2015-11-16T11:11:08-06:00 2014-12-31 720398470 HEARD MCELROY & VESTAL LLC 333 TEXAS STREET SUITE 1525 SHREVEPORT LA 71101 990 2014-01-01 760497352 INSTITUTE OF ORTHOPEDIC RESEARCH AND EDUCATION INST 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 JIM BOCELL MD PRESIDENT 7136104270 2015-11-06 1 ROY E PRESTWOOD P00419967 3184291525 2015-11-06 2014 2016-02-25 16:41:14Z JAMES BOCELL MD 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 1405346 0 X WWW.IORE.NET X 1995 TX IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 5 5 25 15 0 0 738000 850000 472084 554560 104004 108 1446 678 1315534 1405346 0 0 0 0 929047 860868 0 0 0 449396 457274 1378443 1318142 -62909 87204 204844 298614 8774 14664 196070 283950 X IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 0 0 28784 55235 EXPERIMENTAL SIMULATION OF TRIBO-CORROSION OF MODULAR JUNCTIONS IN TOTAL HIP PROSTHESESTHE ALARMING INCIDENCE OF ADVERSE TISSUE REACTIONS IN PATIENTS WITH METAL-ON-METAL TOTAL HIP REPLACEMENTS HAS LED TO INCREASED ATTENTION ON THE OCCURRENCE OF TRIBO-CORROSION OF THE MODULAR HEAD-NECK JUNCTION. THIS PHENOMENON LEADS TO SEVERE TISSUE REACTIONS WITH IRREVERSIBLE DAMAGE OF BONE, MUSCLE AND NERVE SECONDARY TO THE FORMATION OF "PSEUDOTUMORS" EXTENDING FROM THE JOINT CAPSULE. HE FACTORS RESPONSIBLE FOR THIS DEVASTATING COMPLICATION INCLUDE THE DESIGN OF THE PROSTHETIC COMPONENTS, THEIR MATERIAL OF MANUFACTURE, AND THE METHOD OF INTRAOPERATIVE ASSEMBLY. PREVIOUS INVESTIGATORS HAVE SHOWN THAT THE IMPLANT DAMAGE PATTERNS SEEN IN IMPLANT RETRIEVALS CAN BE REPRODUCED IN VITRO USING LONG-TERM PHYSICAL SIMULATION, HOWEVER THIS IS OFTEN IMPRACTICAL DUE TO THE COST AND DURATION OF REPETITIVE LOADING IN THE LABORATORY. AN ALTERNATIVE APPROACH IS TO USE AN ACCELERATED SCREENING TEST TO PREDICT WHICH COMBINATIONS OF MATERIALS AND DESIGNS WILL PROVIDE ACCEPTABLE PERFORMANCE IN CLINICAL USE. GIVEN THE LARGE ASSORTMENT OF VARIABLES KNOWN TO INFLUENCE THE IN VIVO PERFORMANCE OF MODULAR JUNCTIONS, WE HAVE EMBARKED ON PHYSICAL AND VIRTUAL METHODS OF PREDICTING THE IMPACT OF THESE PARAMETERS PRIOR TO CONDUCTING LONG-TERM PHYSICAL TESTS. DURING 2014, THE INSTITUTE OF ORTHOPEDIC RESEARCH & EDUCATION DEVELOPED STANDARD TEST METHODS OF EVALUATING THE PERFORMANCE OF DIFFERENT DESIGN CHOICES, MATERIALS AND TEST CONDITIONS AFFECTING MODULAR JUNCTIONS IN ARTIFICIAL HIPS. THIS WAS COMBINED WITH REAL TIME MEASUREMENTS OF THE ELECTROCHEMICAL CONDITIONS PRESENT AT THE HEAD-NECK JUNCTION (CORROSION RATE AND POTENTIAL). 