2014-11-11T15:09:44-06:00 2013-12-31 131517563 LOEB & TROPER LLP 655 THIRD AVENUE 12TH FLOOR NEW YORK NY 10017 990 2013-01-01 134043587 NEW YORK STRUCTURAL BIOLOGY CENTER INC NEWY 2129390660 89 CONVENT AVENUE NEW YORK NY 10027 WILLA APPEL EXECUTIVE DIRECTOR 2129390660 2014-11-07 1 ISRAEL TANNENBAUM P01589203 2128674000 2013 2015-11-30 17:44:51Z 89 CONVENT AVENUE NEW YORK NY 10027 15984045 0 X WWW.NYSBC.ORG X 1999 NY TO OPERATE A STATE-OF-THE-ART FACILITY FOR RESEARCH IN STRUCTURAL BIOLOGY PROVIDING ADVANCED RESOURCES TO THE FACULTY OF PARTICIPATING MEMBERS OF ITS NINE MEMBER INSTITUTIONS EACH OF WHICH IS A 501(C)(3) ORGANIZATION. 17 17 41 17 0 0 10550182 11823590 0 0 270933 543412 57089 56048 10878204 12423050 400000 400000 0 0 3773260 4039545 0 0 0 8934499 9170721 13107759 13610266 -2229555 -1187216 47592766 46758846 4564502 4718456 43028264 42040390 X THE NYSBC MISSION IS TO PROVIDE ADVANCED RESEARCH RESOURCES TO THE FACULTY OF NYSBC'S 9 MEMBER INSTITUTIONS IN THREE KEY AREAS OF STRUCTURAL BIOLOGY: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; CRYOELECTRON MICROSCOPY; AND X-RAY CRYSTALLOGRAPHY. THESE RESOURCES SERVE MORE THAN 100 PRINCIPAL INVESTIGATORS. IN ADDITION, THE NYSBC SERVES ITS MEMBER INSTITUTIONS BY OFFERING ACCREDITED ACADEMIC COURSES AND INFORMAL SEMINARS; AND BY DEVELOPING MULTI-INSTITUTIONAL RESEARCH COLLABORATIONS. 0 0 3226117 100000 SEE SCHEDULE ONYSBC PROVIDES ACCESS TO HIGH-FIELD NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO FACULTY FROM ITS NINE AFFILIATED INSTITUTIONS. THE NMR FACILITY INSTRUMENTATION INCLUDES 9 NMR SPECTROMETERS: 2 @ 900 MHZ; 3 @ 800 MHZ; AND 1 EACH @ 750, 700, 600 AND 500 MHZ. THE INSTRUMENTS OPERATE 24 HRS/DAY, 7 DAYS/WEEK AND ON AVERAGE WERE EACH AVAILABLE 328 DAYS IN 2013, WITH THE EXCEPTION OF THE 700 WHICH WAS AVAILABLE FOR 249 DAYS DUE TO EXTENDED EQUIPMENT FAILURE. INSTALLATION OF A 10TH NMR INSTRUMENT, A 600 MHZ DYNAMIC NUCLEAR POLARIZATION SOLID STATE NMR (DNP-NMR), WAS COMPLETED IN JULY 2013. THESE RESOURCES ALLOW RESEARCHERS TO DETERMINE THE STRUCTURE OF PROTEINS IN SOLUTION AT ATOMIC RESOLUTION, DATA THAT PROVIDES INSIGHT INTO THE FUNCTIONAL PROPERTIES OF THE PROTEINS. IN 2013, GROUP MEMBERS FROM THE LABORATORIES OF 27 PRINCIPAL INVESTIGATORS FROM THE MEMBER INSTITUTIONS AND 1 INVESTIGATOR FROM NIH NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES MADE USE THESE INSTRUMENTS. DATA COLLECTED WITH THESE INSTRUMENTS PRODUCED 17 PUBLICATIONS IN EMINENT SCIENTIFIC JOURNALS. THE CENTER ALSO CONDUCTED SEVERAL NMR TRAINING SHORT COURSES TO TEACH ADVANCED NMR TECHNIQUES TO 