2012-05-10T17:02:42-04:00 2011-06-30 ERNST & YOUNG US LLP 4370 LA JOLLA VILLAGE DRIVE STE 500 SAN DIEGO CA 92122 990 2010-07-01 952160097 The Salk Institute for Biological Studies SALK 8584534100 PO Box 85800 San Diego CA 921865800 KIM E WITMER 2012-05-10 8585357200 2010 2016-02-24 21:20:13Z WILLIAM BRODY 10010 NO TORREY PINES ROAD LA JOLLA CA 920371099 160394661 false X www.salk.edu X 1960 CA BASIC RESEARCH IN THE FOLLOWING: MOLECULAR BIOLOGY & GENETICS, NEUROSCIENCE, AND PLANT BIOLOGY. 28 25 1019 119 29817 6806 114311375 120830531 0 0 5553384 4885274 2147694 2055609 122012453 127771414 0 0 0 0 62161799 64525936 0 0 3738055 41589827 46459416 103751626 110985352 18260827 16786062 282360647 344678120 89429170 109026302 192931477 235651818 X INVOLVED IN RESEARCH ACTIVITIES, THE OBJECTIVES OF WHICH ARE THE ADVANCEMENT AND DISSEMINATION OF KNOWLEDGE RELEVANT TO THE HEALTH AND WELLBEING OF MAN. THE OBJECTIVES ARE MET PRIMARILY THROUGH RESEARCH AND ADVANCED INSTRUCTION IN (A) BIOLOGY, (B) THE CAUSE, PREVENTION AND CURE OF DISEASES, AND (C) THE FACTORS AND CIRCUMSTANCES CONDUCIVE TO THE FULFILLMENT OF MAN'S BIOLOGICAL POTENTIAL. false false 95918234 LIST OF ACCOMPLISHMENTS 1. Decoding the disease that perplexes: Salk scientists discover new target for MS: Scientists are closer to solving one of the many mysteries of multiple sclerosis and other demyelinating diseases, thanks to a recent study conducted at the Salk Institute for Biological Studies. The research revealed a previously unknown connection between two ion channels, which, when misaligned, can cause the many bizarre symptoms that characterize the condition. The findings, reported in the October 2010 issue of the Proceedings of the National Academy of Sciences (PNAS), provide fresh insights into the mechanisms underlying MS and suggest a novel target for therapeutic intervention. 2. Modeling autism in a dish: A collaborative effort between researchers at the Salk Institute for Biological Studies and the University of California, San Diego, successfully used human induced pluripotent stem (iPS) cells derived from patients with Rett syndrome to replicate autism in the lab and study the molecular pathogenesis of the disease. Neurons generated from Rett-iPS cells form fewer synapses, the specialized signal transmission points between brain cells. Their findings, published in the Nov. 12, 2010, issue of Cell, revealed disease-specific cellular defects, such as fewer functional connections between Rett neurons, and demonstrated that these symptoms are reversible, raising the hope that, one day, autism maybe turn into a treatable condition. 3. Natural compound shows promise against Huntington's disease: Fisetin, a naturally occurring compound found in strawberries and other fruits and vegetables, slows the onset of motor problems and delays death in three models of Huntington's disease, according to researchers at the Salk Institute for Biological Studies. The study, published in the online edition of Human Molecular Genetics, sets the stage for further investigations into fisetin's neuroprotective properties in Huntington's and other neurodegenerative conditions. Huntington's disease (HD) is an inherited disorder that destroys neurons in certain parts of the brain and slowly erodes victims' ability to walk, talk and reason. It is caused by a kind of genetic stutter, which leads to the expansion of a trinucleotide repeat in the huntingtin protein. When the length of the repeated section reaches a certain threshold, the bearer will develop Huntington's disease. In fact, the longer the repeat, the earlier symptoms develop and the greater their severity. 