﻿<?xml version="1.0" encoding="utf-8"?>
<Return xmlns="http://www.irs.gov/efile" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" returnVersion="2010v3.4">
  <ReturnHeader binaryAttachmentCount="0">
    <Timestamp>2011-11-15T13:51:43-06:00</Timestamp>
    <TaxPeriodEndDate>2010-12-31</TaxPeriodEndDate>
    <PreparerFirm>
      <PreparerFirmBusinessName>
        <BusinessNameLine1>ANGLINREICHMANNSNELLGROVE&amp;ARMSTRONGPC</BusinessNameLine1>
      </PreparerFirmBusinessName>
      <PreparerFirmUSAddress>
        <AddressLine1>305 QUALITY CIRCLE</AddressLine1>
        <City>HUNTSVILLE</City>
        <State>AL</State>
        <ZIPCode>358065539</ZIPCode>
      </PreparerFirmUSAddress>
    </PreparerFirm>
    <ReturnType>990</ReturnType>
    <TaxPeriodBeginDate>2010-01-01</TaxPeriodBeginDate>
    <Filer>
      <EIN>432059317</EIN>
      <Name>
        <BusinessNameLine1>HUDSON-ALPHA INSTITUTE FOR</BusinessNameLine1>
        <BusinessNameLine2>BIOTECHNOLOGY</BusinessNameLine2>
      </Name>
      <NameControl>HUDS</NameControl>
      <Phone>2563270400</Phone>
      <USAddress>
        <AddressLine1>601 GENOME WAY</AddressLine1>
        <City>HUNTSVILLE</City>
        <State>AL</State>
        <ZIPCode>35806</ZIPCode>
      </USAddress>
    </Filer>
    <Officer>
      <Name>TRACI TYREE</Name>
      <Title>CFO</Title>
      <Phone>2563270400</Phone>
      <DateSigned>2011-11-15</DateSigned>
    </Officer>
    <Preparer>
      <Name>TRACY L SAMS CPA</Name>
      <Phone>2565331040</Phone>
      <DatePrepared>2011-11-15</DatePrepared>
    </Preparer>
    <TaxYear>2010</TaxYear>
    <BuildTS>2016-02-24 21:20:13Z</BuildTS>
  </ReturnHeader>
  <ReturnData documentCount="6">
    <IRS990 documentId="RetDoc4" referenceDocumentId="RetDoc6">
      <NameOfPrincipalOfficerPerson>TRACI TYREE</NameOfPrincipalOfficerPerson>
      <AddressPrincipalOfficerUS>
        <AddressLine1>601 GENOME WAY</AddressLine1>
        <City>HUNTSVILLE</City>
        <State>AL</State>
        <ZIPCode>35806</ZIPCode>
      </AddressPrincipalOfficerUS>
      <GrossReceipts>72687118</GrossReceipts>
      <GroupReturnForAffiliates>false</GroupReturnForAffiliates>
      <Organization501c3>X</Organization501c3>
      <WebSite>WWW.HUDSONALPHA.ORG</WebSite>
      <TypeOfOrganizationCorporation>X</TypeOfOrganizationCorporation>
      <YearFormation>2004</YearFormation>
      <StateLegalDomicile>AL</StateLegalDomicile>
      <ActivityOrMissionDescription>THE PRIMARY MISSION OF THE INSTITUTE WILL BE TO USE THE INCREASINGLY POWERFUL RESEARCH TOOLS BEING DEVELOPED IN THE BIOTECHNOLOGY AREA TO BETTER UNDERSTAND THE CAUSES OF CERTAIN DISEASES AND TO APPLY THE FINDINGS OF SUCH RESEARCH TO HELP DEVELOP NEW AND MORE EFFECTIVE TREATMENTS FOR SUCH DISEASES. THE INSTITUTE'S CHARITABLE MISSION CONTEMPLATES NUMEROUS OTHER ACTIVITIES ALL OF WHICH ARE INTENDED TO HELP FURTHER BIOTECH RESEARCH IN ALABAMA.</ActivityOrMissionDescription>
      <NbrVotingMembersGoverningBody>9</NbrVotingMembersGoverningBody>
      <NbrIndependentVotingMembers>9</NbrIndependentVotingMembers>
      <TotalNbrEmployees>191</TotalNbrEmployees>
      <TotalGrossUBI>0</TotalGrossUBI>
      <ContributionsGrantsPriorYear>31364164</ContributionsGrantsPriorYear>
      <ContributionsGrantsCurrentYear>43660727</ContributionsGrantsCurrentYear>
      <ProgramServiceRevenueCY>0</ProgramServiceRevenueCY>
      <InvestmentIncomePriorYear>-173911</InvestmentIncomePriorYear>
      <InvestmentIncomeCurrentYear>1735981</InvestmentIncomeCurrentYear>
      <OtherRevenuePriorYear>2606651</OtherRevenuePriorYear>
      <OtherRevenueCurrentYear>1430032</OtherRevenueCurrentYear>
      <TotalRevenuePriorYear>33796904</TotalRevenuePriorYear>
      <TotalRevenueCurrentYear>46826740</TotalRevenueCurrentYear>
      <GrantsAndSimilarAmntsCY>0</GrantsAndSimilarAmntsCY>
      <BenefitsPaidToMembersCY>0</BenefitsPaidToMembersCY>
      <SalariesEtcPriorYear>7299230</SalariesEtcPriorYear>
      <SalariesEtcCurrentYear>6409222</SalariesEtcCurrentYear>
      <TotalProfFundrsngExpCY>0</TotalProfFundrsngExpCY>
      <TotalFundrsngExpCurrentYear>0</TotalFundrsngExpCurrentYear>
      <OtherExpensePriorYear>22080219</OtherExpensePriorYear>
      <OtherExpensesCurrentYear>28096151</OtherExpensesCurrentYear>
      <TotalExpensesPriorYear>29379449</TotalExpensesPriorYear>
      <TotalExpensesCurrentYear>34505373</TotalExpensesCurrentYear>
      <RevenuesLessExpensesPriorYear>4417455</RevenuesLessExpensesPriorYear>
      <RevenuesLessExpensesCY>12321367</RevenuesLessExpensesCY>
      <TotalAssetsBOY>123084602</TotalAssetsBOY>
      <TotalAssetsEOY>140525594</TotalAssetsEOY>
      <TotalLiabilitiesBOY>5816425</TotalLiabilitiesBOY>
      <TotalLiabilitiesEOY>8921485</TotalLiabilitiesEOY>
      <NetAssetsOrFundBalancesBOY>117268177</NetAssetsOrFundBalancesBOY>
