2011-03-16T11:54:22-04:00 2010-06-30 ERNST & YOUNG US LLP 4370 LA JOLLA VILLAGE DRIVE STE 500 SAN DIEGO CA 92122 990 2009-07-01 952160097 The Salk Institute for Biological Studies SALK 8584534100 PO Box 85800 San Diego CA 921865800 Kim E Witmer 2011-03-15 true 8585357200 2009 2016-02-24 21:20:13Z WILLIAM BRODY 10010 NO TORREY PINES ROAD LA JOLLA CA 920371099 154519760 false X www.salk.edu X 1960 CA Basic research in the following: Molecular biology & genetics, neuroscience, and plant biology. 26 25 988 112 44457 43457 87583830 114311375 0 0 -3687591 5553384 9016090 2147694 92912329 122012453 0 0 0 0 60299662 62161799 0 0 3488217 40095243 41589827 100394905 103751626 -7482576 18260827 229977288 282360647 67005302 89429170 162971986 192931477 Involved in research activities, the objectives of which are the advancement and dissemination of knowledge relevant to the health and well being of man. The objectives are met primarily through research and advanced instruction in (a) biology, (b) the cause, prevention and cure of diseases, and (c) the factors and circumstances conducive to the fulfillment of man's biological potential. false false 87928146 List of Accomplishments 1. Nuclear pore complexes harbor new class of gene regulators, offer clues to gene expression and cancer Nuclear pore complexes are best known as the communication channels that regulate the passage of all molecules to and from a cell's nucleus. Salk researchers have shown that some of the pores' constituent proteins, called nucleoporins, pull double duty as transcription factors regulating the activity of genes active during early development. This is the first time nucleoporins' gene regulatory function has been demonstrated in multicellular organisms, and these findings, reported in Cell, not only reveal a new class of transcription factors but may offer new insights into the mechanisms behind cancer. 2. Stress peptide and receptor may have role in diabetes The neuropeptide corticotropin-releasing factor (CRF) makes cameo appearances throughout the body, but its leading role is as the opening act in the stress response, jump-starting the process along the hypothalamus-pituitary-adrenal (HPA) axis. Salk Institute researchers have found that CRF also plays a part in the pancreas, where it increases insulin secretion and promotes the division of the insulin-producing beta cells. These findings, published in Proceedings of the National Academy of Sciences, may provide new insights into diabetes, particularly type 1, as well as suggest novel targets for drug intervention. 3. The mouse with a human liver: a new model for the treatment of liver disease How do you study-and try to cure in the laboratory-an infection that only humans can get? A team led by Salk Institute researchers has done it by generating a mouse with an almost completely human liver. This "humanized" mouse is susceptible to human liver infections and responds to human drug treatments, providing a new way to test novel therapies for debilitating human liver diseases and other diseases with liver involvement such as malaria. The scientists found that they not only can infect the humanized mouse with Hepatitis B and Hepatitis C, but can then successfully treat this infection using typical drugs. This study shows a real application for the mouse model, making it relevant from both academic and clinical perspectives. The researchers' findings were published in the online edition of the Journal of Clinical Investigation. 