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        <BookValue>8494426</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <OtherSecurities>
        <Description>ALTERNATIVE INVESTMENTS</Description>
        <BookValue>1449721</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <TotalOfBookValueSecurities>9944147</TotalOfBookValueSecurities>
      <OtherAssets>
        <Description>GOODWILL</Description>
        <BookValue>12922168</BookValue>
      </OtherAssets>
      <TotalBookValueOtherAssets>12922168</TotalBookValueOtherAssets>
    </IRS990ScheduleD>
    <IRS990ScheduleI documentId="IRS990ScheduleI">
      <RecordsMaintained>true</RecordsMaintained>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>FAMILY HEALTH INTERNATIONAL</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>PO BOX 13950</AddressLine1>
          <City>RESEARCH TRIANGLE PARK</City>
          <State>NC</State>
          <ZIPCode>27709</ZIPCode>
        </AddressUS>
        <EINOfRecipient>237413005</EINOfRecipient>
        <IRCSection>501(C)(3)</IRCSection>
        <AmountOfCashGrant>1474000</AmountOfCashGrant>
        <PurposeOfGrant>GENERAL SUPPORT</PurposeOfGrant>
      </RecipientTable>
      <TotalNbrOf501C3AndGovtGrants>1</TotalNbrOf501C3AndGovtGrants>
      <TotalNbrOfOtherOrganizations>0</TotalNbrOfOtherOrganizations>
      <Form990ScheduleIPartIV>
        <Identifier>DESCRIPTION OF ORGANIZATION'S PROCEDURES FOR MONITORING THE USE OF GRANTS</Identifier>
        <ReturnReference>SCHEDULE I, PART I, LINE 2</ReturnReference>
        <Explanation>THE FOUNDATION IS CHARTERED TO SUPPORT FAMILY HEALTH INTERNATIONAL (FHI). LEVELS OF SUPPORT ARE DETERMINED BY THE FOUNDATION'S TRUSTEES. TWO OF THE FOUNDATION'S TRUSTEES ARE ALSO MEMBERS OF THE BOARD OF FHI, WHICH PERFORMS ONGOING REVIEWS OF FHI'S OPERATIONS INCLUDING THE USE OF GRANTS RECEIVED.</Explanation>
      </Form990ScheduleIPartIV>
    </IRS990ScheduleI>
    <IRS990ScheduleJ documentId="IRS990ScheduleJ">
      <SeverancePayment>false</SeverancePayment>
      <SupplementalNonqualRetirePlan>false</SupplementalNonqualRetirePlan>
      <EquityBasedCompArrangement>false</EquityBasedCompArrangement>
      <CompBasedOnRevenueOfFilingOrg>false</CompBasedOnRevenueOfFilingOrg>
      <CompBasedOnRevenueRelatedOrgs>false</CompBasedOnRevenueRelatedOrgs>
      <CompBasedNetEarningsFilingOrg>false</CompBasedNetEarningsFilingOrg>
      <CompBasedNetEarningsRelateOrgs>false</CompBasedNetEarningsRelateOrgs>
      <AnyNonFixedPayments>false</AnyNonFixedPayments>
      <InitialContractException>false</InitialContractException>
      <Form990ScheduleJPartII>
        <NamePerson>ROBERT R PRICE</NamePerson>
        <BaseCompensationFilingOrg>0</BaseCompensationFilingOrg>
        <CompBasedOnRelatedOrgs>253768</CompBasedOnRelatedOrgs>
        <BonusFilingOrg>0</BonusFilingOrg>
        <BonusRelatedOrgs>0</BonusRelatedOrgs>
        <OtherCompensationFilingOrg>0</OtherCompensationFilingOrg>
        <OtherCompensationRelatedOrgs>0</OtherCompensationRelatedOrgs>
        <DeferredCompFilingOrg>0</DeferredCompFilingOrg>
        <DeferredCompRelatedOrgs>29400</DeferredCompRelatedOrgs>
        <NontaxableBenefitsFilingOrg>0</NontaxableBenefitsFilingOrg>
        <NontaxableBenefitsRelatedOrgs>6313</NontaxableBenefitsRelatedOrgs>
        <TotalCompensationFilingOrg>0</TotalCompensationFilingOrg>
        <TotalCompensationRelatedOrgs>289481</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
