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          <StateAbbreviationCd>IL</StateAbbreviationCd>
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          <StateAbbreviationCd>CA</StateAbbreviationCd>
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        <IRCSectionDesc>Washington</IRCSectionDesc>
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          <AddressLine1Txt>PO Box 371220</AddressLine1Txt>
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        <ExplanationTxt>Difference between Part I, column e and Part II, Line 3 is investment earnings.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part III, Line 1</FormAndLineReferenceDesc>
        <ExplanationTxt>Benaroya Research Institute at Virginia Mason BRI is a world-renowned medical research institute whose work has resulted in major advances against autoimmune and immune-mediated diseases. One in 20 Americans suffers from one or more autoimmune diseases, such as type 1 diabetes, multiple sclerosis, Crohns disease and rheumatoid arthritis to name a few, and more than one out of every four Americans suffer from diseases of the immune system, such as allergies and asthma. Because these diseases are connected in the way the immune system attacks the body, BRI scientists arent focused on eliminating one or two immune system diseases - they are taking on many more. As a world leader in scientific innovation, BRIs discoveries are having significant impact on people living with these diseases today - by improving the ability to predict disease risk, decreasing disease progression and making therapies safer and better.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part III, Line 4</FormAndLineReferenceDesc>
        <ExplanationTxt>One of the unique qualities of BRI is the close integration of three types of medical research - laboratory research, translational research and clinical research - to improve peoples lives. Our scientists can address both the basic science issues and clinical applications, which is the best way to design studies with the highest potential for success. For BRI, discovery starts in the laboratory. 2014 key outcomes of the Immune Tolerance Network as well as advancements in translational research, diabetes research and other areas of immunological research are highlighted below.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part III, Line 4a</FormAndLineReferenceDesc>
        <ExplanationTxt>Funding for the Immune Tolerance Network ITN was awarded to BRIs Dr. Jerry Nepom in 2014 from the National Istitute of Allergy and Infections Disease NIAID of the National Institutes of Health NIH. The 7-year award, totaling 27 million annually supports the ITN, a research consortium established in 1999 with a primary focus on the development of new tolerogenic approaches for the treatement and prevention of disease in three clinical areas asthma and allergic diseases autoimmune diseases and immune-mediated rejection of transplanted solid organs, tissues and cells. As the Prime recipient of this grant BRI is responsible for the management of the overall grant from NIAID including oversight of all aspects of the Networks infrastructure. The major activities in 2014 were diverse, but centered on preserving the ITNs cohesive project focused environment and establishing the framework necessary for successful management of a large cooperative agreement grant. Key outcomes in 2014 include the following 1 Cross Network Integration A top priority in this reporting period was to continue the successful ITN infrastructure with the funding transition over to BRI. This required careful planning and collaboration as the ITNs major centers of operations are geographically diverse, located in Seattle, San Francisco and Bethesda. As such, very few changes were made to the existing network integration, however new relations and vital connections were developed. 2 Operations and Clinical Trial Support The ITN program team at BRI issued 152 subawards in 2014 in support of 23 active ITN clinical trials and numerous supporting ITN mechanistic trials. 3 Supplemental Funding / Partnerships The transition to the cooperative agreement included a significant budget reduction to the ITNs operating budget of approximately 22. To bridge this funding shortage, ITN central administration focused on identifying additional opportunites for supplemental funding and/or funding partnerships. a Supplemental Funding Opportunities The ITN Porgram Team at BRI submitted three supplemental funding requests in 2014. All three were awarded bringing in additional funding to the ITN BRI. The ITN Program Team was also successful in its application to allow pre-clinical work by the ITN. This greatly increased the supplemental funding opportunities to which the ITN program can apply in the future. b Partnerships Finalization of agreements with pharmaceutical partners for partial funding of two ITN studies with NIAID as the clinical sponsor. 4 Publication Activity In 2014, 24 ITN publications were published in prestigious research journals and were presented at domestic and internatioinal research conferences. These publications represented ITN research in all therapeutic focus areas of the ITN Type 1 Diabetes, Transplant, Autoimmune disease and Allergy and Asthma.</ExplanationTxt>
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        <ExplanationTxt>Translational research is a scientific approach that moves finding from the bench to the bedside and back in an expedient and systematic way. It translates new laboratory discoveries quickly into medical practices. Clinician findings are in turn shared with laboratory scientists to bring medical research full circle This transfer of knowledge between laboratory scientists and physicians leads to improved patient care, health and well-being. The research emphasis of the BRI Translational Research Program is the area of immune-mediated disease. BRI scientists and collaborators work together to study blood and serum samples along with medical and demographic data collected from people with autoimmune and immune-mediated diseases. These include multiple sclerosis, type 1 diabetes, lupus, rheumatoid arthritis, inflammatory bowel disease, allergy and asthma. BRI maintains an extensive biorepository with samples dating back to 2000, including 7 disease categories and a biorepository of healthy people for comparison purposes. Advancements in 2014 include the following 1 Scientists made discoveries that led to the isolation of a type of white blood cells that show up only in people with allergic disease. They also began work to find a unique biomarker that initiates and drives allergies. Identifying a biomarker at the top of the allergic chain reaction will help predict the onset of allergy and lead to novel vaccine approaches. This is especially important in at-risk people such as children with a life-threatening food allergy. 