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        <TotalAmt>0</TotalAmt>
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        <TotalAmt>7388110</TotalAmt>
        <ProgramServicesAmt>6895153</ProgramServicesAmt>
        <ManagementAndGeneralAmt>492957</ManagementAndGeneralAmt>
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      <PensionPlanContributionsGrp>
        <TotalAmt>37513</TotalAmt>
        <ProgramServicesAmt>34776</ProgramServicesAmt>
        <ManagementAndGeneralAmt>2737</ManagementAndGeneralAmt>
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      <OtherEmployeeBenefitsGrp>
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        <ManagementAndGeneralAmt>171365</ManagementAndGeneralAmt>
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      <PayrollTaxesGrp>
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        <ProgramServicesAmt>590424</ProgramServicesAmt>
        <ManagementAndGeneralAmt>54277</ManagementAndGeneralAmt>
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      <FeesForServicesManagementGrp>
        <TotalAmt>338545</TotalAmt>
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        <ManagementAndGeneralAmt>158865</ManagementAndGeneralAmt>
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      <FeesForServicesLegalGrp>
        <TotalAmt>358806</TotalAmt>
        <ProgramServicesAmt>273767</ProgramServicesAmt>
        <ManagementAndGeneralAmt>85039</ManagementAndGeneralAmt>
      </FeesForServicesLegalGrp>
      <FeesForServicesAccountingGrp>
        <TotalAmt>127095</TotalAmt>
        <ManagementAndGeneralAmt>127095</ManagementAndGeneralAmt>
      </FeesForServicesAccountingGrp>
      <FeesForServicesLobbyingGrp>
        <TotalAmt>0</TotalAmt>
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      <FeesForServicesProfFundraising>
        <TotalAmt>0</TotalAmt>
      </FeesForServicesProfFundraising>
      <FeesForSrvcInvstMgmntFeesGrp>
        <TotalAmt>0</TotalAmt>
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        <TotalAmt>660507</TotalAmt>
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      <AdvertisingGrp>
        <TotalAmt>0</TotalAmt>
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      <OfficeExpensesGrp>
        <TotalAmt>507864</TotalAmt>
        <ProgramServicesAmt>169288</ProgramServicesAmt>
        <ManagementAndGeneralAmt>338576</ManagementAndGeneralAmt>
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      <InformationTechnologyGrp>
        <TotalAmt>892978</TotalAmt>
        <ProgramServicesAmt>406670</ProgramServicesAmt>
        <ManagementAndGeneralAmt>486308</ManagementAndGeneralAmt>
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      <RoyaltiesGrp>
        <TotalAmt>150794</TotalAmt>
        <ProgramServicesAmt>150794</ProgramServicesAmt>
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      <OccupancyGrp>
        <TotalAmt>2503559</TotalAmt>
        <ProgramServicesAmt>2217858</ProgramServicesAmt>
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      <TravelGrp>
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        <ProgramServicesAmt>42000</ProgramServicesAmt>
        <ManagementAndGeneralAmt>55818</ManagementAndGeneralAmt>
      </TravelGrp>
      <PymtTravelEntrtnmntPubOfclGrp>
        <TotalAmt>0</TotalAmt>
      </PymtTravelEntrtnmntPubOfclGrp>
      <ConferencesMeetingsGrp>
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        <ProgramServicesAmt>7832</ProgramServicesAmt>
        <ManagementAndGeneralAmt>11770</ManagementAndGeneralAmt>
