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        <ReturnReference>PART I, LINE 3</ReturnReference>
        <Explanation>PART I, LINE 3: THE ORGANIZATION RELIED ON THE METHODS OF ESTABLISHING COMPENSATION FOR THE ORGANIZATION'S CEO/EXECUTIVE DIRECTOR EMPLOYED BY VARIETY CHILDREN'S HOSPITAL D/B/A MIAMI CHILDREN'S HOSPITAL (EIN: 59-0638499). MIAMI CHILDREN'S HOSPITAL USES THE FOLLOWING METHODS TO ESTABLISH SUCH COMPENSATION: - COMPENSATION COMMITTEE - INDEPENDENT COMPENSATION CONSULTANT - WRITTEN EMPLOYMENT CONTRACT - COMPENSATION SURVEY OR STUDY - APPROVAL BY THE BOARD OR COMPENSATION COMMITTEE</Explanation>
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        <ReturnReference>PART III</ReturnReference>
        <Explanation>PART I, LINE 4(B) THE EXECUTIVES PARTICIPATE IN A SUPPLEMENTAL 457(F) DEFINED CONTRIBUTION RETIREMENT ACCOUNT. THE VALUES ARE REPORTED IN SCHEDULE J, PART II, COLUMN C</Explanation>
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    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <Identifier>PROGRAM SERVICE ACCOMPLISHMENTS</Identifier>
        <ReturnReference>FORM 990, PART III, LINE 4A</ReturnReference>
        <Explanation>MIAMI CHILDREN'S RESEARCH INSTITUTE IS ONE OF THE LARGEST PROVIDERS OF PEDIATRIC MEDICAL RESEARCH IN THE SOUTHEASTERN UNITED STATES. IT CURRENTLY PARTICIPATES IN APPROXIMATELY 214 RESEARCH PROTOCOLS INVOLVING NEW MEDICATIONS AND INTERVENTIONS FOR CHILDREN WITH COMPLEX MEDICAL NEEDS. THE MCH RESEARCH INSTITUTE WILL UNDERGO RE-ACCREDITATION IN 2012 BY THE ASSOCIATION OF HUMAN RESEARCH PROTECTION PROGRAMS (AHRPP). HAVING BECOME THE FIRST PEDIATRIC RESEARCH PROGRAM IN THE STATE OF FLORIDA AND ONE OF THE FEW CHILDREN'S HOSPITALS IN THE NATION TO EARN THIS DISTINCTION IN 2009. AHRPP ACCREDITATION AFFIRMS THE HOSPITAL'S COMMITMENT TO MAINTAINING THE MOST STRINGENT STANDARDS IN PROTECTING THE HEALTH OF RESEARCH PARTICIPANTS AND EDUCATING PARTICIPANTS AND THEIR FAMILIES REGARDING RISKS AND POTENTIAL BENEFITS OF TAKING PART IN RESEARCH ACTIVITIES. THE MISSION OF THE MIAMI CHILDREN'S HOSPITAL RESEARCH INSTITUTE IS TO PROMOTE RESEARCH FOR THE ADVANCEMENT OF SCIENCE AND TO GENERATE KNOWLEDGE IN CHILD HEALTH AND PEDIATRIC MEDICINE. THE MCH RESEARCH INSTITUTE PARTICIPATES IN BOTH CLINICAL RESEARCH, WHICH TESTS NEW DIAGNOSTIC PROCEDURES, PHARMACEUTICALS, MEDICAL DEVICES AND INTERVENTIONAL PROCEDURES; AND TRANSLATIONAL RESEARCH, WHICH FOCUSES ON TRANSLATING LABORATORY DISCOVERIES TO THE PATIENT-CARE ENVIRONMENT. HOSPITAL DEPARTMENTS THAT ARE PARTICULARLY ACTIVE IN FOSTERING RESEARCH INCLUDE ADOLESCENT