32605 DEVELOPMENT OF A COMPUTATIONAL SIMULATION OF RELATIVE MOTION AT MODULAR JUNCTIONS IN HIP PROSTHESES. ONE OF THE FREQUENTLY CITED CAUSES OF EXCESSIVE WEAR AND CORROSION OF MODULAR TAPER JOINTS IN HIP PROSTHESES IS MISMATCH IN THE ANGLE OF THE MALE AND FEMALE TAPERS. EXCESSIVE ANGULAR-MISMATCH CAN LEAD TO RELATIVE MOTION AT THE MODULAR INTERFACE, AND TRIBO-CORROSION OF THE HEAD-NECK JUNCTION SECONDARY TO DISRUPTION OF THE PASSIVE OXIDE LAYER. ALTHOUGH MANUFACTURING STANDARDS HAVE BEEN ADOPTED TO DEFINE ACCEPTABLE TOLERANCES FOR TAPER ANGLES OF MATING COMPONENTS, RECENT INVESTIGATIONS OF FAILED PROSTHETIC COMPONENTS HAVE SUGGESTED THAT STRICTER TOLERANCES OR CHANGES IN TAPER DESIGN MAY BE NECESSARY TO AVOID CLINICAL FAILURES SECONDARY TO EXCESSIVE TAPER WEAR AND CORROSION. IN THIS STUDY WE EXAMINE THE EFFECT OF ANGULAR-MISMATCH ON RELATIVE MOTION BETWEEN THE TAPER AND BORE SUBJECTED TO NORMAL GAIT LOAD USING FINITE ELEMENT METHODS.DURING 2014, WE DEVELOPED A COMPUTER SIMULATION OF A MODULAR JUNCTION OF A HIP PROSTHESIS USING A VERIFIED FINITE ELEMENT MODEL CONSISTING OF A CONVERGING HEXAHEDRAL MESH FOR THE TRUNNION (33648 ELEMENTS) AND A TETRAHEDRAL MESH FOR THE FEMORAL HEAD (51182 ELEMENTS). A FRICTION-BASED SLIDING CONTACT WAS DEFINED AT THE TAPER-BORE INTERFACE. A GAIT LOAD OF 1638N (2.34XBW, BW=700N) WAS APPLIED AT AN ANGLE OF 30O TO THE TRUNNION AXIS ON AN ASSEMBLED FEM. A LINEAR STATIC SOLUTION WAS SET UP USING SIEMENS NX-NASTRAN SOLVER. ANGULAR-MISMATCH WAS SIMULATED BY INCREMENTING THE CONICAL HALF-ANGLE OF THE BORE TO EXAMINE THESE CASES: 0O, 0.005O, 0.010O, 0.015O, 0.030O, 0.050O, 0.075O, 0.100O, 0.200O AND 0.300O. RELATIVE INTERFACE MICRO-MOTION AT THE PROXIMAL-MEDIAL POINT OF THE TAPER VARIED LITTLE WITH ANGULAR-MISMATCH FOR TOLERANCES UP TO 0.075O. HOWEVER, A MONOTONIC INCREASE IN MICRO-MOTION WAS SEEN FOR HIGHER TOLERANCES. A SIMILAR TREND WAS OBSERVED WITH RESPECT TO THE AVERAGE CONTACT PRESSURE, MAX VONMISES AND SHEAR STRESSES AT THE PROXIMAL-MEDIAL ASPECT OF THE TAPER. NON-LINEAR CORRELATION TESTS INDICATE A SIGNIFICANT CORRELATION (P<0.0001) OF MISMATCH ANGLE WITH PEAK VONMISES STRESS (R=0.965) AND RELATIVE MICRO-MOTION (R=0.964). 33622 IN VITRO SIMULATION OF BONY ATTACHMENT TO METALLIC IMPLANTS IN 2013, IORE DEVELOPED A LABORATORY SPECIALIZING IN THE EXPERIMENTAL SIMULATION OF INTERFACES BETWEEN ARTIFICIAL AND BIOLOGICAL TISSUES. THROUGH THE ADDITION OF INCUBATORS AND A STERILE WORK AREA TO THIS LABORATORY, IT HAS BEEN POSSIBLE TO CONSTRUCT A PNEUMATICALLY-DRIVEN BIOREACTOR FOR LOADING LIVE CANCELLOUS BONE SPECIMENS IN CONTACT WITH POROUS METAL SURFACES DESIGNED TO SUPPORT DIRECT TISSUE ANCHORAGE OF LOAD-BEARING CEMENTLESS IMPLANTS. DURING 2014 WE VALIDATED THE BIOREACTOR BY DEMONSTRATING THAT IT WOULD SUPPORT ASEPTIC CULTURE CONDITIONS FOR PERIODS OF UP TO 7 WEEKS AY NORMAL BODY TEMPERATURE. BASED ON THIS EXPERIENCE, A NEW, 6-STATION REACTOR WAS DESIGNED AND CONSTRUCTED FOR DEFINITIVE EXPERIMENTS INVOLVING NEW INGROWTH SURFACES GENERATED WITH 3D PRINTING. INITIAL TRIALS HAVE COMPARED OSTEOBLAST PROLIFERATION ON ALTERNATIVE SURFACE PREPARATIONS OF IMPLANT-GRADE TITANIUM-ALUMINUM-VANADIUM ALLOY COUPONS. 