      </ConferencesMeetingsGrp>
      <InterestGrp>
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        <ManagementAndGeneralAmt>1153</ManagementAndGeneralAmt>
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      <PaymentsToAffiliatesGrp>
        <TotalAmt>0</TotalAmt>
      </PaymentsToAffiliatesGrp>
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        <ManagementAndGeneralAmt>68029</ManagementAndGeneralAmt>
      </InsuranceGrp>
      <OtherExpensesGrp>
        <Desc>COLLABORATION TERMINATION FEE</Desc>
        <TotalAmt>15000000</TotalAmt>
        <ProgramServicesAmt>15000000</ProgramServicesAmt>
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      <OtherExpensesGrp>
        <Desc>LAB SUPPLIES</Desc>
        <TotalAmt>6718459</TotalAmt>
        <ProgramServicesAmt>6718459</ProgramServicesAmt>
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      <OtherExpensesGrp>
        <Desc>OUTSOURCED RESEARCH SERVICES</Desc>
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      <OtherExpensesGrp>
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        <ProgramServicesAmt>682104</ProgramServicesAmt>
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      <TotalFunctionalExpensesGrp>
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      <PledgesAndGrantsReceivableGrp>
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      <InventoriesForSaleOrUseGrp>
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      <IntangibleAssetsGrp>
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      <GrantsPayableGrp>
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      <DeferredRevenueGrp>
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      <TaxExemptBondLiabilitiesGrp>
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        <EOYAmt>0</EOYAmt>
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      <EscrowAccountLiabilityGrp>
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      <LoansFromOfficersDirectorsGrp>
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      <MortgNotesPyblScrdInvstPropGrp>
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      <UnsecuredNotesLoansPayableGrp>
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        <EOYAmt>0</EOYAmt>
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        <EOYAmt>861886</EOYAmt>
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      <TotalLiabilitiesGrp>
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        <EOYAmt>11310753</EOYAmt>
      </TotalLiabilitiesGrp>
      <OrganizationFollowsSFAS117Ind>X</OrganizationFollowsSFAS117Ind>
      <UnrestrictedNetAssetsGrp>
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        <EOYAmt>28945149</EOYAmt>
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        <EOYAmt>0</EOYAmt>
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      <PermanentlyRstrNetAssetsGrp>
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      <ReconcilationRevenueExpnssAmt>24034949</ReconcilationRevenueExpnssAmt>
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <AccountantCompileOrReviewInd>false</AccountantCompileOrReviewInd>
      <FSAuditedInd>true</FSAuditedInd>
      <FSAuditedBasisGrp>
        <SeparateBasisFinclStmtInd>X</SeparateBasisFinclStmtInd>
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      <AuditCommitteeInd>false</AuditCommitteeInd>
      <FederalGrantAuditRequiredInd>false</FederalGrantAuditRequiredInd>
    </IRS990>
    <IRS990ScheduleA documentId="IRS990ScheduleA">