2 A new collaboration began in studying a critical question in type I diabetes Why do some people who get type 1 diabetes continue to produce small amounts of insulin over time while others stop Researchers have found at the time of diagnosis with type 1 diabetes that many people continue to produce small amounts of insulin. Since even small amounts of natural insulin production can decrease the long-term effects of diabetes and improve short-term clinical management, scientists search for ways to keep these remaining cells producing insulin. BRIs team of scientists is comparing the genetic and immunological factors that influence levels of insulin production in people with this disease. They intend to utilize this knowledge to develop biomarkers to monitor the immune status of people with type 1 diabetes early in their disease process. The aim would be to design a drug combination that would keep a person with type 1 diabetes producing their own insulin as long as possible. 3 New equipment was purchased that allows acceleration of research discovery through advances in technology. The next generation sequencer, Illumina HiSeq 2500, is Illuminas newest version of the HiSeq instruments and will dramatically increase the sequencing capacity and data yield of the sequencing services offered by the Genomics Core, as well as decrease the cost of sequencing for BRIs labs.</ExplanationTxt>
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        <ExplanationTxt>BRI is dedicated to seeking ways to eliminate type 1 diabetes, while at the same time looking for therapies to prevent, reverse and intervene in the disease at all stages. BRI is an international leader in type 1 diabetes research and has investigated it for more than 30 years, starting with identification of a genetic marker for the disease. Progress in 2014 includes 1 BRI became the TrialNet Hub which supports and advocates for TrialNets clinical centers across the international network, encouraging collaboration and developing processes to streamline recruitment and clinical operations. The TrialNet Network is supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health NIH. The network includes 21 Clinical Centers working in cooperation with more than 200 screening and clinical research sites throughout the United States and seven other countries. TrialNet is dedicated to the study, prevention and early treatment of type 1 diabetes. Clinical trials have identified markers for risk and disease progression in diabetes and are testing therapies to intervene prior to onset of clinical symptoms, by blocking the immune attack on pancreatic beta cells that produce insulin. 2 BRI scientists are investigating the molecular mechanisms of the type 1 diabetes autoimmune response, and of immune interactions with each therapy, to better understand disease progression and uncover new approaches to treatment. These studies are also developing methods to better predict a persons disease risk and provide earlier diagnoses so that patients can begin treatments earlier, at a time when more beta cells remain and more of the insulin production function can be saved. Teams of BRI investigators are developing discovery pipelines for analysis of clinical trial samples to better understand the way different individuals respond to different therapies through interrogation of transcriptional and phenotypic properties of individual immune cells. This information is a cornerstone for tailoring therapy specifically to individuals - the right treatment for the right person at the right time. 3 Through analysis of metabolic and immunological profiles, the Diabetes Research Program and colleagues created new algorithms to track and predict the clinical course of type 1 diabetes, essential for developing innovative prevention and islet preservation therapies.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part III, Line 4d</FormAndLineReferenceDesc>
        <ExplanationTxt>Other Advances. 1 Laboratory studies prospered, particularly in discovering new biomarkers and mechanisms of diseases across a broad scope of immunological dysfunction. 2 Studies in allergies identified important specific molecular signals in people with allergy to shrimp and to grass pollen, which will enable personalized monitoring of people with these conditions. 3 Systems Immunology reported several innovative transcriptional profiling studies, including analysis of sepsis and systemic lupus. 4 Researchers identified a novel profile for melanoma that correlates with poor clinical outcomes related to the immunological response to the tumor. 5 Scientists characterized a new type of immunological recognition in patients with rheumatoid arthritis and type 1 diabetes. 6 The Immunology Research Program described complex interactions within T lymphocytes that determine cell lineage and fate, a balance required for normal homeostasis and immune response. 7 A new Computing Cluster for data-intense projects was launched with expanded capabilities for analysis and storage.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Section A, Line 1a</FormAndLineReferenceDesc>
        <ExplanationTxt>The governing body delegates to an Executive Committee comprised of four officers of the Board and the Chairs of each standing Board Committee, the authority of the Board of Directors in the management of the corporation as may be deemed by the Executive Committee to be appropriate, to be exercised in time periods between regularly scheduled meetings of the Board of Directors provided that the Executive Committee has the authority to act only in time sensitive or emergency situations. The Director and the Executive Director of the corporation serve as ex officio members of the Executive Committee without voting rights. The Executive Committee does not have the authority to amend, alter or repeal the bylaws elect, appoint or remove any member of such Executive Committee or any director or officer of the corporation amend the articles of incorporation adopt a plan of merger or adopt a plan of consolidation with another corporation authorize the sale, lease or exchange of all or substantially all the property and assets of the corporation not in the ordinary course of business authorize the voluntary dissolution of the corporation or revoke proceedings therefore adopt a plan for the distribution of the assets of the corporation or amend, alter or repeal any resolution of the Board which by its terms provides that it shall not be amended, altered or repealed by such Executive Committee. The Executive Committee also serves as the planning committee for the Board of Directors and oversees any compliance issues raised by the Board of Directors.</ExplanationTxt>