4. The pre-history of life: elegantly simple organizing principles seen in ribosomes With few exceptions, all known forms of life on earth rely on the same genetic code to specify the amino acid composition of proteins. Although different hypotheses abound, just how individual amino acids were assigned to specific three-letter combinations or codons during the evolution of the genetic code is still subject to speculation. Taking their hints from relics of this evolution left behind in modern cells, researchers at the Salk Institute concluded that after only two waves of "matching" and some last-minute fiddling, all 20 commonly used amino acids were firmly linked with their respective codons, setting the stage for the emergence of proteins with unique, defined sequences and properties. Their findings, published in the online edition of the Proceedings of the National Academy of Sciences, provide the first in vivo data shedding light on the origin and evolution of the genetic code. 5. Zebrafish study with human heart implications: Cellular grown-ups outperform stem cells in cardiac repair Bony fish like the tiny zebrafish have a remarkable ability that mammals can only dream of: if you lop off a chunk of their heart, they swim sluggishly for a few days but within a month appear perfectly normal because they have healed themselves. How they accomplish this--or, more importantly, why we can't--is one of the significant questions in regenerative medicine today. In a paper published in Nature, researchers at the Salk Institute and the Center of Regenerative Medicine in Barcelona (CMRB) identified a fish heart cell population that is the source of this astonishing healing feat, a finding that could provide insight into how mammalian hearts might be coaxed into repairing themselves after injury brought on by heart attack. 6. Work-life balance: Brain stem cells need their rest too Stem cells in the brain remain dormant until called upon to divide and make more neurons. However, little has been known about the molecular guards that keep them quiet. Scientists from the Salk Institute recently identified the signal that prevents stem cells from proliferating, protecting the brain against too much cell division and ensuring a pool of neural stem cells that lasts a lifetime. The research, published in Cell Stem Cell, highlights the importance of bone morphogenetic factor protein (BMP) signaling for the maintenance of a neural stem cell reservoir throughout adult life and may provide the key to understanding the interplay between exercise, aging and neurogenesis. 7. Connecting the dots: How light receptors get their message across For a plant, light is life. It drives everything from photosynthesis to growth and reproduction. Yet the chain of molecular events that enables light signals to control gene activity and ultimately a plant's architecture remained a mystery. A team of researchers from the Salk Institute and Duke University have now identified the courier that gives the signal to revamp the plant's gene expression pattern after photoreceptors have been activated by light. Their findings, published in Cell, bring scientists a photon closer to being able to harness plants' phenotypic plasticity to help boost agricultural yields and manage weeds under challenging growing conditions. 