2015-11-16T14:04:29-06:00 2014-12-31 131517563 LOEB & TROPER LLP 655 THIRD AVENUE 12TH FLOOR NEW YORK NY 10017 990 2014-01-01 134043587 NEW YORK STRUCTURAL BIOLOGY CENTER INC NEWY 2129390660 89 CONVENT AVENUE NEW YORK NY 10027 WILLA APPEL EXECUTIVE DIRECTOR 2129390660 2015-11-16 1 AARON SHAPIRO P01333816 2128674000 2014 2016-02-25 16:41:14Z DR WILLA APPEL 89 CONVENT AVENUE NEW YORK NY 10027 33838340 0 X WWW.NYSBC.ORG X 1999 NY TO OPERATE A STATE-OF-THE-ART FACILITY FOR RESEARCH IN STRUCTURAL BIOLOGY PROVIDING ADVANCED RESOURCES TO THE FACULTY OF PARTICIPATING MEMBERS OF ITS NINE MEMBER INSTITUTIONS EACH OF WHICH IS A 501(C)(3) ORGANIZATION. 18 18 40 18 0 0 11823590 30914977 0 0 543412 331212 56048 287716 12423050 31533905 400000 400000 0 0 4039545 4144214 0 0 0 9170721 8092586 13610266 12636800 -1187216 18897105 46758846 68047914 4718456 7110531 42040390 60937383 X THE NYSBC MISSION IS TO PROVIDE ADVANCED RESEARCH RESOURCES TO THE FACULTY OF NYSBC'S 9 MEMBER INSTITUTIONS IN THREE KEY AREAS OF STRUCTURAL BIOLOGY: NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; CRYOELECTRON MICROSCOPY; AND X-RAY CRYSTALLOGRAPHY. THESE RESOURCES SERVE MORE THAN 100 PRINCIPAL INVESTIGATORS. IN ADDITION, THE NYSBC SERVES ITS MEMBER INSTITUTIONS BY OFFERING ACCREDITED ACADEMIC COURSES AND INFORMAL SEMINARS; AND BY DEVELOPING MULTI-INSTITUTIONAL RESEARCH COLLABORATIONS. 0 0 3231738 100000 SEE SCHEDULE ONYSBC PROVIDES ACCESS TO HIGH-FIELD NUCLEAR MAGNETIC RESONANCE (NMR) SPECTROSCOPY TO FACULTY FROM ITS NINE AFFILIATED INSTITUTIONS. THE NMR FACILITY INSTRUMENTATION INCLUDES 10 NMR SPECTROMETERS: 2 @ 900 MHZ; 3 @ 800 MHZ; AND 1 EACH @ 750, 700, 600, 500 MHZ AND A 600 MHZ DYNAMIC NUCLEAR POLARIZATION SOLID STATE NMR (DNP-NMR). THE INSTRUMENTS OPERATE 24 HRS/DAY, 7 DAYS/WEEK AND ON AVERAGE WERE EACH AVAILABLE 328 DAYS IN 2014, WITH THE EXCEPTION OF THE 700 AND 600 MHZ INSTRUMENTS WHICH WERE DECOMMISSIONED IN SEPTEMBER 2014. THESE RESOURCES ALLOW RESEARCHERS TO DETERMINE THE STRUCTURE OF PROTEINS IN SOLUTION AT AND IN SOLID STATE ATOMIC RESOLUTION, DATA THAT PROVIDES INSIGHT INTO THE FUNCTIONAL PROPERTIES OF THE PROTEINS. IN 2014, GROUP MEMBERS FROM THE LABORATORIES OF 29 PRINCIPAL INVESTIGATORS FROM THE MEMBER INSTITUTIONS AND 1 INVESTIGATOR FROM A PRIVATE COMPANY MADE USE OF THESE INSTRUMENTS. DATA COLLECTED WITH THESE INSTRUMENTS PRODUCED 28 PUBLICATIONS IN EMINENT SCIENTIFIC JOURNALS. THE CENTER ALSO CONDUCTED SEVERAL NMR TRAINING SHORT COURSES TO TEACH ADVANCED NMR TECHNIQUES TO 9 GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS FROM THE AFFILIATED INSTITUTIONS. 