2012-06-18T13:40:53-07:00 2011-12-31 990 2011-01-01 236434390 THE WISTAR INSTITUTE OF ANATOMY & BIOLOGY WIST 2158989910 3601 Spruce Street Philadelphia PA 191044265 Larry Keinath 2158983742 2012-05-15 2011 2016-02-24 21:20:13Z Larry A Keinath 3601 Spruce Street Philadelphia PA 191044265 128816000 0 X www.wistar.org X 1892 PA Biomedical research with special expertise in cancer research and vaccine development 34 34 467 12 84000 -61000 49900000 68019000 1545000 1526000 1571000 4061000 14057000 18705000 67073000 92311000 0 0 0 0 28280000 29496000 0 0 900000 28058000 30565000 56338000 60061000 10735000 32250000 121142000 159446000 10241000 27404000 110901000 132042000 Established in 1892 as the nation's first independent medical research institution, The Wistar Institute is an international leader in biomedical research with special expertise in cancer research and vaccine development. The Institute works to move its research advances from the laboratory to the clinic as quickly as possible. 0 0 48992000 0 0 CANCER RESEARCH - Wistar has held the prestigious Cancer Center designation for the National Cancer Institute since the first such centers were named in 1976. The Institute is home to preeminent researchers studying the basic science of cancer. Deciphering Cancer Genetics: Wistar is a national leader in illuminating how mutations in genes lead to various cancers. Stem Cell Investigations: Institute researchers are identifying and characterizing cancer stem cells that appear to be responsible for recurrent and treatment-resistant forms of cancer. A Blood Test For The Early Detection Of Lung Cancer: Lung cancer is the top cancer killer, claiming more lives than breast cancer, prostate cancer, and colon cancer combined. By the time it is diagnosed, the disease usually has advanced so far that treatment options are limited. Wistar scientists are developing a blood test that would detect the disease early, potentially saving countless lives. In the lab, their prototype test can diagnose early-stage lung cancer with nearly 90 percent accuracy. Breakthrough May Lead To New Cancer Treatments: A breakthrough by a Wistar researcher may lead to the development of a new class of highly targeted cancer drugs. The scientist decoded a key structure of the enzyme telomerase, which plays a major role in the development of cancer. The enzyme is active in up to 90 percent of human tumors, making it one of the top targets for the creation of new cancer treatments. Exploring The Role Of The Tumor Microenvironment In Disease: Wistar scientists have found that normal cells and molecules that surround a cancer cell - the tumor microenvironment - nurture growing cancer cells, creating a hospitable place for a tumor to grow and spread. Targeting these cells could greatly increase the effectiveness of traditional anti-cancer treatments. Leading The Fight Against Melanoma: Wistar oversees one of the most prestigious melanoma research programs in the world, studying the development of the disease and pursuing treatments for advanced melanoma. 0 0 0 IMMUNOLOGY - Wistar discoveries led to the creation of the rubella vaccine that eradicated "German measles" in the United States, human rabies vaccine used worldwide, and a rotavirus vaccine approved in 2006 that will prevent an illness responsible for hundreds of thousands of children deaths worldwide each year. Today, Wistar Institute Vaccine Center scientists are creating new vaccines against the world's deadliest diseases. Annual Flu Shots - A Thing Of The Past? Wistar researchers are working to develop a universal influenza vaccine that would be effective against all strains of influenza, including avian flu. The vaccine would protect against pandemics and reduce the need for annual flu shots. Working Together To Fight Disease: Wistar researchers are collaborating with leading scientists worldwide to develop vaccines for hepatitis C, malaria, and other potentially deadly diseases. A Global Reach: The Institute has licensed its rabies and rubella vaccine seed stock to companies in China, India, and Russia to help these countries develop affordable vaccines for their own populations. Easing The Pain:Wistar immunologists also are developing novel therapies for autoimmune diseases such as lupus and rheumatoid arthritis. The Secrets Of Regeneration: Wistar scientists have made critical discoveries in understanding how to promote the healing of damaged tissue through regeneration. While the process may have been lost to humans and other mammals as a byproduct of evolution, Wistar researchers are charting the genes responsible for tissue regrowth. 