8. Language as a window into sociability Brainwave activity associated with language processing differs sharply in two disorders with opposite social profiles. People with Williams syndrome, known for their indiscriminate friendliness and ease with strangers, process spoken language differently from people with autism spectrum disorders--characterized by social withdrawal and isolation--found Salk researchers. Their findings, published in Social Cognitive and Affective Neuroscience, will help to generate more specific hypotheses regarding language perception and processing in both Williams syndrome and autism spectrum disorders, as well as the core mechanisms involved in the development of communication and social skills. 9. Use the common cold virus to target and disrupt cancer cells? When a cell is under stress, the tumor suppressor p53 springs into action, activating an army of foot soldiers that initiate a built-in "auto-destruct" mechanism that eliminates virus-infected or otherwise abnormal cells from the body. Maybe not surprisingly, the p53 tumor suppressor pathway is inactivated in almost every human cancer, allowing cells to escape normal growth controls. Yet there is still no rationally designed targeted cancer therapy to treat patients based on the loss of p53. A novel mechanism used by the adenovirus to sidestep the cell's suicide program could go a long way to explain how tumor suppressor genes are silenced in tumor cells and pave the way for a new type of targeted cancer therapy, researchers at the Salk Institute reported in the journal Nature. These new insights change the longstanding definition of how p53 is inactivated in adenovirus-infected cells and will finally allow investigators to develop true p53 tumor-selective oncolytic therapies. 10. Ticking of a cellular clock promotes seismic changes in the chromatin landscape associated with aging Like cats, human cells have a finite number of lives; once they divide a certain number of times, they change shape, slow their pace, and eventually stop dividing, a phenomenon called "cellular senescence." Biologists know that a cellular clock composed of structures at the chromosome end known as telomeres records how many "lives" a cell has expended. Until recently, however, they had not yet defined how the clock's ticking signals the approach of cellular oblivion. In a study published in Nature Structural and Molecular Biology, Salk researchers reported that as cells count down to senescence and telomeres wear down, their DNA undergoes massive changes in the way it is packaged. These changes likely trigger what we call "aging." 11. From eye to brain: Salk researchers map functional connections between retinal neurons at single-cell resolution By comparing a clearly defined visual input with the electrical output of the retina, researchers at the Salk Institute were able to trace for the first time the neuronal circuitry that connects individual photoreceptors with retinal ganglion cells, the neurons that carry visual signals from the eye to the brain. Their measurements, published in Nature, not only reveal computations in a neural circuit at the elementary resolution of individual neurons but also shed light on the neural code used by the retina to relay color information to the brain. Nobody has ev 87928146 true true false true false false false false true true true false false false true false false false true false false false