MEDICINE, RADIOLOGY, CARDIOLOGY, ENDOCRINOLOGY, GASTROENTEROLOGY, GENETICS, HEMATOLOGY-ONCOLOGY, NEUROSCIENCES, NEPHROLOGY, ORTHOPAEDICS, PSYCHIATRY, PULMONOLOGY AND UROLOGY. AS PART OF ITS WORK IN THE FIELD OF HEMATOLOGY-ONCOLOGY RESEARCH, MIAMI CHILDREN'S HOSPITAL MAINTAINS FULL MEMBERSHIP IN CHILDREN'S ONCOLOGY GROUP, A FEDERALLY FUNDED CONSORTIUM OF PEDIATRIC HOSPITALS AND PEDIATRIC DEPARTMENTS CONDUCTING A LARGE ARRAY OF CLINICAL RESEARCH STUDIES OFFERING LATEST ADVANCEMENTS FOR TREATMENT OF CHILDHOOD CANCERS. FUTURE PLANS FOR THE MCH RESEARCH INSTITUTE INCLUDE ESTABLISHING A MOLECULAR RESEARCH CENTER, A UNIQUE PROGRAM THAT COMBINES CLINICAL AND MOLECULAR MEDICINE TO DELIVER CARE DESIGNED EXPRESSLY FOR THE NEEDS OF THE INDIVIDUAL CHILD. 2011 RESEARCH HIGHLIGHTS (1) THE RESEARCH INSTITUTE HAS BEEN INVOLVED IN THE LONG-TERM EFFICACY STUDY OF NEUROPACE'S RNS (REPETITIVE NEURO-SIMULATOR) SYSTEM USED TO CONTROL SEIZURES NOT OTHERWISE TREATABLE BY MEDICATION IN EPILEPSY PATIENTS. THE DEVICE WAS DESIGNED TO CONTINUOUSLY MONITOR ELECTRICAL BRAIN ACTIVITY AND ADJUST THE ELECTRICAL CURRENT BASED ON PATIENT'S UNIQUE PARAMETERS. THE DEVICE RECORDS THE SEIZURE AND DISCHARGES THE APPROPRIATE AMOUNT OF ELECTRICAL CURRENT TO STOP THAT SPECIFIC SEIZURE. PATIENTS OR CARETAKERS ALSO HAVE THE ABILITY TO OVERRIDE THE DEVICE VIA A MAGNET IF THE SEIZURE CONTINUES. (2) THE RESEARCH INSTITUTE CONTINUES ITS COMMITMENT TO PATIENTS IN ACQUIRING REGULATORY APPROVAL FOR DEVICES THAT HAVE NOT BEEN YET APPROVED BY THE FDA OR THAT ARE NEEDED IN EMERGENCY USE ON HUMAN SUBJECTS FOR LIFE-THREATENING SITUATIONS, AND THAT CAN BE PROVIDED IN SPECIAL SITUATIONS THROUGH THE REGULATORY PROCESS TO PATIENTS IN NEED. MORE THAN FOUR PATIENTS RECEIVED THE CHEATHAM PLATINUM COVERED STENT FOR THE TREATMENT OF HEART SURGICAL REPAIR. OBTAINING REGULATORY APPROVAL FOR THESE TYPE OF DEVICES ENHANCES THE QUALITY OF LIFE FOR THESE SPECIFIC PATIENTS WITH UNIQUE MEDICAL CONDITIONS. (3) IN A HOSPITAL ENVIRONMENT, EXEMPT STUDIES ARE USUALLY THE INITIAL STEP IN ACQUIRING KNOWLEDGE TO IDENTIFY POSSIBLE TREATMENTS, MEDICINES, AND PROCESSES THAT ARE BENEFITING PEDIATRIC PATIENTS BY REVIEWING THEIR MEDICAL RECORDS. THE RESEARCH INSTITUTE APPROVED 24 SUCH STUDIES IN 2011 EXPANDING PEDIATRIC MEDICAL KNOWLEDGE THROUGH PUBLICATIONS AND PRESENTATION OF ABSTRACTS AT MEDICAL EVENTS. ONE OF THESE STUDIES "THE USE OF THREE-DIMENSIONAL ROTATIONAL ANGIOGRAPHY TO ASSESS THE PULMONARY CIRCULATION FOLLOWING CAVO-PULMONARY CONNECTION IN PATIENTS WITH SINGLE VENTRICLE" HAS BECOME A ROUTINE DIAGNOSTIC TOOL FOR SPECIFIC PATIENTS AT MIAMI CHILDREN'S HOSPITAL.</Explanation>