      <NetAssetsOrFundBalancesEOY>131604109</NetAssetsOrFundBalancesEOY>
      <InfoInScheduleOPartIII>X</InfoInScheduleOPartIII>
      <MissionDescription>THE PRIMARY MISSION OF THE INSTITUTE WILL BE TO USE THE INCREASINGLY POWERFUL RESEARCH TOOLS BEING DEVELOPED IN THE BIOTECHNOLOGY AREA TO BETTER UNDERSTAND THE CAUSES OF CERTAIN DISEASES AND TO APPLY THE FINDINGS OF SUCH RESEARCH TO HELP DEVELOP NEW AND MORE EFFECTIVE TREATMENTS FOR SUCH DISEASES. THE INSTITUTE'S CHARITABLE MISSION CONTEMPLATES NUMEROUS OTHER ACTIVITIES ALL OF WHICH ARE INTENDED TO HELP FURTHER BIOTECH RESEARCH IN ALABAMA.</MissionDescription>
      <SignificantNewProgramServices>false</SignificantNewProgramServices>
      <SignificantChange>false</SignificantChange>
      <Expense>26893074</Expense>
      <Description>ACTIVITIES, PROGRAMS, AND COLLABORATIONS FOR THE INSTITUTE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF SERVING AS A CATALYST FOR BIOTECHNOLOGY RESEARCH AND DEVELOPEMENT.</Description>
      <Activity2>
        <Expense>834733</Expense>
        <Description>ACTIVITIES, PROGRAMS AND COLLABORATIONS FOR THE INSTITUTE TO ACCOMPLISH ITS CHARITABLE OBJECTIVE OF PROVIDING A VARIETY OF EDUCATIONAL OUTREACH PROGRAMS.</Description>
      </Activity2>
      <TotalProgramServiceExpense>27727807</TotalProgramServiceExpense>
      <DescribedIn501C3 referenceDocumentId="RetDoc2">true</DescribedIn501C3>
      <ScheduleBRequired referenceDocumentId="RetDoc1">true</ScheduleBRequired>
      <PoliticalActivities>false</PoliticalActivities>
      <LobbyingActivities>false</LobbyingActivities>
      <SubjectToProxyTax>false</SubjectToProxyTax>
      <DonorAdvisedFunds referenceDocumentId="RetDoc3">false</DonorAdvisedFunds>
      <ConservationEasements referenceDocumentId="RetDoc3">false</ConservationEasements>
      <CollectionsOfArt referenceDocumentId="RetDoc3">false</CollectionsOfArt>
      <CreditCounseling referenceDocumentId="RetDoc3">false</CreditCounseling>
      <TermOrPermanentEndowments referenceDocumentId="RetDoc3">true</TermOrPermanentEndowments>
      <ReportLandBldgEquip referenceDocumentId="RetDoc3">true</ReportLandBldgEquip>
      <ReportInvestOthSecurities referenceDocumentId="RetDoc3">false</ReportInvestOthSecurities>
      <ReportProgRelInvest referenceDocumentId="RetDoc3">false</ReportProgRelInvest>
      <ReportOtherAssets referenceDocumentId="RetDoc3">false</ReportOtherAssets>
      <ReportOtherLiabilities referenceDocumentId="RetDoc3">true</ReportOtherLiabilities>
      <ReportFin48Footnote referenceDocumentId="RetDoc3">false</ReportFin48Footnote>
      <IndependentAuditFinancialStmt referenceDocumentId="RetDoc3">true</IndependentAuditFinancialStmt>
      <ConsolidatedAuditFinancialStmt referenceDocumentId="RetDoc3">false</ConsolidatedAuditFinancialStmt>
      <School>false</School>
      <ForeignOffice>false</ForeignOffice>
      <ForeignActivities>false</ForeignActivities>
      <MoreThan5000KToOrganizations>false</MoreThan5000KToOrganizations>
      <MoreThan5000KToIndividuals>false</MoreThan5000KToIndividuals>
      <ProfessionalFundraising>false</ProfessionalFundraising>
      <FundraisingActivities>false</FundraisingActivities>
      <Gaming>false</Gaming>
      <Hospital>false</Hospital>
      <GrantsToOrganizations>false</GrantsToOrganizations>
      <GrantsToIndividuals>false</GrantsToIndividuals>
      <ScheduleJRequired referenceDocumentId="RetDoc5">true</ScheduleJRequired>
      <TaxExemptBonds>false</TaxExemptBonds>
      <ExcessBenefitTransaction>false</ExcessBenefitTransaction>
      <PriorExcessBenefitTransaction>false</PriorExcessBenefitTransaction>
      <LoanToOfficerOrDQP>false</LoanToOfficerOrDQP>
      <GrantToRelatedPerson>false</GrantToRelatedPerson>
      <BsnssRltnshpWithOrganization>false</BsnssRltnshpWithOrganization>
      <BsnssRltnshpThruFamilyMember>false</BsnssRltnshpThruFamilyMember>
      <OfficerEntityWithBsnssRltnshp>false</OfficerEntityWithBsnssRltnshp>
      <DeductibleNonCashContributions>false</DeductibleNonCashContributions>
      <DeductibleContributionsOfArt>false</DeductibleContributionsOfArt>
      <Terminated>false</Terminated>
      <PartialLiquidation>false</PartialLiquidation>
      <DisregardedEntity>false</DisregardedEntity>
      <RelatedEntity>false</RelatedEntity>
      <RelatedOrgControlledEntity>false</RelatedOrgControlledEntity>
      <TransactionRelatedEntity>false</TransactionRelatedEntity>
      <TransfersToExemptNonChrtblOrg>false</TransfersToExemptNonChrtblOrg>
      <ActivitiesConductedPartnership>false</ActivitiesConductedPartnership>
      <ScheduleORequired>false</ScheduleORequired>
      <NumberFormsTransmittedWith1096>41</NumberFormsTransmittedWith1096>
      <NumberW2GIncluded>0</NumberW2GIncluded>
      <ComplianceWithBackupWitholding>true</ComplianceWithBackupWitholding>