false true true false false false false false true true false false false true false false false false true true false false true 129 0 true 988 true true true false false false false true true false false false 26 25 false false false false true true true true true false false true true true true true true true true false AR CA CT GA IL KS MD MA MI MN NJ NY ND OH OR PA SC UT VA WA WI X KIM E WITMER 8584534100 10010 NO TORREY PINES ROAD LA JOLLA CA 920371099 Irwin M Jacobs Sr 3.0 X X 0 0 0 Theodore Waitt 2.0 X X 0 0 0 William R Brody MD PhD 50.0 X X 744041 0 91333 Charles H Brandes 0.5 X 0 0 0 Kim Campbell 0.5 X 0 0 0 Linda L Chester 0.5 X 0 0 0 Joanne Chory 0.5 X 0 0 0 Frederick J Dotzler 0.5 X 0 0 0 Gerald R Fink PhD 0.5 X 10000 0 0 Richard C Helmstetter 0.5 X 0 0 0 Jennifer L Howse 0.5 X 0 0 0 Dean Kamen 0.5 X 0 0 0 Greg E Lemke PhD 50.0 X 206603 0 33407 Nancy Lukitsh 0.5 X 0 0 0 Corinne Mentzelopoulos 0.5 X 0 0 0 Howard H Newman PhD 0.5 X 0 0 0 Joseph P Noel 0.5 X 56000 0 0 Ralph S O'Connor 0.5 X 0 0 0 Gerald S Parsky 0.5 X 0 0 0 Frederick Paulsen PhD 0.5 X 0 0 0 Caryl Philips 0.5 X 0 0 0 Conrad T Prebys 0.5 X 0 0 0 Ernest S Rady 0.5 X 0 0 0 Mary Jane Salk 0.5 X 0 0 0 Carla J Shatz PhD 0.5 X 10000 0 0 Darlene M Shiley 0.5 X 0 0 0 Jerre L Stead 2.0 X 0 0 0 David M Stone 0.5 X 0 0 0 Geoffrey M Wahl PhD 50.0 X 246588 0 47332 Harvey P White 0.5 X 0 0 0 Marna C Whittington PhD 0.5 X 0 0 0 M Faye Wilson 0.5 X 0 0 0 Theodore Cranston 2.0 X X 0 0 0 Marsha A Chandler PhD 50.0 X 445608 0 37434 Julia A Miller JD 50.0 X 0 0 0 Kim E Witmer 50.0 X 281866 0 46675 Wiley Vale PhD 50.0 X 316454 0 44578 Inder Verma PhD 50.0 X 300618 0 43561 Fred Gage PhD 50.0 X 300168 0 43561 Anthony Hunter PhD 50.0 X 289062 0 47148 Rebecca R Newman 50.0 X 286565 0 43517 Gary H Silverstein 0.0 X 104583 0 0 3598156 0 478546 84 true true false UC REGENTS SAN DIEGO 9500 GILMAN DRIVE LA JOLLA CA 92093 Trng Program/Subcont 2686394 RUDOLPH SLETTEN INC 10955 VISTA SORRENTO PKWY SAN DIEGO CA 92130 General Contractor 1231617 SCRIPPS RESEARCH INSTITUTE 10550 NO TORREY PINES ROAD LA JOLLA CA 92037 SCIENTIFIC SUBCONTR. 566592 PACWEST SECURITY SERVICES 3303 HARBOR BLVD COSTA MESA CA 92696 SECURITY 490855 P2S ENGINEERING 5000 EAST SPRING STREET LONG BEACH CA 90815 ENGINEERING SERVICES 473364 21 845749 62388258 51077368 1568340 114311375 0 1565165 1565165 0 1929399 1929399 36239042 32250823 3988219 3988219 3988219 208145 845749 256484 -48339 -48339 0 0 GLASS ART TOUR 900099 210825 210825 OIL ROYALTIES 900099 7692 7692 UBI(K-1 FLOW THROUGH INCOME) 900099 44457 44457 3660 3660 266634 122012453 44457 7656621 0 0 0 0 2542014 585007 1751526 205481 0 44624609 38801399 4073296 1749914 3966470 3241358 563218 161894 7775859 6356411 1104132 315316 3252847 2658192 461888 132767 350383 133131 141673 75579 574943 462393 112550 195839 195839 0 0 169201 169201 5199771 4854221 282972 62578 17625 17625 11811339 11139563 358630 313146 2428843 2006169 343569 79105 0 6481335 4829611 1501526 150198 762620 679799 30394 52427 0 843667 657842 96430 89395 13500 13500 0 8303694 7491837 732569 79288 197991 197991 SCIENTIFIC SUBCONTRACTS 2475426 2475426 REPAIRS & PARTS 1485512 1430704 49658 5150 UBI TAXES 499 499 OTHER EXPENSES 277639 93958 167702 15979 103751626 87928146 12335263 3488217 8853826 9892888 18818039 24019050 696658 922470 95000 30000 1805300 1618493 100953 136887 903638 979489 176277139 117403309 56825762 58873830 85525065 80516496 