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        <CurrentTaxYearMinus1Year>0</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>148092</CurrentTaxYear>
        <Total>2933344</Total>
      </OtherIncome170>
      <TotalSupport>156776758</TotalSupport>
      <GrossReceiptsFromAdmissionsEtc>269751</GrossReceiptsFromAdmissionsEtc>
      <PublicSupportPertcentage170>0.88713</PublicSupportPertcentage170>
      <PublicSupportPertcentPriorYear>0.94665</PublicSupportPertcentPriorYear>
      <ThirtyThreePercntTestsCY170>X</ThirtyThreePercntTestsCY170>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="IRS990ScheduleB">
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        <ContributorNameBusiness>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorNameBusiness>
        <ContributorAddressUS>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorAddressUS>
        <AggregateContributions>RESTRICTED</AggregateContributions>
      </ContributorInfo>
    </IRS990ScheduleB>
    <IRS990ScheduleC documentId="IRS990ScheduleC">
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      <TotalDirectLobbying />
      <TotalLobbyingExpenditures />
      <OtherExemptPurposeExpenditures />
      <TotalExemptPurposeExpenditures />
      <LobbyingNontaxableAmount />
      <GrassrootsNontaxableAmount />
      <TotLobbyingGrassrootMinusNonTx />
      <TotLobbyExpendMnsLobbyingNontx />
      <Volunteers>false</Volunteers>
      <PaidStaffOrManagement>false</PaidStaffOrManagement>
      <MediaAdvertisements>false</MediaAdvertisements>
      <MailingsMembers>true</MailingsMembers>
      <PublicationsOrBroadcast>false</PublicationsOrBroadcast>
      <GrantsOtherOrganizations>false</GrantsOtherOrganizations>
      <DirectContactLegislators>true</DirectContactLegislators>
      <DirectContactLegislatorsAmount>43329</DirectContactLegislatorsAmount>
      <RalliesDemonstrations>false</RalliesDemonstrations>
      <OtherActivities>true</OtherActivities>
      <OtherActivitiesAmount>70897</OtherActivitiesAmount>
      <TotalLobbyingExpendituresIIB>114226</TotalLobbyingExpendituresIIB>
      <NotDescribedIn501c3>false</NotDescribedIn501c3>
      <Form990ScheduleCPartIV>
        <Identifier>Schedule C, Part II-B, Line 1(i)</Identifier>
        <Explanation>The Crohn's &amp; Colitis Foundation of America, Inc. (CCFA) pays the Health and Medicine Counsel of Washington D.C. to keep the organization up-to-date on what is transpiring with legislation on Capitol Hill concerning health and medicine. It should be noted that the Health and Medicine Counsel of Washington is a healthcare advocacy group that may lobby on behalf of healthcare organizations; however, it is not paid to directly undertake any lobbying activities on behalf of CCFA. CCFA holds a "Day on the Hill" event every year, in which patients suffering with Crohn's disease volunteer to travel to Washington D.C. to discuss proposed healthcare bills with legislators. The "Day on the Hill" event was conducted during the calendar year 2010, for which expenses were incurred of approximately $43,329. Expenditures of $43,329 for the Day on the Hill of event have been reported on Schedule C, Part II-B, 1(g). Included within the $43,329 are expenses incurred for mailings made to members, legislators or the public (line 1(d)); accordingly the Foundation has marked box 1(d) yes, but not reported an expense on that line (to avoid double-counting).</Explanation>
      </Form990ScheduleCPartIV>
    </IRS990ScheduleC>
    <IRS990ScheduleD documentId="IRS990ScheduleD">
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      <HeldWorksOfArtAmts />
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      <Buildings />
      <LeaseholdImprovements>
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        <Depreciation>166092</Depreciation>
        <BookValue>64564</BookValue>
      </LeaseholdImprovements>
      <Equipment>
        <OtherCostOrOtherBasis>1925004</OtherCostOrOtherBasis>
        <Depreciation>1644417</Depreciation>
        <BookValue>280587</BookValue>
      </Equipment>
      <OtherLandBuildings>
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        <Depreciation>292306</Depreciation>
        <BookValue>118254</BookValue>
      </OtherLandBuildings>
      <TotalOfBookValueLandBuildings>463405</TotalOfBookValueLandBuildings>
      <FederalIncomeTaxLiability>0</FederalIncomeTaxLiability>
      <OtherLiabilities>
        <Description>GIFT ANNUNITY LIABILITY</Description>
        <Amount>529066</Amount>
      </OtherLiabilities>
      <OtherLiabilities>
        <Description>DEFERRED RENT</Description>
        <Amount>160575</Amount>
      </OtherLiabilities>
      <TotalOfAmounts>689641</TotalOfAmounts>
      <TotalRevenue>45192467</TotalRevenue>
      <TotalExpenses>48297842</TotalExpenses>
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      <NetUnrealizedGLOnInvestments>393716</NetUnrealizedGLOnInvestments>
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      <TotalAdjustments>434571</TotalAdjustments>
      <ExcessOrDeficitPerFS>-2670804</ExcessOrDeficitPerFS>
      <TotRevenueEtcAuditedFinclStmt>46600501</TotRevenueEtcAuditedFinclStmt>