      <NumberOfEmployees>191</NumberOfEmployees>
      <EmploymentTaxReturnsFiled>true</EmploymentTaxReturnsFiled>
      <UnrelatedBusinessIncome>false</UnrelatedBusinessIncome>
      <ForeignFinancialAccount>false</ForeignFinancialAccount>
      <ProhibitedTaxShelterTrans>false</ProhibitedTaxShelterTrans>
      <TaxablePartyNotification>false</TaxablePartyNotification>
      <NonDeductibleContributions>false</NonDeductibleContributions>
      <IndoorTanningServices>false</IndoorTanningServices>
      <InfoInScheduleOPartVI>X</InfoInScheduleOPartVI>
      <NbrVotingGoverningBodyMembers>9</NbrVotingGoverningBodyMembers>
      <NumberIndependentVotingMembers>9</NumberIndependentVotingMembers>
      <FamilyOrBusinessRelationship>false</FamilyOrBusinessRelationship>
      <DelegationOfManagementDuties>false</DelegationOfManagementDuties>
      <ChangesToOrganizingDocs>false</ChangesToOrganizingDocs>
      <MaterialDiversionOrMisuse>false</MaterialDiversionOrMisuse>
      <MembersOrStockholders>false</MembersOrStockholders>
      <ElectionOfBoardMembers>false</ElectionOfBoardMembers>
      <DecisionsSubjectToApproval>false</DecisionsSubjectToApproval>
      <MinutesOfGoverningBody>true</MinutesOfGoverningBody>
      <MinutesOfCommittees>true</MinutesOfCommittees>
      <OfficerMailingAddress>false</OfficerMailingAddress>
      <LocalChapters>false</LocalChapters>
      <Form990ProvidedToGoverningBody>true</Form990ProvidedToGoverningBody>
      <ConflictOfInterestPolicy>true</ConflictOfInterestPolicy>
      <AnnualDisclosureCoveredPersons>false</AnnualDisclosureCoveredPersons>
      <RegularMonitoringEnforcement>false</RegularMonitoringEnforcement>
      <WhistleblowerPolicy>false</WhistleblowerPolicy>
      <DocumentRetentionPolicy>false</DocumentRetentionPolicy>
      <CompensationProcessCEO>false</CompensationProcessCEO>
      <CompensationProcessOther>false</CompensationProcessOther>
      <InvestmentInJointVenture>true</InvestmentInJointVenture>
      <WrittenPolicyOrProcedure>true</WrittenPolicyOrProcedure>
      <UponRequest>X</UponRequest>
      <TheBooksAreInCareOf>
        <NamePerson>TRACI TYREE</NamePerson>
        <TelephoneNumber>2563270400</TelephoneNumber>
        <AddressUS>
          <AddressLine1>601 GENOME WAY</AddressLine1>
          <City>HUNTSVILLE</City>
          <State>AL</State>
          <ZIPCode>35806</ZIPCode>
        </AddressUS>
      </TheBooksAreInCareOf>
      <Form990PartVIISectionA>
        <NamePerson>A EUGENE SAPP</NamePerson>
        <Title>DIRECTOR</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>DANNY WINDHAM</NamePerson>
        <Title>DIRECTOR</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>J MILTON HARRIS</NamePerson>
        <Title>DIRECTOR</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>JAMES R HUDSON JR</NamePerson>
        <Title>DIR/CO-COB</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>JOHN R WYNN</NamePerson>
        <Title>DIR/SEC/TREA</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>LONNIE S MCMILLIAN</NamePerson>
        <Title>DIR/CO-COB</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>ROY J NICHOLS</NamePerson>
        <Title>DIRECTOR</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>SAMUEL P MCMANUS</NamePerson>
        <Title>DIRECTOR</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>IRMA TUDER</NamePerson>
        <Title>DIRECTOR</Title>
        <AverageHoursPerWeek>1.00</AverageHoursPerWeek>
        <IndividualTrusteeOrDirector>X</IndividualTrusteeOrDirector>
        <ReportableCompFromOrganization>0</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>RICHARD MYERS</NamePerson>
        <Title>PRESIDENT</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <Officer>X</Officer>
        <ReportableCompFromOrganization>418101</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>O'NEAL SMITHERMAN</NamePerson>
        <Title>EVP</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <Officer>X</Officer>
        <ReportableCompFromOrganization>313840</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>TRACI TYREE</NamePerson>
        <Title>CFO</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <Officer>X</Officer>
        <ReportableCompFromOrganization>147193</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>GREG BARSH</NamePerson>
        <Title>PRINCIPAL IN</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>379612</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>JEREMY SCHMUTZ</NamePerson>
        <Title>ASST. INVEST</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>204525</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>JANE GRIMWOOD</NamePerson>
        <Title>PRIN INVESTG</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>204356</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>SHAWN LEVY</NamePerson>
