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          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
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        <Contributions>3150</Contributions>
        <InvestmentEarningsOrLosses>-1115</InvestmentEarningsOrLosses>
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        <EndOfYearBalance>464754</EndOfYearBalance>
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        <BeginningOfYearBalance>443564</BeginningOfYearBalance>
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        <BeginningOfYearBalance>345999</BeginningOfYearBalance>
        <Contributions>23557</Contributions>
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      </CurrentYearMinus2Years>
      <CurrentYearMinus3Years>
        <BeginningOfYearBalance>376445</BeginningOfYearBalance>
        <Contributions>9668</Contributions>
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        <EndOfYearBalance>345999</EndOfYearBalance>
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      <EndowmentsHeldByUnrelatedOrgs>0</EndowmentsHeldByUnrelatedOrgs>
      <EndowmentsHeldByRelatedOrgs>0</EndowmentsHeldByRelatedOrgs>
      <TotalOfBookValueLandBuildings>0</TotalOfBookValueLandBuildings>
      <TotalRevenue>955351</TotalRevenue>
      <TotalExpenses>838080</TotalExpenses>
      <ExcessOrDeficitForYear>117271</ExcessOrDeficitForYear>
      <NetUnrealizedGLOnInvestments>-34692</NetUnrealizedGLOnInvestments>
      <TotalAdjustments>-34692</TotalAdjustments>
      <ExcessOrDeficitPerFS>82579</ExcessOrDeficitPerFS>
      <TotRevenueEtcAuditedFinclStmt>920659</TotRevenueEtcAuditedFinclStmt>
      <NetUnrealizedGainsInvestments>-34692</NetUnrealizedGainsInvestments>
      <RevenueNotRptdF990>-34692</RevenueNotRptdF990>
      <RevenueSubtotal>955351</RevenueSubtotal>
      <RevenueNotRptdOnFinStmt>0</RevenueNotRptdOnFinStmt>
      <TotalRevenuePerForm990>955351</TotalRevenuePerForm990>
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      <ExpensesNotRptdF990>0</ExpensesNotRptdF990>
      <ExpensesSubtotal>838080</ExpensesSubtotal>
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      <Form990ScheduleDPartXIV>
        <Identifier>DESCRIPTION OF INTENDED USE OF ENDOWMENT FUNDS:</Identifier>
        <ReturnReference>PART V, LINE 4:</ReturnReference>
        <Explanation>THE TEMPORARILY RESTRICTED FUNDS ARE RESTRICTED BY THE DONOR AND ARE RELEASED FROM RESTRICTION UPON SATISFACTION OF THE RESTRICTION BY THE SOCIETY. THE PERMANENTLY RESTRICTED FUNDS ARE RESTRICTED IN PERPETUITY BY THE DONOR. EARNINGS ON THE FUNDS ARE THEN RESTRICTED FOR THE PURPOSE DESIGNATED BY THE DONOR AND ARE RELEASED FROM RESTRICTION UPON SATISFACTION OF THE RESTRICTION BY THE SOCIETY.</Explanation>
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      <Form990ScheduleDPartXIV>
        <Identifier>DESCRIPTION OF UNCERTAIN TAX POSITIONS UNDER FIN 48:</Identifier>
        <ReturnReference>PART X:</ReturnReference>
