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CONDUCTS RESEARCH ON THE FUNCTION AND USE OF COMPONENTS OF BLOOD AND OTHER TISSUES. IDI ALSO TRAINS MEDICAL AND SCIENTIFIC PERSONNEL IN RESEARCH. THE RESEARCH PROJECTS ARE FUNDED BY PRIVATE ORGANIZATIONS AND FEDERAL GOVERNMENT AGENCIES UNDER GRANTS AND CONTRACTS THAT PROVIDE FOR REIMBURSEMENT OF SPECIFIC EXPENDITURES. IDI EMPLOYS 17 PRINCIPAL INVESTIGATORS OF WHICH 4 BELONG TO THE NATIONAL ACADEMY OF SCIENCES AND 5 BELONG TO THE AMERICAN ACADEMY OF ARTS AND SCIENCE. 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SEVEN CRITERIA ARE TO BE USED TO GUIDE IDI IN ITS YEARLY EXPENDITURE DECISIONS: 1) DURATION AND PRESERVATION OF THE ENDOWMENT FUND; 2) THE PURPOSES OF IDI AND THE ENDOWMENT FUND; 3) GENERAL ECONOMIC CONDITIONS; 4) EFFECT OF INFLATION OR DEFLATION; 5) THE EXPECTED TOTAL RETURN FROM INCOME AND THE APPRECIATION OF INVESTMENTS; 6) OTHER RESOURCES OF IDI; AND, 7) THE INVESTMENT POLICY OF IDI. IDI WILL BE REVIEWING THE PROVISIONS OF UPMIFA TO DETERMINE WHAT CHANGES, IF ANY, MAY BE REQUIRED TO THE INVESTING AND SPENDING POLICIES OF THE BOARD. FIN 48 (ASC 740) Footnote PART X, Line 2 The audited financial statements have included the following disclosure related to FIN 48 (ASC 740): The Institute has not identified any uncertain tax positions. East Asia and the Pacific 0 0 Program Services CONFERENCES/EDUCATION 12608 Europe (Including Iceland and Greenland) 0 0 Program Services CONFERENCES/EDUCATION 76143 North America 0 0 Program Services CONFERENCES/EDUCATION 20387 South Asia 0 0 Program Services CONFERENCES/EDUCATION 3935 0 0 0 0 113073 113073 false false false false false false X true true X X X false true false false false false false false false DAVID KIRSHNER 0 462162 0 181116 0 72733 0 46950 0 25741 0 788702 0 89137 CARLEEN BRUNELLI 0 260163 0 77238 0 44497 0 34288 0 20580 0 436766 0 37929 JAMES MANDELL 0 746747 0 725000 0 389937 0 96650 0 33118 0 1991452 0 306250 STUART NOVICK 0 394294 0 152782 0 121230 0 50900 0 24369 0 743575 0 75087 MICHAEL CARROLL 243525 0 0 0 0 0 30625 0 20642 0 294792 0 0 0 TOMAS KIRCHHAUSEN 209772 0 0 0 0 0 24162 0 8106 0 242040 0 0 0 JUDY LIEBERMAN 236564 0 0 0 0 0 29908 0 18986 0 285458 0 0 0 KLAUS RAJEWSKY 265805 0 0 0 0 0 30625 0 8150 0 304580 0 0 0 DENISA WAGNER 236565 0 0 0 0 0 29908 0 22652 0 289125 0 0 0 STEVEN SIMMONS 197207 0 0 0 0 0 20871 0 8891 0 226969 0 0 0 NON-QUALIFIED RETIREMENT PLAN PART I, LINE 4B CHILDREN'S HOSPITAL BOSTON, A RELATED ORGANIZATION, MADE CONTRIBUTIONS TO A SUPPLEMENTAL NON-QUALIFIED