      <MedicalResearchOrganizationInd>X</MedicalResearchOrganizationInd>
      <HospitalNameAndAddressGrp>
        <SupportedOrganizationName>
          <BusinessNameLine1Txt>UC San Diego Medical Center</BusinessNameLine1Txt>
        </SupportedOrganizationName>
        <CityNm>San Diego</CityNm>
        <StateAbbreviationCd>CA</StateAbbreviationCd>
      </HospitalNameAndAddressGrp>
      <HospitalNameAndAddressGrp>
        <SupportedOrganizationName>
          <BusinessNameLine1Txt>Scripps Memorial Hospital La Jolla</BusinessNameLine1Txt>
        </SupportedOrganizationName>
        <CityNm>La Jolla</CityNm>
        <StateAbbreviationCd>CA</StateAbbreviationCd>
      </HospitalNameAndAddressGrp>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="IRS990ScheduleB">
      <ContributorInformationGrp>
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        <ContributorBusinessName>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorBusinessName>
        <ContributorUSAddress>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorUSAddress>
        <TotalContributionsAmt>RESTRICTED</TotalContributionsAmt>
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    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="IRS990ScheduleD">
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      <HeldWorksArtGrp />
      <CYMinus3YrEndwmtFundGrp />
      <CYMinus4YrEndwmtFundGrp />
      <LandGrp />
      <BuildingsGrp />
      <LeaseholdImprovementsGrp>
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        <DepreciationAmt>22057</DepreciationAmt>
        <BookValueAmt>228715</BookValueAmt>
      </LeaseholdImprovementsGrp>
      <EquipmentGrp>
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        <DepreciationAmt>3164107</DepreciationAmt>
        <BookValueAmt>5829295</BookValueAmt>
      </EquipmentGrp>
      <OtherLandBuildingsGrp>
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        <BookValueAmt>29673</BookValueAmt>
      </OtherLandBuildingsGrp>
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      <OtherLiabilitiesOrgGrp>
        <Desc>DEFERRED RENT</Desc>
        <Amt>861886</Amt>
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      <TotalLiabilityAmt>861886</TotalLiabilityAmt>
      <FootnoteTextInd>X</FootnoteTextInd>
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      <RevenueNotReportedAmt>975675</RevenueNotReportedAmt>
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      <ExpensesSubtotalAmt>43450698</ExpensesSubtotalAmt>
      <TotalExpensesPerForm990Amt>43450698</TotalExpensesPerForm990Amt>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>ADDITIONAL INFORMATION</FormAndLineReferenceDesc>
        <ExplanationTxt>INCOME TAXES: THE INSTITUTE IS A QUALIFIED NONPROFIT ORGANIZATION THAT IS GENERALLY EXEMPT FROM FEDERAL AND STATE INCOME TAXES UNDER SECTION 501(C)(3) OF THE INTERNAL REVENUE CODE AND SECTION 23701(D) OF THE CALIFORNIA REVENUE AND TAXATION CODE. THIS EXEMPTION IS FOR ALL INCOME TAXES EXCEPT FOR THOSE ASSESSED ON UNRELATED BUSINESS INCOME (UBI), IF ANY. IN ORDER TO MAINTAIN THAT STATUS, THE INSTITUTE IS PRECLUDED FROM MAKING CERTAIN EXPENDITURES, PRINCIPALLY IN SUPPORT OF POLITICAL PARTIES. MANAGEMENT BELIEVES THAT NO SUCH EXPENDITURES HAVE BEEN MADE. THE INSTITUTE IS NOT A PRIVATE FOUNDATION. THE INSTITUTE ADOPTED ACCOUNTING GUIDANCE RELATING TO ACCOUNTING FOR UNCERTAINTY IN INCOME TAXES, WHICH IS PRIMARILY CODIFIED IN FINANCIAL ACCOUNTING STANDARDS BOARD (FASB) ACCOUNTING STANDARDS CODIFICATION 740. THE INSTITUTE FILES A FORM 990 (RETURN OF ORGANIZATION EXEMPT