        <Title>PRINCIPAL IN</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>161058</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>CARTER WELLS</NamePerson>
        <Title>ADMIN</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>158854</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>NEIL LAMB</NamePerson>
        <Title>ED. DIRECTOR</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>157675</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>CHRIS GUNTER</NamePerson>
        <Title>PRIN INVESTG</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <KeyEmployee>X</KeyEmployee>
        <ReportableCompFromOrganization>155839</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>DEVIN ABSHER</NamePerson>
        <Title>ASST. INVEST</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <HighestCompensatedEmployee>X</HighestCompensatedEmployee>
        <ReportableCompFromOrganization>143743</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>SCOTT CECHOVIC</NamePerson>
        <Title>IT</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <HighestCompensatedEmployee>X</HighestCompensatedEmployee>
        <ReportableCompFromOrganization>140527</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>SCOTT COUCH</NamePerson>
        <Title>IT</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <HighestCompensatedEmployee>X</HighestCompensatedEmployee>
        <ReportableCompFromOrganization>133211</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>JEFF BERTRAND</NamePerson>
        <Title>SR. RESEARCH</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <HighestCompensatedEmployee>X</HighestCompensatedEmployee>
        <ReportableCompFromOrganization>123974</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <Form990PartVIISectionA>
        <NamePerson>PHILLIP EWING</NamePerson>
        <Title>SR. RESEARCH</Title>
        <AverageHoursPerWeek>60.00</AverageHoursPerWeek>
        <HighestCompensatedEmployee>X</HighestCompensatedEmployee>
        <ReportableCompFromOrganization>123792</ReportableCompFromOrganization>
        <ReportableCompFromRelatedOrgs>0</ReportableCompFromRelatedOrgs>
        <OtherCompensation>0</OtherCompensation>
      </Form990PartVIISectionA>
      <TotalReportableCompFromOrg>2966300</TotalReportableCompFromOrg>
      <NumberIndividualsGT100K>20</NumberIndividualsGT100K>
      <FormersListed>false</FormersListed>
      <TotalCompGT150K>true</TotalCompGT150K>
      <CompensationFromOtherSources>false</CompensationFromOtherSources>
      <ContractorCompensation>
        <NameOfContractor>
          <NameBusiness>
            <BusinessNameLine1>CALTECH</BusinessNameLine1>
          </NameBusiness>
        </NameOfContractor>
        <AddressOfContractor>
          <AddressUS>
            <AddressLine1>1200 E CALIFORNIA BLVD</AddressLine1>
            <City>PASADENA</City>
            <State>CA</State>
            <ZIPCode>91125</ZIPCode>
          </AddressUS>
        </AddressOfContractor>
        <DescriptionOfServices>SUB CONTRACT</DescriptionOfServices>
        <Compensation>2555753</Compensation>
      </ContractorCompensation>
      <ContractorCompensation>
        <NameOfContractor>
          <NameBusiness>
            <BusinessNameLine1>STANFORD UNIVERSITY</BusinessNameLine1>
          </NameBusiness>
        </NameOfContractor>
        <AddressOfContractor>
          <AddressUS>
            <AddressLine1>PO BOX 44253</AddressLine1>
            <City>SAN FRANCISCO</City>
            <State>CA</State>
            <ZIPCode>94144</ZIPCode>
          </AddressUS>
        </AddressOfContractor>
        <DescriptionOfServices>SUB CONTRACT</DescriptionOfServices>
        <Compensation>379359</Compensation>
      </ContractorCompensation>
      <ContractorCompensation>
        <NameOfContractor>
          <NameBusiness>
            <BusinessNameLine1>BRADLEY ARANT</BusinessNameLine1>
          </NameBusiness>
        </NameOfContractor>
        <AddressOfContractor>
          <AddressUS>
            <AddressLine1>200 CLINTON AVENUE WEST</AddressLine1>
            <City>HUNTSVILLE</City>
            <State>AL</State>
            <ZIPCode>35801</ZIPCode>
          </AddressUS>
        </AddressOfContractor>
        <DescriptionOfServices>LEGAL SERVICES</DescriptionOfServices>
        <Compensation>200277</Compensation>
      </ContractorCompensation>
      <ContractorCompensation>
        <NameOfContractor>
          <NameBusiness>
            <BusinessNameLine1>UPPSALA UNIVERSITY</BusinessNameLine1>
          </NameBusiness>
        </NameOfContractor>
        <AddressOfContractor>
          <AddressForeign>
            <AddressLine1>PO BOX 256</AddressLine1>
            <City>UPPSALA</City>
            <Country>SW</Country>
          </AddressForeign>
        </AddressOfContractor>