RETIREMENT PLAN FOR THE INDIVIDUALS LISTED BELOW: CARLEEN BRUNELLI $ 22,769 JAMES MANDELL $356,214 DAVID KIRSHNER $ 54,026 STUART NOVICK $102,720 COMPENSATION FROM A RELATED ORGANIZATION PART II COMPENSATION PROVIDED BY A RELATED ORGANIZATION IS FOR EXECUTIVE/EMPLOYEE SERVICES TO CHILDREN'S HOSPITAL CORPORATION; NOT FOR TRUSTEE OR OFFICER OF THE BOARD SERVICES TO CHILDREN'S HOSPITAL CORPORATION OR IMMUNE DISEASE INSTITUTE. COMPENSATION REPORTED IN PRIOR FORM 990 PART II, COLUMN F THE COMPENSATION REPORTED IN PART II, COLUMN B, OF THIS SCHEDULE J (FORM 990) IS FOR THE CALENDAR YEAR 2010 AND A PORTION OF IT MAY HAVE ALREADY BEEN REPORTED ON A PRIOR YEAR FORM 990 AS DEFERRED COMPENSATION. COMPENSATION AMOUNTS IN COLUMN F REFLECTS THE COMPENSATION ALREADY REPORTED IN A PRIOR RETURN AND NEEDS TO BE TAKEN INTO CONSIDERATION TO CORRECT THE OVERSTATEMENT OF THE CUMULATIVE COMPENSATION REPORTED AS PAID TO THE INDIVIDUALS LISTED. 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KEY DEFINITIONS TO UNDERSTAND OUR WORK INCLUDE: IMMUNOLOGY IMMUNOLOGY IS THE STUDY OF THE STRUCTURE AND FUNCTION OF THE IMMUNE SYSTEM, WHICH IS THE BODY'S ORGANIZATION OF ORGANS, TISSUES, CELLS, AND CELL PRODUCTS TO PROTECT ITSELF FROM OTHER ORGANISMS. IMMUNOLOGY TODAY INVOLVES NEARLY EVERY ASPECT OF MEDICAL DISCOVERY, HEALTHCARE, AND DISEASE MANAGEMENT. IMMUNE DEFENSE IMMUNE DEFENSE IS THE COORDINATED AND COMPLICATED REACTION OF THE AGENTS OF THE IMMUNE SYSTEM TO PATHOGENS, CALLED ANTIGENS, WHICH ARE FOREIGN TO THE BODY AND HAVE THE POTENTIAL TO CAUSE DISEASE. NORMAL IMMUNE SURVEILLANCE ALSO HELPS TO KEEP DAMAGED CELLS FROM PROLIFERATING INTO CANCER. IMMUNE DEFENSE RESEARCH AT THE IMMUNE DISEASE INSTITUTE, INC. IS TARGETED AT DEVELOPMENT OF DEFENSES AGAINST BIOTERRORISM, VACCINES AGAINST VIRAL AND OTHER INFECTIONS, AND NEW MEANS TO PREVENT OR TREAT TYPES OF CANCER. INFLAMMATION INFLAMMATION IS A PROTECTIVE GATHERING OF IMMUNE CELLS AND MOLECULES AT A SITE OF INFECTION. NORMALLY A HEALTHY RESPONSE, INFLAMMATION CAN BECOME PROLONGED AND WREAK HAVOC ON BODY TISSUES. HEART DISEASE, ALZHEIMER'S, ULCERS, AND FRAILTY IN OLD AGE APPEAR TO BE LINKED TO A STATE OF CHRONIC INFLAMMATION TRIGGERED BY THE IMMUNE RESPONSE. DELEGATION OF CONTROL OVER MANAGEMENT DUTIES FORM 990, PART VI, SECTION A, LINE 3 ON FEBRUARY 20, 2009, IDI AND CHILDREN'S MEDICAL CENTER CORPORATION (CMCC) EXECUTED AN ENDOWMENT INVESTMENT AGREEMENT THAT CREATED A COMBINED ACCOUNT MANAGED BY CMCC AND INVESTED IN A MANNER CONSISTENT WITH THE INVESTMENT OF OTHER CMCC ENDOWED FUNDS. UPON TRANSFER