4. Melanopsin looks on the bright side of life: Better known as the light sensor that sets the body's biological clock, melanopsin also plays an important role in vision: Via its messengers--so-called melanopsin-expressing retinal ganglion cells, or mRGCs--it forwards information about the brightness of incoming light directly to conventional visual centers in the brain, reports an international collaboration of scientists in the December 7, 2010, issue of PLoS Biology. The findings reveal a new role for mRGCs during image-forming vision and suggest that these cells could make a significant contribution to assessing the intensity of light and supporting vision even in people with advanced retinal degeneration, the researchers say. 5. How cells running on empty trigger fuel recycling: Researchers at the Salk Institute for Biological Studies have discovered how AMPK, a metabolic master switch that springs into gear when cells run low on energy, revs up a cellular recycling program to free up essential molecular building blocks in times of need. In a paper published in the Dec. 23, 2010, edition of Science Express, a team led by Reuben Shaw, PhD., Howard Hughes Medical Institute Early Career Scientist and Hearst Endowment assistant professor in the Salk's Molecular and Cell Biology Laboratory, reports that AMPK activates a cellular recycling process known as autophagy by activating an enzyme, known as ATG1, that jumpstarts the process. 6. Conversion of brain tumor cells into blood vessels thwarts treatment efforts: Glioblastoma, the most common and lethal form of brain cancer and the disease that killed Massachusetts Senator Ted Kennedy, resists nearly all treatment efforts, even when attacked simultaneously on several fronts. One explanation can be found in the tumor cells' unexpected flexibility, discovered researchers at the Salk Institute for Biological Studies. When faced with a life-threatening oxygen shortage, glioblastoma cells can shift gears and morph into blood vessels to ensure the continued supply of nutrients, reports a team led by Inder Verma, Ph.D., in a feature article in the January 2011 issue of the Proceedings of the National Academy of Sciences. 7. Hungering for longevity--Salk scientists identify the confluence of aging signals: Substantial evidence suggests that lifespan is increased if an organism restricts its daily calorie intake, a spartan regime that some say works by just making life seem longer. A team of scientists from the Salk Institute of Biological Studies has discovered a molecular switch flipped by hunger that could not only make longevity more appetizing but identify drug targets for patients with aging-related diseases such as type II diabetes or cancer. In the February 17, 2011, issue of Nature, Howard Hughes Medical Institute investigator Andrew Dillin, Ph.D., an associate professor in the Molecular and Cell Biology Laboratory, and Howard Hughes Medical Institute early career scientist Reuben Shaw, Ph.D., an assistant professor in the Molecular and Cell Biology Laboratory and the Dulbecco Laboratory for Cancer Research, report for the first time that deactivation of a protein called CRTC1 in roundworms increases their lifespan, most likely mediating the effects of calorie restriction. 