        <DescriptionOfServices>SUB CONTRACT</DescriptionOfServices>
        <Compensation>158498</Compensation>
      </ContractorCompensation>
      <ContractorCompensation>
        <NameOfContractor>
          <NameBusiness>
            <BusinessNameLine1>J SMITH LANIER</BusinessNameLine1>
          </NameBusiness>
        </NameOfContractor>
        <AddressOfContractor>
          <AddressUS>
            <AddressLine1>P O BOX 6087</AddressLine1>
            <City>HUNTSVILLE</City>
            <State>AL</State>
            <ZIPCode>35813</ZIPCode>
          </AddressUS>
        </AddressOfContractor>
        <DescriptionOfServices>INSURANCE</DescriptionOfServices>
        <Compensation>117680</Compensation>
      </ContractorCompensation>
      <NumberOfContractorsGT100K>6</NumberOfContractorsGT100K>
      <GovernmentGrants>38612135</GovernmentGrants>
      <AllOtherContributions>5048592</AllOtherContributions>
      <TotalContributions>43660727</TotalContributions>
      <InvestmentIncome>
        <TotalRevenueColumn>1264510</TotalRevenueColumn>
        <ExclusionAmount>1264510</ExclusionAmount>
      </InvestmentIncome>
      <GrossRents>
        <Real>1430032</Real>
      </GrossRents>
      <RentalIncomeOrLoss>
        <Real>1430032</Real>
      </RentalIncomeOrLoss>
      <NetRentalIncomeOrLoss>
        <TotalRevenueColumn>1430032</TotalRevenueColumn>
        <ExclusionAmount>1430032</ExclusionAmount>
      </NetRentalIncomeOrLoss>
      <GrossAmountSalesAssets>
        <Securities>26331849</Securities>
      </GrossAmountSalesAssets>
      <LessCostOthBasisSalesExpenses>
        <Securities>25860378</Securities>
      </LessCostOthBasisSalesExpenses>
      <GainOrLoss>
        <Securities>471471</Securities>
      </GainOrLoss>
      <NetGainOrLossInvestments>
        <TotalRevenueColumn>471471</TotalRevenueColumn>
        <RelatedOrExemptFunctionIncome>471471</RelatedOrExemptFunctionIncome>
      </NetGainOrLossInvestments>
      <TotalRevenue>
        <TotalRevenueColumn>46826740</TotalRevenueColumn>
        <RelatedOrExemptFunctionIncome>471471</RelatedOrExemptFunctionIncome>
        <ExclusionAmount>2694542</ExclusionAmount>
      </TotalRevenue>
      <CompCurrentOfficersDirectors>
        <Total>2441933</Total>
        <ProgramServices>1403945</ProgramServices>
        <ManagementAndGeneral>1037988</ManagementAndGeneral>
      </CompCurrentOfficersDirectors>
      <OtherSalariesAndWages>
        <Total>1266874</Total>
        <ProgramServices>601319</ProgramServices>
        <ManagementAndGeneral>665555</ManagementAndGeneral>
      </OtherSalariesAndWages>
      <PensionPlanContributions>
        <Total>474293</Total>
        <ProgramServices>309965</ProgramServices>
        <ManagementAndGeneral>164328</ManagementAndGeneral>
      </PensionPlanContributions>
      <OtherEmployeeBenefits>
        <Total>1632161</Total>
        <ProgramServices>1057781</ProgramServices>
        <ManagementAndGeneral>574380</ManagementAndGeneral>
      </OtherEmployeeBenefits>
      <PayrollTaxes>
        <Total>593961</Total>
        <ProgramServices>388172</ProgramServices>
        <ManagementAndGeneral>205789</ManagementAndGeneral>
      </PayrollTaxes>
      <FeesForServicesLegal>
        <Total>290905</Total>
        <ManagementAndGeneral>290905</ManagementAndGeneral>
      </FeesForServicesLegal>
      <FeesForServicesAccounting>
        <Total>43500</Total>
        <ManagementAndGeneral>43500</ManagementAndGeneral>
      </FeesForServicesAccounting>
      <FeesForServicesInvstMgmntFees>
        <Total>96132</Total>
        <ManagementAndGeneral>96132</ManagementAndGeneral>
      </FeesForServicesInvstMgmntFees>
      <Advertising>
        <Total>35127</Total>
        <ManagementAndGeneral>35127</ManagementAndGeneral>
      </Advertising>
      <OfficeExpenses>
        <Total>572248</Total>
        <ProgramServices>615820</ProgramServices>
        <ManagementAndGeneral>-43572</ManagementAndGeneral>
      </OfficeExpenses>
      <InformationTechnology>
        <Total>193950</Total>
        <ProgramServices>3349</ProgramServices>
        <ManagementAndGeneral>190601</ManagementAndGeneral>
      </InformationTechnology>
      <Occupancy>
        <Total>4435141</Total>
        <ProgramServices>1872773</ProgramServices>
        <ManagementAndGeneral>2562368</ManagementAndGeneral>
      </Occupancy>
      <Travel>
        <Total>122032</Total>
        <ProgramServices>85566</ProgramServices>
        <ManagementAndGeneral>36466</ManagementAndGeneral>
      </Travel>
      <Interest>
        <Total>5431</Total>
        <ManagementAndGeneral>5431</ManagementAndGeneral>
      </Interest>
      <DepreciationDepletion>
        <Total>1566244</Total>
        <ProgramServices>1029928</ProgramServices>
        <ManagementAndGeneral>536316</ManagementAndGeneral>
