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        <OtherCompensation>32605</OtherCompensation>
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      <TotalReportableCompFromOrg>2358112</TotalReportableCompFromOrg>
      <TotalReportableCompFrmRltdOrgs>0</TotalReportableCompFrmRltdOrgs>
      <TotalOtherCompensation>233080</TotalOtherCompensation>
      <NumberIndividualsGT100K>39</NumberIndividualsGT100K>
      <FormersListed>false</FormersListed>
      <TotalCompGT150K>true</TotalCompGT150K>
      <CompensationFromOtherSources>false</CompensationFromOtherSources>
      <ContractorCompensation>
        <NameOfContractor>
          <NamePerson>CAPITAL GUARDIAN TRUST COMPANY</NamePerson>
        </NameOfContractor>
        <AddressOfContractor>
          <AddressUS>
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        </AddressOfContractor>
        <DescriptionOfServices>INVESTMENT MANAGER</DescriptionOfServices>
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      </ContractorCompensation>
      <ContractorCompensation>
        <NameOfContractor>
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          <AddressUS>
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        </AddressOfContractor>
        <DescriptionOfServices>CONTRACTING SERVICES</DescriptionOfServices>
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      </ContractorCompensation>
      <ContractorCompensation>
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        <AddressOfContractor>
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        </AddressOfContractor>
        <DescriptionOfServices>INVESTMENT MANAGER</DescriptionOfServices>
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      <ContractorCompensation>
        <NameOfContractor>
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      <ContractorCompensation>
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      <OtherRevenueMisc>
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      <TotalRevenue>
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      <GrantsToDomesticOrgs>
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      </GrantsToDomesticOrgs>
      <GrantsToDomesticIndividuals>
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      </GrantsToDomesticIndividuals>
      <ForeignGrants>
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      </ForeignGrants>
      <BenefitsToMembers>
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      <CompCurrentOfficersDirectors>
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        <ProgramServices>128950</ProgramServices>
        <ManagementAndGeneral>914759</ManagementAndGeneral>
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      <CompDisqualPersons>
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        <ProgramServices>17336344</ProgramServices>
        <ManagementAndGeneral>2173266</ManagementAndGeneral>
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      <PensionPlanContributions>
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      <OtherEmployeeBenefits>
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      <PayrollTaxes>
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      <FeesForServicesManagement>
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      </FeesForServicesManagement>
      <FeesForServicesLegal>
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        <ManagementAndGeneral>86393</ManagementAndGeneral>
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      <FeesForServicesAccounting>
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      <FeesForServicesLobbying>
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      <FeesForServicesProfFundraising>
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      <Advertising>
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      <TravelEntrtnmntPublicOfficials>
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      <PaymentsToAffiliates>
