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      <Description>Focusing on seven key areas of discovery - reproductive development, pregnancy and newborns, gynecology, reproductive physiology and fertility, infectious diseases, female cancers, and women's wellness - Magee-Womens Research Institute &amp; Foundation is conducting unprecedented research in: * Genomic and Epigenomic Networks Through the study of genetics and the changes that occur at a cellular level, physician-scientists are now able to identify cells responsible for birth defects, cancer, and other diseases. Magee is at the forefront of the research that is crucial to take the next step - to create preventative measures to develop more effective, less toxic therapies tailored to an individual patient's illness, making the promise of gender-specific, personalized medicine a reality. * Life Course Science Life course science studies the influence of early or midlife events on the health of the individual later in life and the future health of their children. For example, diverse factors play a significant role in future brain development and research has shown that low-birth-weight babies have a higher risk of diabetes, obesity, and heart disease. By leading the research in this area, Magee scientists are creating better interventions for prevention of disease and improved health among women and their children. * Germ Cell Biology Magee has redefined aging for several conditions that affect mature women, such as menopause, osteoporosis, and pelvic floor health. Now, its physician-scientists are taking this innovative research a step further, focusing on the process of reproductive aging at a young age to better understand aging in ovarian and testicular germ cells, as well as in the placenta. By doing so, they will gain a clearer understanding of premature aging of these organs, and discover the impact on fertility, pregnancy, and general women's wellness. * Gender-based Biology and Personalized Medicine Through interaction with researchers at the University of Pittsburgh, Magee researchers are better defining the role of gender in many non-reproductive diseases. Probing beyond the X- or Y-chromosomes, they are better defining genomic gender, and the impact of female physiology on conditions that were historically only studied in males, which is essential for affecting a personalized approach to medicine and wellness.</Description>
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        <ReturnReference>Form 990, Part VI, Section B, Line 11b</ReturnReference>
        <Explanation>After completion by the Manager of Accounting, the Form 990 is reviewed internally by the Director of Finance and externally by a representative of the National Exempt Organization Tax Services Division of Ernst and Young LLP. Effective with the 2013 Form 990 filing, in addition to the current process the organization's newly formed Audit Committee will be responsible for reviewing the Form 990 and reporting the results of their review including a copy of the Form 990 to the Board of Directors prior to filing.</Explanation>
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        <Explanation>Conflict of Interest Policy is regularly and consistently enforced and monitored. Training of the policy is given to new employees during Orientation. Policy is overseen by the Research Advisory Committee. Annually, the Executive Administrator submits data related to the number of investigators who submitted Statements of Outisde Interests and Activities along with details of remedial action taken, if applicable.</Explanation>
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      <GeneralExplanation>
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        <Explanation>Conflict of Interest Policy is posted on the organization's website (www.mwrif.org). Governing documents and financial statements are available in the organization's business office located at 3339 Ward Street, Pittsburgh, PA 15213</Explanation>
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