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      <ReconcilationRevenueExpenses>-932431</ReconcilationRevenueExpenses>
      <MethodOfAccountingAccrual>X</MethodOfAccountingAccrual>
      <AccountantCompileOrReview>false</AccountantCompileOrReview>
      <FSAudited>true</FSAudited>
      <FSAuditedBasis>
        <FinancialStatementConsolidated>X</FinancialStatementConsolidated>
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        <CurrentTaxYearMinus1Year>25969643</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>36278602</CurrentTaxYear>
        <Total>120822196</Total>
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      <Total170>
        <CurrentTaxYearMinus4Years>24178834</CurrentTaxYearMinus4Years>
        <CurrentTaxYearMinus3Years>16057142</CurrentTaxYearMinus3Years>
        <CurrentTaxYearMinus2Years>18337975</CurrentTaxYearMinus2Years>
        <CurrentTaxYearMinus1Year>25969643</CurrentTaxYearMinus1Year>
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        <Total>120822196</Total>
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      <AmountsSubstContributorsTotal>32255276</AmountsSubstContributorsTotal>
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      <GrossInvestmentIncome170>
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        <CurrentTaxYearMinus1Year>17558</CurrentTaxYearMinus1Year>
        <CurrentTaxYear>9937</CurrentTaxYear>
        <Total>494756</Total>
      </GrossInvestmentIncome170>
      <TotalSupport>121316952</TotalSupport>
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      <ThirtyThreePercntTestsCY170>X</ThirtyThreePercntTestsCY170>
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          <AddressLine2>RESTRICTED</AddressLine2>
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        </ContributorAddressUS>
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      <Equipment>
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        <Depreciation>743041</Depreciation>
        <BookValue>111423</BookValue>
      </Equipment>
      <TotalOfBookValueLandBuildings>209312</TotalOfBookValueLandBuildings>
      <Form990ScheduleDPartXIII>
        <Identifier>LIABILITY UNDER FIN 48 FOOTNOTE</Identifier>
        <ReturnReference>SCHEDULE D, PAGE 3, PART X</ReturnReference>
        <Explanation>THE ORGANIZATION HAS EVALUATED ITS TAX POSITIONS TAKEN FOR ALL OPEN TAX YEARS AND HAS NOT IDENTIFIED ANY UNCERTAIN TAX POSITIONS WHICH WOULD REQUIRE DISCLOSURE IN THE CONSOLIDATED FINANCIAL STATEMENTS. CURRENTLY, THE ORGANIZATION IS NO LONGER SUBJECT TO EXAMINATION BY THE INTERNAL REVENUE SERVICE (IRS) FOR YEARS BEFORE 2008. THE ORGANIZATION IS NOT CURRENTLY UNDER AUDIT NOR HAS THE ORGANIZATION BEEN CONTACTED BY THE IRS.</Explanation>
      </Form990ScheduleDPartXIII>
      <Form990ScheduleDPartXIII>
        <Identifier>SUPPLEMENTAL FINANCIAL INFORMATION</Identifier>
        <ReturnReference>SCHEDULE D, PAGE 4, PART XIII</ReturnReference>
        <Explanation>THE PRESENTATION OF FUNCTIONAL EXPENSES ON THIS TAX RETURN DIFFERS FROM THE CONSOLIDATED FINANCIAL STATEMENTS DUE TO THE FOLLOWING ITEMS: 1) 1,000,000 GRANT FROM THE FOUNDATION TO ITS RELATED ORGANIZATION, JAEB CENTER FOR RESEARCH TRUST, INC. THIS TRANSACTION IS ELIMINATED IN THE CONSOLIDATED FINANCIAL STATEMENTS. 2) DONATIONS OF 101,295 ARE REPORTED AS 100% PROGRAM SERVICES ON LINE 2, GRANTS ON THE 990, PART IX. IN THE FINANCIALS, 74,483 OF THIS AMOUNT IS ALLOCATED TO MANAGEMENT &amp; GENERAL EXPENSE. 3) 34,524 EQUIPMENT REIMBURSEMENT FROM A GRANT IS RECLASSED FROM CONTRIBUTIONS TO EXPENSE. 9,149 IS REPORTED AS PROGRAM SERVICES AND 25,375 AS MANAGEMENT &amp; GENERAL EXPENSE. 4) VARIOUS OTHER COSTS TOTALING 1,026 ARE MOVED TO PROGRAM SERVICES FROM MANAGEMENT &amp; GENERAL EXPENSE BECAUSE OF THE DETAILED PRESENTATION ON THE 990.</Explanation>
