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        <ReturnReference>Schedule J, Part I, Line 1a</ReturnReference>
        <Explanation>Senior executives utilized domestic charter and first class air travel on a limited basis during FY11. In some instances, a spouse accompanied the senior executives on their RTI business as dictated by local tradition and protocol. The officers reimbursed RTI for non-business spousal travel expenses, and therefore, no income was imputed for spousal travel costs. A tax gross up payment was made to a newly hired senior executive to assist with the executive's relocation. Two highly compensated employees received tax gross up payments related to their international assignments. Two business club memberships, where leaders in industry and business gather, are maintained for RTI business purposes. No taxable compensation has been imputed to the senior executives who use these club memberships exclusively for RTI business purposes.</Explanation>
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        <Identifier>SchJ_P01_S00_L04</Identifier>
        <ReturnReference>Schedule J, Part I, Line 4</ReturnReference>
        <Explanation>In recognition of Dr. Haynes' long service to the institution, her compensation and retirement benefits relative to the market, and retaining Dr. Haynes through 2011, the Board provided Dr. Haynes a supplemental retirement benefit. The amount accrued for this benefit during calendar year 2010 was $433,615. The Institute implemented a long-term incentive plan designed to reward executives for ensuring the organization's finances are strong, and to retain executives. This plan recognizes that the executives' total compensation is below market. Rather than increasing salaries, annual incentives, or supplemental retirement benefits, the Board implemented a cash based retention plan which is dependent on the institution's continued strong performance. Amounts accrued during calendar year 2010 are as follows: V Haynes $24,931; J Gibson $14,811; E Holden $14,514; J Hunter-Cevera $14,477; L Maggart $13,462; S Sethi $13,857; A Mangel $12,186; E Story $10,183; J Trainham $2,390; and M Roberts $1,925.</Explanation>
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        <Identifier>SchJ_P01_S00_L07</Identifier>
        <ReturnReference>Schedule J, Part I, Line 7</ReturnReference>
        <Explanation>RTI maintains variable compensation plans which are reviewed and approved annually by the Compensation Committee of the Board as well as the full Board to establish appropriate measurable targets and objectives along with incentive amounts. Actual performance under the plans is reviewed after the performance period and approved by the Compensation Committee and full Board as well. Amounts paid under these plans during calendar year 2010 are as follows: V Haynes $145,428; J Gibson $90,000; E Holden $95,000; J Hunter-Cevera $62,000; L Maggart $80,000; S Sethi $60,000; A Mangel $90,000; E Story $60,000; J Trainham $22,000; S Snyder $36,000; E Sax $33,500; M Roberts $35,000; C Buchholz $18,500; R Johnson $25,000; L Cravens $17,000; R Zerbonia $13,840; and L Gilliland $37,000. These amounts are included in Schedule J, Part II, column (B)(ii). J Trainham received a non fixed payment of $30,000 in connection with his relocation upon employment with RTI during calendar year 2010. This payment was reported as taxable income and is included in Schedule J, Part II, column (B)(iii).</Explanation>
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        <Identifier>SchJ_P01_S00_L08</Identifier>
        <ReturnReference>Schedule J, Part I, Line 8</ReturnReference>
        <Explanation>RTI recruits its executive leadership from the national labor market, and this practice can introduce additional variability into each executive's initial compensation package. Accordingly, amounts were paid and accrued during the 2010 calendar year that emanated from RTI's offer of employment to certain executives and these items were included in the executive's employment agreement with RTI. Amounts paid were reported as taxable income and are included in the 2010 bonus categorization for each executive that received such payment. Any unpaid accruals are included in the 2010 deferred compensation categorization.</Explanation>
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        <Identifier>SchJ_P02_S00_L00</Identifier>
        <ReturnReference>Schedule J, Part II</ReturnReference>