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        <ProgramServices>8316677</ProgramServices>
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      <OtherExpenses>
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      <OtherExpenses>
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        <ProgramServices>1944340</ProgramServices>
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      <OtherExpenses>
        <Description>EQUIP PURCH/RENT REPAIR MAIN</Description>
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      <AllOtherExpenses>
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      <TotalFunctionalExpenses>
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        <Explanation>THE INSTITUTE BELONGS TO MEMBER ORGANIZATIONS WHICH MAY ENGAGE IN LOBBYING ACTIVITIES. AMOUNT REPORTED IN PART II-B, LINE 1I REPRESENTS THE ENTIRE AMOUNT OF DUES PAID.</Explanation>
      </Form990ScheduleCPartIV>
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      <OtherSecurities>
        <Description>ABSOLUTE INCOME EQUITY SEC</Description>
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      <OtherSecurities>
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      <OtherSecurities>
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      <OtherSecurities>
        <Description>PRIVATE EQUITY- FUNDS OF FUNDS</Description>
        <BookValue>30219715</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <OtherSecurities>
        <Description>PRIVATE EQUITY - INDUSTRY/VAR</Description>
        <BookValue>29158706</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <OtherSecurities>
        <Description>PRIVATE EQUITY - REAL ESTATE</Description>
        <BookValue>27678676</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
      </OtherSecurities>
      <OtherSecurities>
        <Description>CASH &amp; CASH EQUIVALENTS</Description>
        <BookValue>3175016</BookValue>
        <MethodOfValuation>F</MethodOfValuation>
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      <TotalOfBookValueSecurities>392885971</TotalOfBookValueSecurities>
      <FederalIncomeTaxLiability>0</FederalIncomeTaxLiability>
      <OtherLiabilities>
        <Description>POST RETIREMENT HEALTH BENEFIT</Description>
        <Amount>3310070</Amount>
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      <TotalOfAmounts>3310070</TotalOfAmounts>
      <TotalRevenue>64468527</TotalRevenue>
      <TotalExpenses>70673639</TotalExpenses>
      <ExcessOrDeficitForYear>-6205112</ExcessOrDeficitForYear>
      <NetUnrealizedGLOnInvestments>-35765622</NetUnrealizedGLOnInvestments>
      <OtherAmount>-1621405</OtherAmount>
      <TotalAdjustments>-37387027</TotalAdjustments>
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      <TotRevenueEtcAuditedFinclStmt>32893089</TotRevenueEtcAuditedFinclStmt>
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      <RevenueNotRptdF990>-31575438</RevenueNotRptdF990>
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      <TotalRevenuePerForm990>64468527</TotalRevenuePerForm990>
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      <TotalExpensesPerForm990>70673639</TotalExpensesPerForm990>
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        <Explanation>THE INSTITUTE'S PRIOR YEAR ENDOWMENT FUND ACCOUNTING WAS RESTATED IN CONNECTION WITH ITS FY 2012 FINANCIAL STATEMENTS TO MORE ACCURATELY REFLECT THE INSTITUTE'S USE OF ENDOWMENT FUNDS.</Explanation>
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      <Form990ScheduleDPartXIV>
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        <Explanation>THE INSTITUTE'S ENDOWMENT FUNDS ARE USED TO UNDERWRITE THE RESEARCH PROGRAM OF THE INSTITUTE AS WELL AS TO FUND THE ADMINISTRATION AND OPERATION OF THE INSTITUTE. THE INSTITUTE HAS ADOPTED ENDOWMENT INVESTMENT AND SPENDING POLICIES THAT ATTEMPT TO PROVIDE A PREDICTABLE STREAM OF FUNDING TO THE INSTITUTE'S MISSION, SUPPORTED BY ITS ENDOWMENT, WHILE SEEKING TO MAINTAIN THE PURCHASING POWER OF ENDOWMENT ASSETS. THESE POLICIES DETERMINE THE AMOUNT THAT MAY BE DRAWN FROM ITS ENDOWMENT FUNDS. THE INSTITUTE DRAWS FUNDS FOR RESEARCH AND OPERATIONS, AS APPROVED BY THE BOARD, FROM TOTAL INVESTMENTS.</Explanation>