      <NetUnrealizedGainsInvestments>393716</NetUnrealizedGainsInvestments>
      <DonatedSrvcAndUseOfFacilities>973463</DonatedSrvcAndUseOfFacilities>
      <OtherRevenues>40855</OtherRevenues>
      <RevenueNotRptdF990>1408034</RevenueNotRptdF990>
      <RevenueSubtotal>45192467</RevenueSubtotal>
      <TotalRevenuePerForm990>45192467</TotalRevenuePerForm990>
      <TotExpensesEtcAuditedFinclStmt>49271305</TotExpensesEtcAuditedFinclStmt>
      <DonatedServicesUseOfFacilities>973463</DonatedServicesUseOfFacilities>
      <ExpensesNotRptdF990>973463</ExpensesNotRptdF990>
      <ExpensesSubtotal>48297842</ExpensesSubtotal>
      <TotalExpensesPerForm990>48297842</TotalExpensesPerForm990>
      <Form990ScheduleDPartXIV>
        <Identifier>Reconciliation of Net Assets</Identifier>
        <ReturnReference>Part XI, Line 8</ReturnReference>
        <Explanation>Changes in gift annuities valuations: $40,855</Explanation>
      </Form990ScheduleDPartXIV>
      <Form990ScheduleDPartXIV>
        <Identifier>Reconciliation of Revenue</Identifier>
        <ReturnReference>Part XII, Line 2d</ReturnReference>
        <Explanation>Changes in gift annuities valuations: $40,855</Explanation>
      </Form990ScheduleDPartXIV>
      <Form990ScheduleDPartXIV>
        <Identifier>Income Taxes</Identifier>
        <ReturnReference>Part X</ReturnReference>
        <Explanation>The Foundation adopted guidance that clarifies the accounting for uncertainty in tax positions taken or expected to be taken in a tax return, including issues relating to financial statement recognition and measurement as of January 1, 2010. This section provides that the tax effects from an uncertain tax position can be recognized in the financial statements only if the position is "more-likely-than-not" to be sustained if the position were to be challenged by a taxing authority. The assessment of the tax position is based solely on the technical merits of the position, without regard to the likelihood that the tax position may be challenged. The Foundation is exempt from income tax under the Code, however, is subject to tax on income unrelated to its exempt purposes, unless that income is otherwise excluded under the Code. The tax years ending 2007, 2008, 2009 and 2010 are still open to audit for both federal and state purposes. The adoption of this guidance did not have an impact on the Foundation's financial statements as management believes that there are no uncertain tax positions within its financial statements.</Explanation>
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    </IRS990ScheduleD>
    <IRS990ScheduleF documentId="IRS990ScheduleF">
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        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>Grantmaking</TypeOfActivitiesConducted>
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      </AcctsActvsOutUSTable>
      <AcctsActvsOutUSTable>
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        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>Grantmaking</TypeOfActivitiesConducted>
        <SpecificServicesProvided>research</SpecificServicesProvided>
        <TotalExpenditures>64238</TotalExpenditures>
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      <AcctsActvsOutUSTable>
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        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>Grantmaking</TypeOfActivitiesConducted>
        <SpecificServicesProvided>research</SpecificServicesProvided>
        <TotalExpenditures>16297</TotalExpenditures>
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      <TotalNumberOfOffices>0</TotalNumberOfOffices>
      <TotalNumberOfEmployees>0</TotalNumberOfEmployees>
      <SubtotalAmountSpent>311943</SubtotalAmountSpent>
      <TotalAmountSpent>311943</TotalAmountSpent>
      <GrantsToOrgsOutsideUS>
        <Region>Middle East/North Africa</Region>
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      <GrantsToOrgsOutsideUS>
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      <GrantsToOrgsOutsideUS>
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      <GrantsToOrgsOutsideUS>
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      </GrantsToOrgsOutsideUS>
      <GrantsToOrgsOutsideUS>
        <Region>europe</Region>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
        <AmountOfCashGrant>130433</AmountOfCashGrant>
        <MannerOfCashDisbursement>wire</MannerOfCashDisbursement>
      </GrantsToOrgsOutsideUS>
      <GrantsToOrgsOutsideUS>
        <Region>Europe</Region>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
        <AmountOfCashGrant>32175</AmountOfCashGrant>
        <MannerOfCashDisbursement>wire</MannerOfCashDisbursement>
      </GrantsToOrgsOutsideUS>
      <GrantsToOrgsOutsideUS>
        <Region>europe</Region>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
        <AmountOfCashGrant>29550</AmountOfCashGrant>
        <MannerOfCashDisbursement>wire</MannerOfCashDisbursement>
      </GrantsToOrgsOutsideUS>
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      <TransferToForeignCorp>false</TransferToForeignCorp>
      <InterestInForeignTrust>false</InterestInForeignTrust>
      <OwnForeignCorp>false</OwnForeignCorp>