FROM INCOME TAX) ANNUALLY. WHEN THESE RETURNS ARE FILED, IT IS HIGHLY CERTAIN THAT SOME POSITIONS TAKEN WOULD BE SUSTAINED UPON EXAMINATION BY THE TAXING AUTHORITIES, WHILE OTHERS ARE SUBJECT TO UNCERTAINTY ABOUT THE MERITS OF THE TAX POSITION TAKEN OR THE AMOUNT OF THE POSITION THAT WOULD ULTIMATELY BE SUSTAINED. EXAMPLES OF TAX POSITIONS COMMON TO THE INSTITUTE INCLUDE SUCH MATTERS AS THE TAX-EXEMPT STATUS OF THE ENTITY AND VARIOUS POSITIONS RELATIVE TO POTENTIAL SOURCES OF UBI. UBI IS REPORTED ON FORM 990-T, AS APPROPRIATE. THE BENEFIT OF TAX POSITION IS RECOGNIZED IN THE FINANCIAL STATEMENTS IN THE PERIOD DURING WHICH, BASED ON ALL AVAILABLE EVIDENCE, MANAGEMENT BELIEVES IT IS MORE LIKELY THAN NOT THAT THE POSITION WILL BE SUSTAINED UPON EXAMINATION, INCLUDING THE RESOLUTION OF APPEALS OR LITIGATION PROCESSES, IF ANY. TAX POSITIONS ARE NOT OFFSET OR AGGREGATED WITH OTHER POSITIONS. TAX POSITIONS THAT MEET THE MORE-LIKELY-THAN-NOT RECOGNITION THRESHOLD ARE MEASURED AS THE LARGEST AMOUNT OF TAX BENEFIT THAT IS MORE THAN 50 PERCENT LIKELY TO BE REALIZED ON SETTLEMENT WITH THE APPLICABLE TAXING AUTHORITY. THE PORTION OF THE BENEFITS ASSOCIATED WITH TAX POSITIONS TAKEN THAT EXCEEDS THE AMOUNT MEASURED AS DESCRIBED ABOVE IS REFLECTED AS A LIABILITY FOR UNRECOGNIZED TAX BENEFITS IN THE ACCOMPANYING STATEMENTS OF FINANCIAL POSITION, ALONG WITH ANY ASSOCIATED INTEREST AND PENALTIES THAT WOULD BE PAYABLE TO THE TAXING AUTHORITIES UPON EXAMINATION. AS OF AUGUST 31, 2015 AND 2014, THE INSTITUTE HAS ADDRESSED UNCERTAINTY IN ITS INCOME TAX POSITION UNDER THE GUIDANCE, AND THERE ARE NO UNRECOGNIZED/DERECOGNIZED TAX BENEFITS REQUIRING AN ACCRUAL. FORMS 990 AND 990-T FILED BY THE INSTITUTE ARE SUBJECT TO EXAMINATION BY THE INTERNAL REVENUE SERVICE UP TO THREE YEARS FROM THE EXTENDED DUE DATE OF EACH RETURN. MANAGEMENT BELIEVES FORMS 990 AND 990-T HAVE BEEN FILED APPROPRIATELY.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleD>
    <IRS990ScheduleJ documentId="IRS990ScheduleJ">
      <SeverancePaymentInd>false</SeverancePaymentInd>
      <SupplementalNonqualRtrPlanInd>false</SupplementalNonqualRtrPlanInd>
      <EquityBasedCompArrngmInd>false</EquityBasedCompArrngmInd>
      <CompBasedOnRevenueOfFlngOrgInd>false</CompBasedOnRevenueOfFlngOrgInd>
      <CompBsdOnRevRelatedOrgsInd>false</CompBsdOnRevRelatedOrgsInd>
      <CompBsdNetEarnsFlngOrgInd>false</CompBsdNetEarnsFlngOrgInd>
      <CompBsdNetEarnsRltdOrgsInd>false</CompBsdNetEarnsRltdOrgsInd>
      <AnyNonFixedPaymentsInd>false</AnyNonFixedPaymentsInd>
      <InitialContractExceptionInd>false</InitialContractExceptionInd>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>Matthew Tremblay</PersonNm>
        <TitleTxt>Secretary</TitleTxt>
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        <CompensationBasedOnRltdOrgsAmt>0</CompensationBasedOnRltdOrgsAmt>
        <BonusFilingOrganizationAmount>0</BonusFilingOrganizationAmount>
        <BonusRelatedOrganizationsAmt>0</BonusRelatedOrganizationsAmt>
        <OtherCompensationFilingOrgAmt>0</OtherCompensationFilingOrgAmt>
        <OtherCompensationRltdOrgsAmt>0</OtherCompensationRltdOrgsAmt>
        <DeferredCompensationFlngOrgAmt>26250</DeferredCompensationFlngOrgAmt>
        <DeferredCompRltdOrgsAmt>0</DeferredCompRltdOrgsAmt>
        <NontaxableBenefitsFilingOrgAmt>0</NontaxableBenefitsFilingOrgAmt>
        <NontaxableBenefitsRltdOrgsAmt>0</NontaxableBenefitsRltdOrgsAmt>
        <TotalCompensationFilingOrgAmt>195700</TotalCompensationFilingOrgAmt>
        <TotalCompensationRltdOrgsAmt>0</TotalCompensationRltdOrgsAmt>