52681711 76233941 3671336 29137103 229977288 282360647 15344752 13805497 10248872 10149807 35751397 58684592 5660281 6789274 67005302 89429170 X 48592081 60292274 42190188 48789959 72189717 83849244 162971986 192931477 229977288 282360647 X false true true X true true X 87626170 88756153 102548502 87583830 114311374 480826029 87626170 88756153 102548502 87583830 114311374 480826029 3809905 477016124 1418249 1641652 1297051 2714020 3494564 10565536 116343 145660 105259 44457 411719 2873 2074 22714 3678 222177 253516 492056800 0.96943 0.96955 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED false false false false false false false false true 2930 2930 false false OTHER ACTIVITIES PART II-B, LINE 1I PAID MEMBERSHIP DUES TO RESEARCH AND BIOMEDICAL ORGANIZATIONS, A PORTION OF WHICH ARE CONSIDERED LOBBYING. ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES $ 720 CALIFORNIA HEALTHCARE INSTITUTE $1,250 NATIONAL ASSOCIATION FOR BIOMEDICAL RESEARCH $ 960 71360759 11356891 8833640 2130745 89420545 83049682 2721386 -12462264 1948045 71360759 0.01090 0.98910 false false 1153930 1153930 69755166 36260084 33495082 47109382 37230976 9878406 54765514 43912249 10853265 3493147 3493147 58873830 ALTERNATIVE INVESTMENTS 76230828 F STOCKS NOT-PUBLICLY TRADED <5% 3113 C 76233941 FUNDS HELD BY TRUSTEE 25251219 DEFERRED GIFTS 2830126 COSTS OF ISSUANCE 1055758 29137103 0 DEFERRED RETIREMENT OBLIGATION 6789274 6789274 122012453 103751626 18260827 11698666 -10177563 1521103 19781930 122245530 11698666 -11722073 -23407 122268937 -256484 -256484 122012453 102463600 -1288026 -1288026 103751626 103751626 CHANGE IN NET ASSETS Part XI, Line 8 Investment gains in excess of amount designated for current operations under spending policy - ($11,722,073) Postretirement benefit changes other than net periodic benefit cost - $955,978 Debt defeasance costs - $588,532 RECONCILIATION OF REVENUE PER AUDITED FS WITH REVENUE PER RETURN Part XII, Line 2d Investment gains in excess of amount designated for current operations - ($11,722,073) Reconciliation of Revenue per Audited FS with Revenue per Return Part XII, Line 4b Fundraising events expenses - ($256,484) ENDOWMENT FUNDS USES PART V, LINE 4 ENDOWMENT INCOME INTENDED TO BE USED FOR RESEARCH, OPERATING, AND LECTURESHIP EXPENSES. Reconciliation of Expenses per Audited FS with Expenses per Return Part XIII, Line 2d Postretirement benefit changes other than net periodic benefit cost - ($955,978) Debt Defeasance costs - ($588,532) Fundraising events expenses netted with revenues on return on Part VIII, line 8b - $256,484 Central America and the Caribbean Program Services Attended conference 5832 East Asia and the Pacific Program Services Attended conference 24247 Europe (Including Iceland and Greenland) Program Services Attended conference 95226 Europe (Including Iceland and Greenland) Program Services Scientific subcontract 248829 North America Program Services Attended conference 1970 South America Program Services Attended conference` 31886 Europe (Including Iceland and Greenland) Fundraising Central America and the Caribbean Investments 407990 CONCERT 787449 640249 147200 66040 120000 GALA DINNER 215845 182500 33345 34454 12500 1 50600 23000 27600 23490 1053894 845749 208145 123984 132500 256484 -48339 X X true true X X X X X X true true false false false false false true false William R Brody MD PhD 536743 0 0 0 207298 0 83333 0 8000 0 835374 0 0 