      <PassiveForeignInvestCo>false</PassiveForeignInvestCo>
      <ForeignPartnership>false</ForeignPartnership>
      <BoycottCountries>false</BoycottCountries>
      <Form990ScheduleFPartV>
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        <Explanation>The process for monitoring grants to researchers outside the United States is the same as the process undertaken for those inside the United States. (See Schedule I) Grants are awarded for specific projects for specific research and CCFA requires the researcher to issue progress reports periodically as the project is being done. Most awards are gifted for a period of 3 years and if the progress reports do not show significant strides in the research, the grant will not be approved for additional funding and will be terminated.</Explanation>
      </Form990ScheduleFPartV>
    </IRS990ScheduleF>
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      <EmailSolicitations>X</EmailSolicitations>
      <PhoneSolicitations>X</PhoneSolicitations>
      <InPersonSolicitations>X</InPersonSolicitations>
      <SolicitationOfNonGovtGrants>X</SolicitationOfNonGovtGrants>
      <SolicitationOfGovtGrants>X</SolicitationOfGovtGrants>
      <SpecialFundraisingEvents>X</SpecialFundraisingEvents>
      <AgreementRefFundraising>true</AgreementRefFundraising>
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        <NameOfIndividual>infocision management corporation</NameOfIndividual>
        <AddressUS>
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          <AddressLine2>ATTN ACCOUNTING DEPT</AddressLine2>
          <City>AKRON</City>
          <State>OH</State>
          <ZIPCode>44333</ZIPCode>
        </AddressUS>
        <Activity>tele- marketing</Activity>
        <FundraiserControlOfFunds>false</FundraiserControlOfFunds>
        <GrossReceipts>292975</GrossReceipts>
        <AmountRetainedByContractor>36750</AmountRetainedByContractor>
        <NetToOrganization>256225</NetToOrganization>
      </FundraiserActivityInformation>
      <FundraiserActivityInformation>
        <NameOfIndividual>thompson habib denison</NameOfIndividual>
        <Activity>direct mail</Activity>
        <FundraiserControlOfFunds>false</FundraiserControlOfFunds>
        <GrossReceipts>2460496</GrossReceipts>
        <AmountRetainedByContractor>108584</AmountRetainedByContractor>
        <NetToOrganization>2351912</NetToOrganization>
      </FundraiserActivityInformation>
      <FundraiserActivityInformation>
        <NameOfIndividual>sanky communication</NameOfIndividual>
        <Activity>direct mail</Activity>
        <FundraiserControlOfFunds>false</FundraiserControlOfFunds>
        <GrossReceipts>1190621</GrossReceipts>
        <AmountRetainedByContractor>110540</AmountRetainedByContractor>
        <NetToOrganization>1080081</NetToOrganization>
      </FundraiserActivityInformation>
      <TotalGrossReceipts>3944092</TotalGrossReceipts>
      <TotalRetainedByContractors>255874</TotalRetainedByContractors>
      <TotalNetToOrganization>3688218</TotalNetToOrganization>
      <LicensedStates>AL</LicensedStates>
      <LicensedStates>AK</LicensedStates>
      <LicensedStates>AZ</LicensedStates>
      <LicensedStates>AR</LicensedStates>
      <LicensedStates>CA</LicensedStates>
      <LicensedStates>CO</LicensedStates>
      <LicensedStates>CT</LicensedStates>
      <LicensedStates>DE</LicensedStates>
      <LicensedStates>DC</LicensedStates>
      <LicensedStates>FL</LicensedStates>
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      <LicensedStates>HI</LicensedStates>
      <LicensedStates>ID</LicensedStates>
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      <LicensedStates>IN</LicensedStates>
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      <LicensedStates>MA</LicensedStates>
      <LicensedStates>MI</LicensedStates>
      <LicensedStates>MN</LicensedStates>
      <LicensedStates>MS</LicensedStates>
      <LicensedStates>MO</LicensedStates>
      <LicensedStates>MT</LicensedStates>
      <LicensedStates>NE</LicensedStates>
      <LicensedStates>NV</LicensedStates>
      <LicensedStates>NH</LicensedStates>
      <LicensedStates>NJ</LicensedStates>
      <LicensedStates>NM</LicensedStates>
      <LicensedStates>NY</LicensedStates>
      <LicensedStates>NC</LicensedStates>
      <LicensedStates>ND</LicensedStates>
      <LicensedStates>OH</LicensedStates>
      <LicensedStates>OK</LicensedStates>
      <LicensedStates>OR</LicensedStates>
      <LicensedStates>PA</LicensedStates>
      <LicensedStates>RI</LicensedStates>
      <LicensedStates>SC</LicensedStates>
      <LicensedStates>SD</LicensedStates>
      <LicensedStates>TN</LicensedStates>
      <LicensedStates>TX</LicensedStates>
      <LicensedStates>UT</LicensedStates>
      <LicensedStates>VT</LicensedStates>
      <LicensedStates>VA</LicensedStates>
      <LicensedStates>WA</LicensedStates>
      <LicensedStates>WV</LicensedStates>
      <LicensedStates>WI</LicensedStates>
      <LicensedStates>WY</LicensedStates>
      <EventsInformation>
        <NameOfEvent1>take steps</NameOfEvent1>
        <GrossReceiptsEvent1>8257224</GrossReceiptsEvent1>
        <CharitableContributionsEvent1>7622498</CharitableContributionsEvent1>
