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        <Description>DEPOSITS WITH TRUSTEE</Description>
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      <TotalBookValueOtherAssets>255742384</TotalBookValueOtherAssets>
      <FederalIncomeTaxLiability>0</FederalIncomeTaxLiability>
      <OtherLiabilities>
        <Description>CAPITAL LEASE OBLIGATIONS</Description>
        <Amount>378054</Amount>
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      <TotalOfAmounts>378054</TotalOfAmounts>
      <TotalRevenue>284343280</TotalRevenue>
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      <TotalRevenuePerForm990>284343280</TotalRevenuePerForm990>
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      <ExpensesSubtotal>275175417</ExpensesSubtotal>
      <TotalExpensesPerForm990>275175417</TotalExpensesPerForm990>
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      <Form990ScheduleDPartXIV>
        <Identifier>OTHER LIABILITIES</Identifier>
        <ReturnReference>SCHEDULE D, PART X, LINE 2</ReturnReference>
        <Explanation>THE BROAD INSTITUTE DOES NOT HAVE A FIN 48 (ASC 740) STATEMENT.</Explanation>
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    </IRS990ScheduleD>
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        <NumberOfEmployees>0</NumberOfEmployees>
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        <TotalExpenditures>676578</TotalExpenditures>
      </AcctsActvsOutUSTable>
      <AcctsActvsOutUSTable>
        <Region>Europe (Including Iceland and Greenland)</Region>
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        <NumberOfEmployees>0</NumberOfEmployees>
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      <AcctsActvsOutUSTable>
        <Region>Middle East and North Africa</Region>
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      <AcctsActvsOutUSTable>
        <Region>Sub-Saharan Africa</Region>
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      <TotalNumberOfOffices>0</TotalNumberOfOffices>
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          <State>MA</State>
          <ZIPCode>02215</ZIPCode>
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          <State>MA</State>
          <ZIPCode>02142</ZIPCode>
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          <City>CAMBRIDGE</City>
          <State>MA</State>
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          <City>BOSTON</City>
          <State>MA</State>
          <ZIPCode>021142517</ZIPCode>
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          <ZIPCode>02139</ZIPCode>
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        </RecipientNameBusiness>
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          <AddressLine1>3003 SOUTH STATE ST</AddressLine1>
          <City>ANN ARBOR</City>
          <State>MI</State>
          <ZIPCode>48109</ZIPCode>
        </AddressUS>
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          <AddressLine1>1425 MADISON AVENUE</AddressLine1>
          <City>NEW YORK</City>
          <State>NY</State>
          <ZIPCode>10029</ZIPCode>
        </AddressUS>
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        <AddressUS>
          <AddressLine1>1156 HIGH ST</AddressLine1>
          <City>SANTA CRUZ</City>
          <State>CA</State>
          <ZIPCode>95064</ZIPCode>
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          <BusinessNameLine1>OREGON HEALTH &amp; SCIENCE UNIVERSITY</BusinessNameLine1>
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          <AddressLine1>0690 SW BANCROFT ST</AddressLine1>
          <City>PORTLAND</City>
          <State>OR</State>
          <ZIPCode>97239</ZIPCode>
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          <BusinessNameLine1>THE PENNSYLVANIA STATE UNIVERSITY</BusinessNameLine1>
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        <AddressUS>
          <AddressLine1>110 TECH CENTER</AddressLine1>
          <City>UNIVERSITY PARK</City>
          <State>PA</State>
