2014-11-17T10:23:57-06:00 2013-12-31 720398470 HEARD MCELROY & VESTAL LLC 333 TEXAS STREET SUITE 1525 SHREVEPORT LA 71101 990 2013-01-01 760497352 INSTITUTE OF ORTHOPEDIC RESEARCH AND EDUCATION INST 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 JIM BOCELL MD PRESIDENT 7136104270 2014-11-11 1 ROY E PRESTWOOD P00419967 3184291525 2013 2015-11-30 17:44:51Z JAMES BOCELL MD 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 1315534 0 X WWW.IORE.NET X 1995 TX IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 5 5 26 15 0 0 850000 738000 422957 472084 800 104004 1091 1446 1274848 1315534 0 0 0 0 879994 929047 0 0 0 459845 449396 1339839 1378443 -64991 -62909 275138 204844 16159 8774 258979 196070 X IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 0 0 180882 158490 BAYLOR COLLEGE OF MEDICINE: POST-GRADUATE RESEARCH PROJECTS IN SPORTS MEDICINE.DURING THE 2013, IORE SUPPORTED ACADEMIC RESEARCH PROJECTS COMPLETED BY POST-GRADUATE SPORTS MEDICINE FELLOWS FROM BAYLOR COLLEGE OF MEDICINE. THESE PROJECTS RANGED FROM CADAVERIC STUDIES SIMULATING MUSCULO-SKELETAL FUNCTION TO COMPUTER SIMULATION OF THE RESULTS OF SURGICAL PROCEDURES. TYPICAL RESEARCH STUDIES INCLUDED:WE WORKED WITH A POST-GRADUATE FELLOW IN SPORTS MEDICINE TO PERFORM A RESEARCH STUDY EXAMINING THE EFFECT OF DIFFERENT SURGICAL PLANS USED TO MODIFY THE SHAPE OF THE HEAD-NECK JUNCTION OF THE FEMUR ON THE RESULTING RANGE OF MOTION OF THE HIP JOINT. THIS SURGICAL PROCEDURE, CALLED OSTEOCHONDROPLASTY, IS FREQUENTLY PERFORMED IN ATHLETES AND DANCE PERFORMERS WITH SKELETAL ABNORMALITIES THAT ARE THOUGHT TO BE A PRECURSOR OF ARTHRITIS AND DEGENERATIVE HIP DISEASE. ONCE WE DEVELOPED CASE-SPECIFIC SURGICAL PLANS AND PERFORMED TRIALS OF THEIR IMPACT ON HIP MOTION USING COMPUTER SIMULATIONS, WE EXPERIMENTED WITH METHODS OF IMPLEMENTING EACH PLAN IN CADAVERIC SPECIMENS WITH THE ASSISTANCE OF POST-GRADUATE FELLOWS AND EXPERIENCED HIP SURGEONS. THE RESULTS OF THIS STUDY WERE SUMMARIZED IN A POWERPOINT PRESENTATION WHICH WAS DELIVERED TO A SCIENTIFIC CONFERENCE HOSTED BY THE DEPARTMENT OF ORTHOPAEDIC SURGERY AT BAYLOR COLLEGE OF MEDICINE. WE PERFORMED A BIOMECHANICAL STUDY TO INVESTIGATE THE CONTRIBUTION OF THE ANTERIOR LATERAL LIGAMENT OF THE KNEE TO THE MECHANICAL STABILITY OF THE JOINT AFTER RECONSTRUCTION OF A RUPTURE OF THE ANTERIOR CRUCIATE LIGAMENT. RECENT WORLDWIDE PRESS COVERAGE HAS DECLARED THAT BELGIAN INVESTIGATORS HAVE "DISCOVERED" A NEW LIGAMENT WITHIN THE KNEE, THE ANTERIOR LATERAL LIGAMENT (ALL). ONE CLAIM POPULARIZED IN THESE REPORTS IS THAT THIS STRUCTURE PROVIDES ROTATIONAL AND TRANSLATIONAL STABILITY TO THE KNEE, ESPECIALLY