12 GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS FROM THE AFFILIATED INSTITUTIONS.EXPENSES $3,226,117 GRANTS $100,000 3251413 SEE SCHEDULE ORESEARCH CONDUCTED AT THE CRYOELECTRON MICROSCOPY FACILITY IS AIMED AT DETERMINING THE FUNCTION OF MACROMOLECULES FROM THEIR OBSERVED STRUCTURES. LOWER RESOLUTION IMAGING IS USED TO BRIDGE THE GAP BETWEEN THE STRUCTURES PRODUCED FROM LIGHT MICROSCOPY IMAGING AND THE ATOMIC RESOLUTION STRUCTURES DETERMINED BY OTHER MEANS SUCH AS NMR AND X-RAY DIFFRACTION. THE FACILITY HAS FOUR ELECTRON MICROSCOPES: 1 @ 120KV, 2 @ 200 KV, 1 @ 300 KV, AS WELL AS A DUAL-BEAM FOCUSED ION BEAM SCANNING ELECTRON MICROSCOPE. THREE PERMANENT STAFF MEMBERS PROVIDE TECHNICAL SUPPORT FOR STRUCTURAL ANALYSIS OF MACROMOLECULES AND MAINTAIN THE INSTRUMENTS. IN 2013, THE CRYOELECTRON MICROSCOPY FACILITY SERVED 36 PRINCIPAL INVESTIGATORS FROM AFFILIATED INSTITUTIONS AND THEIR STAFF MEMBERS. THIS WORK RESULTED IN 8,183 HOURS OF MICROSCOPE TIME USED IN 682 SESSIONS. THE CENTER HELD ITS ANNUAL CRYO-EM COURSE TO TEACH ADVANCED ELECTRON MICROSCOPY TECHNIQUES TO GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS. THE CEM FACILITY HOSTS REGULAR SCIENTIFIC SEMINARS AND DISCUSSIONS TO ENABLE IT TO REMAIN ON THE PULSE OF ONGOING ACTIVITIES IN THE FIELD. NINE (9) PUBLICATIONS RESULTED FROM RESEARCH IN THE CEM FACILITY IN 2013.EXPENSES $3,251,413 814957 SEE SCHEDULE ONYSBC HAS X-RAY CRYSTALLOGRAPHY RESOURCES AT THE NATIONAL SYNCHROTRON LIGHT SOURCE (NSLS) FACILITY AT BROOKHAVEN NATIONAL LABORATORY ON LONG ISLAND AND AT ITS MAIN FACILITY IN NEW YORK CITY. TWO EXPERIMENTAL STATIONS, "BEAMLINES", X4A AND X4C, ARE OPERATED AT NSLS FOR THE BENEFIT OF NYSBC SCIENTISTS, INCLUDING USERS FROM THE NORTHEAST STRUCTURAL GENOMICS CENTER (NESG) AND THE NEW YORK CENTER FOR MEMBRANE PROTEIN STUDY (NYCOMPS), BOTH OF WHICH ARE FUNDED BY THE NIH PROTEIN STRUCTURE INITIATIVE. THE BEAMLINES ALSO SERVE GENERAL USERS AT THE NSLS. THE RESEARCH GOAL IS TO UNDERSTAND BIOCHEMICAL AND CELLULAR FUNCTIONS OF BIOLOGICAL MACROMOLECULES. IN 2013, X4A AND X4C EACH DELIVERED MORE THAN 3,000 HOURS OF X-RAY BEAM. MORE THAN 20 PRINCIPAL INVESTIGATORS WERE SERVED FOR SYNCHROTRON-BASED DATA COLLECTION AND DATA ANALYSES. IN 2013, THERE WERE 11 PUBLICATIONS FROM X4A AND 9 PUBLICATIONS FROM X4C. THERE WERE 31 PROTEIN DATA BANK (PDB) DEPOSITS FROM X4A AND 22 FROM X4C FOR 2013. A SECOND HOME-SOURCE DETECTOR SYSTEM WAS ADDED TO THE X-RAY FACILITY AT THE NYSBC - NEW YORK CITY LOCATION IN 2010. THE TWO SYSTEMS ARE USED FOR SCREENING AND FOR DIFFRACTION CHARACTERIZATION OF CRYSTALS