    </IRS990ScheduleJ>
    <IRS990ScheduleL documentId="IRS990ScheduleL">
      <Form990ScheduleLPartIV>
        <NameOfInterestedPerson>
          <NamePerson>Hughes Business Activities</NamePerson>
        </NameOfInterestedPerson>
        <Relationship>SEE SCHEDULE O</Relationship>
        <AmountOfTransaction>15900</AmountOfTransaction>
        <DescriptionOfTransaction>SEE SCHEDULE O</DescriptionOfTransaction>
        <SharingOfRevenues>false</SharingOfRevenues>
      </Form990ScheduleLPartIV>
    </IRS990ScheduleL>
    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <GeneralExplanation>
        <Identifier>DESCRIPTION OF CLASSES OF PERSONS AND THE NATURE OF THEIR RIGHTS</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 7A</ReturnReference>
        <Explanation>FIVE OF THE SIX TRUSTEES OF THE FOUNDATION ARE ELECTED BY THE BOARD OF DIRECTORS OF FAMILY HEALTH INTERNATIONAL, A 501(C)(3) ORGANIZATION FOR WHICH THE FOUNDATION PROVIDES SUPPORT. THE FIVE TRUSTEES APPOINTED BY THE FHI BOARD OF DIRECTORS HAVE THE POWER TO APPOINT TWO ADDITIONAL TRUSTEES.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>DESCRIBE PROCESS USED BY MANAGEMENT &amp;/OR GOVERNING BODY TO REVIEW 990</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 11A</ReturnReference>
        <Explanation>FORM 990 IS PREPARED BY ERNST &amp; YOUNG, BASED UPON INFORMATION PROVIDED BY THE FOUNDATION'S ASSISTANT TREASURER AND LEGAL COUNSEL. AFTER APPROVAL BY THE ASSISTANT TREASURER AND LEGAL COUNSEL, COPIES ARE MADE AVAILABLE FOR REVIEW, COMMENTS AND CORRECTION BY EACH MEMBER OF THE BOARD OF TRUSTEES PRIOR TO FILING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>DESCRIPTION OF PROCESS TO MONITOR TRANSACTIONS FOR CONFLICTS OF INTEREST</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 12C</ReturnReference>
        <Explanation>THE FOUNDATION'S CONFLICTS OF INTEREST POLICY, ADOPTED BY THE BOARD OF TRUSTEES, IS APPLICABLE TO EACH TRUSTEE AND OFFICER (THE FOUNDATION DOES NOT HAVE EMPLOYEES). THE POLICY ADDRESSES PROCEDURES FOR ANY CONFLICTS OF INTEREST THAT MAY ARISE. LEGAL COUNSEL IS NOTIFIED OF POTENTIAL OR ACTUAL CONFLICTS, AND ASSISTS IN ENSURING THE PROCEDURES CONTAINED IN THE POLICY FOR ADDRESSING CONFLICTS ARE FOLLOWED. A FORM DISCLOSING ANY CONFLICTS OF INTEREST, IS COMPLETED BY EACH TRUSTEE AND OFFICER AT THE TIME OF APPOINTMENT. ALL CONFLICT OF INTEREST STATEMENTS ARE FILED WITH THE CHAIR OF THE BOARD. THE POLICY REQUIRES DISCLOSURE ON AN ONGOING BASIS OF ANY CONFLICTS AS THEY ARISE. ADDITIONALLY, IN JULY OF EACH YEAR, THE FOUNDATION'S ASSISTANT SECRETARY OBTAINS A DISCLOSURE STATEMENT FROM EACH TRUSTEE AND OFFICER TO BE FILED WITH THE CHAIR OF THE BOARD.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>OFFICES &amp; POSITIONS FOR WHICH PROCESS WAS USED, &amp; YEAR PROCESS WAS BEGUN</Identifier>
        <ReturnReference>FORM 990, PART VI, LINES 15A &amp; 15B</ReturnReference>
        <Explanation>THE FOUNDATION DOES NOT HAVE EMPLOYEES. MOST OF THE FOUNDATION'S FUNDS UNDER INVESTMENT MANAGEMENT ARE MANAGED BY INDEPENDENT PROFESSIONAL MANAGERS PURSUANT TO CONTRACTS APPROVED BY THE BOARD. THE BOARD COMPENSATES ONE OFFICER (THE ASSISTANT TREASURER) TO MAINTAIN THE FOUNDATION'S FINANCIAL RECORDS, AND TO OTHERWISE PERFORM THE DUTIES WHICH THE BOARD DELEGATES TO HIM. THAT COMPENSATION, FOR PART-TIME SERVICES, IS PURSUANT TO A SERVICES CONTRACT APPROVED BY THE BOARD. TRUSTEES ARE COMPENSATED WITH AN HONORARIUM FOR ATTENDANCE AT BOARD MEETINGS. THAT HONORARIUM RATE IS BASED UPON A SENIOR EXECUTIVE SERVICE RATE ESTABLISHED BY THE US GOVERNMENT.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>AVAIL OF GOV DOCS, COI POLICY, &amp; FINANCIAL STMTS TO GEN PUBLIC</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 19</ReturnReference>