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          <BusinessNameLine1>PLASMA PROTEOME INSTITUTE INC</BusinessNameLine1>
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          <State>DC</State>
          <ZIPCode>20009</ZIPCode>
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          <State>CA</State>
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          <ZIPCode>15213</ZIPCode>
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          <AddressLine1>13800 OLD GENTILLY</AddressLine1>
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          <State>LA</State>
          <ZIPCode>70129</ZIPCode>
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          <AddressLine1>115 MILL STREET</AddressLine1>
          <City>BELMONT</City>
          <State>MA</State>
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          <BusinessNameLine1>REGENTS OF THE UNIVERSITY OF MINNESOTA</BusinessNameLine1>
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          <City>MINNEAPOLIS</City>
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        <AmountOfCashGrant>64590</AmountOfCashGrant>
        <PurposeOfGrant>PROGRAM SUPPORT</PurposeOfGrant>
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      <RecipientTable>
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          <BusinessNameLine1>SANARIA INC</BusinessNameLine1>
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          <AddressLine1>9800 MEDICAL CENTER DR</AddressLine1>
          <City>ROCKVILLE</City>
          <State>MD</State>
          <ZIPCode>20850</ZIPCode>
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        <EINOfRecipient>562354362</EINOfRecipient>
        <IRCSection>N/A</IRCSection>
        <AmountOfCashGrant>481856</AmountOfCashGrant>
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      <RecipientTable>
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          <BusinessNameLine1>THE UNIVERSITY OF MISSISSIPPI</BusinessNameLine1>
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        <AddressUS>
          <AddressLine1>2500 NORTH STATE STREET</AddressLine1>
          <City>JACKSON</City>
          <State>MS</State>
          <ZIPCode>39216</ZIPCode>
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        <EINOfRecipient>646008520</EINOfRecipient>
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      <RecipientTable>
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          <BusinessNameLine1>TULANE UNIVERSITY SCHOOL OF MEDICINE</BusinessNameLine1>
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          <AddressLine1>1430 TULANE AVE</AddressLine1>
          <City>NEW ORLEANS</City>
          <State>LA</State>
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      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>UC REGENTS UNIVERSITY OF CALIFORNIA</BusinessNameLine1>
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          <AddressLine1>9500 GILMAN DR</AddressLine1>
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          <State>CA</State>
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        <EINOfRecipient>956006144</EINOfRecipient>
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      <RecipientTable>
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          <BusinessNameLine1>UNIVERSITY OF PENNSYLVANIA</BusinessNameLine1>
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          <BusinessNameLine1>UNIVERSITY OF WASHINGTON FOUNDATION</BusinessNameLine1>
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          <State>WA</State>
          <ZIPCode>98195</ZIPCode>
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      <RecipientTable>
        <RecipientNameBusiness>
          <BusinessNameLine1>THE UNIVERSITY OF TEXAS-HOUSTON</BusinessNameLine1>
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        <AddressUS>
          <AddressLine1>PO BOX 20186</AddressLine1>
          <City>HOUSTON</City>
          <State>TX</State>
          <ZIPCode>77225</ZIPCode>