        <GrossRevenueEvent1>634726</GrossRevenueEvent1>
        <OtherDirectExpensesEvent1>634726</OtherDirectExpensesEvent1>
        <NameOfEvent2>team challenge</NameOfEvent2>
        <GrossReceiptsEvent2>8151091</GrossReceiptsEvent2>
        <CharitableContributionsEvent2>6224394</CharitableContributionsEvent2>
        <GrossRevenueEvent2>1926697</GrossRevenueEvent2>
        <OtherDirectExpensesEvent2>1926697</OtherDirectExpensesEvent2>
        <TotalNumberOfOtherEvents>312</TotalNumberOfOtherEvents>
        <GrossReceiptsOtherEvents>10648804</GrossReceiptsOtherEvents>
        <CharitableContribOtherEvents>8007458</CharitableContribOtherEvents>
        <GrossRevenueOtherEvents>2641346</GrossRevenueOtherEvents>
        <OtherDirectExpensesOtherEvents>2641346</OtherDirectExpensesOtherEvents>
        <GrossReceiptsTotal>27057119</GrossReceiptsTotal>
        <CharitableContributionsTotal>21854350</CharitableContributionsTotal>
        <GrossRevenueTotalEvents>5202769</GrossRevenueTotalEvents>
        <OtherDirectExpensesTotalEvents>5202769</OtherDirectExpensesTotalEvents>
        <DirectExpenseSummaryEvents>5202769</DirectExpenseSummaryEvents>
      </EventsInformation>
      <GamingInformation>
        <VolunteerLaborBingo>false</VolunteerLaborBingo>
        <VolunteerLaborPullTabs>false</VolunteerLaborPullTabs>
        <GrossRevenueOtherGaming>292975</GrossRevenueOtherGaming>
        <OtherDirectExpensesOtherGaming>16313</OtherDirectExpensesOtherGaming>
        <VolunteerLaborOtherGaming>false</VolunteerLaborOtherGaming>
        <GrossRevenueTotalGaming>292975</GrossRevenueTotalGaming>
        <OtherDirectExpensesTotalGaming>16313</OtherDirectExpensesTotalGaming>
        <DirectExpenseSummaryGaming>16313</DirectExpenseSummaryGaming>
        <NetGamingIncomeSummary>276662</NetGamingIncomeSummary>
      </GamingInformation>
      <StatesWhereGamingConducted>CA</StatesWhereGamingConducted>
      <StatesWhereGamingConducted>FL</StatesWhereGamingConducted>
      <StatesWhereGamingConducted>GA</StatesWhereGamingConducted>
      <StatesWhereGamingConducted>MI</StatesWhereGamingConducted>
      <StatesWhereGamingConducted>NY</StatesWhereGamingConducted>
      <StatesWhereGamingConducted>PA</StatesWhereGamingConducted>
      <StatesWhereGamingConducted>WA</StatesWhereGamingConducted>
      <Licensed>false</Licensed>
      <ExplanationIfNo>Schedule O</ExplanationIfNo>
      <LicenseSuspendedEtc>true</LicenseSuspendedEtc>
      <ExplanationIfYes>Schedule O</ExplanationIfYes>
      <GamingWithNonmembers>false</GamingWithNonmembers>
      <MemberOfOtherEntity>false</MemberOfOtherEntity>
      <PercentageOfGamingOthrFacility>1.00000</PercentageOfGamingOthrFacility>
      <NameOfGamingRecKeeperPerson>See Schedule O</NameOfGamingRecKeeperPerson>
      <ContractWith3rdPartyForGamRev>false</ContractWith3rdPartyForGamRev>
      <GamingManagerNamePerson>See Schedule O</GamingManagerNamePerson>
      <CharitableDistribRequired>false</CharitableDistribRequired>
      <Form990ScheduleGPartIV>
        <Identifier>Schedule G, part II - Fundraising Events</Identifier>
        <Explanation>The Crohn's &amp; Colitis Foundation of America, Inc. ("CCFA") has over 50,000 members and 41 chapters nationwide. Essential to CCFA's mission is its ongoing fundraising efforts that enable it to fund further research, as well as educational and support activities. CCFA raises more than $40 million annually through memberships, fundraising events, sponsorships, and other programs. Since the organization compiles its special events information for financial statements purposes on an aggregate basis, CCFA is unable to determine precisely how much of the gross revenue generated from special events is derived from pure contributions and how much from services rendered. To that end, CCFA is reporting, for 990 purposes, an amount as "services rendered" that equals the expense of conducting the event since it is reasonable to project that the costs of holding each event were passed through to the attendees.</Explanation>
      </Form990ScheduleGPartIV>
      <Form990ScheduleGPartIV>
        <Identifier>Schedule G, Part III - Gaming Activities</Identifier>
        <Explanation>The Crohn's &amp; Colitis Foundation of America, Inc. only partakes in gaming activities to the extent the organization holds a raffle or game of chance during a gala, dinner or other special event. Each chapter is responsible for conducting its own special event activities and, as such, the organization does not have one person who oversees all gaming activities for purposes of Schedule G, Part III, Lines 14 &amp; 16. Raffles are conducted as part of special events and not as separate fundraising activities. Chapters are responsible for securing applicable licenses and complying with reporting requirements. For the period covered by this return, only seven chapters held raffles: California, Florida, Georgia, Michigan, New York, Pennsylvania, and Washington.</Explanation>
      </Form990ScheduleGPartIV>
    </IRS990ScheduleG>
    <IRS990ScheduleI documentId="IRS990ScheduleI">
      <RecordsMaintained>true</RecordsMaintained>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Baylor College of Medicine</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>6621 Fannin Street</AddressLine1>