        <Explanation>THE FOUNDATION IS CHARTERED UNDER THE NON-PROFIT CORPORATION ACT OF THE STATE OF NORTH CAROLINA. ITS CHARTER (ARTICLES OF INCORPORATION) IS AVAILABLE ON-LINE THROUGH THE WEBSITE OF THE NORTH CAROLINA SECRETARY OF STATE. ITS FORM 990, INCLUDING FINANCIAL STATEMENTS AND INFORMATION ON ITS CONFLICTS OF INTEREST POLICY, IS PROVIDED UPON REQUEST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>AVERAGE HOURS WORKED FOR RELATED ORGANIZATIONS</Identifier>
        <ReturnReference>FORM 990, PART VII, SECTION A</ReturnReference>
        <Explanation>1. TORREY C. BROWN AND EDWARD W. WHITEHORNE WORK 2 HOURS PER WEEK ON FAMILY HEALTH INTERNATIONAL. 2. ROBERT R. PRICE AND MARIE PORTER WORK 40 HOURS PER WEEK ON FAMILY HEALTH INTERNATIONAL. 3. ROBERT W. HUGHES WORKS 32 HOURS PER WEEK ON NOVELLA CLINICAL, INC. 4. THOMAS M. ZIZIC WORKS 1.5 HOURS PER WEEK ON NOVELLA CLINICAL, INC.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>BUSINESS TRANSACTIONS INVOLVING INTERESTED PERSONS</Identifier>
        <ReturnReference>SCHEDULE L, PART IV</ReturnReference>
        <Explanation>(A) NAME OF INTERESTED PERSON: HUGHES BUSINESS ACTIVITIES (B) RELATIONSHIP: ROBERT HUGHES, ASSISTANT TREASURER OF FAMILY HEALTH INTERNATIONAL FOUNDATION, IS OWNER OF HUGHES BUSINESS ACTIVITIES (C) AMOUNT: $15,900 (D) DESCRIPTION: ACCOUNTING SERVICES (E) SHARING OF ORGANIZATION'S REVENUES: NO</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
    <IRS990ScheduleR documentId="IRS990ScheduleR">
      <Form990ScheduleRPartII>
        <NameOfDisregardedEntity>
          <BusinessNameLine1>FAMILY HEALTH INTERNATIONAL</BusinessNameLine1>
        </NameOfDisregardedEntity>
        <AddressUS>
          <AddressLine1>PO BOX 13950</AddressLine1>
          <City>RSRCH TRNGLE PK</City>
          <State>NC</State>
          <ZIPCode>27709</ZIPCode>
        </AddressUS>
        <EIN>237413005</EIN>
        <PrimaryActivities>GLOBAL HEALTH</PrimaryActivities>
        <LegalDomicileState>NC</LegalDomicileState>
        <ExemptCodeSection>501(C)(3)</ExemptCodeSection>
        <PublicCharityStatus>9</PublicCharityStatus>
        <DirectControllingEntityName>
          <BusinessNameLine1>NA</BusinessNameLine1>
        </DirectControllingEntityName>
      </Form990ScheduleRPartII>
      <Form990ScheduleRPartIV>
        <NameOfRelatedOrg>
          <BusinessNameLine1>NOVELLA CLINICAL INC</BusinessNameLine1>
        </NameOfRelatedOrg>
        <AddressUS>
          <AddressLine1>4309 EMPEROR BLVD SUITE 400</AddressLine1>
          <City>DURHAM</City>
          <State>NC</State>
          <ZIPCode>27703</ZIPCode>
        </AddressUS>
        <EIN>562095062</EIN>
        <PrimaryActivity>CLINICAL TRIALS</PrimaryActivity>
        <LegalDomicileState>DE</LegalDomicileState>
        <DirectControllingEntityName>
          <BusinessNameLine1>NA</BusinessNameLine1>
        </DirectControllingEntityName>
        <TypeOfEntity>C CORP</TypeOfEntity>
        <ShareOfTotalIncome>97763049</ShareOfTotalIncome>
        <ShareOfEOYAssets>38892080</ShareOfEOYAssets>