        <Explanation>RTI was established in 1958 by Duke University and The University of North Carolina system as the founding tenant of the Research Triangle Park in NC. It has grown into one of the world's leading independent nonprofit research organizations and is dedicated to conducting research and development that improves the human condition by turning knowledge into practice. Based on RTI's corporate governance structure, compensation of those Board Members employed by supported organizations (i.e. Duke and the UNC System) is reported on rows (ii) and was obtained from the 990 information request questionnaire that was distributed to these listed persons and from Duke University. These amounts were paid by either Duke University or The University of North Carolina (UNC System). Given the supporting relationship with these universities, RTI is required to report these amounts; however, RTI has no influence over this compensation. The reportable compensation of four of the top five highest compensated employees reported in Schedule J, Part II, column (B)(iii) includes additional compensation (i.e. danger pay, housing &amp; other allowances) related to an international assignment. In connection with his employment with RTI, J Trainham participated in various scientific research collaborations with the UNC System, including an appointment as adjunct professor during FY11. RTI received reimbursements from the UNC System for costs related to these research services.</Explanation>
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        <Explanation>V Haynes and J Gibson served on the Board of Directors of the for-profit companies Ziptronix and Nextreme, respectively, representing RTI's interest in each of the companies. These companies were spun-off from RTI's research divisions in March 2000 and December 2004, respectively. RTI holds a minority interest in each company. No directors fee or other compensation was received for serving in these positions.</Explanation>
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        <Explanation>During FY11, RTI received a donation of a seven piece "Crossing Cultures" artwork for display in an office building on RTI's main campus. The value assigned to this artwork by the donor was less than $5,000. No revenue was recorded on the books by RTI.</Explanation>
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      <GeneralExplanation>
        <Identifier>F990_P03_S00_L04a</Identifier>
        <ReturnReference>Form 990, Part III, Line 4a</ReturnReference>
        <Explanation>HEALTH RESEARCH is our largest single field of study, encompassing research that ranges from studies of the human genome and the development of new drug compounds to national surveys of health behaviors and the implementation of global health programs. Our activities in DRUG DISCOVERY AND DEVELOPMENT include working with pharmaceutical companies and government agencies to bring new medicines to market, and to ensure the safety and efficacy of those in the marketplace. As part of a comprehensive EDUCATION AND TRAINING RESEARCH program, our experts conduct rigorous studies used to assess and improve the quality of early development, education, and employment programs in the United States and many other countries. We also provide training solutions for forensic scientists and law enforcement. RTI is a leader in SURVEY RESEARCH and SURVEY STATISTICS. With a staff of highly skilled researchers using advanced data collection systems and techniques, we offer broad-based survey services for public and private sector studies. Our SURVEY RESEARCH SERVICES include study design, instrument development and evaluation, pretests and pilot studies, mail surveys, telephone surveys, face-to-face field surveys, Web surveys, records abstraction, collection of biological specimens, mixed-mode surveys, subject tracing, focus groups, and health registries. Our STATISTICS RESEARCH experts conduct complex statistical analyses to support wide ranging research programs in both laboratory and social sciences as well as ensure the quality, validity, and reliability of our research products and results by applying quality control and assurance procedures from sampling design through data collection and analysis. Our multidisciplinary ECONOMIC &amp; SOCIAL RESEARCH team includes experts in economics, demography, health, education, urban planning, and public financing. We provide independent, objective information and analyses that help to inform and improve public policy discourse and advance economic and social development decision making in technology economics and policy, crime and justice, and food and agricultural policy. We provide ADVANCED TECHNOLOGY RESEARCH &amp; DEVELOPMENT services through the identification, development, application, and transfer of leading-edge technologies in areas including Materials Science; Electronics; Microfabrication; Information Technology; Innovation Advising; and Technology Economics &amp; Policy. Our ENERGY RESEARCHERS develop advanced energy technologies to address today's significant energy challenges, such as climate change, energy security, energy efficiency, sustainability, and water conservation, Our research supports national and worldwide goals of reliable, sustainable, economically viable, and secure energy supplies. We are a leading provider of ENVIRONMENTAL RESEARCH SERVICES for the U.S. Environmental Protection Agency and other government agencies. We conduct large-scale environmental management projects for both government and industry, helping them make critical policy and regulatory decisions. Our LABORATORY &amp; CHEMISTRY SERVICES support RTI research with state-of-the-art instrumentation, technologies, and processes. Our lab specifications and procedures emphasize quality control and excellence at every level of activity to meet the expectations and needs of our clients.</Explanation>
