2013-11-09T19:30:19-06:00 2012-12-31 131517563 LOEB & TROPER LLP 655 THIRD AVENUE 12TH FLOOR NEW YORK NY 10017 990 2012-01-01 134043587 NEW YORK STRUCTURAL BIOLOGY CENTER INC NEWY 2129390660 89 CONVENT AVENUE NEW YORK NY 10027 WILLA APPEL 2129390660 2013-10-25 1 FREDERICK H ROTHMAN P01275277 2128674000 2012 2016-02-24 21:20:13Z WILLA APPEL 89 CONVENT AVENUE NEW YORK NY 10027 12874736 0 X WWW.NYSBC.ORG X 1999 NY TO OPERATE A STATE-OF-THE-ART FACILITY FOR RESEARCH IN STRUCTURAL BIOLOGY PROVIDING ADVANCED RESOURCES TO THE FACULTY OF PARTICIPATING MEMBERS OF ITS NINE MEMBER INSTITUTIONS EACH OF WHICH IS A 501(C)(3) ORGANIZATION. 17 17 39 0 0 0 13962318 10550182 0 0 66499 270933 516962 57089 14545779 10878204 400000 400000 0 0 3644740 3773260 0 0 0 10125116 8934499 14169856 13107759 375923 -2229555 50598257 47592766 5478929 4564502 45119328 43028264 X THE NYSBC MISSION IS TO PROVIDE ADVANCED RESEARCH RESOURCES TO THE FACULTY OF NYSBC'S 9 MEMBER INSTITUTIONS IN THREE KEY AREAS OF STRUCTURAL BIOLOGY: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; CRYOELECTRON MICROSCOPY; AND X-RAY CRYSTALLOGRAPHY. THESE RESOURCES SERVE MORE THAN 100 PRINCIPAL INVESTIGATORS. IN ADDITION, THE NYSBC SERVES ITS MEMBER INSTITUTIONS BY OFFERING ACCREDITED ACADEMIC COURSES AND INFORMAL SEMINARS; AND BY DEVELOPING MULTI-INSTITUTIONAL RESEARCH COLLABORATIONS. 0 0 2832878 100000 SEE SCHEDULE ONYSBC PROVIDES ACCESS TO HIGH-FIELD NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO FACULTY FROM ITS NINE AFFILIATED INSTITUTIONS. THE NMR FACILITY INSTRUMENTATION INCLUDES 9 NMR SPECTROMETERS: 2 @ 900 MHZ; 3 @ 800 MHZ; AND 1 EACH @ 750, 700, 600 AND 500 MHZ. THE INSTRUMENTS OPERATE 24 HRS/DAY, 7 DAYS/WEEK AND ON AVERAGE WERE EACH AVAILABLE 330 DAYS IN 2012. INSTALLATION OF A 10TH NMR INSTRUMENT, A 600 MHZ DYNAMIC NUCLEAR POLARIZATION SOLID STATE NMR (DNP-NMR), WAS BEGUN IN THE THIRD QUARTER OF 2012 AND IS EXPECTED TO BE COMPLETED IN 2013. THESE RESOURCES ALLOW RESEARCHERS TO DETERMINE THE STRUCTURE OF PROTEINS IN SOLUTION AT ATOMIC RESOLUTION, DATA THAT PROVIDES INSIGHT INTO THE FUNCTIONAL PROPERTIES OF THE PROTEINS. IN 2012, 38 PRINCIPAL INVESTIGATORS FROM MEMBER INSTITUTIONS AND 1 FROM NIH NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES AND THEIR STAFF MEMBERS USED THESE INSTRUMENTS. DATA COLLECTED WITH THESE INSTRUMENTS PRODUCED 30 PUBLICATIONS IN EMINENT SCIENTIFIC JOURNALS. THE CENTER ALSO CONDUCTED SEVERAL NMR COURSES TO TEACH ADVANCED NMR TECHNIQUES TO GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS FROM THE AFFILIATED INSTITUTIONS. IN 2012, 17 STUDENTS PARTICIPATED IN THE NMR SPECTROSCOPY OF MACROMOLECULES COURSE AND 16 STUDENTS IN THE NMR TRAINING SHORT COURSE. 