8. Aging, interrupted: The current pace of population aging is without parallel in human history but surprisingly little is known about the human aging process, because lifespans of eight decades or more make it difficult to study. Now, researchers at the Salk Institute for Biological Studies replicated premature aging in the lab, allowing them to study aging-related disease in a dish. In the February 23, 2011, advance online edition of the journal Nature, Juan-Carlos Izpisa Belmonte, Ph.D., a professor in the Salk Institute's Gene Expression Laboratory, and his team report that they successfully generated induced pluripotent stem (iPS) cells from skin cells obtained from patients with Hutchinson-Gilford progeria, who age eight to 10 times faster than the rest of us, and differentiated them into smooth muscle cells displaying the telltale signs of vascular aging. 9. Patients' own cells yield new insights into the biology of schizophrenia: After a century of studying the causes of schizophrenia, the most persistent disabling condition among adults, the cause of the disorder remains unknown. Now induced pluripotent stem cells (iPSCs) generated from schizophrenic patients have brought researchers from the Salk Institute for Biological Studies a step closer to a fundamental understanding of the biological underpinnings of the disease. In their study, published in the April 13, 2011, advance online issue of the journal Nature, the Salk team reports both that neurons generated from these patient-derived iPSCs made fewer connections with each other, and that Loxapine, an antipsychotic drug commonly used to treat schizophrenia, restored neuronal connectivity in iPSC neurons from all patients. 10. A new ending to an old "tail": In stark contrast to normal cells, which only divide a finite number of times before they enter into a permanent state of growth arrest or simply die, cancer cells never cease to proliferate. Now, scientists at the Salk Institute for Biological Studies have uncovered an important clue to one of the mechanisms underlying cancer cell immortality. Their findings, published in the April 22, 2011, issue of Molecular Cell, reveal an unanticipated structure at chromosome ends, which could be a key ingredient in the biological "elixir of life," potentially making it an attractive chemotherapeutic target to cut short the life of a cancer cell. 11. "Fasting pathway" points the way to new class of diabetes drugs. HDAC inhibitors may provide a novel way to cut excessive blood glucose levels at the source: A uniquely collaborative study by researchers at the Salk Institute for Biological Studies uncovered a novel mechanism that turns up glucose production in the liver when blood sugar levels drop, pointing towards a new class of drugs for the treatment of metabolic disease. Their findings, published in the May 13, 2011, issue of the journal Cell, revealed a crucial role for so called histone deacetylases (HDACs), a group of enzymes that is the target of the latest generation of cancer drugs. HDACs get sugar production rolling when blood glucose levels run low after prolonged periods of fasting or during the night. 