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      <GeneralExplanation>
        <Identifier>F990_P06_S0A_L02</Identifier>
        <ReturnReference>Form 990, Part VI, Section A, Line 2</ReturnReference>
        <Explanation>T Darden &amp; E Johnson - Family Relationship; T Darden &amp; W Moore - Business Relationship; T Darden &amp; P Rizzo - Business Relationship; P Lange &amp; J Siedow - Business Relationship; P Lange &amp; P Wynn - Business Relationship; W Moore &amp; P Rizzo - Business Relationship; W Moore &amp; E Johnson - Business Relationship; W Moore &amp; P Scott - Business Relationship; T Darden &amp; E Johnson - Business Relationship; T Darden &amp; R Ingram - Business Relationship; R Ingram &amp; P Wynn - Business Relationship</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0A_L06</Identifier>
        <ReturnReference>Form 990, Part VI, Section A, Line 6</ReturnReference>
        <Explanation>Research Triangle Institute is a non-profit corporation incorporated under the laws of the State of North Carolina. The Members of the corporation include the persons who at the time occupy the following positions: President, The University of North Carolina; President, Duke University; One member of the Board of Trustees of Duke University, appointed by the Chair of the Board of Trustees of Duke University, for one or more terms of three years; and One member of the Board of Governors of The University of North Carolina, appointed by the Chair of the Board of Governors of The University of North Carolina, for one or more terms of three years. The Members shall elect the Governors, review and act on fundamental corporate transactions approved by the Governors, and take such other actions as may be required by law. No part of the earnings of the Corporation shall inure to the benefit of any member or individual.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0A_L07a</Identifier>
        <ReturnReference>Form 990, Part VI, Section A, Line 7a</ReturnReference>
        <Explanation>The Members shall elect the Governors as described in the Bylaws of the Corporation.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0A_L07b</Identifier>
        <ReturnReference>Form 990, Part VI, Section A, Line 7b</ReturnReference>
        <Explanation>The Members shall review and act on fundamental corporate transactions approved by the Governors, and take such other actions as may be required by law. Fundamental corporate transactions are described in the Articles of Incorporation.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0B_L11b</Identifier>
        <ReturnReference>Form 990, Part VI, Section B, Line 11b</ReturnReference>
        <Explanation>The Form 990 with required schedules was provided to the full Board of Governors prior to filing via posting on RTI's hosted board communication solution, Directors Desk. In addition, RTI management reviewed the process and steps undertaken in completing the form on multiple occasions with the Audit and Compensation Committees of the Board, including a review of the file ready form with the Audit Committee prior to dissemination to the full Board.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0B_L12c</Identifier>
        <ReturnReference>Form 990, Part VI, Section B, Line 12c</ReturnReference>
        <Explanation>Members of the Board of Governors, Officers, and Key Employees are required to complete an annual conflict of interest disclosure in accordance with the organization's policies and procedures. Each disclosure is reviewed by the Audit Committee Chair, Chair of the Board of Governors, or the Chief Ethics Officer to determine whether a conflict of interest exists, and if so, whether it appears to be significant and may warrant further review according to the standards and guidelines of the policy.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0B_L15</Identifier>
        <ReturnReference>Form 990, Part VI, Section B, Line 15</ReturnReference>
        <Explanation>Each year, Research Triangle Institute (the "Institute") management seeks the review and approval of the Institute's Compensation Committee and Board of Governors ("Board") to ensure that the total compensation packages for its Chief Executive Officer (CEO) and other senior executives listed below are reasonable. The CEO and other senior executives are not involved in the Compensation Committee and Board's decision regarding the reasonableness of the executive compensation packages. The Compensation Committee and Board use independent compensation surveys conducted by nationally recognized independent firms. The independent survey includes compensation paid by comparable institutions (taxable as well as non-taxable) for functionally comparable positions and in comparable geographic labor markets. The Compensation Committee and Board also use an independent executive compensation consulting firm to review