OF IDI'S ENDOWMENT TO AN ACCOUNT CONTROLLED BY CMCC, CMCC INVESTED $20,000,000 ALONGSIDE OF IDI'S FUNDS TO CREATE THE COMBINED IDI ACCOUNT. ALL NET INVESTMENT EARNINGS OF THIS COMBINED ACCOUNT SHALL BE USED EXCLUSIVELY FOR THE BENEFIT OF IDI UNTIL AT LEAST THE FIFTH ANNIVERSARY OF THE EFFECTIVE DATE. GOVERNANCE, MANAGEMENT, AND DISCLOSURE FORM 990, PART VI, SECTION A, LINES 6 AND 7A ON DECEMBER 24, 2008, THE BOARD OF TRUSTEES OF IDI AND THE MEMBERS OF THE BOARD OF TRUSTEES OF THE CHILDREN'S MEDICAL CENTER CORPORATION (CMCC), A MASSACHUSETTS NONPROFIT CORPORATION, ENTERED INTO A FIVE YEAR AFFILIATION AGREEMENT (THE AGREEMENT) TO MAKE IDI CMCC'S SIXTH MULTIDISCIPLINARY RESEARCH PROGRAM, THE PROGRAM IN CELLULAR AND MOLECULAR MEDICINE (THE PROGRAM). THE EFFECTUATION OF THE AFFILIATION WAS SUBJECT TO NAMING CMCC AS THE SOLE CORPORATE MEMBER OF IDI, ADOPTION BY IDI OF AMENDED AND RESTATED ARTICLES OF ORGANIZATION, ADOPTION OF AMENDED AND RESTATED BYLAWS, AND THE MODIFICATION OF THE IDI BOARD OF TRUSTEES. THE DATE THESE CONDITIONS WERE SATISFIED IS CONSIDERED THE "CLOSING" DATE OF THE AFFILIATION AGREEMENT. ON FEBRUARY 20, 2009 (THE CLOSING DATE) PURSUANT TO THE AFFILIATION AGREEMENT, IDI AMENDED ITS ARTICLES OF ORGANIZATION AND BYLAWS TO NAME CMCC AS ITS SOLE CORPORATE MEMBER. THE COMPOSITION OF IDI'S BOARD OF TRUSTEES WAS AMENDED SUCH THAT CMCC HAS THE AUTHORITY TO APPOINT THE MAJORITY OF TRUSTEES. ON MARCH 3, 2010, IMMUNE DISEASE INSTITUTE CHANGED THEIR FISCAL YEAR END FROM JUNE 30 TO SEPTEMBER 30. FORM 990 REVIEW PROCESS FORM 990, PART VI, SECTION B, LINE 11A THE FORM 990 IS COMPLETED BY IDI MANAGEMENT WITH THE HELP OF KPMG LLP, INDEPENDENT TAX CONSULTANT. THE FORM 990 IS THEN EMAILED TO EACH BOARD MEMBER FOR REVIEW. THE BOARD HAS A CHANCE TO ASK QUESTIONS PRIOR TO THE FORM 990 DUE DATE OF AUGUST 15. A FINAL COPY OF THE FORM 990 IS DISTRIBUTED TO EACH VOTING MEMBER OF THE GOVERNING BODY PRIOR TO FILING. CONFLICT OF INTEREST POLICY FORM 990, PART VI, SECTION B, LINE 12C EMPLOYEES SHALL CONDUCT BUSINESS ACTIVITIES IN A PROFESSIONAL MANNER CONSISTENT WITH THEIR FIDUCIARY RESPONSIBILITIES TO IDI AND SHALL EXERCISE PARTICULAR CARE SO THAT NO DETRIMENT TO IDI RESULTS FROM CONFLICTS BETWEEN THEIR PERSONAL FINANCIAL INTERESTS AND THOSE OF IDI. AN EMPLOYEE IS CONSIDERED TO HAVE A CONFLICT OF INTEREST WHEN THE EMPLOYEE, OR ANY OF HIS FAMILY OR ASSOCIATES: "HAS AN EXISTING OR POTENTIAL FINANCIAL OR OTHER INTEREST WHICH IMPAIRS OR MIGHT APPEAR TO IMPAIR THE EMPLOYEE'S INDEPENDENCE OF JUDGMENT IN THE DISCHARGE OF HIS RESPONSIBILITIES