GROWN AT NYSBC.EXPENSES $814,957 4806897 300000 NYSBC COMPLETED A 5-YEAR GRANT IN 2010 FUNDED BY THE NIH PROTEIN STRUCTURE INITIATIVE. THE GRANT, THE NEW YORK CONSORTIUM OF MEMBRANE PROTEIN STRUCTURE (NYCOMPS), FOCUSED ON THE STRUCTURES OF MEMBRANE PROTEINS, WHICH ARE HIGHLY IMPORTANT BIOMOLECULES IN HUMAN HEALTH AND DISEASE. THE RESEARCH SOLVED 10 NOVEL STRUCTURES, MANY OF WHICH WERE PUBLISHED IN HIGHLY RANKED JOURNALS, INCLUDING FOUR "NATURE" PUBLICATIONS. AS A RESULT OF THESE ACCOMPLISHMENTS, IN 2010, NYSBC WAS AWARDED TWO NEW 5-YEAR NIGMS PROTEIN STRUCTURE INITIATIVE GRANTS: A 5-YEAR CONTINUATION OF NYCOMPS; AND THE TRANSCONTINENTAL EM INITIATIVE FOR MEMBRANE PROTEIN STRUCTURE (TEMIMPS). THESE TWO AWARDS SUPPORT STRUCTURAL DETERMINATION OF INTEGRAL MEMBRANE PROTEINS, UTILIZING X-RAY CRYSTALLOGRAPHIC AND CYROELECTRON MICROSCOPY APPROACHES, RESPECTIVELY.IN 2013, NYCOMPS AND TEMIMPS PUBLISHED EIGHT PAPERS DESCRIBING NOVEL INTEGRAL MEMBRANE PROTEIN STRUCTURES SOLVED BY X-RAY DIFFRACTION AND CRYOELECTRON MICROSCOPY: INCLUDING THREE IN THE PRESTIGIOUS NATURE FAMILY OF JOURNALS. NYCOMPS AND TEMIMPS MEMBER LABORATORIES ALSO PUBLISHED FIVE PAPERS DESCRIBING ADVANCEMENTS IN METHODOLOGY AND TECHNOLOGY DEVELOPMENT. SUCH TECHNICAL DEVELOPMENTS ASSIST OUR OWN WORK AND ARE ALSO BENEFICIAL TO THE PROGRESS OF THE FIELD OF STRUCTURAL BIOLOGY AS A WHOLE. 4806897 300000 12099384 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 22 0 41 1 0 0 0 0 0 0 0 0 0 0 X 17 17 0 0 0 0 1 1 1 1 1 0 0 0 1 1 1 1 1 1 0 0 NY X WILLA APPEL EXECUTIVE DIRECTOR 2129390660 89 CONVENT AVENUE NEW YORK NY 10027 DR DAVID HIRSH CHAIRMAN 4.00 X X 0 0 0 DR ALLEN M SPIEGEL SECRETARY 0.10 X X 0 0 0 DR ERIC COTTINGTON TREASURER 0.20 X X 0 0 0 DR MARK GIRVIN DIRECTOR 0.10 X 0 0 0 DR GILLIAN SMALL DIRECTOR 0.10 X 0 0 0 DR ANN MCDERMOTT DIRECTOR 0.10 X 0 0 0 DR CHRISTOPHER LIMA DIRECTOR 0.10 X 0 0 0 MR IRA M MILLSTEIN ESQ DIRECTOR 0.10 X 0 0 0 DR MING-MING ZHOU DIRECTOR 0.10 X 0 0 0 DR ANEEL AGGARWAL DIRECTOR 0.10 X 0 0 0 DR PAUL HORN DIRECTOR 0.10 X 0 0 0 DR SETH DARST DIRECTOR 0.10 X 0 0 0 DR TIMOTHY PO'CONNOR DIRECTOR 0.10 X 0 0 0 DR FREDERICK MAXFIELD DIRECTOR 0.10 X 0 0 0 DR RANAJEET GHOSE DIRECTOR 0.10 X 0 0 0 DR CARMEN MANNELLA DIRECTOR 0.10 X 0 0 0 DR MICHAEL KOONCE DIRECTOR 0.10 X 0 0 0 DR WILLA APPEL EXECUTIVE DIRECTOR 37.50 X 353050 0 48902 MR DANIEL MURPHY PHYSICAL PLANT MANAGER 37.50 X 121983 0 38541 DRMICHAEL GOGER NMR MANAGER 37.50 X 145730 0 14573 DR XIAOCHUN YANG SR. 