2841448 SEE SCHEDULE ORESEARCH CONDUCTED AT THE CRYOELECTRON MICROSCOPY FACILITY IS AIMED AT DETERMINING THE FUNCTION OF MACROMOLECULES FROM THEIR OBSERVED STRUCTURES. LOWER RESOLUTION IMAGING IS USED TO BRIDGE THE GAP BETWEEN THE STRUCTURES PRODUCED FROM LIGHT MICROSCOPY IMAGING AND THE ATOMIC RESOLUTION STRUCTURES DETERMINED BY OTHER MEANS SUCH AS NMR AND X-RAY DIFFRACTION. THE FACILITY HAS FOUR ELECTRON MICROSCOPES: 1 @ 120KV, 2 @ 200 KV, 1 @ 300 KV, AS WELL AS A DUAL-BEAM FOCUSED ION BEAM SCANNING ELECTRON MICROSCOPE. THREE PERMANENT STAFF MEMBERS PROVIDE TECHNICAL SUPPORT FOR STRUCTURAL ANALYSIS OF MACROMOLECULES AND MAINTAIN THE INSTRUMENTS. IN 2014, THE CRYOELECTRON MICROSCOPY FACILITY SERVED 56 PRINCIPAL INVESTIGATORS FROM AFFILIATED INSTITUTIONS AND THEIR STAFF MEMBERS. THIS WORK RESULTED IN 10,350 HOURS OF MICROSCOPE TIME USED IN 899 SESSIONS. THE CENTER HELD ITS ANNUAL CRYO-EM COURSE TO TEACH ADVANCED ELECTRON MICROSCOPY TECHNIQUES TO GRADUATE STUDENTS AND POSTDOCTORAL FELLOWS. THE CEM FACILITY HOSTS REGULAR SCIENTIFIC SEMINARS AND DISCUSSIONS TO ENABLE IT TO REMAIN ON THE PULSE OF ONGOING ACTIVITIES IN THE FIELD. EIGHT (8) PUBLICATIONS RESULTED FROM RESEARCH IN THE CEM FACILITY IN 2014. 840339 SEE SCHEDULE ONYSBC HAS X-RAY CRYSTALLOGRAPHY RESOURCES AT THE NATIONAL SYNCHROTRON LIGHT SOURCE (NSLS) FACILITY AT BROOKHAVEN NATIONAL LABORATORY ON LONG ISLAND AND AT ITS MAIN FACILITY IN NEW YORK CITY. TWO EXPERIMENTAL STATIONS, "BEAMLINES", X4A AND X4C, ARE OPERATED AT NSLS FOR THE BENEFIT OF NYSBC SCIENTISTS, INCLUDING USERS FROM THE NORTHEAST STRUCTURAL GENOMICS CENTER (NESG) AND THE NEW YORK CENTER FOR MEMBRANE PROTEIN STUDY (NYCOMPS), BOTH OF WHICH ARE FUNDED BY THE NIH PROTEIN STRUCTURE INITIATIVE. THE BEAMLINES HAVE ALSO DEDICATED 25% OF BEAM TIME TO SERVE NSLS GENERAL USERS. THE RESEARCH GOAL IS TO UNDERSTAND STRUCTURES AND FUNCTIONS OF BIOLOGICAL MACROMOLECULES IN BIOCHEMICAL AND CELLULAR EVENTS. IN 2014, X4A AND X4C EACH DELIVERED MORE THAN 2,300 HOURS OF X-RAY BEAM. MORE THAN 20 PRINCIPAL INVESTIGATORS WERE SERVED FOR SYNCHROTRON-BASED DATA COLLECTION AND DATA ANALYSES. IN 2014, THERE WERE 11 PUBLICATIONS FROM X4A AND 6 PUBLICATIONS FROM X4C. THERE WERE 46 PROTEIN DATA BANK (PDB) STRUCTURE DEPOSITS FROM X4A AND X4C FOR 2014. A SECOND HOME-SOURCE DETECTOR SYSTEM WAS ADDED TO THE X-RAY FACILITY AT THE NYSBC - NEW YORK CITY LOCATION IN 2010. THE TWO SYSTEMS ARE USED FOR SCREENING AND FOR DIFFRACTION CHARACTERIZATION OF CRYSTALS GROWN AT NYSBC. 