763980 499365 OTHER ORTHOPEDIC RESEARCH PROJECTS. 763980 499365 858991 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 14 0 1 25 1 0 0 0 0 0 0 0 0 0 0 X 5 5 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 X X KIM MCCONN 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 X JAMES BOCELL MD PRESIDENT 1.00 X X 0 0 0 BRADLEY WEINER MD VICE PRESIDENT 1.00 X X 0 0 0 STEVEN INCAVO MD DIRECTOR 0.50 X 0 0 0 KENNETH MATHIS MD DIRECTOR 1.00 X 0 0 0 WILLIAM J BRYAN MD DIRECTOR 0.50 X 0 0 0 0 0 0 0 0 0 0 0 850000 850000 RESEARCH SERVICES 541700 554560 554560 554560 108 108 638 638 MISCELLANEOUS 900099 40 40 40 1405346 554600 0 746 732430 585944 146486 44669 35735 8934 29715 23772 5943 54054 43243 10811 4959 4959 87714 87714 56840 56840 21991 21991 79944 79944 SUPPLIES 100046 92813 7233 SERVICES 75316 13108 62208 MEALS & ENTERTAINMENT 12291 12291 MOVING EXPENSES 7887 7887 10286 2577 7709 1318142 858991 459151 0 55725 130042 31200 57200 577198 465826 117919 111372 204844 298614 8774 14664 8774 14664 X 0 0 0 0 196070 283950 196070 283950 204844 298614 87204 676 0 X 0 0 0 X 150000 600000 850000 738000 850000 3188000 595087 307577 422957 472084 554560 2352265 745087 907577 1272957 1210084 1404560 5540265 0 196904 151626 348530 196904 151626 348530 5191735 86768 109603 800 104004 108 301283 86768 109603 800 104004 108 301283 1734 1800 1091 1446 678 6749 833589 1018980 1274848 1315534 1405346 5848297 0.88770 0.77040 0.05150 0.07080 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 90000 34713 55287 487198 431113 56085 111372 FORM 990, PART VI, SECTION B, LINE 11 A COPY OF THE 990 IS PROVIDED TO THE ORGANIZATION'S GOVERNING BODY BEFORE IT IS FILED. FORM 990, PART VI, SECTION B, LINE 12C THE BOARD REGULARLY AND CONSISTENTLY MONITORS AND ENFORCES THE COMPLIANCE WITH THE CONFLICT OF INTEREST POLICY BY OVERSEEING THE OPERATIONS OF THE ORGANIZATION. FORM 990, PART VI, SECTION B, LINE 15 THE PROCESS FOR DETERMINING COMPENSATION INCLUDES A REVIEW AND APPROVAL OF THE BOARD, COMPARABILITY DATA, AND CONTEMPORANEOUS SUBSTANTIATION. FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION MAKES ITS GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS AVAILABLE TO THE PUBLIC UPON REQUEST. 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