12. It's not easy being green. Salk scien 95918234 true true false true false false false false true true true false false true false true false false false true false false false true false false false false true true false false false false false false false false false false true false false false false true true false false false true X 148 0 true 1019 true true true false false false false true true false false false false X 28 25 false false false false true true true true true false false true true true true true true true true false AL AK AZ AR CA CT GA HI IL KS KY ME MD MA MI MN MS NH NJ NM NY NC OH OK OR PA RI SC TN UT VA WA WV WI X KIM E WITMER 8584534100 10010 NO TORREY PINES ROAD LA JOLLA CA 920371099 Irwin M Jacobs SM ScD 3.0 X X 0 0 0 Darlene M Shiley 2.0 X X Theodore Waitt 2.0 X X 0 0 0 William R Brody MD PhD 50.0 X X 841193 0 110550 Charles H Brandes 2.0 X X 0 0 0 Kim Campbell 0.5 X 0 0 0 Linda L Chester 0.5 X 0 0 0 Joanne Chory PhD 0.5 X 5000 0 0 Frederick J Dotzler 0.5 X 0 0 0 Richard C Helmstetter 0.5 X 0 0 0 Jennifer L Howse PhD 0.5 X 0 0 0 Dean Kamen 0.5 X 0 0 0 Greg E Lemke PhD 50.0 X 226627 0 31217 Nancy Lukitsh 0.5 X 0 0 0 Corinne Mentzelopoulos 0.5 X 0 0 0 Howard H Newman PhD 0.5 X 0 0 0 Ralph S O'Connor 0.5 X 0 0 0 Gerald S Parsky 0.5 X 0 0 0 Frederick Paulsen PhD 0.5 X 0 0 0 Caryl Philips 0.5 X 0 0 0 Conrad T Prebys 0.5 X 0 0 0 Ernest S Rady 0.5 X 0 0 0 Mary Jane Salk 0.5 X 0 0 0 Carla J Shatz PhD 0.5 X 10000 0 0 Jerre L Stead 2.0 X 0 0 0 David M Stone 0.5 X 0 0 0 Geoffrey M Wahl PhD 50.0 X 238569 0 45464 Harvey P White 0.5 X 0 0 0 Marna C Whittington PhD 0.5 X 0 0 0 M Faye Wilson 0.5 X 0 0 0 Thomas D Albright PhD 50.0 X 224491 0 44017 Benjamin H Lewis 0.5 X 0 0 0 Faye H Russell 0.5 X 0 0 0 Marsha A Chandler PhD 50.0 X 406691 0 33414 Kim E Witmer 50.0 X 279350 0 46089 Julia A Miller JD 50.0 X 236758 0 13038 Inder Verma PhD 50.0 X 349280 0 43375 Wylie E Vale PhD 50.0 X 320265 0 42449 Fred H Gage PhD 50.0 X 300918 0 43375 Rebecca R Newman 50.0 X 289915 0 43279 Dennis D O'Leary PhD 50.0 X 286557 0 47244 4015614 0 543511 83 false true false RUDOLPH SLETTEN INC 10955 VISTA SORRENTO PKWY SAN DIEGO CA 92130 General Contractor 5354971 UC REGENTS SAN DIEGO 9500 GILMAN DRIVE LA JOLLA CA 92093 TRNG PROGRAM/SUBCONT 1947401 P2S ENGINEERING 5000 EAST SPRING STREET LONG BEACH CA 90815 ENGINEERING SERVICES 855712 SAN DIEGO GAS ELECTRIC PO BOX 129831 SAN DIEGO CA 92112 FACILITIES & MAINT. 507195 PACWEST SECURITY SERVICES 3303 HARBOR BLVD COSTA MESA CA 92696 SECURITY 407152 24 860042 69500984 50469505 1448709 120830531 0 1395345 1395345 0 2090489 2090489 35461978 356115 32029121 311414 3432857 44701 3489929 12371 3477558 211405 860042 282712 -71307 -71307 0 0 NOTE RECBLE INTEREST 900099 2280 2280 OIL ROYALTIES 900099 16701 16701 UBI(K-1 FLOW THROUGH INCOME) 900099 17446 17446 36427 127771414 29817 6911066 0 0 0 0 2927700 827164 1908726 191810 0 47191689 41592416 3815624 1783649 4242692 3723367 343082 176243 6722005 5899200 543570 279235 3441850 3020551 278323 142976 457615 99563 324365 33687 905030 848906 56124 250940 250940 0 0 193475 193475 5223787 4525792 468591 229404 4452 4452 13407902 12731875 488126 187901 3072319 2442256 531392 98671 0 5529499 4179002 1188949 161548 812907 679501 46001 87405 0 1109550 811938 109937 187675 0 0 9352736 8666168 522090 164478 180388 180388 SCIENTIFIC SUBCONTRACTS 4246380 4246380 REPAIRS & PARTS 1477279 1448236 24773 4270 UBI TAXES -33007 -33007 OTHER EXPENSES 268164 175919 87594 4651 110985352 95918234 11329063 3738055 0 10968328 9892888 0 24019050 24066906 922470 1367629 30000 0 0 0 1618493 1651234 136887 125109 979489 783427 202765591 118625738 58873830 84139853 80516496 116113310 76233941 91784543 29137103 13677781 282360647 344678120 13805497 19343762 10149807 25466282 58684592 57607080 6789274 6609178 89429170 109026302 X 60292274 80926968 48789959 58620417 83849244 