          <City>Houston</City>
          <State>TX</State>
          <ZIPCode>77030</ZIPCode>
        </AddressUS>
        <EINOfRecipient>741613878</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>50000</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Benaroya Research Institute</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>1201 Ninth Avenue</AddressLine1>
          <City>Seattle</City>
          <State>WA</State>
          <ZIPCode>98101</ZIPCode>
        </AddressUS>
        <EINOfRecipient>910653422</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>29125</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Beth Israel Deaconess Medical Center</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>330 Brookline Avenue</AddressLine1>
          <City>Boston</City>
          <State>MA</State>
          <ZIPCode>02215</ZIPCode>
        </AddressUS>
        <EINOfRecipient>042103881</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>191104</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Brigham &amp; Women's Hospital</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>75 Francis Street</AddressLine1>
          <City>Boston</City>
          <State>MA</State>
          <ZIPCode>02215</ZIPCode>
        </AddressUS>
        <EINOfRecipient>042312909</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>216297</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Brooklyn College of City University of New York</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>2900 Bedford Avenue</AddressLine1>
          <City>Brooklyn</City>
          <State>NY</State>
          <ZIPCode>11210</ZIPCode>
        </AddressUS>
        <EINOfRecipient>131988190</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>92500</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>California Institute of Technology</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>1200 East California Blvd</AddressLine1>
          <City>Pasadena</City>
          <State>CA</State>
          <ZIPCode>91125</ZIPCode>
        </AddressUS>
        <EINOfRecipient>951643307</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>178431</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Case Western Reserve University</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>10900 Euclid Avenue</AddressLine1>
          <City>Cleveland</City>
          <State>OH</State>
          <ZIPCode>44106</ZIPCode>
        </AddressUS>
        <EINOfRecipient>136193105</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
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        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>277402</AmountOfCashGrant>
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          <AddressLine1>513 Parnassus Avenue</AddressLine1>
          <City>San Francisco</City>
          <State>CA</State>
          <ZIPCode>94143</ZIPCode>
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        <EINOfRecipient>946036493</EINOfRecipient>
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          <BusinessNameLine1>University of Chicago</BusinessNameLine1>
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          <AddressLine1>5841 S Maryland Avenue</AddressLine1>
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          <State>IL</State>
          <ZIPCode>60637</ZIPCode>
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        <EINOfRecipient>362177139</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
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          <AddressLine1>13001 East 17th Place</AddressLine1>
          <AddressLine2>PO BOX 6508</AddressLine2>
          <City>Aurora</City>
          <State>CO</State>
          <ZIPCode>80045</ZIPCode>
        </AddressUS>
        <EINOfRecipient>846000555</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>497503</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Connecticut Health Center</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>263 Farmington Avenue</AddressLine1>
          <City>Storrs</City>
          <State>CT</State>
          <ZIPCode>060301319</ZIPCode>
        </AddressUS>
        <EINOfRecipient>521725543</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>143575</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Illinois at Chicago</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>840 S Wood</AddressLine1>
          <City>Chicago</City>
          <State>IL</State>
          <ZIPCode>60612</ZIPCode>
        </AddressUS>
        <EINOfRecipient>376000511</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>108829</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Maryland School of Medicine</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>22 South Greene Street</AddressLine1>
          <City>Baltimore</City>
          <State>MD</State>
          <ZIPCode>21201</ZIPCode>
        </AddressUS>
        <EINOfRecipient>526002033</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>125387</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Massachusetts Medical Center</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>364 Plantation Street</AddressLine1>