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PERIODS ENDING DECEMBER 31, 2010 AND SUBSEQUENT REMAIN SUBJECT TO EXAMINATION BY APPLICABLE TAXING AUTHORITIES 1 TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 630 W 168TH STREET NEW YORK NY 10032 135598093 501(C)(3) 400000 RESEARCH 1 PART I, LINE 2: ALL SUBCONTRACTORS AND/OR GRANT RECIPIENTS SIGN AN AGREEMENT WITH NYSBC TO PERFORM WORK IN ACCORDANCE WITH PROJECT AIMS AND SPONSOR GUIDELINES. NYSBC REVIEWS INVOICES AND REQUESTS BACK UP DOCUMENTATION, AS NEEDED, IN ORDER TO REVIEW AND APPROVE ALLOWABLE EXPENSES. THE GRANTS & CONTRACTS MANAGER ALSO MONITORS EXPENDITURES ON SUBCONTRACTOR/GRANTEE INVOICES IN ORDER TO ENSURE ALIGNMENT WITH THE ORIGINAL BUDGET. NYSBC ALSO REQUESTS AND REVIEWS INSURANCE CERTIFICATES AND A-133 REPORTS ON AN ANNUAL BASIS. NYSBC'S INVESTIGATOR RECEIVES PROGRESS REPORTS FROM SUBCONTRACTORS/GRANTEES. PROGRESS REPORTS ARE SUBMITTED AT LEAST ON AN ANNUAL BASIS TO THE SPONSORING AGENCIES. DURING THE PROJECT PERIOD, NYSBC'S ADMINISTRATION AND PROGRAM STAFF ARE IN CONTACT WITH THE SUBCONTRACTOR/GRANTEE STAFF TO DISCUSS PROGRAM PROGRESS, PREPARE PRESENTATIONS FOR SCIENTIFIC MEETINGS AND TO DISCUSS ADMINISTRATIVE MATTERS. X X 0 0 0 0 0 0 0 0 0 DR WILLA APPEL EXECUTIVE DIRECTOR 353050 0 0 0 0 0 35555 0 13347 0 401952 0 0 0 MR DANIEL MURPHY PHYSICAL PLANT MANAGER 121983 0 0 0 0 0 11562 0 26979 0 160524 0 0 0 DRMICHAEL GOGER NMR MANAGER 145730 0 0 0 0 0 14573 0 0 0 160303 0 0 0 DR XIAOCHUN YANG SR. RESEARCH ASSOCIATE 116844 0 0 0 0 0 12200 0 25212 0 154256 0 0 0 FORM 990, PART VI, SECTION A, LINE 6 ON JUNE 30, 1999, THE CORPORATION ENTERED INTO A MEMBERS CONTRIBUTION AGREEMENT (THE AGREEMENT) WITH ITS MEMBER PARTIES. THE AGREEMENT INCLUDED, AMONG OTHER THINGS, A LEGAL REQUIREMENT THAT THE THEN NINE MEMBER INSTITUTIONS (ALL TAX-EXEMPT UNDER THE INTERNAL REVENUE CODE) MAKE A STIPULATED CAPITAL CONTRIBUTION IN ORDER TO FUND THE CORPORATION'S CONSTRUCTION OF A RESEARCH FACILITY AND ACQUISITION OF HIGH-FIELD NUCLEAR MAGNETIC RESONANCE INSTRUMENTS. AT PRESENT EIGHT (8) CURRENT MEMBERS ALSO MAKE ANNUAL OPERATING CONTRIBUTIONS. (CUNY IS EXEMPT FROM THIS REQUIREMENT BY VIRTUE OF ITS CAPITAL IN-KIND CONTRIBUTION OF LAND AND A BUILDING). ANNUAL OPERATING CONTRIBUTIONS ENTITLE EACH MEMBER INSTITUTION TO A PRO-RATA SHARE OF TIME ON THE INSTRUMENTS OWNED AND OPERATED BY THE CORPORATION. FORM 990, PART VI, SECTION A, LINE 7A AS PROVIDED FOR IN THE BY-LAWS, THE SUSTAINING, CONTRIBUTING AND ASSOCIATE MEMBER REPRESENTATIVES VOTE BY CLASS FOR BOARD DIRECTORS USING PRINCIPLES OF CUMULATIVE VOTING. IN EACH CASE, MEMBERS OF A CLASS DIVIDE THEIR VOTES EVENLY AMONG THE INDIVIDUALS NOMINATED BY THE