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    </IRS990ScheduleD>
    <IRS990ScheduleI documentId="RetDoc5">
      <RecordsMaintained>true</RecordsMaintained>
      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>JAEB CENTER RESEARCH TRUST INC</BusinessNameLine1>
        </RecipientNameBusiness>
        <AddressUS>
          <AddressLine1>15310 AMBERLY DRIVE</AddressLine1>
          <City>TAMPA</City>
          <State>FL</State>
          <ZIPCode>33647</ZIPCode>
        </AddressUS>
        <EINOfRecipient>270717710</EINOfRecipient>
        <IRCSection>501C3</IRCSection>
        <AmountOfCashGrant>1000000</AmountOfCashGrant>
        <PurposeOfGrant>INVESTMENT</PurposeOfGrant>
      </RecipientTable>
      <TotalNbrOf501C3AndGovtGrants>1</TotalNbrOf501C3AndGovtGrants>
      <Form990ScheduleIPartIV>
        <Identifier>PROCEDURES FOR MONITORING THE USE OF GRANT FUNDS INSIDE THE UNITED STATES</Identifier>
        <ReturnReference>SCHEDULE I, PAGE 1, PART I, LINE 2</ReturnReference>
        <Explanation>THE ORGANIZATION GIVES GRANTS TO THEIR RELATED NON-PROFIT ORGANIZATION TO INVEST. WHEN FUNDS ARE GIVEN BACK TO JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC., THEY ARE USED BY THE ORGANIZATION IN THEIR EXEMPT PURPOSE.</Explanation>
      </Form990ScheduleIPartIV>
    </IRS990ScheduleI>
    <IRS990ScheduleJ documentId="RetDoc6">
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      <BoardOrCommitteeApproval>X</BoardOrCommitteeApproval>
      <SeverancePayment>false</SeverancePayment>
      <SupplementalNonqualRetirePlan>false</SupplementalNonqualRetirePlan>
      <EquityBasedCompArrangement>false</EquityBasedCompArrangement>
      <CompBasedOnRevenueOfFilingOrg>false</CompBasedOnRevenueOfFilingOrg>
      <CompBasedOnRevenueRelatedOrgs>false</CompBasedOnRevenueRelatedOrgs>
      <CompBasedNetEarningsFilingOrg>false</CompBasedNetEarningsFilingOrg>
      <CompBasedNetEarningsRelateOrgs>false</CompBasedNetEarningsRelateOrgs>
      <AnyNonFixedPayments>false</AnyNonFixedPayments>
      <InitialContractException>false</InitialContractException>
      <Form990ScheduleJPartII>
        <NamePerson>ROY W BECK MD PHD</NamePerson>
        <Title>EXECUTIVE DIRECTOR</Title>
        <BaseCompensationFilingOrg>390712</BaseCompensationFilingOrg>
        <NontaxableBenefitsFilingOrg>98850</NontaxableBenefitsFilingOrg>
        <TotalCompensationFilingOrg>489562</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>CRAIG KOLLMAN</NamePerson>
        <Title>DIR BIOSTATISTICS</Title>
        <BaseCompensationFilingOrg>165828</BaseCompensationFilingOrg>
        <NontaxableBenefitsFilingOrg>41954</NontaxableBenefitsFilingOrg>
        <TotalCompensationFilingOrg>207782</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>PAMELA MOKE</NamePerson>
        <Title>DIR COMPUTING SVCS</Title>
        <BaseCompensationFilingOrg>163050</BaseCompensationFilingOrg>
        <NontaxableBenefitsFilingOrg>41252</NontaxableBenefitsFilingOrg>
        <TotalCompensationFilingOrg>204302</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>B MICHELLE MELIA</NamePerson>
        <Title>SR BIOSTATISTICIAN</Title>
        <BaseCompensationFilingOrg>156341</BaseCompensationFilingOrg>
        <NontaxableBenefitsFilingOrg>39554</NontaxableBenefitsFilingOrg>
        <TotalCompensationFilingOrg>195895</TotalCompensationFilingOrg>