          <City>Worcester</City>
          <State>MA</State>
          <ZIPCode>016052324</ZIPCode>
        </AddressUS>
        <EINOfRecipient>043167352</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>117975</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Miami</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>1475 NW 12th Avenue</AddressLine1>
          <City>miami</City>
          <State>FL</State>
          <ZIPCode>33136</ZIPCode>
        </AddressUS>
        <EINOfRecipient>590624458</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>89104</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Michigan</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>200 Zina Pitcher Place</AddressLine1>
          <AddressLine2>4410 Kresge 111</AddressLine2>
          <City>Ann Arbor</City>
          <State>MI</State>
          <ZIPCode>481090586</ZIPCode>
        </AddressUS>
        <EINOfRecipient>386006309</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>49992</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of New Mexico</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>1 University of New Mexico</AddressLine1>
          <City>Albuquerque</City>
          <State>NM</State>
          <ZIPCode>87131</ZIPCode>
        </AddressUS>
        <EINOfRecipient>856000642</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>128700</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
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      <RecipientTable>
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          <BusinessNameLine1>University of North Carolina at Chapel Hill</BusinessNameLine1>
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        <AddressUS>
          <AddressLine1>104 Airport Drive</AddressLine1>
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          <State>NC</State>
          <ZIPCode>27599</ZIPCode>
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        <EINOfRecipient>566001393</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>632872</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
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          <BusinessNameLine1>University of Pennsylvania School of Medicine</BusinessNameLine1>
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          <AddressLine1>415 Curie Boulevard</AddressLine1>
          <City>Philadelphia</City>
          <State>PA</State>
          <ZIPCode>19104</ZIPCode>
        </AddressUS>
        <EINOfRecipient>231352685</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>73251</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Rochester School of Medicine</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>601 Elmwood Avenue</AddressLine1>
          <City>Rochester</City>
          <State>NY</State>
          <ZIPCode>14642</ZIPCode>
        </AddressUS>
        <EINOfRecipient>160743209</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>135850</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of South Carolina</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>921 Assembly St room 301</AddressLine1>
          <City>Columbia</City>
          <State>SC</State>
          <ZIPCode>29208</ZIPCode>
        </AddressUS>
        <EINOfRecipient>570967350</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>11259</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Texas Medical Branch</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>301 University Boulevard</AddressLine1>
          <City>Galveston</City>
          <State>TX</State>
          <ZIPCode>775551070</ZIPCode>
        </AddressUS>
        <EINOfRecipient>746000949</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>166733</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
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      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>University of Texas Southwestern Medical Center at</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>5323 Harry Hines Boulevard</AddressLine1>
          <City>Dallas</City>
          <State>TX</State>
          <ZIPCode>752358884</ZIPCode>
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          <State>VA</State>
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        </RecipientNameBusiness>
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          <AddressLine1>Box 357190</AddressLine1>
          <City>Seattle</City>
          <State>WA</State>
          <ZIPCode>981957190</ZIPCode>
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        <EINOfRecipient>846000555</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
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      <RecipientTable>
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          <BusinessNameLine1>Vanderbilt University</BusinessNameLine1>
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          <AddressLine1>21st and Garland Avenue</AddressLine1>
          <City>Nashville</City>
          <State>TN</State>
          <ZIPCode>372322576</ZIPCode>
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          <BusinessNameLine1>Washington University School of Medicine</BusinessNameLine1>