AFTER ACL INJURY. THIS SUGGESTS THAT SURGICAL REPAIR OF THIS STRUCTURE MAY ENHANCE THE OUTCOME OF SURGICAL RECONSTRUCTION OF THE ACL, AND MAY EXPLAIN THE VARIABILITY OF THE OUTCOME OF THESE PROCEDURES. TO EXAMINE THESE QUESTIONS, WE USED A COMPUTER-CONTROLLED KNEE TESTING MACHINE TO MEASURE THE STABILITY OF CADAVERIC KNEES WITH AND WITHOUT AN INTACT ACL, AND WITH FURTHER LOSS OF THE ALL. WE THEN RETESTED EACH KNEE AFTER SEQUENTIAL RECONSTRUCTION OF THE ACL AND THE ALL. THIS WORK SHOWED THAT THE ALL HAS NEGLIGIBLE EFFECT ON THE STABILITY OF THE CRUCIATE INTACT KNEE, BUT THAT MODEST IMPROVEMENT S COULD BE OBTAINED AFTER ACL RECONSTRUCTION. WE DEVELOPED AN AUTOMATED METHOD OF GENERATING A PIVOT-SHIFT WITHIN THE CADAVERIC KNEE DURING FLEXION UNDER THE ACTION OF VALGUS AND INTERNAL ROTATION MOMENTS. THIS METHODOLOGY WAS APPLIED TO AN EXPERIMENT CONDUCTED BY ONE OF THE BAYLOR SPORTS MEDICINE FELLOWS WHO STUDIED THE EFFECT OF TESTING VARIABLES AND MUSCLE FORCES ON THE SUBLUXATION OF THE TIBIA ACCOMPANYING KNEE FLEXION AFTER ACL RUPTURE (KNOWN AS THE "PIVOT-SHIFT" PHENOMENON). 41054 DEVELOPMENT OF A BIOMATERIALS RESEARCH FACILITYIORE EMBARKED UPON A DEVELOPMENT PROGRAM IN BIOMATERIALS AND TISSUE ENGINEERING THROUGH CONVERSION OF EXISTING LABORATORY SPACE ALREADY OCCUPIED IN HOUSTON METHODIST HOSPITAL TO SUPPORT WORK INVOLVING BIOLOGICAL MATERIALS. THE FOCUS OF THIS FACILITY WILL BE THE EXPERIMENTAL SIMULATION OF INTERFACES BETWEEN ARTIFICIAL AND BIOLOGICAL TISSUES. THROUGH THE ADDITION OF INCUBATORS AND A STERILE WORK AREA TO THIS LABORATORY, IT HAS BEEN POSSIBLE TO CONSTRUCT A PNEUMATICALLY-DRIVEN BIOREACTOR FOR LOADING TENDON SPECIMENS HARVESTED FROM ANIMALS. THIS CONSTRUCT ALLOWS TISSUES TO BE CYCLICALLY LOADED WHILE BEING SUSPENDED UNDER PHYSIOLOGIC CONDITIONS. PILOT WORK PERFORMED WITH TENDON SPECIMENS SHOWED THAT THIS TECHNIQUE ALLOWS TISSUES TO REMAIN VIABLE FOR A PERIOD OF AT LEAST 2 WEEKS POST-HARVEST. THIS METHODOLOGY HAS BEEN USED AS THE BASIS FOR GRANT APPLICATIONS AIMED AT STUDYING FACTORS AFFECTING THE FIXATION OF ROTATOR CUFF REPAIRS IN THE SHOULDER. ADDITIONAL STUDIES USING THE SAME FACILITIES HAVE BEEN PLANNED TO EXAMINE THE PERFO 110779 109000 METHODIST-CORNELL POST-GRADUATE RESEARCH PROJECTS IN SPORTS MEDICINE AND JOINT REPLACEMENT.THE STAFF OF IORE WORKED IN COLLABORATION WITH THE FACULTY OF THE METHODIST-CORNELL DEPARTMENT OF ORTHOPAEDIC SURGERY IN TRAINING POST-GRADUATE FELLOWS IN RESEARCH. WE UNDERTOOK RESEARCH PROJECTS ON THE FOLLOWING TOPICS, WITH FINANCIAL SUPPORT FROM THE METHODIST DEPARTMENT OF ORTHOPAEDIC SURGERY:AN INVESTIGATION OF THE EFFECT OF MENISCAL ALLOGRAFT