        <Explanation>THE ACCOUNTING STANDARD ON ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES ADDRESSES THE DETERMINATION OF WHETHER TAX BENEFITS CLAIMED OR EXPECTED TO BE CLAIMED ON A TAX RETURN SHOULD BE RECORDED IN THE FINANCIAL STATEMENTS. UNDER THAT GUIDANCE, THE SOCIETY MAY RECOGNIZE THE TAX BENEFIT FROM AN UNCERTAIN TAX POSITION ONLY IF IT IS MORE LIKELY THAN NOT THAT THE TAX POSITION WILL BE SUSTAINED ON EXAMINATION BY TAXING AUTHORITIES BASED ON THE TECHNICAL MERITS OF THE POSITION. EXAMPLES OF TAX POSITIONS INCLUDE THE TAX-EXEMPT STATUS OF THE SOCIETY AND VARIOUS POSITIONS RELATED TO THE POTENTIAL SOURCES OF UNRELATED BUSINESS TAXABLE INCOME (UBIT). THE TAX BENEFITS RECOGNIZED IN THE FINANCIAL STATEMENTS FROM SUCH A POSITION ARE MEASURED BASED ON THE LARGEST BENEFIT THAT HAS A GREATER THAN 50% LIKELIHOOD OF BEING REALIZED UPON ULTIMATE SETTLEMENT. THERE WERE NO UNRECOGNIZED TAX BENEFITS IDENTIFIED OR RECORDED AS LIABILITIES FOR FISCAL YEARS 2011 AND 2010. THE SOCIETY'S POLICY WOULD BE TO RECOGNIZE INTEREST AND PENALTIES, IF ANY, ON TAX POSITIONS RELATED TO ITS UNRECOGNIZED TAX BENEFITS IN INCOME TAX EXPENSE IN THE FINANCIAL STATEMENTS. NO INTEREST AND PENALTIES WERE ASSESSED OR RECORDED DURING FISCAL YEARS 2011 AND 2010.</Explanation>
      </Form990ScheduleDPartXIV>
    </IRS990ScheduleD>
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      <GrantRecordsMaintained>0</GrantRecordsMaintained>
      <AcctsActvsOutUSTable>
        <Region>EUROPE (INCLUDING ICELAND &amp; GREENLAND) -</Region>
        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>GRANTS TO RECIPIENTS</TypeOfActivitiesConducted>
        <TotalExpenditures>3650</TotalExpenditures>
      </AcctsActvsOutUSTable>
      <AcctsActvsOutUSTable>
        <Region>SOUTH ASIA - AFGHANISTAN, BANGLADESH,</Region>
        <NumberOfOffices>0</NumberOfOffices>
        <NumberOfEmployees>0</NumberOfEmployees>
        <TypeOfActivitiesConducted>GRANTS TO RECIPIENTS</TypeOfActivitiesConducted>
        <TotalExpenditures>2800</TotalExpenditures>
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      <SubtotalNumberOfEmployees>0</SubtotalNumberOfEmployees>
      <ContNumberOfOffices>0</ContNumberOfOffices>
      <ContNumberOfEmployees>0</ContNumberOfEmployees>
      <TotalNumberOfOffices>0</TotalNumberOfOffices>
      <TotalNumberOfEmployees>0</TotalNumberOfEmployees>
      <SubtotalAmountSpent>6450</SubtotalAmountSpent>
      <ContAmountSpent>0</ContAmountSpent>
      <TotalAmountSpent>6450</TotalAmountSpent>
      <GrantsToIndOutsideUS>
        <TypeOfAssistance>TRAVEL GRANT</TypeOfAssistance>
        <Region>EUROPE (INCLUDING ICELAND &amp; GREENLAND) -</Region>
        <NumberOfRecipients>3</NumberOfRecipients>
        <AmountOfCashGrant>3650</AmountOfCashGrant>
        <MannerOfCashDisbursement>CHECK OR WIRE TRANSFER</MannerOfCashDisbursement>
      </GrantsToIndOutsideUS>
      <GrantsToIndOutsideUS>
        <TypeOfAssistance>TRAVEL GRANT</TypeOfAssistance>
        <Region>SOUTH ASIA - AFGHANISTAN, BANGLADESH,</Region>
        <NumberOfRecipients>1</NumberOfRecipients>
        <AmountOfCashGrant>2800</AmountOfCashGrant>
        <MannerOfCashDisbursement>CHECK OR WIRE TRANSFER</MannerOfCashDisbursement>
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      <TransferToForeignCorp>0</TransferToForeignCorp>
      <InterestInForeignTrust>0</InterestInForeignTrust>
      <OwnForeignCorp>0</OwnForeignCorp>
      <PassiveForeignInvestCo>0</PassiveForeignInvestCo>
      <ForeignPartnership>0</ForeignPartnership>
      <BoycottCountries>0</BoycottCountries>
      <Form990ScheduleFPartV>
        <Identifier>PROCEDURE FOR MONITORING GRANTS OUTSIDE THE U.S.:</Identifier>