      </Form990ScheduleDPartXIV>
      <Form990ScheduleDPartXIV>
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        <Explanation>WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ("THE INSTITUTE") DID NOT REPORT A LIABILITY FOR UNCERTAIN TAX POSITIONS. THE INSTITUTE'S FIN 48 FOOTNOTE IS AS FOLLOWS: FOR TAX PURPOSES, THE INSTITUTE HAS BEEN DESIGNATED AS A PUBLICLY SUPPORTED EDUCATIONAL INSTITUTE UNDER SECTION 501(C)(3) OF THE INTERNAL REVENUE CODE. THE INSTITUTE COMPLIES WITH AUTHORITATIVE GUIDANCE AND ACCOUNTING FOR AND DISCLOSURE OF UNCERTAINTY IN TAX POSITIONS.</Explanation>
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      <PolicyStatementInBrochuresEtc>true</PolicyStatementInBrochuresEtc>
      <PolicyPublViaBroadcastMedia>true</PolicyPublViaBroadcastMedia>
      <MaintRacialCompositionRecords>true</MaintRacialCompositionRecords>
      <MaintScholarshipsRecords>true</MaintScholarshipsRecords>
      <MaintCopiesOfBrochuresEtc>true</MaintCopiesOfBrochuresEtc>
      <MaintCopiesOfAllSolicitations>true</MaintCopiesOfAllSolicitations>
      <DiscriminateRaceStudentsRights>false</DiscriminateRaceStudentsRights>
      <DiscriminateRaceAdmissPolicies>false</DiscriminateRaceAdmissPolicies>
      <DiscriminateRaceEmplmnFaculty>false</DiscriminateRaceEmplmnFaculty>
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      <DiscriminateRaceEducPolicies>false</DiscriminateRaceEducPolicies>
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      <DiscriminateRaceAthleticProg>false</DiscriminateRaceAthleticProg>
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      <Form990ScheduleEPartII>
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    </IRS990ScheduleE>
    <IRS990ScheduleF documentId="IRS990ScheduleF">
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        <NumberOfEmployees>0</NumberOfEmployees>
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      <SubtotalNumberOfEmployees>0</SubtotalNumberOfEmployees>
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      <TotalNumberOfEmployees>0</TotalNumberOfEmployees>
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      <TotalAmountSpent>116321915</TotalAmountSpent>
      <TransferToForeignCorp>true</TransferToForeignCorp>
      <InterestInForeignTrust>false</InterestInForeignTrust>
      <OwnForeignCorp>true</OwnForeignCorp>
      <PassiveForeignInvestCo>true</PassiveForeignInvestCo>
      <ForeignPartnership>true</ForeignPartnership>
      <BoycottCountries>false</BoycottCountries>
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      <WrittenPolicyReTAndEExpenses>false</WrittenPolicyReTAndEExpenses>
      <SubstantiationRequired>true</SubstantiationRequired>
      <CompensationCommittee>X</CompensationCommittee>
      <Form990OfOtherOrganizations>X</Form990OfOtherOrganizations>
      <BoardOrCommitteeApproval>X</BoardOrCommitteeApproval>
      <SeverancePayment>false</SeverancePayment>
      <SupplementalNonqualRetirePlan>false</SupplementalNonqualRetirePlan>
      <EquityBasedCompArrangement>false</EquityBasedCompArrangement>
      <CompBasedOnRevenueOfFilingOrg>false</CompBasedOnRevenueOfFilingOrg>
      <CompBasedOnRevenueRelatedOrgs>false</CompBasedOnRevenueRelatedOrgs>
      <CompBasedNetEarningsFilingOrg>false</CompBasedNetEarningsFilingOrg>
      <CompBasedNetEarningsRelateOrgs>false</CompBasedNetEarningsRelateOrgs>
      <AnyNonFixedPayments>true</AnyNonFixedPayments>
      <InitialContractException>false</InitialContractException>
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        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
