affects the liver, could be reversed with a single drug. The study, led by Duc Dong, Ph.D. and published in the Proceedings of the National Academy of Sciences, has the potential to transform treatment for this rare disease and may also have implications for more common diseases. Sanford Burnham Prebys announces start of Phase 2 clinical trial of DS-1211 in individuals with pseudoxanthoma elasticum A Phase 2 clinical trial has started of DS-1211 in individuals with pseudoxanthoma elasticum (PXE), a rare multisystem genetic disease that causes calcium deposits in soft tissue resulting in considerable morbidity. DS-1211 is a potential first-in-class small molecule developed through a research collaboration between Daiichi Sankyo and Sanford Burnham Prebys. The foundational science for DS-1211 was conducted by Jose Luis Millan, Ph.D. The Conrad Prebys Center for Chemical Genomics played a key role in the development of DS-1211 by leading the drug discovery effort. Immunity and Pathogenesis Pumping the brakes on autoimmune disease In a study published in Structure, researchers at Sanford Burnham Prebys have revealed the structure and function of a drug called LY3361237, which can reduce the harmful activity of the immune system to help treat autoimmune diseases. Their work laid the foundation for a new treatment that's currently in a Phase 2 clinical trial for lupus, an autoimmune disease affecting multiple organs in the body. Carl Ware, Ph.D. was corresponding author for the study.
Form 990, Part VI, Line 11b Review of form 990 by governing body	PROCESS USED BY MANAGEMENT AND/OR GOVERNING BODY TO REVIEW FORM 990: THE 990 IS PREPARED BY THE FINANCE DEPARTMENT. IT IS REVIEWED BY THE INSTITUTE'S TAX ADVISORS, SELECTED MEMBERS OF MANAGEMENT INCLUDING THE CFO AND AUDIT COMMITTEE, AND PROVIDED TO MEMBERS OF THE BOARD PRIOR TO FILING.
Form 990, Part VI, Line 12c Conflict of interest policy	DESCRIPTION OF PROCESS TO MONITOR TRANSACTIONS FOR CONFLICT OF INTEREST: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE HAS A CONFLICT OF INTEREST POLICY THAT REQUIRES ALL TRUSTEES, PRINCIPAL OFFICERS OR MEMBERS OF A COMMITTEE WITH BOARD DELEGATED POWERS TO ANNUALLY CONFIRM THEIR RECEIPT OF THE CONFLICT OF INTEREST POLICY AND DISCLOSE ANY NEW ASSOCIATIONS OR INTERESTS THAT MIGHT POTENTIALLY POSE A CONFLICT. THIS IS A WRITTEN CONFIRMATION THAT SHE OR HE READ AND UNDERSTANDS THE CONFLICT OF INTEREST POLICY, WILL ABIDE BY THE CONFLICT OF INTEREST POLICY AND CERTIFIES DISCLOSURE OF ALL INTERESTS OR RELATIONSHIPS THAT MAY POSE CONFLICTS. IN ADDITION, EACH YEAR NEW TRUSTEES RECEIVE TRAINING REGARDING THE INSTITUTE'S CONFLICT OF INTEREST POLICY, WHICH INCLUDES HOW TO IDENTIFY A CONFLICT OF INTEREST AND HOW TO HANDLE POSSIBLE CONFLICTS OF INTEREST WHEN THEY ARISE. THE COMPLIANCE DEPARTMENT REVIEWS EACH OF THE STATEMENTS AND ASSESSES WHETHER AN ACTUAL OR POTENTIAL CONFLICT OF INTEREST EXISTS/MAY EXIST AND WHETHER THE INDIVIDUAL SHOULD BE PROHIBITED FROM CONSIDERATION OF RELATED ITEMS. ANY TRUSTEE, PRINCIPAL OFFICER OR MEMBER OF A COMMITTEE WITH BOARD DELEGATED POWERS WITH A CONFLICT IN A MATTER REQUIRING ACTION BY THE BOARD ARE PROHIBITED FROM PARTICIPATING IN THE BOARD'S DELIBERATIONS AND/OR VOTING ON THE PARTICULAR TRANSACTION OR MATTER IN WHICH HE OR SHE HAS AN INTEREST; AND OTHERWISE REFRAIN FROM EXERTING ANY INFLUENCE TO AFFECT A DECISION. HOWEVER, OTHER MEASURES MAY BE REQUIRED, DEPENDING ON THE NATURE OF AND THE ABILITY TO REASONABLY MANAGE A CONFLICT.