the survey data and provide comments opining on the reasonableness of compensation for the Institute's senior executives. In 2010, the study covered the following executive positions: Victoria F Haynes, President &amp; Chief Executive Officer; James J Gibson, Executive Vice President &amp; Chief Financial Officer; Satinder K Sethi, Executive Vice President, Operations Group; Lon E Maggart, Executive Vice President, International Development Group; E Wayne Holden, Executive Vice President, Social, Statistical and Environmental Sciences; Jennie Hunter-Cevera, Executive Vice President, Discovery and Analytical Sciences; G Edward Story, Senior Vice President, General Counsel, and Corporate Secretary; Allen W Mangel, Senior Vice President, Health Solutions; Martha J Roberts, Unit Vice President, Chief HR Officer; and James A Trainham, Vice President, Stategic Energy Initiatives.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0B_L16b</Identifier>
        <ReturnReference>Form 990, Part VI, Section B, Line 16b</ReturnReference>
        <Explanation>RTI and its staff belong to and participate in consortiums and associations that are consistent with RTI's mission to improve the human condition. These affiliations are neither in form nor substance a joint venture for federal income taxation. While RTI has not entered into a joint venture with a taxable entity, RTI has adopted a joint venture policy in order to evaluate its participation for federal income tax purposes. Additionally, certain federal contracts are awarded on a cost share basis whereby a cost share subcontractor reimburses RTI for a percentage of the total contract cost. Cost share arrangements exist primarily with unrelated taxable entitites.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P06_S0C_L19</Identifier>
        <ReturnReference>Form 990, Part VI, Section C, Line 19</ReturnReference>
        <Explanation>The organization makes its governing documents, conflict of interest policy and financial statements available to the public upon request.</Explanation>
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      <GeneralExplanation>
        <Identifier>F990_P07_S0A_L01a</Identifier>
        <ReturnReference>Form 990, Part VII, Section A, Line 1a</ReturnReference>
        <Explanation>In connection with his employment with RTI, J Trainham participated in various scientific research collaborations with the UNC System, including an appointment as adjunct professor during FY11. RTI received reimbursements from the UNC System for costs related to these research services.</Explanation>
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      <GeneralExplanation>
        <Identifier>F990_P07_S0A_L01b</Identifier>
        <ReturnReference>Form 990, Part VII, Section A, Line 1b</ReturnReference>
        <Explanation>RTI was established in 1958 by Duke University and The University of North Carolina system as the founding tenant of the Research Triangle Park in NC. It has grown into one of the world's leading independent nonprofit research organizations and is dedicated to conducting research and development that improves the human condition by turning knowledge into practice. Based on RTI's corporate governance structure, compensation of those Board Members employed by supported organizations (i.e. Duke and the UNC System) is reported in column (E) and was obtained from the 990 information request questionnaire that was distributed to these listed persons and from Duke University. These amounts were paid by either Duke University or The University of North Carolina (UNC System). Given the supporting relationship with these universities, RTI is required to report these amounts; however, RTI has no influence over this compensation. The following individuals listed on Part VII, Section A, column (A) devoted an estimated average of 40 hours per week to Duke University (the related supported organization): J Siedow and P Wynn. P Lange devoted an estimated average of 65 hours per week to Duke University and an estimated average of 1 hour per week to several organizations related to Duke University.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>F990_P11_S00_L05</Identifier>
        <ReturnReference>Form 990, Part XI, Line 5</ReturnReference>
        <Explanation>Equity in gains of affiliates &amp; subsidiaries = 3,070,070; Pension related changes = (641,330); Unrealized market losses = (4,041,101)</Explanation>
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          <City>Research Triangle Park</City>
          <State>NC</State>
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        <EIN>560686338</EIN>
        <PrimaryActivities>None</PrimaryActivities>
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          <City>Chapel Hill</City>
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          <AddressLine1>PO Box 12574</AddressLine1>
          <City>Research Triangle Park</City>
          <State>NC</State>
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          <State>NC</State>
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          <State>NC</State>