        <Explanation>SCHEDULE F, PART I, LINE 2: TRAVEL GRANT RECIPIENTS HAVE TO APPLY AND THE MEMBERSHIP COMMITTEE MAKES THE DECISION ON WHOM TO AWARD THE TRAVEL GRANTS TO. THE AWARDS ARE MONITORED BY THE STAFF OF ISSX. IF A RECIPIENT IS FOUND TO NOT HAVE FULFILLED THE ELIGIBILITY CRITERIA, THE AWARD WILL BE CANCELLED AND/OR FORFEITED.</Explanation>
      </Form990ScheduleFPartV>
    </IRS990ScheduleF>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 3</ReturnReference>
        <Explanation>THE SOCIETY HAS CONTRACTED WITH SMITHBUCKLIN TO PERFORM ALL MANAGEMENT FUNCTIONS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 6</ReturnReference>
        <Explanation>ISSX IS A MEMBERSHIP ORGANIZATION FOR ANYONE ENGAGED IN RESEARCH IN XENOBIOTICS, OR IN THE ADMINISTRATION AND/OR REGULATION OF SUCH RESEARCH, OR ANYONE WHO EXPRESSES A SCIENTIFIC INTEREST IN THE FIELD WILL BE ELIGIBLE FOR MEMBERSHIP. THERE WILL BE NO RESTRICTIONS BECAUSE OF PLACE OF BIRTH, RESIDENCE, NATIONALITY, SEX, RACE OR CREED. MEMBERSHIP CATEGORIES ARE SET FORTH IN THE BY-LAWS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION A, LINE 7A</ReturnReference>
        <Explanation>ELECTED COUNCILORS: THERE SHALL BE A MINIMUM OF THREE (3) AND MAXIMUM OF ELEVEN (11) COUNCILORS WITH THE ACTUAL NUMBER OF COUNCILORS TO BE DETERMINED BY THE COUNCIL THROUGH A COUNCIL RESOLUTION. SEVEN COUNCILORS SHALL BE ELECTED ON A BIENNIAL BASIS TO SERVE 2-YEAR TERMS. COUNCILORS MAY SERVE NO MORE THAN TWO SUCCESSIVE 2-YEAR TERMS BUT MAY SERVE ADDITIONAL TERMS AFTER AN ABSENCE FROM COUNCIL MEMBERSHIP OF AT LEAST 1 YEAR.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 11</ReturnReference>
        <Explanation>THE CLIENT MANAGER PERFORMS AN INITIAL REVIEW AND THE EXECUTIVE DIRECTOR PERFORMS A FINAL REVIEW BEFORE EMAILING A COPY TO THE COUNCIL PRIOR TO FILING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION B, LINE 12C</ReturnReference>
        <Explanation>IN CONNECTION WITH ANY ACTUAL OR POSSIBLE CONFLICT OF INTEREST, AN INTERESTED PERSON MUST DISCLOSE THE EXISTENCE OF THE FINANCIAL INTEREST AND BE GIVEN THE OPPORTUNITY TO DISCLOSE ALL MATERIAL FACTS TO THE COUNCIL MEMBERS AND MEMBERS OF COMMITTEES WITH GOVERNING BOARD DELEGATED POWERS CONSIDERING THE PROPOSED TRANSACTION OR ARRANGEMENT. THE REMAINING COUNCIL MEMBERS SHALL DECIDE IF A CONFLICT OF INTEREST EXISTS. AFTER DISCLOSURE OF THE FINANCIAL INTEREST AND ALL MATERIAL FACTS, AND AFTER ANY DISCUSSION WITH THE INTERESTED PERSON, HE/SHE SHALL LEAVE THE COUNCIL MEETING WHILE THE DETERMINATION OF A CONFLICT OF INTEREST IS DISCUSSED AND VOTED UPON.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <ReturnReference>FORM 990, PART VI, SECTION C, LINE 19</ReturnReference>
        <Explanation>THE GOVERNING DOCUMENTS, POLICIES, AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>CHANGES IN NET ASSETS OR FUND BALANCES:</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 5:</ReturnReference>
        <Explanation>NET UNREALIZED LOSSES ON INVESTMENTS: -34,692.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>OVERSIGHT OF AUDITOR</Identifier>
        <ReturnReference>FORM 990, PART XII, LINE 2C</ReturnReference>
        <Explanation>THE SOCIETY HAS AN AUDIT COMMITTEE WHICH ASSUMES RESPONSIBILITY FOR OVERSIGHT AND SELECTION OF THE INDEPENDENT AUDITOR.</Explanation>
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