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      <RecipientTable>
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          <BusinessNameLine1>SCRIPPS RESEARCH INSTITUTE</BusinessNameLine1>
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          <AddressLine1>10550 N TORREY PINES RD</AddressLine1>
          <City>LA JOLLA</City>
          <State>CA</State>
          <ZIPCode>92037</ZIPCode>
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        <AmountOfCashGrant>68312</AmountOfCashGrant>
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      <RecipientTable>
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          <BusinessNameLine1>SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE</BusinessNameLine1>
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      <Form990ScheduleJPartIII>
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        <CurrentRefunding>false</CurrentRefunding>
        <AdvanceRefunding>false</AdvanceRefunding>
        <FinalAllocationMade>false</FinalAllocationMade>
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        <OwningBondFinancedProperty>false</OwningBondFinancedProperty>
        <AnyLeaseArrangements>false</AnyLeaseArrangements>
        <MngmentCntrctBondFinancdPrprty>false</MngmentCntrctBondFinancdPrprty>
        <AnyResearchAgreements>false</AnyResearchAgreements>
        <PrcntgePrvtBusinessUseByOthers>0.00000</PrcntgePrvtBusinessUseByOthers>
        <PercentageOfPrvtBusinessReUBI>0.00000</PercentageOfPrvtBusinessReUBI>
        <TotalPrivateBusinessUse>0.00000</TotalPrivateBusinessUse>
        <PostIssuanceComplianceProcdrs>false</PostIssuanceComplianceProcdrs>
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      <Form990ScheduleKPartIV>
        <Form8038TFiled>false</Form8038TFiled>
        <VariableRateIssue>false</VariableRateIssue>
        <HedgeIdentifiedInBooksAndRecds>false</HedgeIdentifiedInBooksAndRecds>
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        <GrossProceedsInvested>false</GrossProceedsInvested>
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      <Form990ScheduleKPartVI>
        <Identifier>SEE SCHEDULE O</Identifier>
        <ReturnReference>0</ReturnReference>
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    </IRS990ScheduleK>
    <IRS990ScheduleM documentId="IRS990ScheduleM">
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      <ArtHistoricalTreasures />
      <ArtFractionalInterest />
      <BooksAndPublications />
      <ClothingAndHouseholdGoods />
      <CarsAndOtherVehicles />
      <BoatsAndPlanes />
      <IntellectualProperty />
      <SecuritiesPubliclyTraded>
        <NonCashCheckbox>X</NonCashCheckbox>
        <NumberOfContributions>2</NumberOfContributions>
        <NoncashContribsRptdF990>3625546</NoncashContribsRptdF990>
        <MethodOfDeterminingRevenues>MKT PRICE</MethodOfDeterminingRevenues>
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      <SecuritiesMiscellaneous />
      <QualifiedContribHistStruct />
      <QualifiedContribOther />
      <RealEstateResidential />
      <RealEstateCommercial />
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      <Collectibles />
      <FoodInventory />
      <DrugsAndMedicalSupplies />
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      <ScientificSpecimens />
      <ArchaeologicalArtifacts />
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        <NonCashCheckbox>X</NonCashCheckbox>
        <Description>RESEARCH EQUIPMENT</Description>
        <NumberOfContributions>1</NumberOfContributions>
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        <MethodOfDeterminingRevenues>REPLACEMENT COST</MethodOfDeterminingRevenues>
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    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <GeneralExplanation>
        <Identifier>STATEMENT OF PROGRAM SERVICE ACCOMPLISHMENTS</Identifier>
        <ReturnReference>FORM 990, PART III, LINE 4A</ReturnReference>