0 0 0 TRAINING AND OUTREACH - From its inception, The Wistar Institute has been dedicated to providing students with the tools they need to tackle the challenges of scientific discovery. The Institute has also made supporting science and cancer education a priority from high school students to postdoctoral researchers to underserved populations in the community. Educating Area Youth: Wistar offers internships, tours, and contests to area high school students to stimulate and nurture their interests in science. The Institute also offers a two-year training program for biomedical technicians in partnership with Community College of Philadelphia. Engaging The Community: The Institute hosts community events including lectures by noted science authors that are designed to stimulate science learning and discussion. Wistar also hosts public health forums designed to educate laypersons on the latest in cancer science and prevention. Preparing The Scientists Of Tomorrow: Training tomorrow's top scientific investigators is key to Wistar's mission. Over the past decade, nearly 1,000 researchers, from predoctoral students to postdoctoral fellows and visiting scientists, have trained at Wistar. 0 0 0 48992000 1 1 0 1 0 0 0 1 0 1 1 1 0 0 1 1 1 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 1 0 0 1 65 0 1 467 1 1 1 0 0 0 0 1 1 0 0 0 0 0 0 X 34 34 1 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 CA FL NJ NY PA X Stephen E Tustin CPA 2154956887 3601 Spruce Street Philadelphia PA 191044265 Brian H Dovey 0.00 X X 0 0 0 Richard Horowitz 0.00 X X 0 0 0 Helen P Pudlin 0.00 X X 0 0 0 Maida Milone 0.00 X X 0 0 0 Seymour S Preston III 0.00 X X 0 0 0 Elizabeth McKee Anderson 0.00 X 0 0 0 Robert S Blank 0.00 X 0 0 0 Dani Bolognesi PhD 0.00 X 0 0 0 Douglas D Briggs 0.00 X 0 0 0 Ira Brind 0.00 X 0 0 0 Ronald Caplan 0.00 X 0 0 0 Daniel Fitzpatrick 0.00 X 0 0 0 Robert A Fox 0.00 X 0 0 0 Herbert Kean MD 0.00 X 0 0 0 Hilary Koprowski MD 0.00 X 0 0 0 Faye Olivieri-Kozich 0.00 X 0 0 0 Dan W Matthias 0.00 X 0 0 0 Susan S McDonald 0.00 X 0 0 0 I Wistar Morris 0.00 X 0 0 0 Albert Ominsky Esq 0.00 X 0 0 0 Vincent Price PhD 0.00 X 0 0 0 Samuel V Rhoads 0.00 X 0 0 0 Robert H Rock 0.00 X 0 0 0 Gerald B Rorer 0.00 X 0 0 0 Adele K Schaeffer 0.00 X 0 0 0 Paul J Schmitt 0.00 X 0 0 0 Milton S Schneider 0.00 X 0 0 0 Judith Soltz Esq 0.00 X 0 0 0 Lawrence V Stein 0.00 X 0 0 0 Arthur L Stokes MD 0.00 X 0 0 0 Kevin M Tucker 0.00 X 0 0 0 David V Wachs 0.00 X 0 0 0 Daniel H Wheeler Esq 0.00 X 0 0 0 Edward Ziff PhD 0.00 X 0 0 0 Russel Kaufman MD 65.00 X 685000 0 48000 Dario Altieri 55.00 X 341000 0 51000 Larry Keinath 55.00 X 251000 0 48000 Elizabeth O'Brien 40.00 X 243000 0 62000 Peter Corrado 55.00 X 188000 0 51000 David Speicher PhD 55.00 X 226000 0 39000 Hildegund Ertl MD 55.00 X 222000 0 45000 Meenhard Herlyn DVM 55.00 X 217000 0 60000 Frank Rauscher PhD 55.00 X 204000 0 34000 Ellen Pure PhD 55.00 X 202000 0 45000 2779000 0 483000 41 0 1 0 L F Driscoll Co LLC 9 Presidential Blvd P O Box 468 Bala Cynwyd PA 19004 Construction Management 4700000 Ballinger 833 Chestnut Street Suite 1400 Philadelphia PA 19107 Architecture Engineering Planning Interior Design 1824000 Laredo Mechanical LLC P O Box 250 Plymouth Meeting PA 19462 HVAC Services 544000 ABM Mid-Atlantic Inc 420 Feheley Drive King of Prussia PA 19406 Janitorial 514000 Schnader Harrison Segal & Lewis LLP 1600 Market Street Suite 3600 Philadelphia PA 19103 Legal Services 246000 12 0 0 402000 0 55444000 12173000 1276000 68019000 Scientific Research 541700 1526000 1526000 0 0 0 0 0 0 1526000 1614000 0 0 1614000 0 0 0 0 18008000 0 0 18008000 0 0 38761000 0 36314000 0 2447000 0 2447000 0 0 2447000 74000 402000 191000 -117000 0 -117000 Other Investment Income 900099 710000 0 0 710000 Sale of Specialized Services 541900 84000 0 84000 0 Other Income 900099 20000 0 0 20000 0 0 0 0 814000 92311000 1526000 84000 22682000 1969000 124000 1845000 0 19916000 14761000 4827000 328000 2406000 1655000 715000 36000 3832000 2735000 1032000 65000 1373000 944000 408000 21000 198000 198000 83000 83000 237000 237000 89000 89000 2223000 1089000 993000 141000 33000 1000 32000 397000 69000 317000 11000 646000 173000 461000 12000 4295000 37000 4258000 