96104433 192931477 235651818 282360647 344678120 X 16786062 25934279 X false true true X true true X 88756153 102548502 87583830 114311374 120830531 514030390 88756153 102548502 87583830 114311374 120830531 514030390 7608919 506421471 1641652 1297051 2714020 3494564 3483205 12630492 145660 105259 44457 295376 2074 22714 3678 222177 18981 269624 527225882 0.96050 0.96940 X OTHER INCOME PART II, LINE 10 DESCRIPTION: GLASS ART TOUR 2006: 0 2007: 0 2008: 0 2009: 210825 2010: 0 DESCRIPTION: OIL ROYALTIES 2006: 2074 2007: 22714 2008: 3678 2009: 7692 2010: 16701 DESCRIPTION: NOTE RECEIVABLE INTEREST 2009: 3660 2010: 2280 RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED false false false false false false false false true 2930 2930 false OTHER ACTIVITIES PART II-B, LINE 1I PAID MEMBERSHIP DUES TO RESEARCH AND BIOMEDICAL ORGANIZATIONS, A PORTION OF WHICH ARE CONSIDERED LOBBYING. ASSOCIATION OF INDEPENDENT RESEARCH INSTITUTES $ 720 CALIFORNIA HEALTHCARE INSTITUTE $1,250 NATIONAL ASSOCIATION FOR BIOMEDICAL RESEARCH $ 960 89420545 12288420 15274598 3489940 113493623 71360759 11356891 8833640 2130745 89420545 83049682 2721386 -12462264 1948045 71360759 0.01010 0.98990 false false 0 1153930 1153930 0 67891138 35460943 32430195 0 48843999 37854935 10989064 0 60097200 45309860 14787340 24779324 24779324 84139853 ALTERNATIVE INVESTMENTS 91781429 F STOCKS NOT-PUBLICLY TRADED <5% 3114 C 91784543 1508 DEFERRED RETIREMENT OBLIGATIONS 6607670 6609178 127771414 110985352 16786062 25934281 -24729736 1204545 17990607 129754420 25934281 -24233987 1700294 128054126 -282712 -282712 127771414 111763813 778461 778461 110985352 110985352 CHANGE IN NET ASSETS Part XI, Line 8 Other Investment gains in excess of amount designated for current operations under endowment spending policy - ($24,233,987); Postretirement benefit changes other than net periodic benefit cost - ($495,749) RECONCILIATION OF REVENUE PER AUDITED FS WITH REVENUE PER RETURN Part XII, Lines 2d Investment gains in excess of amount designated for current operations - ($24,233,987) Reconciliation of Revenue per Audited FS with Revenue per Return Part XII, Line 4b Fundraising events expenses - $282,712 ENDOWMENT FUNDS USES PART V, LINE 4 ENDOWMENT INCOME INTENDED TO BE USED FOR AND TO SUPPORT RESEARCH, OPERATIONS, AND LECTURESHIP EXPENSES. Reconciliation of Expenses per Audited FS with Expenses per Return Part XIII, Line 2d Postretirement benefit changes other than net periodic benefit cost - $495,749; Fundraising events expenses netted with revenues on return on Part VIII, line 8b - $282,712 Central America and the Caribbean Program Services Attended conference 4187 North America Program Services Attended conference 12573 East Asia and the Pacific Program Services Attended conference 39978 Europe (Including Iceland and Greenland) Program Services Attended conference 136583 Middle East and North Africa Program Services Attended conference 4911 South America Program Services Attended conference 1320 South Asia Program Services Attended conference 4490 Sub-Saharan Africa Program Services Attended conference 2383 Europe (Including Iceland and Greenland) Program Services Scientific subcontract 286148 South America Program Services Scientific subcontract 14121 North America Program Services Scientific subcontract 307 507001 507001 true false false true false false EGION: EUROPE ACTIVITIES CONDUCTED: PROGRAM SERVICES SPECIFIC SERVICE: SCIENTIFIC SUBCONTRACTS REGION: SOUTH AMERICA ACTIVITIES CONDUCTED: PROGRAM