      </DepreciationDepletion>
      <Insurance>
        <Total>99794</Total>
        <ManagementAndGeneral>99794</ManagementAndGeneral>
      </Insurance>
      <OtherExpenses>
        <Description>DIRECT EXPENDITURES</Description>
        <Total>20030076</Total>
        <ProgramServices>20030076</ProgramServices>
      </OtherExpenses>
      <OtherExpenses>
        <Description>FUNDRAISING</Description>
        <Total>163970</Total>
        <ProgramServices>21083</ProgramServices>
        <ManagementAndGeneral>142887</ManagementAndGeneral>
      </OtherExpenses>
      <OtherExpenses>
        <Description>CONSULTING FEES</Description>
        <Total>130892</Total>
        <ProgramServices>92395</ProgramServices>
        <ManagementAndGeneral>38497</ManagementAndGeneral>
      </OtherExpenses>
      <OtherExpenses>
        <Description>SMALL EQUIPMENT</Description>
        <Total>60111</Total>
        <ProgramServices>52006</ProgramServices>
        <ManagementAndGeneral>8105</ManagementAndGeneral>
      </OtherExpenses>
      <OtherExpenses>
        <Description>MEALS &amp; ENTERTAINMENT</Description>
        <Total>45026</Total>
        <ProgramServices>32484</ProgramServices>
        <ManagementAndGeneral>12542</ManagementAndGeneral>
      </OtherExpenses>
      <AllOtherExpenses>
        <Total>205572</Total>
        <ProgramServices>131145</ProgramServices>
        <ManagementAndGeneral>74427</ManagementAndGeneral>
      </AllOtherExpenses>
      <TotalFunctionalExpenses>
        <Total>34505373</Total>
        <ProgramServices>27727807</ProgramServices>
        <ManagementAndGeneral>6777566</ManagementAndGeneral>
        <Fundraising>0</Fundraising>
      </TotalFunctionalExpenses>
      <CashNonInterestBearing>
        <BOY>1150952</BOY>
        <EOY>1596602</EOY>
      </CashNonInterestBearing>
      <SavingsAndTempCashInvestments>
        <BOY>15870594</BOY>
        <EOY>5191724</EOY>
      </SavingsAndTempCashInvestments>
      <PledgesAndGrantsReceivable>
        <BOY>4869084</BOY>
        <EOY>4823316</EOY>
      </PledgesAndGrantsReceivable>
      <AccountsReceivable>
        <BOY>1598815</BOY>
        <EOY>1342040</EOY>
      </AccountsReceivable>
      <PrepaidExpensesDeferredCharges>
        <BOY>199263</BOY>
        <EOY>919409</EOY>
      </PrepaidExpensesDeferredCharges>
      <LandBuildingsEquipmentBasis>82874535</LandBuildingsEquipmentBasis>
      <LandBldgEquipmentAccumDeprec>8592193</LandBldgEquipmentAccumDeprec>
      <LandBuildingsEquipmentBasisNet>
        <BOY>72953064</BOY>
        <EOY>74282342</EOY>
      </LandBuildingsEquipmentBasisNet>
      <InvestmentsPubTradedSecurities>
        <BOY>25390830</BOY>
        <EOY>51048994</EOY>
      </InvestmentsPubTradedSecurities>
      <InvestmentsOtherSecurities>
        <BOY>1052000</BOY>
        <EOY>1052000</EOY>
      </InvestmentsOtherSecurities>
      <OtherAssetsTotal>
        <EOY>269167</EOY>
      </OtherAssetsTotal>
      <TotalAssets>
        <BOY>123084602</BOY>
        <EOY>140525594</EOY>
      </TotalAssets>
      <AccountsPayableAccruedExpenses>
        <BOY>3604715</BOY>
        <EOY>5129233</EOY>
      </AccountsPayableAccruedExpenses>
      <OtherLiabilities>
        <BOY>2211710</BOY>
        <EOY>3792252</EOY>
      </OtherLiabilities>
      <TotalLiabilities>
        <BOY>5816425</BOY>
        <EOY>8921485</EOY>
      </TotalLiabilities>
      <FollowSFAS117>X</FollowSFAS117>
      <UnrestrictedNetAssets>
        <BOY>94768177</BOY>
        <EOY>109104109</EOY>
      </UnrestrictedNetAssets>
      <TemporarilyRestrictedNetAssets>
        <BOY>22500000</BOY>
        <EOY>22500000</EOY>
      </TemporarilyRestrictedNetAssets>
      <TotalNetAssetsFundBalances>
        <BOY>117268177</BOY>
        <EOY>131604109</EOY>
      </TotalNetAssetsFundBalances>
      <TotalLiabNetAssetsFundBalances>
        <BOY>123084602</BOY>
        <EOY>140525594</EOY>
      </TotalLiabNetAssetsFundBalances>
      <ReconcilationRevenueExpenses>12321367</ReconcilationRevenueExpenses>
      <ReconcilationOtherChanges>2014565</ReconcilationOtherChanges>
      <MethodOfAccountingAccrual>X</MethodOfAccountingAccrual>
      <AccountantCompileOrReview>false</AccountantCompileOrReview>
      <FSAudited>true</FSAudited>
      <AuditCommittee>true</AuditCommittee>
      <FederalGrantAuditRequired>true</FederalGrantAuditRequired>
      <FederalGrantAuditPerformed>true</FederalGrantAuditPerformed>
    </IRS990>
    <IRS990ScheduleA documentId="RetDoc2">
      <PubliclySupportedOrg170b1Avi>X</PubliclySupportedOrg170b1Avi>
      <GiftsGrantsContribReceived170>
        <CurrentTaxYearMinus4Years>18184393</CurrentTaxYearMinus4Years>
        <CurrentTaxYearMinus3Years>33457630</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>7768487</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>31364164</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>43660727</CurrentTaxYear>