Form 990, Part VI, Line 15a Process to establish compensation of top management official	PROCESS FOR DETERMINING COMPENSATION: COMPENSATION FOR THE CEO, THE PRESIDENT, CHIEF FINANCIAL OFFICER, AND OTHER KEY EMPLOYEES IS ESTABLISHED ACCORDING TO INSTITUTE POLICIES WHICH ARE DESIGNED TO MEET THE IRS STANDARD FOR "REBUTTABLE PRESUMPTION OF REASONABLENESS". THE COMPENSATION COMMITTEE OF THE BOARD OF TRUSTEES, CONSISTING OF THREE INDEPENDENT TRUSTEES, REVIEWS COMPARABILITY DATA AT LEAST EVERY TWO YEARS PROVIDED BY AN INDEPENDENT EXTERNAL CONSULTANT/RESOURCE THAT INCORPORATES AND EVALUATES INSTITUTE DATA AND THAT OF COMPARABLE ORGANIZATIONS AND MARKETS FROM WHICH THE INSTITUTE DRAWS ITS EXECUTIVE TALENT. UTILIZING THIS INFORMATION, THE COMPENSATION COMMITTEE, WHICH TYPICALLY SEEKS TO ESTABLISH COMPENSATION BETWEEN THE 50TH AND THE 75TH PERCENTILE OF THE COMPARABILITY DATA, MAKES A DETERMINATION WHETHER THE PROPOSED COMPENSATION IS REASONABLE. THE COMPENSATION COMMITTEE HAS BEEN DELEGATED AUTHORITY BY THE BOARD OF TRUSTEES TO REVIEW AND APPROVE COMPENSATION OF ALL POSITIONS EXCEPT FOR THE CEO. THE CEO'S COMPENSATION PACKAGE IS REVIEWED AND APPROVED INITIALLY BY THE COMPENSATION COMMITTEE AND THEN GOES TO THE EXECUTIVE COMMITTEE FOR FINAL APPROVAL. THE COMPENSATION COMMITTEE CONTEMPORANEOUSLY AND ADEQUATELY DOCUMENTS THE BASIS FOR ITS DETERMINATION AND RECOMMENDATION TO THE EXECUTIVE COMMITTEE. IF APPROVED BY THE EXECUTIVE COMMITTEE, THE CEO COMPENSATION PACKAGE IS THEN IMPLEMENTED AND SUCH DOCUMENTATION IS KEPT IN THE WRITTEN AND ELECTRONIC RECORDS OF THE BOARD OF TRUSTEES. THE PROCESS WAS LAST COMPLETED ON JUNE 27, 2023 FOR THE FOLLOWING POSITIONS: 1) PRESIDENT & CEO 2) CFO & TREASURER 3) GENERAL COUNSEL & SECRETARY 4) CHIEF DEVELOPMENT OFFICER 5) SVP DRUG DISCOVERY & DEVELOPMENT 6) PROGRAM DIRECTOR/PROFESSOR 7) CANCER CENTER DIRECTOR/PROFESSOR 8) INFECTIOUS & INFLAMMATORY DISEASE CENTER DIRECTOR/PROFESSOR
Form 990, Part VI, Line 15b Process to establish compensation of other employees	see above
Form 990, Part VI, Line 19 Required documents available to the public	PROCESS FOR MAKING DOCUMENTS AVAILABLE TO THE PUBLIC DOCUMENTS ARE AVAILABLE UPON REQUEST
Form 990, Part VIII, Line 11d Other Miscellaneous Revenue	- Total Revenue: 12685, Related or Exempt Function Revenue: 12685, Unrelated Business Revenue: , Revenue Excluded from Tax Under Sections 512, 513, or 514: ;
Schedule F, Part I, Line 3 Program Service Activities	Sanford Burnham Prebys Medical Discovery Institute does not maintain ongoing operations in foreign jurisdictions. However, the Institute's scientist do travel to various scientific conferences in other countries to share the Institute's scientific discoveries, as well as, to learn from other scientists across the world.
Schedule F, Part I, Line 3(e) Type of Service	Specific Program Service Activity in all regions is agents attending and/or speaking at scientific conferences and collaborations.
Schedule F, Part I, Line 3(f) Accounting Method	The accrual method of accounting was used to determine the amounts in Part I, line 3, column F.