SERVICES SPECIFIC SERVICE: SCIENTIFIC SUBCONTRACTS NO. OF EMPLOYEES IN THE REGION PART I, LINE 3, COLUMN (C) SCIENTISTS TRAVEL TO FOREIGN COUNTRIES TO ATTEND CONFERENCES. WE DO NOT DEEM THESE ACTIVITIES TO CONSTITUTE WORKING IN THE REGION. ACCOUNTING METHOD PART I, LINE 3, COLUMN (F) ACCRUAL METHOD CONCERT 1011697 827792 183905 113077 153000 GOLF TOURNAMENT 59750 32250 27500 16635 0 1071447 860042 211405 129712 153000 282712 -71307 X X true true X X X X X X false true false false false false false true false William R Brody MD PhD 643008 0 0 0 198185 0 100000 0 10550 0 951743 0 0 0 Marsha A Chandler PhD 397928 0 0 0 8763 0 31850 0 1564 0 440105 0 0 0 Greg E Lemke PhD 199936 0 0 0 26691 0 26206 0 5011 0 257844 0 0 0 Geoffrey M Wahl PhD 235072 0 0 0 3497 0 31347 0 14117 0 284033 0 0 0 Thomas D Albright PhD 223442 0 0 0 1049 0 29900 0 14117 0 268508 0 0 0 Inder Verma PhD 296508 0 0 52772 0 32825 0 10550 0 392655 0 0 0 Wylie E Vale PhD 305508 0 0 0 14757 0 31899 0 10550 0 362714 0 0 0 Fred H Gage PhD 296508 0 0 0 4410 0 32825 0 10550 0 344293 0 0 0 Rebecca R Newman 282508 0 0 0 7407 0 32729 0 10550 0 333194 0 0 0 Dennis D O'Leary PhD 254942 0 0 0 31615 0 33127 0 14117 0 333801 0 0 0 Kim E Witmer 276842 0 0 0 2508 0 32717 0 13372 0 325439 0 0 0 Julia A Miller JD 236263 0 0 0 495 0 0 0 13038 0 249796 0 0 0 QUESTIONS REGARDING COMPENSATION PART I, LINE 1A FIRST-CLASS OR CHARTER TRAVEL: MARSHA CHANDLER, EVP/COO - $8,511; NOT TAXABLE - ACCOUNTABLE PLAN. REBECCA NEWMAN, VP DEVELOPMENT & COMMUNICATIONS - $2,153; NOT TAXABLE - ACCOUNTABLE PLAN. QUESTIONS REGARDING HOUSING ALLOWANCE OR RESIDENCE PART I, LINE 1A A HOUSING ALLOWANCE IS PROVIDED AND REPORTED AS TAXABLE COMPENSATION. SUPPLEMENTAL NONQUALIFIED RETIREMENT PLAN PART I, LINE 4B DEFERRED COMPENSATION PLAN (SECTION 457(F)) WAS ESTABLISHED FOR THE PRESIDENT. THE INSTITUTE'S CONTRIBUTION TO THE PLAN AND THE EARNINGS FROM THE CONTRIBUTION WILL BECOME 100% VESTED UPON THE PRESIDENT'S COMPLETION OF 5 YEARS OF SERVICE. NO PAYOUTS FROM THE PLAN WERE MADE DURING THE YEAR. NON-FIXED PAYMENTS PART I, LINE 7 JOANNE CHORY - $5,000 FOR ACADEMIC COUNCIL CHAIR-ELECT GREG E. LEMKE - $10,000 FOR ACADEMIC COUNCIL CHAIR AND $14,875 FOR TANGIBLE MATERIAL AGREEMENT; CARLA W. SHATZ - $10,000 FOR NON-RESIDENT FELLOW WYLIE VALE - $7,000 FOR LICENSING CONSULTING. CA STATEWIDE COMM DEV AUTHORITY 680164610 130911S92 2005-08-11 25712839 See Part V false false false COUNTY OF SAN DIEGO 956000934 797391R50 2010-05-27 37207949 See Part V false false false 5155000 25712839 686939 true false true true 37207949 1407498 523682 17023667 6718580 2012 true false false true 0.00000 0.00000 0.00000 false true false true false 0.00000 0.00000 0.00000 true false false false false false true false false false false false true DATES FOR REFUNDED ISSUES PART I, LINES A(F) AND B(F) LINE A(F) - REFUND 03/30/94 ISSUE LINE B(F) - REFUND 04/13/00 ISSUE AND RENOVATE AND EQUIPMENT FACILITY X 12 1448709 MARKET VALUE false true false GOVERNING BODY AND MANAGEMENT FORM 990, PART VI, SECTION A, LINES 6, 7a, 7b LINE 6: MEMBERSHIP OF THE CORPORATION CONSISTS OF THE PERSONS ELECTED TO THE BOARD OF TRUSTEES AND THREE MEMBERS FROM AMONG THE RESIDENT AND NON-RESIDENT FELLOWS AND PROFESSORS CHOSEN AND ELECTED ANNUALLY BY THE RESIDENT AND NON-RESIDENT FELLOWS AND PROFESSORS. LINE 7a: THE MEMBERS OF THE CORPORATION ELECT THE TRUSTEES. LINE 7b: THE MEMBERS OF THE CORPORATION MAY ALTER, AMEND, OR REPEAL THE BY-LAWS BY VOTE. POLICIES FORM 990, PART VI, SECTION