      </Form990ScheduleJPartII>
      <Form990ScheduleJPartII>
        <NamePerson>CHIN-HSING CHEN</NamePerson>
        <Title>BIOSTATISTICIAN</Title>
        <BaseCompensationFilingOrg>134107</BaseCompensationFilingOrg>
        <NontaxableBenefitsFilingOrg>33929</NontaxableBenefitsFilingOrg>
        <TotalCompensationFilingOrg>168036</TotalCompensationFilingOrg>
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      <Form990ScheduleJPartII>
        <NamePerson>ADAM GLASSMAN</NamePerson>
        <Title>DIRECTOR DRCRNET</Title>
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        <NontaxableBenefitsFilingOrg>31925</NontaxableBenefitsFilingOrg>
        <TotalCompensationFilingOrg>158112</TotalCompensationFilingOrg>
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        <NameOfInterestedPerson>
          <NamePerson>T1D FIRST INC</NamePerson>
        </NameOfInterestedPerson>
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        <AmountOfTransaction>10678485</AmountOfTransaction>
        <DescriptionOfTransaction>CEO SERVES ON BOARD</DescriptionOfTransaction>
        <SharingOfRevenues>false</SharingOfRevenues>
      </Form990ScheduleLPartIV>
      <Form990ScheduleLPartV>
        <Identifier>ADDITIONAL INFORMATION</Identifier>
        <ReturnReference>SCHEDULE L PART V</ReturnReference>
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      </Form990ScheduleLPartV>
    </IRS990ScheduleL>
    <IRS990ScheduleO documentId="RetDoc8">
      <GeneralExplanation>
        <Identifier>ORGANIZATION'S MISSION</Identifier>
        <ReturnReference>FORM 990 - ORGANIZATION'S MISSION</ReturnReference>
        <Explanation>DEVELOP, DESIGN AND COORDINATE CLINICAL TRIALS IN OPHTHALMOLOGY AND DIABETES INCLUDING FUNCTIONING AS THE COORDINATING CENTER FOR THOSE TRIALS AND CONDUCTING THE STATISTICAL ANALYSIS AND PREPARATION OF MANUSCRIPTS AND OTHER PUBLICATIONS RESULTING FROM THOSE TRIALS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>ORGANIZATION'S PROCESS USED TO REVIEW FORM 990</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 11B</ReturnReference>
        <Explanation>THE BOARD OF DIRECTORS RECEIVES FORM 990 VIA E-MAIL AND ARE INVITED TO PROVIDE QUESTIONS, COMMENTS, AND SUGGESTIONS PRIOR TO THE FORM'S FILING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>ENFORCEMENT OF CONFLICTS POLICY</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 12C</ReturnReference>
        <Explanation>CONFLICT OF INTEREST FORMS ARE REQUESTED EVERY YEAR AND REVIEWED BY PROJECT CHAIRPERSON FOR INVESTIGATORS/COORDINATORS ETC., BY COMPLIANCE OFFICER AND IRB CHAIR FOR INVESTIGATORS THAT ARE COVERED BY JAEB IRB AND BY HR DIRECTOR FOR JAEB CENTER FOR HEALTH RESEARCH FOUNDATION, INC. EMPLOYEES NOT COVERED BY JAEB IRB.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>COMPENSATION PROCESS FOR TOP OFFICIAL</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 15A</ReturnReference>
        <Explanation>THE SALARY OF THE EXECUTIVE DIRECTOR IS REVIEWED ANNUALLY BY THE SALARY SUB-COMMITTEE OF THE BOARD. INCREASES ARE HELD AT 3% PER YEAR.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>COMPENSATION PROCESS FOR OFFICERS</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 15B</ReturnReference>
        <Explanation>ALL OTHER SALARIES ARE REVIEWED BY EXECUTIVE DIRECTOR IN CONJUNCTION WITH WRITTEN ANNUAL PERFORMANCE REVIEW.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>GOVERNING DOCUMENTS DISCLOSURE EXPLANATION</Identifier>
        <ReturnReference>FORM 990, PAGE 6, PART VI, LINE 19</ReturnReference>