        <Total>134435401</Total>
      </GiftsGrantsContribReceived170>
      <Total170>
        <CurrentTaxYearMinus4Years>18184393</CurrentTaxYearMinus4Years>
        <CurrentTaxYearMinus3Years>33457630</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>7768487</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>31364164</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>43660727</CurrentTaxYear>
        <Total>134435401</Total>
      </Total170>
      <AmountsSubstContributorsTotal>1004679</AmountsSubstContributorsTotal>
      <PublicSupportTotal170>133430722</PublicSupportTotal170>
      <GrossInvestmentIncome170>
        <CurrentTaxYearMinus4Years>3101118</CurrentTaxYearMinus4Years>
        <CurrentTaxYearMinus3Years>2752847</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>2292203</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>3725709</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>2694542</CurrentTaxYear>
        <Total>14566419</Total>
      </GrossInvestmentIncome170>
      <TotalSupport>149001820</TotalSupport>
      <PublicSupportPertcentage170>0.89550</PublicSupportPertcentage170>
      <PublicSupportPertcentPriorYear>0.86320</PublicSupportPertcentPriorYear>
      <ThirtyThreePercntTestsCY170>X</ThirtyThreePercntTestsCY170>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="RetDoc1">
      <ContributorInfo>
        <ContributorNumber>RESTRICTED</ContributorNumber>
        <ContributorNameBusiness>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorNameBusiness>
        <ContributorAddressUS>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorAddressUS>
        <AggregateContributions>RESTRICTED</AggregateContributions>
      </ContributorInfo>
    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="RetDoc3">
      <DisclosedOrgsLegalControl>false</DisclosedOrgsLegalControl>
      <DisclosedForCharitablePurposes>false</DisclosedForCharitablePurposes>
      <WrittenPolicyMonitoring>false</WrittenPolicyMonitoring>
      <Sect170hRequirementsSatisfied>false</Sect170hRequirementsSatisfied>
      <SolicitedAssetsForSale>false</SolicitedAssetsForSale>
      <AgentTrusteeEtc>false</AgentTrusteeEtc>
      <IncludedOnFS>false</IncludedOnFS>
      <CurrentYear>
        <BeginningOfYearBalance>25522957</BeginningOfYearBalance>
        <InvestmentEarningsOrLosses>3479883</InvestmentEarningsOrLosses>
        <AdministrativeExpenses>96132</AdministrativeExpenses>
        <EndOfYearBalance>28906708</EndOfYearBalance>
      </CurrentYear>
      <CurrentYearMinus1Year>
        <BeginningOfYearBalance>20358541</BeginningOfYearBalance>
        <Contributions>1500000</Contributions>
        <InvestmentEarningsOrLosses>3768975</InvestmentEarningsOrLosses>
        <AdministrativeExpenses>104559</AdministrativeExpenses>
        <EndOfYearBalance>25522957</EndOfYearBalance>
      </CurrentYearMinus1Year>
      <CurrentYearMinus2Years>
        <BeginningOfYearBalance>24827223</BeginningOfYearBalance>
        <Contributions>387689</Contributions>
        <InvestmentEarningsOrLosses>-4730408</InvestmentEarningsOrLosses>
        <OtherExpenditures>9150</OtherExpenditures>
        <AdministrativeExpenses>116813</AdministrativeExpenses>
        <EndOfYearBalance>20358541</EndOfYearBalance>
      </CurrentYearMinus2Years>
      <BoardDesignatedEOYBalance>1.00000</BoardDesignatedEOYBalance>
      <EndowmentsHeldByUnrelatedOrgs>false</EndowmentsHeldByUnrelatedOrgs>
      <EndowmentsHeldByRelatedOrgs>false</EndowmentsHeldByRelatedOrgs>
      <AreRelatedOrgsListedScheduleR>false</AreRelatedOrgsListedScheduleR>
      <Land>
        <OtherCostOrOtherBasis>7590122</OtherCostOrOtherBasis>
        <BookValue>7590122</BookValue>
      </Land>
      <LeaseholdImprovements>
        <OtherCostOrOtherBasis>64730249</OtherCostOrOtherBasis>
        <Depreciation>4840723</Depreciation>
        <BookValue>59889526</BookValue>
      </LeaseholdImprovements>
      <Equipment>
        <OtherCostOrOtherBasis>10554164</OtherCostOrOtherBasis>
        <Depreciation>3751470</Depreciation>
        <BookValue>6802694</BookValue>
      </Equipment>
      <TotalOfBookValueLandBuildings>74282342</TotalOfBookValueLandBuildings>
      <OtherLiabilities>
        <Description>DEFERRED INCOME</Description>
        <Amount>2929275</Amount>
      </OtherLiabilities>
      <OtherLiabilities>
        <Description>ACCRUED EXPENSES</Description>
        <Amount>862977</Amount>
      </OtherLiabilities>
      <TotalOfAmounts>3792252</TotalOfAmounts>
      <TotalRevenue>46826740</TotalRevenue>
      <TotalExpenses>34505373</TotalExpenses>
      <ExcessOrDeficitForYear>12321367</ExcessOrDeficitForYear>
      <NetUnrealizedGLOnInvestments>2014565</NetUnrealizedGLOnInvestments>