B, LINES 11A, 12C AND 15A/B LINE 11A: THE FORM 990 IS PREPARED BY THE INSTITUTE, INTERNALLY REVIEWED BY THE SR. DIRECTOR OF FINANCE AND THE CHIEF FINANCIAL OFFICER AND EXTERNALLY REVIEWED BY THE TAX DEPARTMENT OF A PUBLIC ACCOUNTING FIRM. A COPY OF THE PREPARED FORM 990 IS PROVIDED TO ALL BOARD MEMBERS AND THE AUDIT COMMITTEE FOR REVIEW AND DISCUSSION OF THE FORM 990 PRIOR TO ELECTRONIC FILING. LINE 12C: ANNUALLY, THE CONFLICT OF INTEREST DISCLOSURE STATEMENT IS SENT OUT FOR COMPLETION BY THE MEMBERS OF THE BOARD OF TRUSTEES, SENIOR MEMBERS OF ADMINISTRATION AND RESEARCHERS. THE DESIGNATED OFFICIAL FOR EACH GROUP REVIEWS THE COMPLETED FORMS AND BRINGS ANY POTENTIAL CONFLICT OF INTEREST TO THE RESPECTIVE COMMITTEES FOR REVIEW. UPON DETERMINATION THAT A CONFLICT OF INTEREST EXISTS, THE FOLLOWING CONDITIONS OR RESTRICTIONS MAY BE IMPOSED: A. MONITORING OF ACTIVITIES GENERATING THE CONFLICT BY ANOTHER MEMBER; B. DISQUALIFICATION FROM PARTICIPATION IN THE ACTIVITIES GIVING RISE TO THE CONFLICT; C. MODIFICATION OF RESPONSIBILITIES TO AVOID CONFLICTS; D. PUBLIC DISCLOSURE OR DIVESTITURE OF SIGNIFICANT FINANCIAL INTERESTS; E. MODIFICATION OF THE RESEARCH PLAN OR REMOVAL OF THE AFFECTED RESEARCHER FROM THE RESEARCH; F. SEVERANCE OF RELATIONSHIP THAT CREATES ACTUAL OR POTENTIAL CONFLICTS; G. TERMINATION OF EMPLOYMENT. LINE 15A/B: AN INDEPENDENT CONSULTANT WAS RETAINED BY THE SALK INSTITUTE TO ADVISE ON COMPENSATION ISSUES. MARKET ANALYSIS ON THE COMPETITIVENESS OF THE BASE SALARY AND TOTAL COMPENSATION (INCLUDING BENEFITS) FOR THE CEO, EVP, AND CFO WERE CONDUCTED IN 2010. THE INDEPENDENT CONSULTANT EVALUATED TOTAL COMPENSATION COMPARED TO LIKE ROLES AMONG ORGANIZATIONS PROVIDING SUBSTANTIALLY SIMILAR SERVICES IN THE RESEARCH INDUSTRY, INCLUDING BOTH FOR-PROFIT AND NOT-FOR-PROFIT ORGANIZATIONS. THE CONSULTANT CONSIDERED THE SIZE AND SCOPE OF OPERATIONS OF THE INCUMBENTS. THE CONSULTANT GAVE THE OPINION THAT THE TOTAL COMPENSATION FALLS WELL WITHIN A REASONABLE RANGE OF COMPETITIVE PRACTICES. THE CONSULTANT'S REPORTS WERE REVIEWED BY THE EXECUTIVE COMMITTEE WHICH SERVED AS THE COMPENSATION COMMITTEE, EXCLUDING PERSONS WITH A CONFLICT OF INTEREST WITH RESPECT TO THE COMPENSATION ARRANGEMENT. DOCUMENTATION AND RECORDKEEPING WITH RESPECT TO THE DELIBERATIONS AND DECISIONS REGARDING THE COMPENSATION PACKAGE WERE INCLUDED IN THE MINUTES OF THE EXECUTIVE COMMITTEE MEETING. A COPY OF THE CONSULTANT'S REPORTS WAS ATTACHED TO THE MINUTES OF THE MEETING. DISCLOSURE FORM 990, PART VI, SECTION C, LINE 19 UPON REQUEST, THE OFFICE OF THE CHIEF FINANCIAL OFFICER MAKES AVAILABLE TO THE PUBLIC ITS GOVERNING DOCUMENTS AND CONFLICT OF INTEREST POLICY. FINANCIAL STATEMENTS ARE AVAILABLE ON THE SALK WEB SITE. UNREALIZED GAIN PART XI, LINE 5 UNREALIZED GAIN $25,934,279 COMPENSATION OF DIRECTORS PART VII, DIRECTORS COMPENSATION THE FOLLOWING INDIVIDUALS WERE COMPENSATED FOR THE FOLLOWING SERVICES AND NOT PAID AS TRUSTEES: JOANNE CHORY, PH.D. - ACADEMIC COUNCIL CHAIR-ELECT GREG E. LEMKE, PH.D. - PROFESSOR CARLA J. SHATZ, PH.D. - NON-RESIDENT FELLOW GEOFFREY M. WAHL, PH.D. - PROFESSOR THOMAS D. ALBRIGHT, PH.D. - PROFESSOR LA JOLLA BIOLOGICAL LABORATORIES PO BOX 85800 - FINANCE SAN DIEGO CA 921865800 953655649 Research CA 501(C)(3) 7 NA SALK INSTITUTE COMMERCIAL SERVICES CORP PO BOX 85800 - FINANCE SAN DIEGO CA 921865800 232159172 MGMT SERVICES PA NA C 135 57418 1.00000 false false false false false false false false false false false false true true false false false false