4084713 300000 NYSBC COMPLETED A 5-YEAR GRANT IN 2010 FUNDED BY THE NIH PROTEIN STRUCTURE INITIATIVE. THE GRANT, THE NEW YORK CONSORTIUM OF MEMBRANE PROTEIN STRUCTURE (NYCOMPS), FOCUSED ON THE STRUCTURES OF MEMBRANE PROTEINS, WHICH ARE HIGHLY IMPORTANT BIOMOLECULES IN HUMAN HEALTH AND DISEASE. THE RESEARCH SOLVED 10 NOVEL STRUCTURES, MANY OF WHICH WERE PUBLISHED IN HIGHLY RANKED JOURNALS, INCLUDING FOUR "NATURE" PUBLICATIONS. AS A RESULT OF THESE ACCOMPLISHMENTS, IN 2010, NYSBC WAS AWARDED TWO NEW 5-YEAR NIGMS PROTEIN STRUCTURE INITIATIVE GRANTS: A 5-YEAR CONTINUATION OF NYCOMPS; AND THE TRANSCONTINENTAL EM INITIATIVE FOR MEMBRANE PROTEIN STRUCTURE (TEMIMPS). THESE TWO AWARDS SUPPORT STRUCTURAL DETERMINATION OF INTEGRAL MEMBRANE PROTEINS, UTILIZING X-RAY CRYSTALLOGRAPHIC AND CYROELECTRON MICROSCOPY APPROACHES, RESPECTIVELY.IN 2014, NYCOMPS AND TEMIMPS PUBLISHED SEVEN PAPERS DESCRIBING NOVEL INTEGRAL MEMBRANE PROTEIN STRUCTURES SOLVED BY X-RAY DIFFRACTION AND CRYOELECTRON MICROSCOPY; INCLUDING THREE IN THE PRESTIGIOUS NATURE AND SCIENCE FAMILIES OF JOURNALS. 4084713 300000 10998238 1 1 0 1 0 0 0 0 0 0 1 0 0 0 0 1 1 0 0 0 0 0 0 0 0 0 0 1 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 18 0 40 1 0 0 0 0 0 0 0 0 0 0 X 18 18 0 0 0 0 1 1 1 1 1 0 0 0 1 1 1 1 1 1 0 0 NY X DR WILLA APPEL EXECUTIVE DIRECTOR 2129390660 89 CONVENT AVENUE NEW YORK NY 10027 DR DAVID HIRSH CHAIRMAN 4.00 X X 0 0 0 DR ALLEN SPIEGEL SECRETARY 0.10 X X 0 0 0 DR ERIC COTTINGTON TREASURER 0.20 X X 0 0 0 DR MARK GIRVIN DIRECTOR 0.10 X 0 0 0 DR GILLIAN SMALL DIRECTOR 0.10 X 0 0 0 DR ANN MCDERMOTT DIRECTOR 0.10 X 0 0 0 DR CHRISTOPHER LIMA DIRECTOR 0.10 X 0 0 0 DR MING-MING ZHOU DIRECTOR 0.10 X 0 0 0 DR ANEEL AGGARWAL DIRECTOR 0.10 X 0 0 0 DR PAUL HORN DIRECTOR 0.10 X 0 0 0 DR SETH DARST DIRECTOR 0.10 X 0 0 0 DR TIMOTHY PO'CONNOR DIRECTOR 0.10 X 0 0 0 DR KEVIN GARDNER DIRECTOR 0.10 X 0 0 0 DR FREDERICK MAXFIELD DIRECTOR 0.10 X 0 0 0 DR ERASMUS SCHNEIDER DIRECTOR 0.10 X 0 0 0 DR PATRICK VAN ROEY DIRECTOR 0.10 X 0 0 0 IRA MILLSTEIN ESQ DIRECTOR 0.10 X 0 0 0 MR LESLIE GREENGARD DIRECTOR 0.10 X 0 0 0 DR WILLA APPEL EXECUTIVE DIRECTOR 37.50 X 363718 0 50927 DRMICHAEL GOGER SR. SCIENTIST & NMR MANAGER 37.50 X 149791 0 14979 MR DANIEL S MURPHY PHYSICAL PLANT MANAGER 37.50 X 133524 0 40311 MR JOSEPH LIDESTRI SR. SCIENTIST & MGR. OF BE 37.50 X 133016 0 16165 DR XIAOCHUN YANG SR. RESEARCH ASSOCIATE 37.50 X 119552 0 38459 MS VERONICA MURRAY SENIOR GRANTS & CONTRACTS 37.50 X 102590 0 22285 1002191 0 183126 8 0 1 0 TECHNOLOGY SOLUTION PARTNERS LLC 2 TRAP FALLS ROAD SUITE 401 SHELTON CT 06484 INFORMATION TECHNOLOGY, INFRASTRUCTURE M 328925 US SECURITY PO BOX 931703 ATLANTA GA 31193 SECURITY SERVICES 135362 21 11061216 19853761 30914977 185431 185431 2450216 2304435 145781 145781 145781 MISCELLANEOUS 900099 266904 266904 LIQUIDATED DAMAGES 900099 20812 20812 287716 31533905 0 0 618928 400000 400000 414645 136833 277812 2888522 2463312 425210 257815 221700 36115 345839 281329 64510 237393 188525 48868 74594 20000 54594 93317 2989 90328 49400 49400 4016 4016 39330 39330 60331 60331 67937 37270 30667 381588 236821 144767 1483713 1267617 216096 59340 40338 19002 38306 34164 4142 2877533 2792665 84868 247550 200760 46790 SUBCONTRACTORS EXPENSE 1862623 1862623 LAB SUPPLIES AND EQUIPM 676155 676155 76853 70790 6063 12636800 10998238 1638562 0 800 800 1401964 5292331 1422993 15090152 43411 32903 402099 196469 70499494 29496234 37336030 41003260 6151549 6431999 46758846 68047914 2633208 3950870 2085248 3159661 4718456 7110531 X 42040390 44818426 16118957 42040390 60937383 46758846 68047914 18897105 -112 0 X X 0 1 X 1 1 1 X 9501601 13962318 10550182 11823590 30914977 76752668 9501601 13962318 10550182 11823590 30914977 76752668 17369129 59383539 32640 99289 182927 171388 185431 671675 101276 516962 57089 56048 287716 1019091 78443434 0.75700 0.89850 X SCHEDULE A, PART II, LINE 10, EXPLANATION OF OTHER INCOME: MISCELLANEOUS LIQUIDATED DAMAGES RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 0 0 0 0 0 0 1 4016 0 0 4016 0 PART II-B, LINE 1: LOBBYING ACTIVITIES CONSISTED OF THE FOLLOWING: MEETING WITH EXECUTIVE DIRECTOR AND LEGISLATIVE PERSONNEL REGARDING POTENTIAL FUNDING FOR 2014 AND 2015; REVIEWED AND COMMENTED ON NYSBC BUDGET PROPOSAL MEMO AND SUPPORTING DOCUMENTS; E-MAIL REGARDING NYSBC CAPITAL FUNDING REQUEST; MEETING WITH EXECUTIVE DIRECTOR AND LEGISLATIVE PERSONNEL REGARDING NYSBC PROJECT; CONFERENCE WITH EXECUTIVE DIRECTOR AND UPSTATE UNIVERSITY REGARDING POTENTIAL COLLABORATION. 4253220 1311409 2941811 25952718 7530283 18422435 31565325 20654542 10910783 8728231 8728231 41003260 X 31494463 -112 -112 31494575 39330 39330 31533905 12597470 0 12597470 39330 39330 12636800 PART X, LINE 2: UNCERTAINTY IN INCOME TAXES - THE CORPORATION HAS DETERMINED THAT THERE ARE NO MATERIAL UNCERTAIN TAX POSITIONS THAT REQUIRE RECOGNITION OR DISCLOSURE IN THE FINANCIAL STATEMENTS. PERIODS ENDING DECEMBER 31, 2011 AND SUBSEQUENT REMAIN SUBJECT TO