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        <MethodOfDeterminingRevenues>INDEPENDENT VALUATION</MethodOfDeterminingRevenues>
      </SecuritiesPubliclyTraded>
      <AnyPropertyThatMustBeHeld>0</AnyPropertyThatMustBeHeld>
      <ReviewProcessUnusualNCGifts>0</ReviewProcessUnusualNCGifts>
      <ThirdPartiesUsed>0</ThirdPartiesUsed>
    </IRS990ScheduleM>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 2</ReturnReference>
        <Explanation>J. CRAIG VENTER IS THE CEO OF THE J. CRAIG VENTER INSTITUTE, SYNTHETIC GENOMICS, INC., AND SYNTHETIC GENOMICS VACCINES, INC. HE IS THE CHAIRMAN OF THE J. CRAIG VENTER INSTITUTE, A CO-CHAIRMAN OF AGRADIS, INC., AND A BOARD MEMBER OF SYNTHETIC GENOMICS, INC. AND SYNTHETIC GENOMIC VAACCINES, INC. HE IS A SHAREHOLDER OF SYNTHETIC GENOMIC, INC. JCVI TRUSTEE AND EMPLOYEE HAMILTON O. SMITH IS A CO-FOUNDER, BOARD MEMBER, OFFICER, EMPLOYEE, AND SHAREHOLDER OF SYNTHETIC GENOMICS, INC. JCVI TRUSTEE AND EMPLOYEE KEN NEALSON IS A MEMBER OF THE SCIENTIFIC ADVISORY BOARD OF SYNTHETIC GENOMICS, INC. AND IS A CONSULTANT. JCVI EMPLOYEE CLYDE HUTCHISON IS THE CHAIRMAN OF THE SCIENTIFIC ADVISORY BOARD OF SYTHETIC GENOMICS, INC. AND IS A SHAREHOLDER OF SYNTHETIC GENOMICS, INC. ERLING NORRBY IS A BOARD MEMBER OF THE J. CRAIG VENTER INSTITUTE AND SYNTHETIC GENOMICS VACCINES, INC. JCVI BOARD MEMBERS THEODORE DANFORTH, WILLIAM HARMAN, AND DEAN ORNISH ARE SHAREHOLDERS OF SYNTHETIC GENOMICS, INC. JCVI BOARD MEMBERS THEODORE DANFORTH AND WILLIAM HARMAN ARE SHAREHOLDERS OF SYNTHETIC GENOMIC VACCINES, INC. ALFONSO ROMO IS A BOARD MEMBER OF SYNTHETIC GENOMICS, INC. AND IS CO-CHAIRMAN OF ARGADIS, INC.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 11</ReturnReference>
        <Explanation>THE AUDIT COMMITTEE OF THE BOARD REVIEWED THE FORM 990 AND THE SUPPORTING SCHEDULES WITH THE CFO AND THE ORGANIZATION'S PREPARER IN DETAIL. A COMPLETE COPY OF THE FORM 990 AND SUPPORTING SCHEDULES WAS ALSO PROVIDED TO THE FULL BOARD FOR REVIEW AND APPROVAL PRIOR TO BEING FILED.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 12C</ReturnReference>
        <Explanation>JCVI MONITORS COMPLIANCE OF ITS CONFLICT OF INTEREST POLICY THROUGH AN ANNUAL SOLICITATION OF CONFLICT OF INTEREST STATEMENT FROM TRUSTEES, OFFICERS, AND EMPLOYEES.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 15</ReturnReference>
        <Explanation>JCVI USES MERCER, AN OUTSIDE COMPENSATION CONSULTANT, TO PROVIDE A LIST OF COMPARABLE SALARIES FOR THE CEO AND OFFICERS. THESE ARE REVIEWED BY THE JCVI COMPENSATION COMMITTEE AND CEO BEFORE A FINAL DETERMINATION IS MADE.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION C, LINE 19</ReturnReference>
        <Explanation>THESE DOCUMENTS ARE NOT GENERALLY MADE AVAILABLE TO THE PUBLIC.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>CHANGES IN NET ASSETS OR FUND BALANCES:</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 5:</ReturnReference>
        <Explanation>NET UNREALIZED LOSSES ON INVESTMENTS: -2,765,002. LOSS IN AFFILIATES -169,085. UBIT LOSS FROM PARTNERSHIPS 7,894. TOTAL TO FORM 990, PART XI, LINE 5: -2,926,193.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>OVERSIGHT OF AUDIT:</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 2C</ReturnReference>
        <Explanation>THERE HAVE BEEN NO CHANGES DURING THE YEAR IN THE PROCESS FOR OVERSIGHT OF THE AUDIT OF THE FINANCIAL STATEMENTS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>AVERAGE HOURS PER WEEK:</Identifier>
        <ReturnReference>FORM 990, PART VII, SECTION A., LINE 1</ReturnReference>
        <Explanation>FOLLOWING OFFICERS AND EXECUTIVES ROUTINELY WORK MORE THAN 40 HOURS PER WEEK: J. CRAIG VENTER, MARK ADAMS, JULIE ADELSON, ROBERT FRIEDMAN, KAREN NELSON AND AIMEE TURNER.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
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      <Form990ScheduleRPartIV>
        <NameOfRelatedOrg>
          <BusinessNameLine1>VENTER INSTITUTE VACCINES INC</BusinessNameLine1>
        </NameOfRelatedOrg>
        <AddressUS>
          <AddressLine1>9704 MEDICAL CENTER DRIVE</AddressLine1>
          <City>ROCKVILLE</City>
          <State>MD</State>
          <ZIPCode>20850</ZIPCode>
        </AddressUS>
        <EIN>271936205</EIN>
        <PrimaryActivity>INACTIVE</PrimaryActivity>
        <LegalDomicileState>MD</LegalDomicileState>
        <TypeOfEntity>C</TypeOfEntity>
        <PercentageOwnership>1.00000</PercentageOwnership>
      </Form990ScheduleRPartIV>
      <ReceiptOfIntAnnRentsRoyalties>0</ReceiptOfIntAnnRentsRoyalties>
      <GiftGrantOrCapContrToOtherOrg>0</GiftGrantOrCapContrToOtherOrg>
      <GiftGrantOrCapContrFrOtherOrg>0</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>0</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>0</LoansOrGuaranteesFromOtherOrg>
      <SaleOfAssetsToOtherOrg>0</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>0</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>0</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>0</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>0</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>0</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>0</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>0</SharingOfFacilities>
      <SharingOfPaidEmployees>0</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>0</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>0</ReimbursementPaidByOtherOrg>
      <OtherTransferToOtherOrg>0</OtherTransferToOtherOrg>
      <OtherTransferFromOtherOrg>0</OtherTransferFromOtherOrg>
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