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        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
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        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
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        <OtherCompensationFilingOrg>92944</OtherCompensationFilingOrg>
        <OtherCompensationRelatedOrgs>0</OtherCompensationRelatedOrgs>
        <DeferredCompFilingOrg>23214</DeferredCompFilingOrg>
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        <NontaxableBenefitsFilingOrg>3733</NontaxableBenefitsFilingOrg>
        <NontaxableBenefitsRelatedOrgs>0</NontaxableBenefitsRelatedOrgs>
        <TotalCompensationFilingOrg>323558</TotalCompensationFilingOrg>
        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
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        <BonusFilingOrg>0</BonusFilingOrg>
        <BonusRelatedOrgs>0</BonusRelatedOrgs>
        <OtherCompensationFilingOrg>11458</OtherCompensationFilingOrg>
        <OtherCompensationRelatedOrgs>0</OtherCompensationRelatedOrgs>
        <DeferredCompFilingOrg>27839</DeferredCompFilingOrg>
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        <NontaxableBenefitsFilingOrg>4746</NontaxableBenefitsFilingOrg>
        <NontaxableBenefitsRelatedOrgs>0</NontaxableBenefitsRelatedOrgs>
        <TotalCompensationFilingOrg>329114</TotalCompensationFilingOrg>
        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>DR HIDDE PLOEGH</NamePerson>
        <BaseCompensationFilingOrg>221221</BaseCompensationFilingOrg>
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        <BonusFilingOrg>0</BonusFilingOrg>
        <BonusRelatedOrgs>0</BonusRelatedOrgs>
        <OtherCompensationFilingOrg>57790</OtherCompensationFilingOrg>
        <OtherCompensationRelatedOrgs>0</OtherCompensationRelatedOrgs>
        <DeferredCompFilingOrg>25649</DeferredCompFilingOrg>
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        <NontaxableBenefitsFilingOrg>5978</NontaxableBenefitsFilingOrg>
        <NontaxableBenefitsRelatedOrgs>0</NontaxableBenefitsRelatedOrgs>
        <TotalCompensationFilingOrg>310638</TotalCompensationFilingOrg>
        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>DR RUDOLF JAENISCH</NamePerson>
        <BaseCompensationFilingOrg>257021</BaseCompensationFilingOrg>
        <CompBasedOnRelatedOrgs>0</CompBasedOnRelatedOrgs>
        <BonusFilingOrg>0</BonusFilingOrg>
        <BonusRelatedOrgs>0</BonusRelatedOrgs>
        <OtherCompensationFilingOrg>9565</OtherCompensationFilingOrg>
        <OtherCompensationRelatedOrgs>0</OtherCompensationRelatedOrgs>
        <DeferredCompFilingOrg>27846</DeferredCompFilingOrg>
        <DeferredCompRelatedOrgs>0</DeferredCompRelatedOrgs>
        <NontaxableBenefitsFilingOrg>6578</NontaxableBenefitsFilingOrg>
        <NontaxableBenefitsRelatedOrgs>0</NontaxableBenefitsRelatedOrgs>
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        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>DR ROBERT WEINBERG</NamePerson>
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        <CompBasedOnRelatedOrgs>0</CompBasedOnRelatedOrgs>
        <BonusFilingOrg>0</BonusFilingOrg>
        <BonusRelatedOrgs>0</BonusRelatedOrgs>
        <OtherCompensationFilingOrg>7408</OtherCompensationFilingOrg>
        <OtherCompensationRelatedOrgs>0</OtherCompensationRelatedOrgs>
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        <NontaxableBenefitsRelatedOrgs>0</NontaxableBenefitsRelatedOrgs>
        <TotalCompensationFilingOrg>284800</TotalCompensationFilingOrg>
        <TotalCompensationRelatedOrgs>0</TotalCompensationRelatedOrgs>
        <CompReportPrior990FilingOrg>0</CompReportPrior990FilingOrg>
        <CompReportPrior990RelatedOrgs>0</CompReportPrior990RelatedOrgs>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartIII>
        <Identifier>SCHEDULE J, PART I, LINES 1A &amp; 1B:</Identifier>