EXAMINATION BY APPLICABLE TAXING AUTHORITIES 1 TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 630 W 168TH STREET NEW YORK NY 10032 135598093 501(C)(3) 400000 RESEARCH 1 PART I, LINE 2: ALL SUBCONTRACTORS AND/OR GRANT RECIPIENTS SIGN AN AGREEMENT WITH NYSBC TO PERFORM WORK IN ACCORDANCE WITH PROJECT AIMS AND SPONSOR GUIDELINES. NYSBC REVIEWS INVOICES AND REQUESTS BACK UP DOCUMENTATION, AS NEEDED, IN ORDER TO REVIEW AND APPROVE ALLOWABLE EXPENSES. THE GRANTS & CONTRACTS MANAGER ALSO MONITORS EXPENDITURES ON SUBCONTRACTOR/GRANTEE INVOICES IN ORDER TO ENSURE ALIGNMENT WITH THE ORIGINAL BUDGET. NYSBC ALSO REQUESTS AND REVIEWS INSURANCE CERTIFICATES AND A-133 REPORTS ON AN ANNUAL BASIS. NYSBC'S INVESTIGATOR RECEIVES PROGRESS REPORTS FROM SUBCONTRACTORS/GRANTEES. PROGRESS REPORTS ARE SUBMITTED AT LEAST ON AN ANNUAL BASIS TO THE SPONSORING AGENCIES. DURING THE PROJECT PERIOD, NYSBC'S ADMINISTRATION AND PROGRAM STAFF ARE IN CONTACT WITH THE SUBCONTRACTOR/GRANTEE STAFF TO DISCUSS PROGRAM PROGRESS, PREPARE PRESENTATIONS FOR SCIENTIFIC MEETINGS AND TO DISCUSS ADMINISTRATIVE MATTERS. X X 0 0 0 0 0 0 0 0 0 DR WILLA APPEL EXECUTIVE DIRECTOR 363718 0 0 0 0 0 36533 0 14394 0 414645 0 0 0 DRMICHAEL GOGER SR. SCIENTIST & NMR MANAGER 149791 0 0 0 0 0 14979 0 0 0 164770 0 0 0 MR DANIEL S MURPHY PHYSICAL PLANT MANAGER 133524 0 0 0 0 0 14188 0 26123 0 173835 0 0 0 DR XIAOCHUN YANG SR. RESEARCH ASSOCIATE 119552 0 0 0 0 0 12444 0 26015 0 158011 0 0 0 FORM 990, PART VI, SECTION A, LINE 6 ON JUNE 30, 1999, THE CORPORATION ENTERED INTO A MEMBERS CONTRIBUTION AGREEMENT (THE AGREEMENT) WITH ITS MEMBER PARTIES. THE AGREEMENT INCLUDED, AMONG OTHER THINGS, A LEGAL REQUIREMENT THAT THE THEN NINE MEMBER INSTITUTIONS (ALL TAX-EXEMPT UNDER THE INTERNAL REVENUE CODE) MAKE A STIPULATED CAPITAL CONTRIBUTION IN ORDER TO FUND THE CORPORATION'S CONSTRUCTION OF A RESEARCH FACILITY AND ACQUISITION OF HIGH-FIELD NUCLEAR MAGNETIC RESONANCE INSTRUMENTS. AT PRESENT EIGHT (8) CURRENT MEMBERS ALSO MAKE ANNUAL OPERATING CONTRIBUTIONS. (CUNY IS EXEMPT FROM THIS REQUIREMENT BY VIRTUE OF ITS CAPITAL IN-KIND CONTRIBUTION OF LAND AND A BUILDING). ANNUAL OPERATING CONTRIBUTIONS ENTITLE EACH MEMBER INSTITUTION TO A PRO-RATA SHARE OF TIME ON THE INSTRUMENTS OWNED AND OPERATED BY THE CORPORATION. FORM 990, PART VI, SECTION A, LINE 7A AS PROVIDED FOR IN THE BY-LAWS, THE SUSTAINING, CONTRIBUTING AND ASSOCIATE MEMBER REPRESENTATIVES VOTE BY CLASS FOR BOARD DIRECTORS USING PRINCIPLES OF CUMULATIVE VOTING. IN EACH CASE, MEMBERS OF A