3253912 SEE SCHEDULE ORESEARCH CONDUCTED AT THE CRYOELECTRON MICROSCOPY FACILITY IS AIMED AT DETERMINING THE FUNCTION OF MACROMOLECULES FROM THEIR OBSERVED STRUCTURES. LOWER RESOLUTION IMAGING IS USED TO BRIDGE THE GAP BETWEEN THE STRUCTURES PRODUCED FROM LIGHT MICROSCOPY IMAGING AND THE ATOMIC RESOLUTION STRUCTURES DETERMINED BY OTHER MEANS SUCH AS NMR AND X-RAY DIFFRACTION. THE FACILITY HAS FOUR ELECTRON MICROSCOPES: 1 @ 120KV, 2 @ 200 KV, 1 @ 300 KV, AS WELL AS A DUAL-BEAM FOCUSED ION BEAM SCANNING ELECTRON MICROSCOPE. THREE PERMANENT STAFF MEMBERS PROVIDE TECHNICAL SUPPORT FOR STRUCTURAL ANALYSIS OF MACROMOLECULES AND MAINTAIN THE INSTRUMENTS. IN 2012, THE CRYOELECTRON MICROSCOPY FACILITY SERVED 31 PRINCIPAL INVESTIGATORS FROM AFFILIATED INSTITUTIONS AND THEIR STAFF MEMBERS. THIS WORK RESULTED IN 8,585 HOURS OF MICROSCOPE TIME USED IN 822 SESSIONS. THE CENTER HELD ITS ANNUAL CRYO-EM COURSE TO TEACH ADVANCED ELECTRON MICROSCOPY TECHNIQUES TO GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS. THE CEM FACILITY HOSTED THE TEMIMPS ANNUAL MEETING IN MAY, 2012. THE CEM FACILITY HOSTS REGULAR SCIENTIFIC SEMINARS AND DISCUSSIONS TO ENABLE IT TO REMAIN ON THE PULSE OF ONGOING ACTIVITIES IN THE FIELD. EIGHT (8) PUBLICATIONS RESULTED FROM RESEARCH IN THE CEM FACILITY IN 2012. 2875602 0 SEE SCHEDULE ONYSBC HAS X-RAY CRYSTALLOGRAPHY RESOURCES AT THE NATIONAL SYNCHROTRON LIGHT SOURCE (NSLS) FACILITY AT BROOKHAVEN NATIONAL LABORATORY ON LONG ISLAND AND AT ITS MAIN FACILITY IN NEW YORK CITY. TWO EXPERIMENTAL STATIONS, "BEAMLINES", X4A AND X4C, ARE OPERATED AT NSLS FOR THE BENEFIT OF NYSBC SCIENTISTS, INCLUDING USERS FROM THE NORTHEAST STRUCTURAL GENOMICS CENTER (NESG) AND THE NEW YORK CENTER FOR MEMBRANE PROTEIN STUDY (NYCOMPS), BOTH OF WHICH ARE FUNDED BY THE NIH PROTEIN STRUCTURE INITIATIVE. THE BEAMLINES ALSO SERVE GENERAL USERS AT THE SYNCHROTRON FACILITY. THE RESEARCH GOAL IS TO UNDERSTAND BIOCHEMICAL AND CELLULAR FUNCTIONS OF BIOLOGICAL MACROMOLECULES. IN 2012, X4A DELIVERED 3,696 HOURS (98 SESSIONS) OF X-RAY BEAM, AND X4C DELIVERED 2,392 HOURS (77 SESSIONS) OF X-RAY BEAM. TWENTY-SIX (26) PRINCIPAL INVESTIGATORS WERE SERVED. PRODUCTIVITY IS MEASURED BY