      <TotalAdjustments>2014565</TotalAdjustments>
      <ExcessOrDeficitPerFS>14335932</ExcessOrDeficitPerFS>
      <TotRevenueEtcAuditedFinclStmt>48841305</TotRevenueEtcAuditedFinclStmt>
      <NetUnrealizedGainsInvestments>2014565</NetUnrealizedGainsInvestments>
      <RevenueNotRptdF990>2014565</RevenueNotRptdF990>
      <RevenueSubtotal>46826740</RevenueSubtotal>
      <TotalRevenuePerForm990>46826740</TotalRevenuePerForm990>
      <TotExpensesEtcAuditedFinclStmt>34505373</TotExpensesEtcAuditedFinclStmt>
      <ExpensesSubtotal>34505373</ExpensesSubtotal>
      <TotalExpensesPerForm990>34505373</TotalExpensesPerForm990>
      <Form990ScheduleDPartXIV>
        <Identifier>INTENDED USES FOR ENDOWMENT FUNDS</Identifier>
        <ReturnReference>SCHEDULE D, PAGE 2, PART V, LINE 4</ReturnReference>
        <Explanation>ENDOWMENT FUNDS ARE SET ASIDE TO PROVIDE THE INSTITUTE WITH A FUTURE INCOME STREAM FOR OPERATIONS.</Explanation>
      </Form990ScheduleDPartXIV>
    </IRS990ScheduleD>
    <IRS990ScheduleJ documentId="RetDoc5">
      <BoardOrCommitteeApproval>X</BoardOrCommitteeApproval>
      <SeverancePayment>false</SeverancePayment>
      <SupplementalNonqualRetirePlan>false</SupplementalNonqualRetirePlan>
      <EquityBasedCompArrangement>false</EquityBasedCompArrangement>
      <CompBasedOnRevenueOfFilingOrg>false</CompBasedOnRevenueOfFilingOrg>
      <CompBasedOnRevenueRelatedOrgs>false</CompBasedOnRevenueRelatedOrgs>
      <CompBasedNetEarningsFilingOrg>false</CompBasedNetEarningsFilingOrg>
      <CompBasedNetEarningsRelateOrgs>false</CompBasedNetEarningsRelateOrgs>
      <AnyNonFixedPayments>false</AnyNonFixedPayments>
      <InitialContractException>false</InitialContractException>
      <Form990ScheduleJPartII>
        <NamePerson>RICHARD MYERS</NamePerson>
        <BaseCompensationFilingOrg>418101</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>418101</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>O'NEAL SMITHERMAN</NamePerson>
        <BaseCompensationFilingOrg>313840</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>313840</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>GREG BARSH</NamePerson>
        <BaseCompensationFilingOrg>379612</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>379612</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>JEREMY SCHMUTZ</NamePerson>
        <BaseCompensationFilingOrg>204525</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>204525</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>JANE GRIMWOOD</NamePerson>
        <BaseCompensationFilingOrg>204356</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>204356</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>SHAWN LEVY</NamePerson>
        <BaseCompensationFilingOrg>161058</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>161058</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>CARTER WELLS</NamePerson>
        <BaseCompensationFilingOrg>158854</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>158854</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>NEIL LAMB</NamePerson>
        <BaseCompensationFilingOrg>157675</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>157675</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>CHRIS GUNTER</NamePerson>
        <BaseCompensationFilingOrg>155839</BaseCompensationFilingOrg>
        <TotalCompensationFilingOrg>155839</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="RetDoc6">
      <GeneralExplanation>
        <Identifier>ORGANIZATION'S MISSION</Identifier>
        <ReturnReference>FORM 990 - ORGANIZATION'S MISSION</ReturnReference>
        <Explanation>THE PRIMARY MISSION OF THE INSTITUTE WILL BE TO USE THE INCREASINGLY POWERFUL RESEARCH TOOLS BEING DEVELOPED IN THE BIOTECHNOLOGY AREA TO BETTER UNDERSTAND THE CAUSES OF CERTAIN DISEASES AND TO APPLY THE FINDINGS OF SUCH RESEARCH TO HELP DEVELOP NEW AND MORE EFFECTIVE TREATMENTS FOR SUCH DISEASES. THE INSTITUTE'S CHARITABLE MISSION CONTEMPLATES NUMEROUS OTHER ACTIVITIES ALL OF WHICH ARE INTENDED TO HELP FURTHER BIOTECH RESEARCH IN ALABAMA.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>ORGANIZATION'S PROCESS USED TO REVIEW FORM 990</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 11B</ReturnReference>
        <Explanation>FORM 990 IS PROVIDED TO CFO BY TAX PREPARER FOR REVIEW PRIOR TO FILING. CFO IN TURNS DISTRIBUTES COPY OF FORM 990 TO MEMBERS OF THE GOVERNING BODY AND COMMUNICATES BACK TO TAX PREPARER BEFORE FINAL RETURN IS FILED.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>GOVERNING DOCUMENTS DISCLOSURE EXPLANATION</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 19</ReturnReference>
        <Explanation>NO DOCUMENTS AVAILABLE TO THE PUBLIC</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
  </ReturnData>
</Return>