CLASS DIVIDE THEIR VOTES EVENLY AMONG THE INDIVIDUALS NOMINATED BY THE MEMBERS. THIS ELECTION OCCURS AT EVERY ANNUAL MEETING. FORM 990, PART VI, SECTION A, LINE 7B MEMBERS HAVE THE POWER TO ELECT BOARD DIRECTORS OF THE CORPORATION AND ARE ENTITLED TO VOTE ON ALL OTHER BUSINESS OF THE CORPORATION ON WHICH MEMBERS OF A NOT-FOR-PROFIT CORPORATION ARE ENTITLED TO VOTE PURSUANT TO NOT-FOR-PROFIT CORPORATION LAWS OF THE STATE OF NEW YORK OR PURSUANT TO THE BY-LAWS OF THE CORPORATION. FORM 990, PART VI, SECTION B, LINE 11 THE EXECUTIVE DIRECTOR HAS BEEN DESIGNATED TO REVIEW AND APPROVE THE FORM 990 ON BEHALF OF ITS BOARD OF DIRECTORS PRIOR TO FILING WITH THE IRS. THE ACCOUNTING STAFF AND THE EXECUTIVE DIRECTOR COMPLETE A 990 QUESTIONNAIRE PROVIDED TO NYSBC BY ITS INDEPENDENT AUDIT FIRM. A DRAFT FORM 990 IS THEN PREPARED BY THE INDEPENDENT AUDIT FIRM. IT IS REVIEWED AND APPROVED BY THE EXECUTIVE DIRECTOR OF THE CORPORATION BEFORE THE FINAL FORM 990 IS SUBMITTED TO THE IRS. THE FORM 990 IS THEN MADE AVAILABLE TO THE REMAINING MEMBERS OF THE BOARD OF DIRECTORS UPON REQUEST. FORM 990, PART VI, SECTION B, LINE 12C THE BOARD OF DIRECTORS APPROVED THE CREATION OF A CONFLICTS RESOLUTION COMMITTEE COMPOSED OF MEMBERS OF THE BOARD OF DIRECTORS. NYSBC'S CONFLICT OF INTEREST POLICY IS REVIEWED AND REVISED PERIODICALLY BY THE ORGANIZATION'S OFFICERS AND COUNSEL. ALL EMPLOYEES ARE PROVIDED WITH A COPY OF THE POLICY AND ARE REQUIRED TO COMPLETE A CONFLICT OF INTEREST DISCLOSURE FORM ANNUALLY. DISCLOSURE FORMS ARE REVIEWED BY THE EXECUTIVE DIRECTOR AND CONFLICTS ARE SUBMITTED TO THE CONFLICTS RESOLUTION COMMITTEE FOR APPROPRIATE ACTION, IF NECESSARY. THE CONFLICT OF INTEREST POLICY IS POSTED ON NYSBC'S INTRANET. FORM 990, PART VI, SECTION B, LINE 15A THE EXECUTIVE COMMITTEE OF THE BOARD OF DIRECTORS DETERMINES COMPENSATION FOR THE ORGANIZATION'S EXECUTIVE DIRECTOR. THE PROCESS INCLUDES A COMPARISON OF COMPENSATION FOR A SIMILAR POSITION AT SIMILAR INSTITUTIONS. THE EXECUTIVE COMMITTEE MEETS TO DISCUSS EXECUTIVE COMPENSATION. COMPARISON ADMINISTRATOR DATA WAS REVIEWED FROM IVY LEAGUE SCHOOLS AND A COHORT OF NOT-FOR-PROFIT RESEARCH INSTITUTES (MERCER SURVEY). IN FEBRUARY 2014 THE EXECUTIVE COMMITTEE HELD A MEETING REGARDING WILLA APPEL'S COMPENSATION FOR FISCAL YEAR 2014. FORM 990, PART VI, SECTION C, LINE 19 THE CORPORATION'S GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS ARE AVAILABLE TO THE PUBLIC UPON REQUEST. FORM 990, PART XII, LINE 2C: THE PROCESS HAS NOT CHANGED FROM THE PRIOR YEAR.