        </RecipientNameBusiness>
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          <AddressLine1>660 S Euclid Avenue</AddressLine1>
          <City>St Louis</City>
          <State>MO</State>
          <ZIPCode>63110</ZIPCode>
        </AddressUS>
        <EINOfRecipient>126238900</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>592307</AmountOfCashGrant>
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      </RecipientTable>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>Yale University School of Medicine</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>300 Cedar Street</AddressLine1>
          <City>New Haven</City>
          <State>CT</State>
          <ZIPCode>06520</ZIPCode>
        </AddressUS>
        <EINOfRecipient>590624458</EINOfRecipient>
        <IRCSection>501(c )(3)</IRCSection>
        <AmountOfCashGrant>293145</AmountOfCashGrant>
        <PurposeOfGrant>RESEARCH</PurposeOfGrant>
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      <TotalNbrOf501C3AndGovtGrants>60</TotalNbrOf501C3AndGovtGrants>
      <TotalNbrOfOtherOrganizations>0</TotalNbrOfOtherOrganizations>
      <Form990ScheduleIPartIV>
        <Identifier>Grants</Identifier>
        <ReturnReference>Part I, Line 1</ReturnReference>
        <Explanation>The Crohn's &amp; Colitis Foundation of America, Inc. ("CCFA") is a non-profit organization dedicated to finding the cure for Crohn's disease and ulcerative colitis. To accomplish this, the Foundation subsidizes research into both diseases. Grants are awarded for specific projects for specific research and CCFA requires the researcher to issue progress reports periodically as the project is being completed. Most awards are gifted for a period of 3 years and a progress report to the CCFA Board of Directors is required on an annual basis. If the progress reports do not show significant strides in the research, the grant will not be approved for additional funding and will be terminated.</Explanation>
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      <Form990ScheduleJPartIII>
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        <ReturnReference>Part I, Line 4a</ReturnReference>
        <Explanation>In 2010, the Foundation made a severance payment to Chief Financial Officer, Michael Galvin. Mr. Galvin received $114,190 of severance, which has been reported in Schedule J, Part II, column (b)(iii).</Explanation>
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    </IRS990ScheduleJ>
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      <Form990ScheduleLPartIV>
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        </NameOfInterestedPerson>
        <Relationship>Board Member</Relationship>
        <AmountOfTransaction>270000</AmountOfTransaction>
        <DescriptionOfTransaction>See Schedule O</DescriptionOfTransaction>
        <SharingOfRevenues>false</SharingOfRevenues>
      </Form990ScheduleLPartIV>
      <Form990ScheduleLPartIV>
        <NameOfInterestedPerson>
          <NamePerson>Tyler Hillstrom</NamePerson>
        </NameOfInterestedPerson>
        <Relationship>Son-in-law - Board Member</Relationship>
        <AmountOfTransaction>53854</AmountOfTransaction>
        <DescriptionOfTransaction>See Schedule O</DescriptionOfTransaction>
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      </Form990ScheduleLPartIV>
      <Form990ScheduleLPartV>
        <Identifier>Form 990, Schedule L, Part IV</Identifier>
        <Explanation>Board of Trustees member, David Alberga, is the President and CEO of Active Network, Inc., an organization that transacts business with the Crohn's &amp; Colitis Foundation of America, Inc. ("CCFA") CCFA uses a website to process online contributions for its special events; this website is affilated with Active Network, Inc. CCFA paid $270,000 to Active Network Inc. This transaction has been fully disclosed in CCFA's audited financial statements. Additionally, Tyler Hillstrom, Interim Executive Director, and Michael Koss, Board of Trustees member, have a family relationship. Mr. Hillstrom was compensated by CCFA in the amount of $53,854 the year ending December 31, 2010.</Explanation>
      </Form990ScheduleLPartV>
    </IRS990ScheduleL>
    <IRS990ScheduleM documentId="IRS990ScheduleM">
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      <ArtHistoricalTreasures />
      <ArtFractionalInterest />
      <BooksAndPublications />
      <ClothingAndHouseholdGoods />
      <CarsAndOtherVehicles />
      <BoatsAndPlanes />
      <IntellectualProperty />
      <SecuritiesPubliclyTraded>
        <NonCashCheckbox>X</NonCashCheckbox>
        <NumberOfContributions>85</NumberOfContributions>
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      <SecuritiesMiscellaneous />
      <QualifiedContribHistStruct />
      <QualifiedContribOther />
      <RealEstateResidential />
      <RealEstateCommercial />
      <RealEstateOther />
      <Collectibles />
      <FoodInventory />
      <DrugsAndMedicalSupplies />
      <Taxidermy />
      <HistoricalArtifacts />
      <ScientificSpecimens />
      <ArchaeologicalArtifacts />