        <PercentageOwnership>0.87630</PercentageOwnership>
      </Form990ScheduleRPartIV>
      <Form990ScheduleRPartIV>
        <NameOfRelatedOrg>
          <BusinessNameLine1>MATRIX CLINICAL SOLUTIONS LTD</BusinessNameLine1>
        </NameOfRelatedOrg>
        <AddressForeign>
          <AddressLine1>WALKERN RD 3G1-3QP</AddressLine1>
          <City>STEVENAGE</City>
          <ProvinceOrState>HERTFORDSHIRE</ProvinceOrState>
          <Country>UK</Country>
        </AddressForeign>
        <PrimaryActivity>CLINICAL TRIALS</PrimaryActivity>
        <LegalDomicileForeignCountry>UK</LegalDomicileForeignCountry>
        <DirectControllingEntityName>
          <BusinessNameLine1>NOVELLA CLINIC</BusinessNameLine1>
        </DirectControllingEntityName>
        <TypeOfEntity>LTD</TypeOfEntity>
      </Form990ScheduleRPartIV>
      <Form990ScheduleRPartIV>
        <NameOfRelatedOrg>
          <BusinessNameLine1>MATRIX CONTRACT RESEARCH LTD</BusinessNameLine1>
        </NameOfRelatedOrg>
        <AddressForeign>
          <AddressLine1>WALKERN RD SG1-3QP</AddressLine1>
          <City>STEVENAGE</City>
          <ProvinceOrState>HERTFORDSHIRE</ProvinceOrState>
          <Country>UK</Country>
        </AddressForeign>
        <PrimaryActivity>CLINICAL RESEARCH</PrimaryActivity>
        <LegalDomicileForeignCountry>UK</LegalDomicileForeignCountry>
        <DirectControllingEntityName>
          <BusinessNameLine1>NOVELLA CLINIC</BusinessNameLine1>
        </DirectControllingEntityName>
        <TypeOfEntity>LTD</TypeOfEntity>
      </Form990ScheduleRPartIV>
      <ReceiptOfIntAnnRentsRoyalties>true</ReceiptOfIntAnnRentsRoyalties>
      <GiftGrantOrCapContrToOtherOrg>true</GiftGrantOrCapContrToOtherOrg>
      <GiftGrantOrCapContrFrOtherOrg>false</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>true</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>false</LoansOrGuaranteesFromOtherOrg>
      <SaleOfAssetsToOtherOrg>false</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>false</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>false</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>false</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>false</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>false</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>false</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>false</SharingOfFacilities>
      <SharingOfPaidEmployees>false</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>false</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>false</ReimbursementPaidByOtherOrg>
      <OtherTransferToOtherOrg>false</OtherTransferToOtherOrg>
      <OtherTransferFromOtherOrg>false</OtherTransferFromOtherOrg>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>NOVELLA CLINICAL INC</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>A</TransactionType>
        <AmountInvolved>463334</AmountInvolved>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>FAMILY HEALTH INTERNATIONAL</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>B</TransactionType>
        <AmountInvolved>1474000</AmountInvolved>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>NOVELLA CLINICAL INC</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>D</TransactionType>
        <AmountInvolved>1500000</AmountInvolved>
      </TransactionsRelatedOrgsTable>
    </IRS990ScheduleR>
  </ReturnData>
</Return>