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        <ExplanationTxt>Virginia Mason Health System VMHS is the sole corporate member of Benaroya Research Institute at Virginia Mason BRI. VMHS as the sole voting member has the following approval rights a election or appointment of Directors and Officers of the Board of Directors b removal of Directors and Officers of the Board of Directors including any executive officer of the corporation c approval of all long-range and short-range plans proposed by the Board of Directors d approval of the annual capital and operating budgets proposed by the Board of Directors e approval of the borrowing of funds where the amount borrowed is in excess of Five Hundred Thousand Dollars 500,000 f approval of the sale, lease, exchange, mortgage, pledge or disposal of all or substantially all of the property and assets g approval of all amendments to or repeal of the Agreement Agreement Association or the Bylaws of the corporation h all other rights and powers as specified in the Washington Nonprofit Corporation Act.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 11b</FormAndLineReferenceDesc>
        <ExplanationTxt>The Virginia Mason Health System Audit and Compliance Committee ACC, a committee composed of independent community members has been delegated responsibility for oversight of the annual Form 990 preparation process including a selection, engagement, and review of the performance of the independent tax preparer b review of the annual draft Form 990 tax return, and c recommendation of the final Form 990 tax return for review to the BRI Board of Directors. Annually, at the September meeting, management and the tax preparer provides the ACC with an initial draft of the Form 990 and present an overview of the Form 990 preparation process. The final draft Form 990 is reviewed and approved by the ACC in November followed by a Board review of the final Form 990 prior to filing. The final Form 990 tax return is provided to each member of the Board of Directors via electronic delivery.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>The Virginia Mason Health System Governance Committee has been delegated accountability for oversight of the process for disclosure, evaluation and management of conflict of interest involving any member of the Benaroya Research Institute at Virginia Mason BRI Board of Directors, executive leadership or key employees Covered Person. Pursuant to the Conflict of Interest Policy, an annual conflict of interest questionnaire is distributed to all Covered Persons. In addition, a Covered Person has an on-going duty to disclose the existence of a conflict of interest at any time an actual or potential conflict arises. Each Covered Person is required upon appointment and annually thereafter to attest to a statement that affirms that such person has a received a copy of the Conflict of Interest Policy b has read and understands the Policy c has agreed to comply with the Policy and d understands that BRI is a charitable organization and that in order to maintain its federal tax exemption must engage in activities that accomplish its tax-exempt purposes. Written disclosures are reviewed by the Governance Committee to determine if an actual or potential conflict of interest exists and if so, how it should be managed. The Covered Person is informed in writing regarding the determination the Conflict of Interest Management Plan. No Covered Person with an actual or potential conflict of interest shall engage in an activity on BRIs behalf related to the disclossed actual or potential Conflict of Interest unless such activity is permitted by the Conflict of Interest Management Plan or until the Covered Person has undertaken all steps set forth in the Management Plan to manage, reduce or eliminate the conflict. All Covered Person have a duty to disclose the existence of any actual or potential conflict of interest with respect to meeting agenda items. The Conflict of Interest Policy requires that copies of the Conflict of Interest Questionnaire be completed annually by each covered Person and any Conflict of Interest Managemenet Plan be maintained.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, Line 15</FormAndLineReferenceDesc>
        <ExplanationTxt>The VMHS Compensation and Benefits board Committee, a committee composed solely of independent directors none of whom have a conflict of interest, is accountable for setting reasonable total compensation packages for each executive, officer and key employee Executive consistent with VMHS/BRIs philosophy and principles. The Committee approves annual goals and performance criteria which are used in determining merit increases and variable compensation opportunities. The Committee assesses performance against these goals. The Committee selects and engages a qualified independent compensation consultant to review and analyze the total compensation and benefits packages of the Executives. The Committee as part of its analysis obtsins from the compensation consultant appropriate comparability data including total compensation paid by similarly situated organizations for positions that are functionally comparable to each of the Executives. The Committee will consider the significant terms of the agreement with each Executive including the total compensation to be paid and the employees duties and responsibilities. Consistent with VMHS/BRIs compensation philosophy and principles, the Committee approves total compensation packages for each of the Executives based on information presented to the Committee, reasonableness and the best interest of BRI. The Committees decisions regarding compensation for each Executive are documented in written resolutions and minutes of the Committee. The Committee promptly reports its actions to the VMHS board which reports are reflected in the Boards minutes. The individual positions who were reviewed in 2014 were the Board Director, Carla Greenbaum, BRI Director, and Executive Director and Chief Financial Officer.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Section C, Line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>The organizations Articles, Bylaws, Conflict of Interest Policy and financial statements are made available upon request.</ExplanationTxt>
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