THE NUMBER OF PUBLICATIONS AND THE NUMBER OF STRUCTURE DEPOSITS INTO THE PROTEIN DATA BANK (PDB). IN 2012, THERE WERE 24 PUBLICATIONS FROM X4A AND 16 PUBLICATIONS FROM X4C. THERE WERE 26 PDB DEPOSITS FROM X4A AND 28 FROM X4C FOR 2012. A SECOND HOME-SOURCE DETECTOR SYSTEM WAS ADDED TO THE X-RAY FACILITY AT THE NYSBC - NEW YORK CITY LOCATION IN 2010. THE TWO SYSTEMS ARE USED FOR SCREENING AND FOR DIFFRACTION CHARACTERIZATION OF CRYSTALS GROWN AT NYSBC. 2501083 300000 NYSBC COMPLETED A 5-YEAR GRANT IN 2010 FUNDED BY THE NIH'S PROTEIN STRUCTURE INITIATIVE. THE RESEARCH SOLVED 10 NOVEL STRUCTURES, MANY OF WHICH WERE PUBLISHED IN HIGHLY RANKED JOURNALS, SUCH AS "NATURE". AS A RESULT OF THESE ACCOMPLISHMENTS, NYSBC WAS AWARDED (IN 2010) TWO NEW 5-YEAR NIGMS PROTEIN STRUCTURE INITIATIVE GRANTS: THE NEW YORK CONSORTIUM ON MEMBRANE PROTEIN STRUCTURE (NYCOMPS) AND THE TRANSCONTINENTAL EM INITIATIVE FOR MEMBRANE PROTEIN STRUCTURE (TEMIMPS). THESE TWO AWARDS WILL SUPPORT RESEARCH TOWARDS STRUCTURE DETERMINATION OF INTEGRAL MEMBRANE PROTEINS, UTILIZING X-RAY CRYSTALLOGRAPHIC AND CYROELECTRON MICROSCOPY APPROACHES, RESPECTIVELY.SINCE 2010, NYCOMPS AND TEMIMPS MEMBER LABORATORIES HAVE PUBLISHED MORE THAN 14 PAPERS DESCRIBING NOVEL INTEGRAL MEMBRANE PROTEIN STRUCTURES SOLVED BY X-RAY DIFFRACTION AND CRYOELECTRON MICROSCOPY, INCLUDING SIX THAT APPEARED IN "NATURE". NYCOMPS AND TEMIMPS MEMBER LABORATORIES ALSO PUBLISHED MORE THAN 16 PAPERS DESCRIBING ADVANCEMENTS IN METHODOLOGY AND TECHNOLOGY DEVELOPMENT. SUCH TECHNICAL DEVELOPMENTS ASSIST OUR OWN WORK AND ARE BENEFICIAL TO THE PROGRESS OF STRUCTURAL BIOLOGY AS A WHOLE. FOR EXAMPLE, TWO PAPERS DESCRIBING PROTEIN STRUCTURES SOLVED BY X-RAY CRYSTALLOGRAPHY WERE PUBLISHED AS A DIRECT RESULT OF THE METHODOLOGIES DEVELOPED BY NYCOMPS MEMBER LABS. 2501083 300000 11463475 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 28 0 39 1 0 0 0 0 0 0 0 0 0 0 X 17 17 0 0 0 0 1 1 1 1 1 0 0 0 1 1 1 1 1 1 0 0 NY X WILLA APPEL EXECUTIVE DIRECTOR 2129390660 89 CONVENT AVENUE NEW YORK NY 10027 DR DAVID HIRSH 4.00 X X 0 0 0 DR LAWRENCE S STURMAN 0.10 X X 0 0 0 DR ALLEN M SPIEGEL 0.10 X X 0 0 0 DR ERIC COTTINGTON 0.20 X X 0 0 0 DR MARK GIRVIN 0.10 X 0 0 0 DR GILLIAN SMALL 0.10 X 0 0 0 DR ANN MCDERMOTT 0.10 X 0 0 0 DR CHRISTOPHER LIMA 0.10 X 0 0 0 MR IRA M MILLSTEIN ESQ 0.10 X 0 0 0 DR MING-MING ZHOU 0.10 X 0 0 0 DR ANEEL AGGARWAL 0.10 X 0 0 0 DR PAUL HORN 0.10 X 0 0 0 DR SETH DARST 0.10 X 0 