TRANSPLANTATION ON THE BIOMECHANICS OF THE KNEE MENISCUS, BOTH IN TERMS OF ITS MOTION AND DEFORMATION DURING KNEE FUNCTION, AND THE PRESSURES TRANSMITTED TO THE CARTILAGE ON THE PROXIMAL SURFACE OF THE TIBIA. EXPERIMENTS WERE ALSO PERFORMED TO MEASURE THE SENSITIVITY OF THESE MEASURES TO THE ACCURACY OF PLACEMENT OF THE GRAFT ON THE SURFACE OF THE HOST BONE. WORKING WITH A FELLOW IN JOINT RECONSTRUCTION, WE INVESTIGATED ALTERNATIVE STRATEGIES FOR PERFORMING REVISION HIP REPLACEMENT IN THE PRESENCE OF DAMAGE (TRIBO-CORROSION) TO THE MODULAR NECK WHEN THE FEMORAL COMPONENT IS FOUND TO BE RIGIDLY FIXED TO THE FEMUR. IN THESE CASES IT IS HIGHLY DESIRABLE TO LEAVE THE PRIMARY FEMORAL STEM IN SITU AND REPLACE THE ORIGINAL FEMORAL HEAD AND THE ACETABULAR LINER/ACETABULAR CUP. ALTHOUGH THIS IS UNIVERSALLY ACCEPTED IF THE FEMORAL TAPER IS IN PRISTINE CONDITION, ONCE CORROSIVE DAMAGE IS PRESENT IT IS UNCLEAR WHETHER THE INTERFACE FORMED BETWEEN THE ORIGINAL TRUNNION AND A NEW HEAD OR SLEEVE WILL BE CAPABLE OF WITHSTANDING FUNCTIONAL LOADING OF THE JOINT WITHOUT SLIPPAGE OR FURTHER TRIBO-CHEMICAL DAMAGE. WE INVESTIGATED THIS QUESTION THROUGH MECHANICAL TESTING OF WORN FEMORAL COMPONENTS OBTAINED FROM REVISION SURGERY. IN EACH CASE, A PRISTINE FEMORAL HEAD WAS PROCURED FROM THE MANUFACTURER AND REASSEMBLED ON THE MATING TAPER OF THE FEMORAL COMPONENT USING A MECHANICAL TESTING MACHINE. LOADING CONDITIONS WITHIN THE BODY WERE THEN SIMULATED IN THE TESTING MACHINE AND THE RELATIVE MOTION AT THE HEAD-NECK JUNCTION WAS MEASURED WITH AN ARRAY OF HIGH PRECISION TRANSDUCERS. THIS PROCEDURE WAS PERFORMED WITH BOTH COBALT-BASED AND TITANIUM-BASED FEMORAL STEMS. A THIRD STUDY WAS UNDERTAKEN WITH A JOINT REPLACEMENT FELLOW TO EXAMINE THE CONFLICT BETWEEN ALIGNMENT OF TOTAL KNEE REPLACEMENTS AND VARIATIONS IN THE SHAPE OF THE HUMAN TIBIA. THIS TOPIC IS OF IMPORTANCE IN JOINT REPLACEMENT WHERE THE ALIGNMENT OF THE IMPLANTED COMPONENTS WITH RESPECT TO THE MECHANICAL AXIS OF THE LOWER EXTREMITY AFFECTS THE LONGEVITY OF BONY FIXATION. IN THE CASE OF TIBIAL FIXATION, STEMS ARE OFTEN ATTACHED TO THE IMPLANT TO ALLOW FIXATION THROUGH CONTACT WITH THE INTRAMEDULLARY CANAL WHERE THE BONE IS STRONGER AND MORE RIGID. THIS IS ESPECIALLY TRUE IN REVISION CASES. HOWEVER, IN SOME TIBIAE, THE CANAL IS BOWED, POTENTIALLY LEADING TO MISALIGNMENT OF THE IMPLANT AND MALPLACEMENT ON THE PREPARED SURFACE OF THE BONE. IN THIS STUDY, IORE STAFF ASSISTED THE TRAINEE IN PREPARING COMPUTER MODELS OF A SET OF TIBIAS AND PERFORMING ANATOMIC MEASUREMENTS TO DETERMINE: A) THE PREVALENCE OF SIGNIFICANT CURVATURE OF THE INTRAMEDULLARY CANAL;B) THE DEVIATION OF THE IMPLANT FROM IDEAL PLACEMENT WHEN IMPLANTED WITH A STEM EXTENSION GAINING PURCHASE IN THE PROXIMAL HALF OF THE TIBIA; C) THE COMBINATIONS OF STEM LENGTH AND DIAMETER THAT MAY BE SELECTED FOR SUPPLEMENTARY FIXATION OF TIBIAL COMPONENTS WITHOUT CAUSING MAL-POSITIONING. 