MEMBERS. THIS ELECTION OCCURS AT EVERY ANNUAL MEETING. FORM 990, PART VI, SECTION A, LINE 7B MEMBERS HAVE THE POWER TO ELECT BOARD DIRECTORS OF THE CORPORATION AND ARE ENTITLED TO VOTE ON ALL OTHER BUSINESS OF THE CORPORATION ON WHICH MEMBERS OF A NOT-FOR-PROFIT CORPORATION ARE ENTITLED TO VOTE PURSUANT TO NOT-FOR-PROFIT CORPORATION LAWS OF THE STATE OF NEW YORK OR PURSUANT TO THE BY-LAWS OF THE CORPORATION. FORM 990, PART VI, SECTION B, LINE 11 THE CHAIRMAN OF THE FINANCE COMMITTEE HAS BEEN DESIGNATED TO REVIEW AND APPROVE THE FORM 990 ON BEHALF OF ITS BOARD OF DIRECTORS PRIOR TO FILING WITH THE IRS. THE ACCOUNTING STAFF AND THE EXECUTIVE DIRECTOR COMPLETE A 990 QUESTIONNAIRE PROVIDED TO NYSBC BY ITS INDEPENDENT AUDIT FIRM. A DRAFT FORM 990 IS THEN PREPARED BY THE INDEPENDENT AUDIT FIRM. IT IS REVIEWED AND APPROVED BY THE CHAIRMAN OF THE FINANCE COMMITTEE AND THE EXECUTIVE DIRECTOR OF THE CORPORATION BEFORE THE FINAL FORM 990 IS SUBMITTED TO THE IRS. THE FORM 990 IS THEN MADE AVAILABLE TO THE REMAINING MEMBERS OF THE BOARD OF DIRECTORS UPON REQUEST. FORM 990, PART VI, SECTION B, LINE 12C THE BOARD OF DIRECTORS APPROVED THE CREATION OF A CONFLICTS RESOLUTION COMMITTEE COMPOSED OF MEMBERS OF THE BOARD OF DIRECTORS. NYSBC'S CONFLICT OF INTEREST POLICY IS REVIEWED AND REVISED PERIODICALLY BY THE ORGANIZATION'S OFFICERS AND COUNSEL. ALL EMPLOYEES ARE PROVIDED WITH A COPY OF THE POLICY AND ARE REQUIRED TO COMPLETE A CONFLICT OF INTEREST DISCLOSURE FORM ANNUALLY. DISCLOSURE FORMS ARE REVIEWED BY THE EXECUTIVE DIRECTOR AND CONFLICTS ARE SUBMITTED TO THE CONFLICTS RESOLUTION COMMITTEE FOR APPROPRIATE ACTION, IF NECESSARY. THE CONFLICT OF INTEREST POLICY IS POSTED ON NYSBC'S INTRANET. FORM 990, PART VI, SECTION B, LINE 15A THE EXECUTIVE COMMITTEE OF THE BOARD OF DIRECTORS DETERMINES COMPENSATION FOR THE ORGANIZATION'S EXECUTIVE DIRECTOR. THE PROCESS INCLUDES A COMPARISON OF COMPENSATION FOR A SIMILAR POSITION AT SIMILAR INSTITUTIONS. THE EXECUTIVE COMMITTEE MEETS TO DISCUSS EXECUTIVE COMPENSATION. COMPARISON ADMINISTRATOR DATA WAS REVIEWED FROM IVY LEAGUE SCHOOLS AND A COHORT OF NOT-FOR-PROFIT RESEARCH INSTITUTES (MERCER SURVEY). ON FEBRUARY 4, 2013, THE EXECUTIVE COMMITTEE HELD A MEETING REGARDING WILLA APPEL'S COMPENSATION FOR FISCAL YEAR 2013. FORM 990, PART VI, SECTION C, LINE 19 THE CORPORATION'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, WHISTLEBLOWER POLICY WITHIN THE SCIENTIFIC MISCONDUCT POLICY AND ITS FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. FORM 990, PART XII, LINE 2C THE PROCESS HAS NOT CHANGED SINCE PRIOR YEAR.