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      <Form990ScheduleMPartII>
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        <Explanation>The Foundation often receives contributions of publicly traded securities. The Foundation's investment manager or brokerage firm is tasked with selling these securities.</Explanation>
      </Form990ScheduleMPartII>
    </IRS990ScheduleM>
    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <GeneralExplanation>
        <Identifier>Governing Body and management</Identifier>
        <ReturnReference>Part VI, Line 2</ReturnReference>
        <Explanation>Irwin Rosenthal and Suzanne Rosenthal, co-founders of the Crohn's and Colitis Foundation of America, Inc., have a family relationship.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Policies</Identifier>
        <ReturnReference>Part VI, Line 11</ReturnReference>
        <Explanation>The Form 990 was prepared by a national accounting firm in conjunction with the organization's financial department. A copy of the draft Form 990 was circulated to each member of the Audit Committee, a standing committee of the Board of Trustees, for discussion and comment. Each committee Member was provided an opportunity to comment on the information contained in the 990 prior to its filing with the Internal Revenue Service.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Policies</Identifier>
        <ReturnReference>Part VI, Line 12</ReturnReference>
        <Explanation>Each officer, director, trustee and key employee of the Crohn's &amp; Colitis Foundation of America, Inc. ("CCFA") is required to annually disclose any conflicts of interest that arise by virtue of employment, board service, or position with CCFA. CCFA monitors compliance with its conflict of interest policy through an annual questionnaire/disclosure statement that is distributed to these individuals. Potential conflicts are investigated immediately.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Policies</Identifier>
        <ReturnReference>Part VI, Line 15</ReturnReference>
        <Explanation>The Crohn's &amp; Colitis Foundation is dependent on experienced and qualified leadership to achieve its goals. Factors such as annual gross revenues, geographic locations, tenure, mission and other factors help determine senior leadership compensation. The President's compensation is determined on an annual basis by the Chairman of the Board using guidelines and comparability data provided in a 2009-2010 National Compensation Study of Chief Staff Executives as statistically prepared by an independent research firm. The Foundation has taken further initiative to benchmark executive level pay by hiring an independent compensation consultant to review and validate the compensation it pays all employees. CCFA anticipates that the consultant will continue the Foundation's policy of relying on benchmarking surveys and other industry data to compare the salaries CCFA pays to its executives with compensation paid to executives of other not for profit organizations of similar size.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>disclosures</Identifier>
        <ReturnReference>part vi, line 19</ReturnReference>
        <Explanation>The taxpayer makes its Form 990 available to the public by retaining a copy at its place of business and on its website at www.ccfa.org. The Form 990 is likewise published on the internet at www.guidestar.org. The organization's financial statements are posted on its website. Governing documents and conflict of interest policy are not ordinarily made available to the public, but if requested, will be provided at management's discretion.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>Contributions</Identifier>
        <ReturnReference>Part VIII - Noncash contributions</ReturnReference>
        <Explanation>The Crohn's &amp; Colitis Foundation of America, Inc. ("CCFA") has utilized the services of Car Program, Inc., an organization that receives donated vehicles, sells them and remits the net proceeds to several charitable organizations. The vehicles are not donated directly to CCFA nor does CCFA have ownership rights to them. In 2010, CCFA received $34,511 in revenues from this program. Additionally, CCFA receives considerable in-kind contributions primarily in the form of donated public service announcements on television and radio stations. The value of such in-kind contributions, based upon information provided by third-party media services, is reflected in the statement of activities as contributed airtime revenue and health professional education and public information program service expense. Since donated services are not reported on the Form 990, CCFA has not reported the contributed airtime on Schedule M nor on Part VIII, Line 1(g). For the year ending December 31, 2010, contributed airtime amounted to $973,463.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>reconciliation of net assets</Identifier>
        <ReturnReference>part xi, line 5</ReturnReference>
        <Explanation>Changes in gift annuities valuations: $ 40,855 Unrealized gain: 392,082 --------- $432,937 =========</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
  </ReturnData>
</Return>