        <Explanation>DAVID PAGE RECEIVES A HOUSING ALLOWANCE. NO WRITTEN POLICY IS CURRENTLY IN PLACE, HOWEVER, THE BOARD APPROVED HOUSING ALLOWANCE IS PART OF THE COMPENSATION PACKAGE FOR THE DIRECTOR OF THE INSTITUTE.</Explanation>
      </Form990ScheduleJPartIII>
      <Form990ScheduleJPartIII>
        <Identifier>SCHEDULE J, PART I, LINE 7 &amp; PART II, COLUMN (B)(II):</Identifier>
        <Explanation>THE BONUS REPORTED IN COLUMN B(II) REPRESENTS A NON-FIXED PAYMENT MADE TO MS. LAURA SANDER IN RECOGNITION OF MEETING CERTAIN PERFORMANCE GOALS FOR CALENDAR YEARS 2011 AND 2012. MS. KIMBERLY FORNESS ALSO RECEIVED A NON-FIXED BONUS PAYMENT IN RECOGNITION OF MEETING CERTAIN PERFORMANCE GOALS. THIS AMOUNT IS INCLUDED IN FORM 990, PART VII, SECTION A, COLUMN (D).</Explanation>
      </Form990ScheduleJPartIII>
    </IRS990ScheduleJ>
    <IRS990ScheduleK documentId="IRS990ScheduleK">
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        <IssuerName>
          <BusinessNameLine1>MHEFA (2008 LOAN)</BusinessNameLine1>
        </IssuerName>
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        <DateIssued>2008-10-30</DateIssued>
        <IssuePrice>4000000</IssuePrice>
        <DescriptionOfPurpose>EQUIPMENT PURCHASES</DescriptionOfPurpose>
        <Defeased>false</Defeased>
        <OnBehalfOfIssuer>false</OnBehalfOfIssuer>
        <PoolFinancing>true</PoolFinancing>
      </Form990ScheduleKPartI>
      <Form990ScheduleKPartI>
        <IssuerName>
          <BusinessNameLine1>MASS DEVELOPMENT FINANCE AGENCY</BusinessNameLine1>
        </IssuerName>
        <IssuerEIN>043431814</IssuerEIN>
        <CUSIPNumber>57583UEV6</CUSIPNumber>
        <DateIssued>2011-07-01</DateIssued>
        <IssuePrice>43581560</IssuePrice>
        <DescriptionOfPurpose>SEE SCHEDULE O</DescriptionOfPurpose>
        <Defeased>false</Defeased>
        <OnBehalfOfIssuer>false</OnBehalfOfIssuer>
        <PoolFinancing>false</PoolFinancing>
      </Form990ScheduleKPartI>
      <Form990ScheduleKPartII>
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        <TotalProceeds>4000000</TotalProceeds>
        <AmountInReserveFund>0</AmountInReserveFund>
        <CapitalizedInterest>0</CapitalizedInterest>
        <RefundingEscrow>0</RefundingEscrow>
        <IssuanceCostsFromProceeds>30263</IssuanceCostsFromProceeds>
        <CreditEnhancement>0</CreditEnhancement>
        <WorkingCapitalExpenditures>0</WorkingCapitalExpenditures>
        <CapitalExpenditures>3969737</CapitalExpenditures>
        <OtherSpentProceeds>0</OtherSpentProceeds>
        <AmountUnspent>0</AmountUnspent>
        <YearOfSubstCompletion>2011</YearOfSubstCompletion>
        <CurrentRefunding>false</CurrentRefunding>
        <AdvanceRefunding>false</AdvanceRefunding>
        <FinalAllocationMade>true</FinalAllocationMade>
        <AdequateBooksAndRecdsMaintaind>true</AdequateBooksAndRecdsMaintaind>
      </Form990ScheduleKPartII>
      <Form990ScheduleKPartII>
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        <TotalProceeds>43581560</TotalProceeds>
        <AmountInReserveFund>0</AmountInReserveFund>
        <CapitalizedInterest>0</CapitalizedInterest>
        <RefundingEscrow>0</RefundingEscrow>
        <IssuanceCostsFromProceeds>494150</IssuanceCostsFromProceeds>
        <CreditEnhancement>0</CreditEnhancement>
        <WorkingCapitalExpenditures>0</WorkingCapitalExpenditures>
        <CapitalExpenditures>3817539</CapitalExpenditures>
        <OtherSpentProceeds>33000000</OtherSpentProceeds>
        <AmountUnspent>6269871</AmountUnspent>
        <CurrentRefunding>true</CurrentRefunding>
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        <FinalAllocationMade>false</FinalAllocationMade>
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        <AnyResearchAgreements>false</AnyResearchAgreements>
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        <PostIssuanceComplianceProcdrs>true</PostIssuanceComplianceProcdrs>
      </Form990ScheduleKPartIII>
      <Form990ScheduleKPartIII>