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      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 11</ReturnReference>
        <Explanation>THE FOLLOWING DESCRIBES MIAMI CHILDREN'S HOSPITAL RESEARCH INSTITUTE'S PROCESS FOR PROVIDING IT'S BOARD OF DIRECTORS WITH A COPY OF THE FORM 990 AND REVIEWING IT: 1. THE DRAFT TAX FORM 990 WILL BE MAILED TO FINANCE COMMITTEE OF MCH BOARD OF DIRECTORS FOR REVIEW AND COMMENT PRIOR TO REGULARLY SCHEDULED MEETING. 2. THE DRAFT TAX FORM 990 WILL BE REVIEWED WITH THE FINANCE COMMITTEE. 3. QUESTIONS WILL BE ANSWERED AND IF NECESSARY, TAX FORMS WILL BE ADJUSTED. 4. THE FINAL FORM 990 WILL BE POSTED ON THE MCH BOARD OF DIRECTOR'S WEB PORTAL.</Explanation>
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      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 12C</ReturnReference>
        <Explanation>ALL MIAMI CHILDREN'S HOSPITAL RESEARCH INSTITUTE EMPLOYEES ARE INFORMED UPON HIRE, AND ON AN ANNUAL BASIS THEREAFTER, THAT THEY HAVE AN AFFIRMATIVE DUTY TO DISCLOSE ANY ACTUAL, POTENTIAL OR PERCEIVED CONFLICT OF INTEREST. THEY ARE REQUIRED TO COMPLETE A CONFLICT OF INTEREST DISCLOSURE FORM UPON HIRE, ANNUALLY AND WHENEVER A CHANGE IN CIRCUMSTANCES WARRANTS. CONFLICT OF INTEREST DISCLOSURE FORMS ARE FORWARDED TO THE COMPLIANCE DEPARTMENT BY THE TALENT MANAGEMENT AND EFFECTIVENESS DEPARTMENT. THESE FORMS ARE INITIALLY REVIEWED BY COMPLIANCE DEPARTMENT STAFF. WHEN DEEMED NECESSARY, THE COMPLIANCE DEPARTMENT COLLABORATES WITH THE LEGAL DEPARTMENT. CONFLICTS OF INTEREST THAT NECESSITATE BOARD AWARENESS AND ACTION ARE PRESENTED TO THE AUDIT AND COMPLIANCE COMMITTEE OF THE BOARD FOR RESOLUTION AND IMPOSITION OF SANCTIONS, IF WARRANTED. IN ADDITION, ON AN ANNUAL BASIS, BOARD MEMBERS, PRINCIPAL OFFICERS AND BOARD-DELEGATED COMMITTEE MEMBERS SIGN A STATEMENT WHICH AFFIRMS THAT EACH INDIVIDUAL: (A) HAS RECEIVED A COPY OF THE CONFLICT OF INTEREST POLICY; (B) HAS READ AND UNDERSTANDS THE POLICY (C) HAS AGREED TO COMPLY WITH THE POLICY, AND (D) UNDERSTANDS THAT THE HOSPITAL IS A CHARITABLE ORGANIZATION AND THAT IN ORDER TO MAINTAIN ITS FEDERAL EXEMPTION IT MUST ENGAGE PRIMARILY IN ACTIVITIES WHICH ACCOMPLISH ONE OR MORE IF IT'S TAX-EXEMPT PURPOSES. A PROCESS IS IN PLACE FOR MANAGING SITUATIONS IN WHICH IT IS DISCOVERED THAT AN INDIVIDUAL WHO IS COVERED BY THE HOSPITAL'S CONFLICT OF INTEREST POLICY FAILED TO PROPERLY DISCLOSE A POTENTIAL CONFLICT OF INTEREST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 15</ReturnReference>