TO IDI," OR "MAY RECEIVE A MATERIAL, FINANCIAL OR OTHER BENEFIT FROM KNOWLEDGE OF INFORMATION CONFIDENTIAL TO IDI." THE "FAMILY" OF AN EMPLOYEE INCLUDES HIS OR HER SPOUSE, PARENTS, SIBLINGS, CHILDREN AND, IF LIVING IN THE SAME HOUSEHOLD, OTHER RELATIVES. AN "ASSOCIATE" INCLUDES ANY PERSON, TRUST OR ORGANIZATION IN WHICH THE EMPLOYEE OR ANY MEMBER OF HIS OR HER FAMILY: "IS A DIRECTOR, OFFICER, EMPLOYEE, MEMBER, PARTNER, OR TRUSTEE," OR "HAS A FINANCIAL INTEREST THAT ENABLES HIM OR HER, ACTING ALONE OR IN CONJUNCTION WITH OTHERS, TO EXERCISE CONTROL OR INFLUENCE POLICY SIGNIFICANTLY," OR "HAS ANY OTHER MATERIAL ASSOCIATION." THIS POLICY IS TO BE INTERPRETED AND APPLIED IN A MANNER THAT WILL BEST SERVE THE INTERESTS OF IDI. IF AN EMPLOYEE OR OTHER MEMBER OF THE IDI ORGANIZATION BELIEVES THAT HE OR SHE MAY HAVE A CONFLICT OF INTEREST, HE OR SHE SHALL PROMPTLY AND FULLY DISCLOSE THE CONFLICT TO THE PRESIDENT. THIS WILL BE DOCUMENTED USING THE CONFLICT OF INTEREST DISCLOSURE FORM. THE EMPLOYEE IN QUESTION SHALL REFRAIN FROM PARTICIPATING IN THE MATTER TO WHICH THE CONFLICT RELATES UNTIL THAT CONFLICT QUESTION HAS BEEN RESOLVED. IN SOME CASES, HOWEVER, IT MAY BE DETERMINED THAT, AFTER FULL DISCLOSURE TO THOSE CONCERNED, IDI'S INTERESTS ARE BEST SERVED BY THE PARTICIPATION OF THE EMPLOYEE DESPITE THE CONFLICT. ALL EMPLOYEES AND TRUSTEES ARE REQUIRED TO COMPLETE THE CONFLICT OF INTEREST DISCLOSURE FORM ANNUALLY. IF A CONFLICT OF INTEREST IS IDENTIFIED AS A RESULT OF COMPLETING THE DISCLOSURE OR FOR ANY OTHER REASON, THE EMPLOYEE (TRUSTEE) AND THE PRESIDENT WILL WORK TO RESOLVE THE MATTER INCLUDING TAKING WHATEVER ACTION IS NECESSARY TO PRECLUDE THE POSSIBILITY THAT THE IDENTIFIED CONFLICT WILL IMPACT ON AN IDI PURCHASING OR BUSINESS DECISION. THE PRESIDENT WILL REPORT THE CONFLICT TO IDI'S BOARD OF TRUSTEES. A FURTHER ASPECT OF THE IDI'S CONFLICT OF INTEREST POLICY IS INTENDED TO ASSURE THE PROPER USE OF IDI'S RESOURCES. IN THE ABSENCE OF THE APPROPRIATE WRITTEN DISCLOSURE OF CONFLICT OF INTEREST AND ACCEPTABLE RESOLUTION THEREOF, NO MEMBER OF THE IDI ORGANIZATION SHALL INVOLVE OR UTILIZE IDI PERSONNEL, RESOURCES OR VENDORS IN ANY MANNER TO CONDUCT PERSONAL BUSINESS ACTIVITIES OR TO USE THEM FOR PERSONAL FINANCIAL BENEFIT. THIS DOES NOT APPLY TO THE OCCASIONAL USE OF THE TELEPHONE OR COMPUTER TO DEAL WITH INCIDENTAL FAMILY OR PERSONAL MATTERS. THE ROUTINE USE OF IDI RESOURCES TO CONDUCT PERSONAL BUSINESS OUTSIDE OF IDI'S MISSION CONSTITUTES A BREACH OF THE NIH GUIDELINES AND IS A VIOLATION OF IDI'S CONFLICT OF