        <Explanation>ANY MEMBER OF THE PUBLIC CAN COME IN AND INSPECT THE PUBLICLY AVAILABLE PORTIONS OF OUR GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS IN OUR OFFICE DURING REGULAR OFFICE HOURS.</Explanation>
      </GeneralExplanation>
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        </NameOfDisregardedEntity>
        <AddressUS>
          <AddressLine1>15310 AMBERLY DRIVE SUITE 350</AddressLine1>
          <City>TAMPA</City>
          <State>FL</State>
          <ZIPCode>33647</ZIPCode>
        </AddressUS>
        <EIN>270717710</EIN>
        <PrimaryActivities>SUPPORT</PrimaryActivities>
        <LegalDomicileState>FL</LegalDomicileState>
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        <PublicCharityStatus>11B</PublicCharityStatus>
        <DirectControllingEntityNA>N/A</DirectControllingEntityNA>
        <ControlledOrg>false</ControlledOrg>
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      <GiftGrantOrCapContrFrOtherOrg>false</GiftGrantOrCapContrFrOtherOrg>
      <LoansOrGuaranteesToOtherOrg>false</LoansOrGuaranteesToOtherOrg>
      <LoansOrGuaranteesFromOtherOrg>false</LoansOrGuaranteesFromOtherOrg>
      <DividendsRelatedOrganization>false</DividendsRelatedOrganization>
      <SaleOfAssetsToOtherOrg>false</SaleOfAssetsToOtherOrg>
      <PurchaseOfAssetsFromOtherOrg>false</PurchaseOfAssetsFromOtherOrg>
      <ExchangeOfAssets>false</ExchangeOfAssets>
      <RentalOfFacilitiesToOtherOrgs>false</RentalOfFacilitiesToOtherOrgs>
      <RentalOfFacilitiesFrOtherOrgs>false</RentalOfFacilitiesFrOtherOrgs>
      <PerformOfServicesForOtherOrgs>false</PerformOfServicesForOtherOrgs>
      <PerformOfServicesByOtherOrgs>false</PerformOfServicesByOtherOrgs>
      <SharingOfFacilities>true</SharingOfFacilities>
      <SharingOfPaidEmployees>true</SharingOfPaidEmployees>
      <ReimbursementPaidToOtherOrg>false</ReimbursementPaidToOtherOrg>
      <ReimbursementPaidByOtherOrg>false</ReimbursementPaidByOtherOrg>
      <OtherTransferToOtherOrg>false</OtherTransferToOtherOrg>
      <OtherTransferFromOtherOrg>false</OtherTransferFromOtherOrg>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>JAEB CENTER RESEARCH TRUST INC</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>B</TransactionType>
        <AmountInvolved>1000000</AmountInvolved>
        <MethodOfAmtDetermination>CASH</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>JAEB CENTER RESEARCH TRUST INC</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>N</TransactionType>
        <MethodOfAmtDetermination>SEE NOTE</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <TransactionsRelatedOrgsTable>
        <NameOfOtherOrganization>
          <BusinessNameLine1>JAEB CENTER RESEARCH TRUST INC</BusinessNameLine1>
        </NameOfOtherOrganization>
        <TransactionType>O</TransactionType>
        <MethodOfAmtDetermination>SEE NOTE</MethodOfAmtDetermination>
      </TransactionsRelatedOrgsTable>
      <Form990ScheduleRPartVII>
        <Identifier>ADDITIONAL INFORMATION</Identifier>
        <ReturnReference>SCHEDULE R</ReturnReference>
        <Explanation>SCHEDULE R PART V LINE 1N TRANSACTIONS WITH RELATED ORGANIZATIONS THE ORGANIZATION SHARES FACILITIES AND EQUIPMENT WITH JAEB CENTER RESEARCH TRUST INC NEITHER ORGANIZATION ASSIGNS A VALUE TO THIS TRANSACTION SCHEDULE R PART V LINE 1O TRANSACTIONS WITH RELATED ORGANIZATIONS THE ORGANIZATION SHARES PAID EMPLOYEES WITH JAEB CENTER RESEARCH TRUST INC AN EMPLOYEE OF JAEB CENTER FOR HEALTH RESEARCH FOUNDATION INC DOES THE BOOKKEEPING FOR THE TRUST</Explanation>
      </Form990ScheduleRPartVII>
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  </ReturnData>
</Return>