        <Explanation>THE ORGANIZATION AND COMPENSATION COMMITTEE OF MIAM CHILDREN'S HOSPITAL RESEARCH INSTITUTE BOARD OF DIRECTORS CONTRACTS WITH AN EXTERNAL CONSULTANT TO OBTAIN MARKET SURVEYS FOR THE CEO AND OTHER EXECUTIVES. THE CONSULTANT ASSISTS THE ORGANIZATION AND COMPENSATION COMMITTEE IN ESTABLISHING A COMPENSATION PROGRAM FOR THE CEO AND OTHER EXECUTIVES. SURVEY RESULTS AND COMPENSATION BEST PRACTICES ARE SHARED WITH THE ORGANIZATION AND COMPENSATION COMMITTEE OF THE BOARD AND USED IN ESTABLISHING EXECUTIVE SALRAY AND BENEFITS PROGRAMS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION C, LINE 19</ReturnReference>
        <Explanation>FORM 990, PART VI, SECTION C, LINE 19: DOCUMENTS THAT ARE REQUIRED TO BE OPEN FOR PUBLIC INSPECTION ARE MADE AVAILABLE UPON REQUEST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>AVERAGE HOURS PER WEEK</Identifier>
        <ReturnReference>PART VII, LINE 1A, COLUMN B</ReturnReference>
        <Explanation>THE OFFICERS LISTED ON PART VII, SECTION A, LINE 1(A), COLUMN B DEVOTED THEIR TIME TO THE ORGANIZATION AND RELATED ORGANIZATIONS AS FOLLOWS: WORKER'S PROFESSIONAL MCH VARIETY COMPENSATION LIABILITY FOUNDATION CHILDREN'S TRUST TRUST INC. HOSPITAL JEFRY BIEHLER, MD 0.1 0.1 0.0 39.3 THOMAS M. CORNISH 0.1 0.1 1.5 1.3 JARET DAVIS, ESQUIRE 0.1 0.1 0.0 1.3 MARIA FRANCO, MD 0.1 0.1 0.0 1.3 MICHAEL FUX 0.1 0.1 0.0 1.3 LUIS GONZALEZ-MENDOZA, MD 0.1 0.1 0.0 39.3 GHISLAIN GOURAIGE, JR. 0.1 0.1 0.0 1.3 DEISE GRANADO-VILLAR, MD 0.1 0.1 0.0 39.3 GARY GREGORY 0.1 0.1 0.5 1.3 JUAN C. MAS 0.1 0.1 0.5 1.3 JAY MASSIRMAN 0.1 0.1 0.0 1.3 STEVEN MCKEAN 0.1 0.1 0.0 1.3 MARIO MURGADO 0.1 0.1 1.5 1.3 PHILIP NEWCOMM, MD 0.1 0.1 0.0 1.3 CARMEN PEREZ 0.1 0.1 0.0 1.3 GENE PRESCOTT 0.1 0.1 0.0 1.3 ALEX SOTO 0.1 0.1 0.0 1.3 KEITH WARD 0.1 0.1 0.0 1.3 PEDRO ALFARO 0.1 0.1 0.0 39.3 NARENDRA KINI, MD 0.1 0.1 0.0 39.3</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>CHANGES IN NET ASSETS OR FUND BALANCES:</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 5:</ReturnReference>
        <Explanation>GRANT REVENUE USED FOR PURCHASE OF PP&amp;E 259,974. NET REALIZED GAIN ON TEMPORARILY RESTRICTED ASSETS 14,446. RECLASS TO RELATED ORGANIZATION 271,566. PRIOR PERIOD ADJUSTMENT -62,371. AMOUNTS REPORTED SEPARATELY -5,830. TOTAL TO FORM 990, PART XI, LINE 5: 477,785.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>EMPLOYEES REPORTED ON W-3</Identifier>
        <ReturnReference>PART V, LINE 2A</ReturnReference>
        <Explanation>VARIETY CHILDREN'S HOSPITAL D/B/A MIAMI CHILDREN'S HOSPITAL ("MCH") IS THE APPOINTED PAY AGENT FOR ALL OF ITS AFFILIATES. AS SUCH ONLY MCH ISSUES FORM W-3.</Explanation>
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