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        <TotalPrivateBusinessUse>0.00000</TotalPrivateBusinessUse>
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        <GrossProceedsInvested>false</GrossProceedsInvested>
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        <ReturnReference>0</ReturnReference>
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      <LoanTable>
        <NamePerson>DAVID PAGE -</NamePerson>
        <PurposeOfLoan>MORTGAGE ASSISTANCE</PurposeOfLoan>
        <LoanFromOrganization>X</LoanFromOrganization>
        <OriginalPrincipalAmount>350000</OriginalPrincipalAmount>
        <BalanceDue>204895</BalanceDue>
        <Default>false</Default>
        <ApprovedByBoard>true</ApprovedByBoard>
        <WrittenAgreement>true</WrittenAgreement>
      </LoanTable>
      <LoanTable>
        <NamePerson>HIDDE PLOEGH -</NamePerson>
        <PurposeOfLoan>MORTGAGE ASSISTANCE</PurposeOfLoan>
        <LoanFromOrganization>X</LoanFromOrganization>
        <OriginalPrincipalAmount>350000</OriginalPrincipalAmount>
        <BalanceDue>181250</BalanceDue>
        <Default>false</Default>
        <ApprovedByBoard>true</ApprovedByBoard>
        <WrittenAgreement>true</WrittenAgreement>
      </LoanTable>
      <TotalBalanceDue>386145</TotalBalanceDue>
      <Form990ScheduleLPartIV>
        <NameOfInterestedPerson>
          <NamePerson>MERCK CO INC</NamePerson>
        </NameOfInterestedPerson>
        <Relationship>DIRECTOR IS OFFICER</Relationship>
        <AmountOfTransaction>140000</AmountOfTransaction>
        <DescriptionOfTransaction>ROYALTY PAYMENTS ON PATENTS</DescriptionOfTransaction>
        <SharingOfRevenues>false</SharingOfRevenues>
      </Form990ScheduleLPartIV>
    </IRS990ScheduleL>
    <IRS990ScheduleM documentId="IRS990ScheduleM">
      <WorksOfArt />
      <ArtHistoricalTreasures />
      <ArtFractionalInterest />
      <BooksAndPublications />
      <ClothingAndHouseholdGoods />
      <CarsAndOtherVehicles />
      <BoatsAndPlanes />
      <IntellectualProperty />
      <SecuritiesPubliclyTraded>
        <NonCashCheckbox>X</NonCashCheckbox>
        <NumberOfContributions>2</NumberOfContributions>
        <NoncashContribsRptdF990>118169</NoncashContribsRptdF990>
        <MethodOfDeterminingRevenues>FMV</MethodOfDeterminingRevenues>
      </SecuritiesPubliclyTraded>
      <SecuritiesCloselyHeldStock />
      <SecuritiesPrtnrshpTrustIntrsts />
      <SecuritiesMiscellaneous />
      <QualifiedContribHistStruct />
      <QualifiedContribOther />
      <RealEstateResidential />
      <RealEstateCommercial />
      <RealEstateOther />
      <Collectibles />
      <FoodInventory />
      <DrugsAndMedicalSupplies />
      <Taxidermy />
      <HistoricalArtifacts />
      <ScientificSpecimens />
      <ArchaeologicalArtifacts />
      <NumberOf8283Received>0</NumberOf8283Received>
      <AnyPropertyThatMustBeHeld>false</AnyPropertyThatMustBeHeld>
      <ReviewProcessUnusualNCGifts>true</ReviewProcessUnusualNCGifts>
      <ThirdPartiesUsed>false</ThirdPartiesUsed>
      <Form990ScheduleMPartII>
        <Identifier>SCHEDULE M, COLUMN B:</Identifier>
        <Explanation>THE INSTITUTE IS REPORTING THE NUMBER OF CONTRIBUTIONS.</Explanation>
      </Form990ScheduleMPartII>
    </IRS990ScheduleM>
    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <GeneralExplanation>
        <Identifier>FORM 990, PART I, LINE 1 &amp; PART III, LINE 1:</Identifier>
        <ReturnReference>ORGANIZATION'S MISSION:</ReturnReference>
        <Explanation>WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ("THE INSTITUTE") ENGAGES IN BIOMEDICAL RESEARCH AND EDUCATION TO FOSTER THE UNDERSTANDING OF BIOLOGICAL SYSTEMS, ORGANISMS, AND PROCESSES, WITH THE ULTIMATE GOAL OF IMPROVING HUMAN HEALTH AND WELL-BEING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART I, LINE 6:</Identifier>