0 Greg E Lemke PhD 200138 0 0 0 6465 0 28221 0 5186 0 240010 0 0 0 Geoffrey M Wahl PhD 234774 0 0 0 11814 0 33758 0 13574 0 293920 0 0 0 Marsha A Chandler PhD 390176 0 0 0 55432 0 35750 0 1684 0 483042 0 0 0 Kim E Witmer 279544 0 0 0 2322 0 33843 0 12832 0 328541 0 0 0 Wiley Vale PhD 306096 0 0 0 10358 0 34891 0 9687 0 361032 0 0 0 Inder Verma PhD 297096 0 0 0 3522 0 33875 0 9686 0 344179 0 0 0 Fred Gage PhD 297096 0 0 0 3072 0 33875 0 9686 0 343729 0 0 0 Anthony Hunter PhD 263954 0 0 0 25108 0 33575 0 13573 0 336210 0 0 0 Rebecca R Newman 283001 0 0 0 3564 0 33831 0 9686 0 330082 0 0 0 Gary H Silverstein 0 0 0 0 104583 0 0 0 0 0 104583 0 0 0 Questions Regarding Compensation Part I, Line 1b First-class or charter travel: Marsha Chandler, EVP/COO - $2,763. Not reported on W-2 (accountable plan). Housing allowance or residence for personal use: In lieu of providing housing to the President; reported on his Form W-2. Severance Payment Part I, Line 4a Gary H. Silverstein - $104,583 Supplemental Nonqualified Retirement Plan Part I, Line 4b Deferred compensation plan (section 457(f)) was estabished for the President. The Institute's contribution to the plan and the earnings from the contribution will become 100% vested upon the President's completion of 5 years of service. Non-fixed payments Part I, Line 7 Marsha Chandler, EVP/COO - $52,000 supplemental payment for additional duties while hiring a President Anthony Hunter, Professor - $10,000 for additional duties as Cancer Center Director CA Statewide Community Development Authority 680164610 130911S92 2005-08-11 25712839 Refinance of research building false false County of San Diego 956000934 797391R50 2010-05-27 37207949 Refinance and central plant expans false false 25712839 686939 true false true true 37207949 12942020 23742247 523682 2012 true false false true 0.00000 0.00000 0.00000 true false true false true true 0.00000 0.00000 0.00000 true false false false false false true false false false false false true JOSEPH NOEL HOME LOAN X 150000 30000 false true true 30000 Joseph P Noel Trustee 10000 Faculty chair Joseph P Noel Trustee 15000 Loan forgivenes Joseph P Noel Trustee 31000 Scholarship X 7 1568340 MARKET VALUE false true true Selling noncash contributions Part I, Line 32b All stock donations are directed to a broker who in turn sells the stocks upon direction by the Chief Financial Officer. The gift is valued based on the market value as of the donation date. After the stock is sold, the broker remits the net amount to the organization. GOVERNING BODY AND MANAGEMENT FORM 990, PART VI, SECTION A, LINES 6, 7a, 7b LINE 6: MEMBERSHIP OF THE CORPORATION CONSISTS OF THE PERSONS ELECTED TO THE BOARD OF TRUSTEES AND THREE MEMBERS FROM AMONG THE RESIDENT AND NON-RESIDENT FELLOWS AND PROFESSORS CHOSEN AND ELECTED ANNUALLY BY THE RESIDENT AND NON-RESIDENT FELLOWS AND PROFESSORS. LINE 7a: THE MEMBERS OF THE CORPORATION ELECT THE TRUSTEES. LINE 7b: THE MEMBERS OF THE CORPORATION MAY ALTER, AMEND, OR REPEAL THE BY-LAWS BY VOTE. POLICIES FORM 990, PART VI, SECTION B, LINES 11A, 12C AND 15A/B LINE 11A: THE FORM 990 IS PREPARED BY THE INSTITUTE, INTERNALLY REVIEWED BY THE SR. DIRECTOR OF FINANCE AND THE CHIEF FINANCIAL OFFICER AND EXTERNALLY REVIEWED BY THE TAX DEPARTMENT OF A PUBLIC ACCOUNTING FIRM. A COPY OF THE PREPARED FORM 990 IS PROVIDED TO ALL BOARD MEMBERS AND THE AUDIT COMMITTEE FOR REVIEW, DISCUSSION, AND APPROVAL OF