293000 191000 94000 8000 65000 46000 19000 20000 20000 4121000 4121000 198000 198000 Subcontracts 10117000 10117000 0 0 Lab supplies and equpment maintenance agreements 6099000 5564000 530000 5000 Allocation of Operations and Maintenance reported in C 0 6717000 -6791000 74000 Allocation of Depreciation expense reported in C 0 3915000 -3936000 21000 1451000 854000 419000 178000 60061000 48992000 10169000 900000 1613000 638000 7123000 27667000 15311000 14806000 71000 81000 714000 889000 75083000 41668000 23663000 33415000 43442000 51569000 29081000 30258000 124000 123000 121142000 159446000 7172000 11614000 0 0 1719000 1493000 0 519000 0 0 0 0 0 593000 0 0 1350000 13185000 10241000 27404000 X 71537000 75305000 15054000 33472000 24310000 23265000 110901000 132042000 121142000 159446000 X 32250000 -11109000 X 0 1 1 X 1 1 X 35240000 35346000 41600000 49900000 68019000 230105000 35240000 35346000 41600000 49900000 68019000 230105000 0 230105000 10447000 12727000 11019000 14623000 20332000 69148000 0 0 0 0 0 0 0 3000 53000 51000 20000 127000 299380000 9762000 0.76861 0.67841 X Miscellaneous income RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 0 0 0 0 0 1 237000 0 0 237000 0 SchC_P2B_S00_L01 Schedule C, Part II-B, Line 1 The Wistar Institute engaged the services of several lobbying firms whose responsibilities are to provide government relations services to the Wistar Institute at the federal and state level, respectively, with regard to both regulatory and legislative issues. Duties include monitoring and tracking legislation which may be of interest to The Wistar Institute and assisting in finding funding sources for programs. 0 0 X 0 12652000 50000 -214000 0 404000 0 12084000 11357000 73000 1502000 0 280000 0 12652000 8726000 1515000 1386000 0 270000 0 11357000 11374000 64000 -2436000 0 276000 0 8726000 0.1852 0.707 0.1078 0 0 0 162000 162000 0 33916000 20117000 13799000 0 3539000 308000 3231000 0 26983000 21243000 5740000 0 10483000 0 10483000 33415000 Isaac J Wistar 1898 fund - Mellon Bank 10296000 F Isaac J Wistar 1893 fund - PNC Bank 1132000 F Isaac J Wistar 1902 Contingent fd - Mellon Bank 572000 F Effingham B Morris Biological fd - Mellon Bank 1445000 F Carlos Frederick MacDonald Res fd - Mellon Bank 189000 F Milton J and Francis H Greenman fd - Mellon Bank 646000 F Charles M and Josephine A Shander fund - PNC Bank 320000 F Hedge and absolute return funds 10573000 F Statutory trust 5085000 F 30258000 0 Accrued pension expense 3838000 Loan payable 9347000 13185000 92311000 60061000 32250000 -6109000 0 0 0 -5000000 -11109000 21141000 85314000 -6109000 0 0 -1079000 -7188000 92502000 0 -191000 -191000 92311000 60252000 0 0 0 191000 191000 60061000 0 0 0 60061000 SchD_P03_S00_L01 Schedule D, Part III, Line 1 Collections consist of Family Memorabilia which is not used in the Institute's operations. SchD_P03_S00_L04 Schedule D, Part III, Line 4 The Institute's Collections constitute a history of medical science in Philadelphia and the history of vaccine development. The museum collections are tied to our Deeds of Trusts and have significant historical value as Wistar was established the first independent nonprofit biomedical research institute in the country. SchD_P05_S00_L04 Schedule D, Part V, Line 4 The Board of Trustees determines the prudent use for the endowment funds for general purposes and to support research and training programs as specified by the various endowment programs. SchD_P10_S00_L02 Schedule D, Part X, Line 2 The Wistar Institute is a non-profit institution whaich has been determined by the Internal Revenue Service to be exempt from federal income taxes under Section 501 (c)(3) of the Internal Revenue Code. The Institute accounts for uncertainties in income taxes in accordance with authoritative guidance, which prescribes a recognition threshold of more-likely-than-not to be sustained upon examination by the appropriate taxing authority. Measurement of the tax uncertainty occurs if the recognition threshold has been met. As of May 4, 2012, the Institute's federal return of Organization Exempt from Income Tax Returns for 2010, 2009, and 2008 remain subject to examination by the IRS. SchD_P11_S00_L08 Schedule D, Part XI, Line 8 Loss on disposal of land, building, and equipment (1,144,000), loss on beneficial interests in trusts (1,079,000), and net loss on pension (2,777,000). SchD_P12_S00_L02d Schedule D, Part XII, Line 2d Net loss