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          <AddressLine1>UI Walecznych</AddressLine1>
          <ProvinceOrState>Warsaw</ProvinceOrState>
          <Country>PL</Country>
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        <PrimaryActivity>European Collaboration</PrimaryActivity>
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        <DirectControllingEntityNA>N/A</DirectControllingEntityNA>
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        </NameOfRelatedOrg>
        <AddressForeign>
          <AddressLine1>Nieuw Mucklenueck</AddressLine1>
          <ProvinceOrState>Pretoria</ProvinceOrState>
          <Country>SF</Country>
        </AddressForeign>
        <PrimaryActivity>Research</PrimaryActivity>
        <LegalDomicileForeignCountry>SF</LegalDomicileForeignCountry>
        <DirectControllingEntityNA>N/A</DirectControllingEntityNA>
        <TypeOfEntity>C</TypeOfEntity>
        <ShareOfTotalIncome>45350</ShareOfTotalIncome>
        <ShareOfEOYAssets>0</ShareOfEOYAssets>
        <PercentageOwnership>1</PercentageOwnership>
      </Form990ScheduleRPartIV>
      <Form990ScheduleRPartIV>
        <NameOfRelatedOrg>
          <BusinessNameLine1>Research Triangle Institute International (Hong Kong) Limited</BusinessNameLine1>
        </NameOfRelatedOrg>
        <AddressForeign>
          <AddressLine1>15 Queens Road Central</AddressLine1>
          <City>Central</City>
          <Country>HK</Country>
        </AddressForeign>
        <PrimaryActivity>Investment Company</PrimaryActivity>
        <LegalDomicileForeignCountry>HK</LegalDomicileForeignCountry>
        <DirectControllingEntityNA>N/A</DirectControllingEntityNA>
        <TypeOfEntity>C</TypeOfEntity>
        <ShareOfTotalIncome>0</ShareOfTotalIncome>
        <ShareOfEOYAssets>125069</ShareOfEOYAssets>
        <PercentageOwnership>1</PercentageOwnership>
      </Form990ScheduleRPartIV>
      <ReceiptOfIntAnnRentsRoyalties>1</ReceiptOfIntAnnRentsRoyalties>
      <GiftGrantOrCapContrToOtherOrg>1</GiftGrantOrCapContrToOtherOrg>
      <GiftGrantOrCapContrFrOtherOrg>0</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>1</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>0</LoansOrGuaranteesFromOtherOrg>
      <SaleOfAssetsToOtherOrg>0</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>0</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>0</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>0</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>0</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>1</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>1</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>1</SharingOfFacilities>
      <SharingOfPaidEmployees>1</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>1</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>1</ReimbursementPaidByOtherOrg>
      <OtherTransferToOtherOrg>1</OtherTransferToOtherOrg>
      <OtherTransferFromOtherOrg>0</OtherTransferFromOtherOrg>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>Sizanang</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>a-i</TransactionType>
        <AmountInvolved>14623</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>Research Triangle Institute International (Hong Kong) Limited</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>b</TransactionType>
        <AmountInvolved>125069</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>RTI-PCCO</BusinessNameLine1>
          <BusinessNameLine2>Parents Child Care Organization</BusinessNameLine2>
        </NameOfOtherOrganization>
        <TransactionType>b</TransactionType>
        <AmountInvolved>95323</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>Sizanang</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>q</TransactionType>
        <AmountInvolved>53369</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>RTI Polska SP zoo</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>q</TransactionType>
        <AmountInvolved>165593</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>RTI Post Retirement Health Benefits Trust</BusinessNameLine1>
          <BusinessNameLine2>RTI VEBA</BusinessNameLine2>
        </NameOfOtherOrganization>
        <TransactionType>p</TransactionType>
        <AmountInvolved>1069097</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>RTI Post Retirement Health Benefits Trust</BusinessNameLine1>
          <BusinessNameLine2>RTI VEBA</BusinessNameLine2>
        </NameOfOtherOrganization>
        <TransactionType>q</TransactionType>
        <AmountInvolved>1057176</AmountInvolved>
        <MethodOfAmtDetermination>Cash value</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <Form990ScheduleRPartVII>
        <Identifier>SchR_P05_S00_L02</Identifier>
        <ReturnReference>Schedule R, Part V, Line 2</ReturnReference>
        <Explanation>In connection with the dissolution of RTI Polska and Sizanang, RTI forgave loans of 165,593 and 53,369, respectively, during FY11.</Explanation>
      </Form990ScheduleRPartVII>
    </IRS990ScheduleR>
  </ReturnData>
</Return>