THE FORM 990 PRIOR TO ELECTRONIC FILING. LINE 12C: MONITORING AND ENFORCING COMPLIANCE WITH THE CONFLICT OF INTEREST POLICY ANNUALLY, THE CONFLICT OF INTEREST DISCLOSURE STATEMENT IS SENT OUT FOR COMPLETION BY THE MEMBERS OF THE BOARD OF TRUSTEES, SENIOR MEMBERS OF ADMINISTRATION, ALL NON-RESEARCH STAFF, AND RESEARCHERS. THE DESIGNATED OFFICIAL FOR EACH GROUP REVIEWS THE COMPLETED FORM AND BRINGS ANY POTENTIAL CONFLICT OF INTEREST TO THE RESPECTIVE COMMITTEES FOR REVIEW. UPON DETERMINATION THAT A CONFLICT OF INTEREST EXISTS, THE FOLLOWING CONDITIONS OR RESTRICTIONS MAY BE IMPOSED: A. MONITORING OF ACTIVITIES GENERATING THE CONFLICT BY ANOTHER MEMBER B. DISQUALIFICATION FROM PARTICIPATION IN THE ACTIVITIES GIVING RISE TO THE CONFLICT C. MODIFICATION OF RESPONSIBILITIES TO AVOID CONFLICTS D. PUBLIC DISCLOSURE OR DIVESTITURE OF SIGNIFICANT FINANCIAL INTERESTS E. MODIFICATION OF THE RESEARCH PLAN OR REMOVAL OF THE AFFECTED RESEARCHER FROM THE RESEARCH F. SEVERANCE OF RELATIONSHIP THAT CREATES ACTUAL OR POTENTIAL CONFLICTS G. TERMINATION OF EMPLOYMENT. LINE 15A/B: DETERMINING COMPENSATION OF CEO, EXECUTIVE DIRECTOR, OR TOP MANAGEMENT OFFICIAL AND OTHER OFFICERS OR KEY EMPLOYEES OF THE ORGANIZATION AN INDEPENDENT CONSULTANT WAS RETAINED BY THE SALK INSTITUTE TO ADVISE ON COMPENSATION ISSUES. MARKET ANALYSIS ON THE COMPETITIVENES OF THE BASE SALARY AND TOTAL COMPENSATION (INCLUDING BENEFITS) FOR THE CEO (2008), EVP (2008), AND CFO (2007) WERE CONDUCTED. THE INDEPENDENT CONSULTANT EVALUATED TOTAL COMPENSATION COMPARED TO LIKE ROLES AMONG OGANIZATIONS PROVIDING SUBSTANTIALLY SIMILAR SERVICES IN THE RESEARCH INDUSTRY, INCLUDING BOTH FOR-PROFIT AND NOT-FOR-PROFIT ORGANIZATIONS. THEY CONSIDERED THE SIZE AND SCOPE OF OPERATIONS, ORGANIZATIONAL COMPLEXITY, AND THE SKILLS AND QUALIFICATIONS OF THE INCUMBENTS. THE CONSULTANT GAVE THE OPINION THAT THE TOTAL COMPENSATION FALLS WELL WITHIN A REASONABLE RANGE OF COMPETITIVE PRACTICES. THE CONSULTANT'S REPORTS WERE REVIEWED BY THE EXECUTIVE COMMITTEE WHICH SERVED AS THE COMPENSATION COMMITTEE, EXCLUDING PERSONS WITH A CONFLICT OF INTEREST WITH RESPECT TO THE COMPENSATION ARRANGEMENT. DOCUMENTATION AND RECORDKEEPING WITH RESPECT TO THE DELIBERATIONS AND DECISIONS REGARDING THE COMPENSATION PACKAGE WERE INCLUDED IN THE MINUTES OF THE EXECUTIVE COMMITTEE MEETING. A COPY OF THE CONSULTANT'S REPORTS WAS ATTACHED TO THE MINUTES OF THE MEETING. DISCLOSURE FORM 990, PART VI, SECTION C, LINE 19 UPON REQUEST, THE OFFICE OF THE CHIEF FINANCIAL OFFICER MAKES AVAILABLE TO THE PUBLIC ITS GOVERNING DOCUMENTS AND CONFLICT OF INTEREST POLICY. FINANCIAL STATEMENTS ARE AVAILABLE ON THE SALK WEB SITE. REFUNDED ISSUES Schedule K, Part I, Lines A and B, Column (f) Line A: Refunded issue dated 03/30/94 Line B: Refunded issue dated 04/13/00 LEASE ARRANGEMENTS SCHEDULE K, PART III, Line 2B THE SOLE CONTRACT WHICH MIGHT BE DEEMED A LEASE RESULTING IN PRIVATE BUSINESS USE IS A CONTRACT WITH THE CAFETERIA VENDOR, WHICH WOULD NOT BE CONSIDERED PRIVATE BUSINESS USE PURSUANT TO C.F.R. S1.141-3(D)(3)(ii) IF THE TERM OF THE USE UNDER THE ARRANGEMENT, INCLUDING ALL RENEWAL OPTONS, WAS NOT LONGER THAN 50 DAYS. THE CURRENT AGREEEMENT PROVIDES FOR A TERM OF 60 DAYS, AND IS RENEWABLE ONLY UPON BOTH PARTIES' AGREEMENT. THE SALK INSTITUTE INTENDS TO AMEND ITS ARRANGEMENT WITH THE VENDOR TO PROVIDE FOR A TERM OF 50 DAYS OR LESS. 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