        <Explanation>THE INSTITUTE DOES NOT FORMALLY TRACK VOLUNTEERS, BUT HAS INCLUDED THE NUMBER OF BOARD MEMBERS AND EXECUTIVE COMMITTEE MEMBERS OF THE BOARD OF ASSOCIATES (FRIENDS OF THE INSTITUTE) THAT ARE UNCOMPENSATED.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, LINE 2:</Identifier>
        <Explanation>JOHN, PETER, AND SUSAN WHITEHEAD (ALL DIRECTORS) HAVE A FAMILY RELATIONSHIP AND A BUSINESS RELATIONSHIP.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, LINE 11B:</Identifier>
        <Explanation>THE PROCESS FOR THE FORM 990 INCLUDES REVIEW BY SENIOR MANAGEMENT, THE AUDIT COMMITTEE, AND THE INDEPENDENT EXTERNAL TAX CONSULTANTS. THE AUDIT COMMITTEE REVIEWS A DRAFT OF THE RETURN AND THE FULL BOARD RECEIVES A FINAL COPY OF THE FORM 990 BEFORE IT IS FILED.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, LINE 12C:</Identifier>
        <Explanation>PROMPTLY AFTER THE END OF EACH FISCAL YEAR OF THE INSTITUTE (JUNE 30), AND IMMEDIATELY FOLLOWING ELECTION TO THE BOARD FOR THE FIRST TIME, DIRECTORS AND OFFICERS SHALL SUBMIT TO THE VICE PRESIDENT, OR SUCH PERSON AS THE DIRECTOR MAY DESIGNATE, A COMPLETED DISCLOSURE STATEMENT REPORTING INFORMATION SPECIFICALLY REQUESTED IN THE STATEMENT AND ALSO REPORTING ON BEHALF OF THEMSELVES, THEIR FAMILY MEMBERS, AND ORGANIZATIONS WITH WHICH THEY HAVE A BUSINESS RELATIONSHIP, ANY ACTUAL OR PLANNED BUSINESS OR OTHER TRANSACTION OR RELATIONSHIP THAT DIRECTLY OR INDIRECTLY INVOLVES THE INSTITUTE OR THAT FOR SOME OTHER REASON COULD BE CONSTRUED AS A CONFLICT OF INTEREST BECAUSE IT MIGHT AFFECT THEIR INDEPENDENT, UNBIASED JUDGMENT WHEN CARRYING OUT THEIR DUTIES FOR THE INSTITUTE. IF A MATTER COMES BEFORE THE BOARD OR ANY COMMITTEE OF THE BOARD IN WHICH A DIRECTOR HAS AN INTEREST (EITHER DIRECTLY OR INDIRECTLY), SUCH DIRECTOR SHOULD WITHDRAW FROM DISCUSSION AND VOTING WHEN THE BOARD OR COMMITTEE ACTS ON SUCH MATTER. CONFLICTS OF INTEREST ARE MONITORED BY THE VICE PRESIDENT AND DIRECTOR WHO ADVISE THE CHAIRMAN OF THE BOARD.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, LINE 15:</Identifier>
        <Explanation>A COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS ANNUALLY REVIEWS AND RECOMMENDS CHANGES TO THE PRESIDENT'S SALARY. FACULTY SALARIES ARE SET BY MASSACHUSETTS INSTITUTE OF TECHNOLOGY ON AN ANNUAL BASIS. ALL OTHER OFFICER SALARIES ARE PART OF A RAISE POOL THAT IS DETERMINED ANNUALLY AND APPROVED BY THE BOARD OF DIRECTORS AS PART OF THE BUDGET APPROVAL PROCESS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART VI, LINE 19:</Identifier>
        <Explanation>THE INSTITUTE'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST. FORM 990, PART IX: FOR THE 2011 FORM 990, THE INSTITUTE ADOPTED A REVISED METHODOLOGY FOR ALLOCATING FUNCTIONAL EXPENSES BETWEEN PROGRAM SERVICE EXPENSES AND MANAGEMENT AND GENERAL EXPENSES TO MORE ACCURATELY REFLECT ACTUAL USE OF INSTITUTE RESOURCES.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, PART XI, LINE 5:</Identifier>
        <Explanation>OTHER CHANGES IN NET ASSETS OR FUND BALANCES: UNREALIZED LOSS ON INVESTMENTS: (35,765,622) LOSS ON DISPOSAL OF FIXED ASSETS: (61,474) LOSS ON RETIREMENT OF BORROWINGS: (172,188) POST-RETIREMENT RELATED CHANGES: (1,387,743) --------------- TOTAL OTHER CHANGES IN NET ASSETS OR FUND BALANCES (37,387,027)</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>FORM 990, SCHEDULE K, PART I, COLUMN F, LINE B:</Identifier>
        <Explanation>DESCRIPTION OF PURPOSE: BUILDING IMPROVEMENTS AND EQUIPMENT PURCHASES; REFUND OF 1993 AND 1995 BONDS. SCHEDULE K, PART III: THE INSTITUTE MONITORS THE USE OF BOND-FINANCED FACILITIES AND EQUIPMENT AND HAS DETERMINED THAT IT HAS NO MANAGEMENT OR SERVICE CONTRACTS, RESEARCH CONTRACTS, UNRELATED TRADE OR BUSINESS ACTIVITIES, OR OTHER ACTIVITIES WITH RESPECT TO BOND-FINANCED EQUIPMENT OR FACILITIES THAT WOULD RESULT IN PRIVATE BUSINESS USE. FORM 990, SCHEDULE K, PART V: CORRECTIVE ACTION POLICY: THE INSTITUTE FORMALIZED A WRITTEN CORRECTIVE ACTION POLICY AFTER THE END OF THE TAX YEAR.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
  </ReturnData>
</Return>