INTEREST POLICY. THE REPEATED VIOLATION OF THIS POLICY BY ANY INDIVIDUAL IS A BASIS FOR DISMISSAL. IDI INVESTIGATORS AT THE LEVEL OF INSTRUCTOR, ASSISTANT PROFESSOR, AND FULL PROFESSOR ARE MEMBERS OF THE HARVARD FACULTY OF MEDICINE. AS SUCH THEY ARE REQUIRED TO FILE A CONFLICT OF INTEREST STATEMENT WITH HARVARD MEDICAL SCHOOL (HMS) ON THE ECOMMONS WEBSITE EACH YEAR IN ORDER TO RETAIN THEIR ACADEMIC APPOINTMENT AND CONDUCT BUSINESS WITH THE UNIVERSITY. COPIES OF THE HMS POLICY, THE FORM FILED, AND THE STATEMENT ON RESEARCH SPONSORED BY INDUSTRY ARE AVAILABLE BY REQUEST. A FACULTY MEMBER IS CONSIDERED TO HAVE A CONFLICT OF INTEREST WHEN HE/SHE, ANY OF HIS/HER FAMILY, OR ANY ASSOCIATED ENTITY POSSESSES A FINANCIAL INTEREST IN AN ACTIVITY WHICH INVOLVES HIS/HER RESPONSIBILITIES AS A MEMBER OF THE FACULTY OF MEDICINE. INCLUDED IN THESE RESPONSIBILITIES ARE ALL ACTIVITIES IN WHICH THE FACULTY MEMBER IS ENGAGED IN THE AREAS OF TEACHING, RESEARCH, PATIENT CARE AND ADMINISTRATION. THE STANDING COMMITTEE ON CONFLICTS OF INTEREST AND COMMITMENT AT HMS IS RESPONSIBLE FOR REVIEWING THE IMPLEMENTATION OF THE POLICY ON A REGULAR BASIS AND PROVIDING OVERSIGHT TO ASSURE THAT THE POLICY IS APPLIED CONSISTENTLY TO ALL FACULTY. COMPENSATION POLICY FORM 990, PART VI, SECTION B, LINE 15 ALL COMPENSATION FOR TOP MANAGEMENT, OFFICERS, AND KEY EMPLOYEES IS APPROVED BY THE BOARD OF DIRECTORS. IDI REVIEWS SEVERAL INDEPENDENT COMPENSATION SURVEYS INCLUDING THE AIRI SURVEY, TSG SURVEY, AND THE MASS BIO-COUNSEL SURVEY. ALL COMPENSATION FOR SENIOR INVESTIGATORS, INVESTIGATORS, AND JUNIOR INVESTIGATORS IS DEVELOPED BY COMPARABLES WITHIN THE LONGWOOD MEDICAL AREA FOR BASIC RESEARCH SCIENTISTS AND APPROVED BY THE BOARD OF DIRECTORS. PUBLIC DISCLOSURE FORM 990, PART VI, SECTION C, LINE 19 THE FORM 990, THE AUDITED FINANCIAL STATEMENTS, AND THE ORGANIZATION'S GOVERNING DOCUMENTS ARE AVAILABLE UPON REQUEST. THE AUDITED FINANCIAL STATEMENTS ARE POSTED ON THE ORGANIZATION'S WEBSITE. IN ADDITION, THE FORM 990 IS AVAILABLE ON THE WEBSITE OF MASSACHUSETTS ATTORNEY GENERAL. RESPONSIBILITY FOR OVERSIGHT OF AUDIT FORM 990, PART XII, LINE 2C IDI'S BOARD OF TRUSTEES IS RESPONSIBLE FOR THE OVERSIGHT OF THE AUDIT, REVIEW, OR COMPILATION OF ITS FINANCIAL STATEMENTS AND THE SELECTION OF AN INDEPENDENT ACCOUNTANT. CHILDREN'S HOSPITAL BOSTON 300 LONGWOOD AVENUE BOSTON MA 02115 042774441 HEALTHCARE MA 501(c)(3) 3 NA BLOOD RESEARCH INSTITUTE INC CLSB 3RD FLOOR 3 BLACKFAN CIRCLE BOSTON MA 02115 043136318 LEASE PROP. 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