on Beneficial Interests in Trusts SchD_P12_S00_L04b Schedule D, Part XII, Line 4b Fundraising event expenses SchD_P13_S00_L02d Schedule D, Part XIII, Line 2d Fundraising event expenses Taxin Golf Tournament 205000 167000 38000 0 10000 41000 0 0 14000 Wistar Gala 271000 235000 36000 0 2000 63000 0 9000 52000 0 476000 402000 74000 0 12000 104000 0 9000 66000 191000 -117000 X X X X 0 1 X X X X X 0 0 0 0 0 0 0 1 0 Russel Kaufman MD 577000 0 76000 0 32000 0 37000 0 11000 0 733000 0 0 0 Dario Altieri 340000 0 0 0 1000 0 37000 0 14000 0 392000 0 0 0 Larry Keinath 217000 0 33000 0 1000 0 37000 0 11000 0 299000 0 0 0 Elizabeth O'Brien 211000 0 31000 0 1000 0 36000 0 26000 0 305000 0 0 0 Peter Corrado 182000 0 5000 0 1000 0 27000 0 24000 0 239000 0 0 0 David Speicher PhD 226000 0 0 0 1000 0 34000 0 4000 0 265000 0 0 0 Hildegund Ertl MD 222000 0 0 0 1000 0 34000 0 10000 0 267000 0 0 0 Meenhard Herlyn DVM 217000 0 0 0 3000 0 35000 0 22000 0 277000 0 0 0 Frank Rauscher PhD 204000 0 0 0 0 0 31000 0 3000 0 238000 0 0 0 Ellen Pure PhD 202000 0 0 0 1000 0 32000 0 12000 0 247000 0 0 0 SchJ_P01_S00_L01a Schedule J, Part I, Line 1a Tax Indemnification and gross-up payments - for tuition benefits; Discretionary spending account - travel and auto allowance for CEO only; Housing allowance for CEO only; Social club dues for CEO only. All amounts included in taxable compensation. SchJ_P01_S00_L01b Schedule J, Part I, Line 1b Tax Indemnification and gross-up payments - yes written policy provided; Discretionary spending account, Housing allowance, and social club dues are provided via employment contract with CEO. SchJ_P01_S00_L07 Schedule J, Part I, Line 7 Non-fixed payments in the form of bonuses. Philadelphia Authority for Industrial Development 232237287 2011-07-29 55000000 Capital project financing 0 0 0 0 0 519000 0 0 0 519000 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 1 0 1 0 0 0 0 X SchK_P02_S00_L03 Schedule K, Part II, Line 3 Draws of bond proceeds occur upon incurring construction costs. X 16 1276000 Fair Market Value 0 0 1 0 SchM_P01_S00_L09 Schedule M, Part I, Line 9 16 items contributed per column (b) represent 16 separate transactions of securities received and sold F990_P06_S0A_L02 Form 990, Part VI, Section A, Line 2 Daniel Wheeler (Trustee) and Robert Fox (Trustee) are In-Laws. Robert Fox (Trustee) and Richard Horowitz (Trustee) are business associates. F990_P06_S0B_L11b Form 990, Part VI, Section B, Line 11b The Audit Committee of the Board of Trustees reviews the 990 prior to filing the return. Also, prior to submission, the Institute posts a copy to the Board's web site and notifies members of its availability for their information. F990_P06_S0B_L12c Form 990, Part VI, Section B, Line 12c Annually covered persons are required to submit Conflict of Interest Disclosures which are reviewed by management. Covered persons include The Wistar Institute's trustees, officers, "key employees." and next 5 most highly compensated employees. Former trustees, officers, key employees and highly compensated employees may continue to be covered persons for up to five years, depending on compensation. A list of the Institute's covered persons is attached. F990_P06_S0B_L15 Form 990, Part VI, Section B, Line 15 The organization uses the following methods to establish compensation of its officers; Compensation committee; independent compensation consultant; Compensation survey or study; and the approval by the Board Compensation committee. F990_P06_S0C_L19 Form 990, Part VI, Section C, Line 19 The Institute's governing documents and conflict of Interest policy are available on the Institute's website (www.wistar.org). The Institute's financial statements are available upon request. F990_P11_S00_L05 Form 990, Part XI, Line 5 Net unrealized losses on investments (6,109,000); Loss on beneficial interests in trusts (1,079,000; Loss on disposal of land, buildings and equipment (1,144,000); and Pension-net loss (2,777,000). Issac J Wistar Foundation 3601 Spruce Street Philadelphia PA 19104 232593436 Inactive PA 501 (c) (3) PF N/A 0 Tall Cell Technology L P c/o The Connelly Fdn One Tower Bridge Suite 1450 West Conshohocken PA 19428 232811246 Licensing PA N/A Related 145000 2000 0 0 1 0.9 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Tall Cell Technology L P a-iii 145000 Cash payment received representing The Wistar Institute's portion in the partnership's royalties.