0 0 DR JOHN TOOZE 0.10 X 0 0 0 DR FREDERICK MAXFIELD 0.10 X 0 0 0 DR RANAJEET GHOSE 0.10 X 0 0 0 DR CARMEN MANNELLA 0.10 X 0 0 0 DR WILLA APPEL 37.50 X 342694 0 47736 MR DANIEL MURPHY 37.50 X 110117 0 39756 DRMICHAEL GOGER 37.50 X 140992 0 14652 DR XIAOCHUN YANG 37.50 X 115850 0 37390 709653 0 139534 4 0 1 0 TECHNOLOGY SOLUTION PARTNERS LLC 2 TRAP FALLS ROAD SUITE 401 SHELTON CT 06484 INFORMATION TECHNOLOGY, INFRASTRUCTURE M 311103 1 6666953 3883229 10550182 182927 182927 2084538 1996532 88006 88006 88006 MISCELLANEOUS 900099 56191 56191 LIQUIDATED DAMAGES 900099 898 898 57089 10878204 0 0 328022 400000 400000 390430 128842 261588 2592285 2055341 536944 241975 192855 49120 337025 254439 82586 211545 156294 55251 15472 15472 79763 17135 62628 46400 46400 36476 36476 72295 70430 1865 15613 2083 13530 353324 255198 98126 1382595 1135606 246989 30881 27609 3272 26207 23397 2810 3212261 3130790 81471 223574 176872 46702 SUBCONTRACTORS EXPENSE 2657943 2657943 LAB SUPPLIES AND EQUIPM 776212 775097 1115 5483 3544 1939 13107759 11463475 1644284 0 500 800 3194843 1995408 2519425 1647932 212221 62107 496669 366022 61812585 23516262 39830874 38296323 4343725 5224174 50598257 47592766 2256490 2116273 3222439 2448229 5478929 4564502 X 45119328 43028264 45119328 43028264 50598257 47592766 -2229555 138491 0 X X 0 1 X 1 1 1 X 9406772 9165915 9501601 13962318 10550182 52586788 9406772 9165915 9501601 13962318 10550182 52586788 4135005 48451783 87233 20554 32640 99289 182927 422643 459433 546986 101276 516962 57089 1681746 54691177 0.88590 0.95330 X SCHEDULE A, PART IV, SUPPLEMENTAL INFORMATION: SCHEDULE A, PART II, LINE 10, EXPLANATION FOR OTHER INCOME: MISCELLANEOUS LIQUIDATED DAMAGES RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 4253220 1098749 3154471 25841238 6228980 19612258 31718127 16188533 15529594 38296323 X 10980219 138491 138491 10841728 36476 36476 10878204 13071283 0 13071283 36476 36476 13107759 DESCRIPTION OF UNCERTAIN TAX POSITIONS UNDER FIN 48: PART X, LINE 2: UNCERTAINTY IN INCOME TAXES - THE CORPORATION HAS DETERMINED THAT THERE ARE NO MATERIAL UNCERTAIN TAX POSITIONS THAT REQUIRE RECOGNITION OR DISCLOSURE IN THE FINANCIAL STATEMENTS. PERIODS ENDING DECEMBER 31, 2009 AND SUBSEQUENT REMAIN SUBJECT TO EXAMINATION BY APPLICABLE TAXING AUTHORITIES 1 TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 630 W 168TH STREET NEW YORK NY 10032 135598093 501(C)(3) 400000 RESEARCH 1 0 PROCEDURE FOR