686753 204594 OTHER ORTHOPEDIC RESEARCH PROJECTS. 686753 204594 1019468 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 20 0 1 26 1 0 0 0 0 0 0 0 0 0 0 X 5 5 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 X X KIM MCCONN 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 X JAMES BOCELL MD PRESIDENT 1.00 X X 0 0 0 BRADLEY WEINER MD VICE PRESIDENT 1.00 X X 0 0 0 STEVEN INCAVO MD DIRECTOR 0.50 X 0 0 0 KENNETH MATHIS MD DIRECTOR 1.00 X 0 0 0 WILLIAM J BRYAN MD DIRECTOR 0.50 X 0 0 0 0 0 0 0 0 0 0 0 738000 738000 RESEARCH SERVICES 541700 472084 472084 472084 167 167 729 729 103837 0 103837 103837 103837 MISCELLANEOUS 900099 717 717 717 1315534 472084 0 105450 750034 600027 150007 40085 32068 8017 78795 63036 15759 60133 48106 12027 42000 42000 5285 5285 2066 2066 8233 8233 367 367 82763 66210 16553 36689 36689 28322 28322 27427 27427 SUPPLIES 139497 113220 26277 SERVICES 44225 35049 9176 REPAIRS 11629 2960 8669 MEALS & ENTERTAINMENT 10649 10649 10244 3221 7023 1378443 1019468 358975 0 116624 55725 41800 31200 561754 443835 116714 117919 275138 204844 16159 8774 16159 8774 X 0 0 0 0 258979 196070 258979 196070 275138 204844 -62909 0 X 0 0 0 X 150000 600000 850000 738000 2338000 1190936 595087 307577 422957 472084 2988641 1190936 745087 907577 1272957 1210084 5326641 0 556910 196904 151626 905440 556910 196904 151626 905440 4421201 104991 86768 109603 800 104004 406166 104991 86768 109603 800 104004 406166 1734 1800 1091 1446 6071 1295927 833589 1018980 1274848 1315534 5738878 0.77040 0.73930 0.07080 0.05580 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 90000 32405 57595 471754 411430 60324 117919 FORM 990, PART VI, SECTION B, LINE 11 A COPY OF THE 990 IS PROVIDED TO THE ORGANIZATION'S GOVERNING BODY BEFORE IT IS FILED. FORM 990, PART VI, SECTION B, LINE 12C THE BOARD REGULARLY AND CONSISTENTLY MONITORS AND ENFORCES THE COMPLIANCE WITH THE CONFLICT OF INTEREST POLICY BY OVERSEEING THE OPERATIONS OF THE ORGANIZATION. FORM 990, PART VI, SECTION B, LINE 15 THE PROCESS FOR DETERMINING COMPENSATION INCLUDES A REVIEW AND APPROVAL OF THE BOARD, COMPARABILITY DATA, AND CONTEMPORANEOUS SUBSTANTIATION. FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION MAKES ITS GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS AVAILABLE TO THE PUBLIC UPON REQUEST. 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