        <Explanation>THE BROAD INSTITUTE OPERATES FOR EDUCATIONAL AND SCIENTIFIC PURPOSES AND IS A NEW KIND OF RESEARCH INSTITUTION AIMED AT PROPELLING THE TRANSFORMATION OF MEDICINE, BY BRINGING POWERFUL NEW APPROACHES TO BEAR ON THE UNDERSTANDING AND TREATMENT OF DISEASE. ITS RESEARCH PROGRAM ENCOMPASSES MULTIDISCIPLINARY AND INTEGRATED PROGRAMS IN MEDICAL AND POPULATION GENETICS, CANCER, INFECTIOUS DISEASE, METABOLIC AND PSYCHIATRIC DISEASES, AS WELL AS RESEARCH IN GENOME BIOLOGY, CELLULAR CIRCUITRY, COMPUTATIONAL BIOLOGY, CHEMICAL BIOLOGY AND NOVEL THERAPEUTICS. THERE WERE A TOTAL OF 509 PUBLICATIONS IN 2011 RESULTING FROM BROAD RESEARCH. THE BROAD INSTITUTE HOLDS AN ANNUAL SCIENTIFIC RETREAT, A TWO-DAY MEETING FEATURING PRESENTATIONS AND POSTERS ON A VARIETY OF RESEARCH PROJECTS ACROSS THE INSTITUTE, ATTENDED BY ALMOST A THOUSAND RESEARCHERS FROM THE BROAD COMMUNITY. THE BROAD DIRECTOR RECEIVED THE ALBANY MEDICAL PRIZE IN MEDICINE AND BIOMEDICAL RESEARCH TO RECOGNIZE FOUNDATIONAL CONTRIBUTIONS TO THE EFFORTS TO DECODE THE HUMAN GENETIC BLUEPRINT. THE BROAD'S EDUCATIONAL OUTREACH PROGRAM ENGAGES BOSTON-CAMBRIDGE AREA HIGH SCHOOL STUDENTS IN SCIENTIFIC RESEARCH BY PROVIDING SUMMER INTERNSHIPS AND SEMESTER-LONG RESEARCH PROJECTS. IN 2011, 31 STUDENTS PARTICIPATED IN A SEMESTER RESEARCH PROJECT AND 12 STUDENTS DID A SUMMER INTERNSHIP AT THE BROAD. IN ADDITION, THE EDUCATIONAL PROGRAM SPONSORS CLASS VISITS TO THE BROAD AND HELD 4 SEMINARS FOR HIGH SCHOOL TEACHERS IN THE COURSE OF THE YEAR, WHICH APPROXIMATELY 73 TEACHERS ATTENDED LAST YEAR. TO HELP INSPIRE YOUNG PEOPLE AND INCREASE THE NUMBER OF SCIENTISTS FROM DIVERSE BACKGROUNDS, THE BROAD'S DIVERSITY INITIATIVE IN SCIENTIFIC RESEARCH OFFERS PROGRAMS FOR MINORITIES AT DIFFERENT STAGES OF THEIR EDUCATION AND CAREERS. IN 2011, 16 HIGH SCHOOL STUDENTS, 15 UNDERGRADUATE STUDENTS, AND TWO FACULTY MEMBERS PARTICIPATED IN THESE PROGRAMS. IN ADDITION, THIS PROGRAM ATTRACTED 165 STUDENTS WHO ATTENDED TWO SITE VISITS AND ANOTHER 140 STUDENTS WHO ATTENDED THE MINORITY AND GENOMICS LECTURE SERIES.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>VOLUNTEERS</Identifier>
        <ReturnReference>FORM 990, PART I, LINE 6</ReturnReference>
        <Explanation>THE BROAD INSTITUTE DOES NOT FORMALLY TRACK VOLUNTEERS BUT HAS INCLUDED THE NUMBER OF BOARD MEMBERS AND COMMITTEE MEMBERS OF THE BOARD OF DIRECTORS THAT ARE UNCOMPENSATED.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>RELATIONSHIPS AMONG</Identifier>
        <ReturnReference>FORM 990 PART VI, LINE 2</ReturnReference>
        <Explanation>PHILLIP SHARP IS AN EMPLOYEE OF THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY AND SUSAN HOCKFIELD IS THE PRESIDENT OF THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY, THEREFORE THEY HAVE A BUSINESS RELATIONSHIP. THEY ARE BOTH DIRECTORS AT THE BROAD INSTITUTE. JEFFREY FLIER IS AN EMPLOYEE OF HARVARD UNIVERSITY AND DREW GILPIN FAUST IS THE PRESIDENT OF HARVARD UNIVERSITY, THEREFORE THEY HAVE A BUSINESS RELATIONSHIP. THEY ARE BOTH DIRECTORS AT THE BROAD INSTITUTE.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>MEMBERS</Identifier>
        <ReturnReference>FORM 990 PART VI, LINE 6</ReturnReference>
        <Explanation>THE MEMBERS OF THE BROAD INSTITUTE CONSIST OF THE MASSACHUSETTS INSTITUTE OF TECHNOLOGY ("MIT"), PRESIDENT AND FELLOWS OF HARVARD COLLEGE ("HARVARD") AND THE ELI AND EDYTHE BROAD FOUNDATION ("THE FOUNDATION").</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>DECISIONS OF THE GOVERNING BODY SUBJECT TO APPROVAL BY MEMBERS</Identifier>
        <ReturnReference>FORM 990 PART VI, LINE 7B</ReturnReference>
        <Explanation>BROAD MEMBERS (HARVARD, MIT AND THE BROAD FOUNDATION) EXERCISE ALL POWERS CONSISTENT WITH THE ACTIVITIES AND AFFAIRS OF THE BROAD INSTITUTE. THE MEMBERS HAVE ALL POWERS AND RIGHTS AS ARE VESTED IN THEM BY LAW, THE ARTICLES OF ORGANIZATION AND THE BY-LAWS, WHICH INCLUDE AMENDMENTS TO THE BY-LAWS AND ARTICLES OF INCORPORATION, THE ELECTION OR REPLACEMENT OF DIRECTORS, DISTRIBUTIONS OF THE ENDOWMENT PRIOR TO JULY 1, 2014 AND DISSOLUTION OF THE INSTITUTE. THE MEMBERS SHALL HOLD AN ANNUAL MEETING FOR ELECTION OF DIRECTORS AND FOR THE CONDUCT OF SUCH OTHER BUSINESS AS MAY COME BEFORE THE MEETING.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>REVIEW OF 990</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 11B</ReturnReference>