MONITORING GRANTS IN THE U.S.: PART I, LINE 2: SCHEDULE I, PART I, LINE 2: ALL SUBCONTRACTORS AND/OR GRANT RECIPIENTS SIGN AN AGREEMENT WITH NYSBC TO PERFORM WORK IN ACCORDANCE WITH PROJECT AIMS AND SPONSOR GUIDELINES. NYSBC REVIEWS INVOICES AND REQUESTS BACK UP DOCUMENTATION, AS NEEDED, IN ORDER TO REVIEW AND APPROVE ALLOWABLE EXPENSES. THE GRANTS & CONTRACTS MANAGER ALSO MONITORS EXPENDITURES ON SUBCONTRACTOR/GRANTEE INVOICES IN ORDER TO ENSURE ALIGNMENT WITH THE ORIGINAL BUDGET. NYSBC ALSO REQUESTS AND REVIEWS INSURANCE CERTIFICATES AND A-133 REPORTS ON AN ANNUAL BASIS. NYSBC'S INVESTIGATOR RECEIVES PROGRESS REPORTS FROM SUBCONTRACTORS/GRANTEES. PROGRESS REPORTS ARE SUBMITTED AT LEAST ON AN ANNUAL BASIS TO THE SPONSORING AGENCIES. DURING THE PROJECT PERIOD, NYSBC'S ADMINISTRATION AND PROGRAM STAFF ARE IN CONTACT WITH THE SUBCONTRACTOR/GRANTEE STAFF TO DISCUSS PROGRAM PROGRESS, PREPARE PRESENTATIONS FOR SCIENTIFIC MEETINGS AND TO DISCUSS ADMINISTRATIVE MATTERS. X X 0 0 0 0 0 0 0 0 0 DR WILLA APPEL 342694 0 0 0 0 0 34436 0 13300 0 390430 0 0 0 DRMICHAEL GOGER 140992 0 0 0 0 0 14149 0 503 0 155644 0 0 0 DR XIAOCHUN YANG 115850 0 0 0 0 0 11845 0 25545 0 153240 0 0 0 FORM 990, PART VI, SECTION A, LINE 6 ON JUNE 30, 1999, THE CORPORATION ENTERED INTO A MEMBERS CONTRIBUTION AGREEMENT (THE AGREEMENT) WITH ITS MEMBER PARTIES. THE AGREEMENT INCLUDED, AMONG OTHER THINGS, A LEGAL REQUIREMENT THAT THE THEN NINE MEMBER INSTITUTIONS (ALL TAX-EXEMPT UNDER THE INTERNAL REVENUE CODE) MAKE A STIPULATED CAPITAL CONTRIBUTION IN ORDER TO FUND THE CORPORATION'S CONSTRUCTION OF A RESEARCH FACILITY AND ACQUISITION OF HIGH-FIELD NUCLEAR MAGNETIC RESONANCE INSTRUMENTS. AT PRESENT EIGHT (8) CURRENT MEMBERS ALSO MAKE ANNUAL OPERATING CONTRIBUTIONS. (CUNY IS EXEMPT FROM THIS REQUIREMENT BY VIRTUE OF ITS CAPITAL IN-KIND CONTRIBUTION OF LAND AND A BUILDING). ANNUAL OPERATING CONTRIBUTIONS ENTITLE EACH MEMBER INSTITUTION TO A PRO-RATA SHARE OF TIME ON THE INSTRUMENTS OWNED AND OPERATED BY THE CORPORATION. FORM 990, PART VI, SECTION A, LINE 7A AS PROVIDED FOR IN THE BY-LAWS, THE SUSTAINING, CONTRIBUTING AND ASSOCIATE MEMBER REPRESENTATIVES VOTE BY CLASS FOR BOARD DIRECTORS USING PRINCIPLES OF CUMULATIVE VOTING. IN EACH CASE, MEMBERS OF A CLASS DIVIDE THEIR VOTES EVENLY AMONG THE INDIVIDUALS NOMINATED BY THE MEMBERS. THIS ELECTION OCCURS AT EVERY ANNUAL MEETING. FORM 990, PART VI, SECTION A, LINE 7B MEMBERS HAVE THE POWER TO ELECT BOARD DIRECTORS OF THE CORPORATION AND ARE ENTITLED TO VOTE ON ALL OTHER BUSINESS OF THE CORPORATION ON WHICH MEMBERS OF A NOT-FOR-PROFIT CORPORATION ARE ENTITLED TO VOTE PURSUANT TO NOT-FOR-PROFIT CORPORATION LAWS OF THE STATE OF NEW YORK OR PURSUANT TO THE BY-LAWS OF THE CORPORATION. FORM 990, PART VI, SECTION B, LINE 11 THE CHAIRMAN OF THE FINANCE COMMITTEE HAS BEEN DESIGNATED TO REVIEW AND APPROVE THE FORM 990 ON BEHALF OF ITS BOARD OF DIRECTORS PRIOR TO FILING WITH THE IRS. THE ACCOUNTING STAFF AND THE EXECUTIVE DIRECTOR COMPLETE A 990 QUESTIONNAIRE PROVIDED TO NYSBC BY ITS INDEPENDENT AUDIT FIRM. A DRAFT FORM 990 IS THEN PREPARED BY THE INDEPENDENT AUDIT FIRM. IT IS REVIEWED AND APPROVED BY THE CHAIRMAN OF THE FINANCE COMMITTEE AND THE EXECUTIVE DIRECTOR OF THE CORPORATION BEFORE THE FINAL FORM 990 IS SUBMITTED TO THE IRS. THE FORM 990 IS THEN MADE AVAILABLE TO THE REMAINING MEMBERS OF THE BOARD OF DIRECTORS UPON REQUEST. FORM 990, PART VI, SECTION B, LINE 12C THE BOARD OF DIRECTORS APPROVED THE CREATION OF A CONFLICTS RESOLUTION COMMITTEE COMPOSED OF MEMBERS OF THE BOARD OF DIRECTORS. NYSBC'S CONFLICT OF INTEREST POLICY IS REVIEWED AND REVISED PERIODICALLY BY THE ORGANIZATION'S OFFICERS AND COUNSEL. ALL EMPLOYEES ARE PROVIDED WITH A COPY OF THE POLICY AND ARE REQUIRED TO COMPLETE A CONFLICT OF INTEREST DISCLOSURE FORM ANNUALLY. DISCLOSURE FORMS ARE REVIEWED BY THE EXECUTIVE DIRECTOR AND CONFLICTS ARE SUBMITTED TO THE CONFLICTS RESOLUTION COMMITTEE FOR APPROPRIATE ACTION, IF NECESSARY. THE CONFLICT OF INTEREST POLICY IS POSTED ON NYSBC'S INTRANET. FORM 990, PART VI, SECTION B, LINE 15A THE EXECUTIVE COMMITTEE OF THE BOARD OF DIRECTORS DETERMINES COMPENSATION FOR THE ORGANIZATION'S EXECUTIVE DIRECTOR. THE PROCESS INCLUDES A COMPARISON OF COMPENSATION FOR A SIMILAR POSITION AT SIMILAR INSTITUTIONS. THE EXECUTIVE COMMITTEE MEETS TO DISCUSS EXECUTIVE COMPENSATION. COMPARISON ADMINISTRATOR DATA WAS REVIEWED FROM IVY LEAGUE SCHOOLS AND A COHORT OF NOT-FOR-PROFIT RESEARCH INSTITUTES (MERCER SURVEY). ON MARCH 1, 2012, THE EXECUTIVE COMMITTEE HELD A MEETING REGARDING WILLA APPEL'S COMPENSATION FOR FISCAL YEAR 2012. FORM 990, PART VI, SECTION C, LINE 19 THE CORPORATION'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, WHISTLEBLOWER POLICY WITHIN THE SCIENTIFIC MISCONDUCT POLICY AND ITS FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. FORM 990, PART XII, LINE 2C THE PROCESS HAS NOT CHANGED SINCE PRIOR YEAR.