        <Explanation>THE BROAD INSTITUTE'S FORM 990 WAS PREPARED WITH THE ASSISTANCE OF THE INSTITUTE'S AUDITORS, PRICEWATERHOUSECOOPERS (PWC). THE DRAFT FORM 990 WAS PROVIDED TO THE INSTITUTE'S SENIOR MANAGEMENT AND AUDIT COMMITTEE FOR REVIEW AND COMMENT. THE FULL BOARD RECEIVED A COMPLETED COPY OF THE FORM 990 PRIOR TO THE FORM BEING FILED WITH THE IRS.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>CONFLICT OF INTEREST POLICY</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 12</ReturnReference>
        <Explanation>EACH DIRECTOR AND OFFICER HAS A DUTY TO PLACE THE INTEREST OF THE INSTITUTE FOREMOST IN ANY DEALING WITH THE INSTITUTE AND HAS A CONTINUING RESPONSIBILITY TO COMPLY WITH THE REQUIREMENTS OF THIS POLICY. EACH DIRECTOR AND OFFICER IS REQUIRED TO ANNUALLY ACKNOWLEDGE HIS OR HER FAMILIARITY WITH THIS POLICY AND DISCLOSE IN WRITING TO THE CHAIRMAN OF THE BOARD ANY EXISTING FINANCIAL OR OTHER MATERIAL INTERESTS SUBJECT TO THIS POLICY BY COMPLETING A CONFLICT OF INTEREST DISCLOSURE STATEMENT. THE CONFLICT OF INTEREST DISCLOSURE STATEMENTS IS REVIEWED BY THE CHAIRMAN OF THE BOARD. ANY ISSUES NOT PREVIOUSLY DISCLOSED ARE REFERRED BY HIM OR HER TO THE BOARD OR APPROPRIATE COMMITTEE. THE CONFLICT OF INTEREST DISCLOSURE STATEMENTS ARE RETAINED IN THE CONFIDENTIAL FILES OF THE CHAIRMAN OF THE BOARD.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>COMPENSATION</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 15</ReturnReference>
        <Explanation>THE BROAD INSTITUTE ENGAGED AN OUTSIDE COMPENSATION CONSULTING FIRM (RADFORD) THAT SPECIALIZES IN THE BIOTECHNOLOGY FIELDS EARLY IN 2009 TO CONDUCT AN EXTERNAL BENCHMARK COMPENSATION STUDY OF SPECIFIC LEADERSHIP POSITIONS. RADFORD PRESENTED THEIR FINAL RECOMMENDATIONS AND FINDINGS TO THE COMPENSATION COMMITTEE WHO THEN REVIEWED AND CONTEMPORANEOUSLY DOCUMENTED THEIR DELIBERATIONS AND DECISIONS. THE TOP FIVE HIGHEST PAID EMPLOYEES AND ALL OFFICERS OTHER THAN THE PRESIDENT/CEO WERE INCLUDED IN RADFORD'S STUDY. THE BROAD INSTITUTE ENGAGED PRICEWATERHOUSECOOPERS TO CONDUCT AN INDEPENDENT STUDY FOR THE PRESIDENT/CEO'S COMPENSATION. THE PWC FINDINGS WERE PRESENTED IN MAY OF 2008. THE COMPENSATION COMMITTEE THEN REVIEWED AND CONTEMPORANEOUSLY DOCUMENTED THEIR DELIBERATIONS AND DECISIONS. THE TERMS OF THE PRESIDENT/CEO'S COMPENSATION PACKAGE WERE JOINTLY AGREED UPON BY BROAD, HARVARD AND MIT (THE INSTITUTE'S FOUNDING MEMBER ORGANIZATIONS). AS A RESULT, A FIVE YEAR EMPLOYMENT AGREEMENT WAS CREATED ON JULY 1, 2009 WHICH OUTLINES THE PRESIDENT/CEO'S COMPENSATION AND BENEFITS PACKAGE.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>AVAILABILITY OF DOCUMENTS</Identifier>
        <ReturnReference>FORM 990, PART VI, LINE 19</ReturnReference>
        <Explanation>THE INSTITUTE'S GOVERNING DOCUMENTS, CONFLICTS OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE ALL AVAILABLE UPON REQUEST. THE INSTITUTE'S AUDITED FINANCIAL STATEMENTS ARE ALSO ATTACHED TO THE ANNUALLY FILED MASSACHUSETTS FORM PC, WHICH IS AVAILABLE TO THE PUBLIC.</Explanation>
      </GeneralExplanation>
      <GeneralExplanation>
        <Identifier>RECONCILIATION OF NET ASSETS</Identifier>
        <ReturnReference>FORM 990, PART XI, LINE 5</ReturnReference>
        <Explanation>NET UNREALIZED GAINS ON INVESTMENTS ($2,847,046) TAX-EXEMPT BONDS SCHEDULE K, PART III, LINE 7 AND PART V ALTHOUGH THE BROAD INSTITUTE HAS ISSUED TAX-EXEMPT DEBT, THE FUNDED PROJECT IS STILL UNDER CONSTRUCTION. THE INSTITUTE IS IN THE PROCESS OF FORMALIZING POST-ISSUANCE COMPLIANCE POLICIES AND PROCEDURES. THEY WILL BE IN PLACE BY THE CLOSE OF FY13.</Explanation>
      </GeneralExplanation>
    </IRS990ScheduleO>
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</Return>