        <CompReportPrior990FilingOrgAmt>0</CompReportPrior990FilingOrgAmt>
        <CompReportPrior990RltdOrgsAmt>0</CompReportPrior990RltdOrgsAmt>
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      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>Arnab ChaterJee</PersonNm>
        <TitleTxt>Director, Medicinal Chemistry</TitleTxt>
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        <CompensationBasedOnRltdOrgsAmt>0</CompensationBasedOnRltdOrgsAmt>
        <BonusFilingOrganizationAmount>0</BonusFilingOrganizationAmount>
        <BonusRelatedOrganizationsAmt>0</BonusRelatedOrganizationsAmt>
        <OtherCompensationFilingOrgAmt>0</OtherCompensationFilingOrgAmt>
        <OtherCompensationRltdOrgsAmt>0</OtherCompensationRltdOrgsAmt>
        <DeferredCompensationFlngOrgAmt>32130</DeferredCompensationFlngOrgAmt>
        <DeferredCompRltdOrgsAmt>0</DeferredCompRltdOrgsAmt>
        <NontaxableBenefitsFilingOrgAmt>0</NontaxableBenefitsFilingOrgAmt>
        <NontaxableBenefitsRltdOrgsAmt>0</NontaxableBenefitsRltdOrgsAmt>
        <TotalCompensationFilingOrgAmt>193242</TotalCompensationFilingOrgAmt>
        <TotalCompensationRltdOrgsAmt>0</TotalCompensationRltdOrgsAmt>
        <CompReportPrior990FilingOrgAmt>0</CompReportPrior990FilingOrgAmt>
        <CompReportPrior990RltdOrgsAmt>0</CompReportPrior990RltdOrgsAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="IRS990ScheduleO">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990 Part VI Line 2</FormAndLineReferenceDesc>
        <ExplanationTxt>PRESIDENT AND BOARD MEMBER PETER SCHULTZ SERVES ON A NUMBER OF OTHER CORPORATE BOARDS WITH BOARD MEMBER ISY GOLDWASSER.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990 Part VI Line 11b</FormAndLineReferenceDesc>
        <ExplanationTxt>INFORMATION USED TO PREPARE THE FORM 990 WAS COMPILED BY CALIBR'S PERSONNEL. THE RETURN WAS PREPARED WITH THE ASSISTANCE OF ITS PUBLIC ACCOUNTING FIRM. THE FORM 990 WAS REVIEWED BY CALIBR'S AUDIT COMMITTEE, WHICH HAS AUTHORITY AND OVERSIGHT OF CALIBR'S AUDIT AND TAX PREPARATION. A COMPLETE COPY OF THE FORM 990 WAS PROVIDED TO THE FULL BOARD AFTER REVIEW BY THE AUDIT COMMITTEE AND PRIOR TO FILING WITH THE IRS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990 Part VI Line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>ON AN ANNUAL BASIS, CALIBR DISTRIBUTES CONFLICT OF INTEREST QUESTIONNAIRES WHICH THE BOARD EMBERS, OFFICERS, AND KEY EMPLOYEES COMPLETE AND RETURN. THE PRESIDENT AND VP OF FINANCE AND OPERATIONS REVIEW THE RETURNED FORMS FOR COMPLIANCE. IF A CONFLICT IS DISCOVERED IT IS ESCALATED TO THE APPROPRIATE PARTY WITHIN CALIBR AND THE PERSON RECUSES HIMSELF OR HERSELF FROM THE GOVERNING BODY'S DELIBERATIONS AND DECISIONS IN THE TRANSACTION, AND THE MEETING MINUTES REFLECT THAT THE PARTY IN QUESTION RECUSED THEMSELVES. IN THE EVENT A CONFLICT ARISES THE INDEPENDENT BOARD MEMBERS DISCUSS THE TRANSACTION, THE ALTERNATIVES, AND EVALUATE WHAT IS BEST FOR THE ORGANIZATION. MEETING MINUTES REFLECT THE DISCUSSIONS AND DECISION, INCLUDING WHO VOTED AND WHO WAS RECUSED FROM DISCUSSION AND VOTING. BOARD MEMBERS ARE REQUIRED TO BRING FORTH ANY NEW CONFLICTS OF INTEREST AS THEY ARISE.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990 Part VI Line 15a</FormAndLineReferenceDesc>
        <ExplanationTxt>IN ACCORDANCE WITH THE GOVERNING PRINCIPLES OF THE INSTITUTE'S DIRECTOR COMPENSATION POLICY, THE MAXIMUM TOTAL CASH COMPENSATION IS TO BE DETERMINED BY PUBLICLY AVAILABLE DATA AS REVIEWED BY NON-EMPLOYEE, DISINTERESTED MEMBERS OF THE BOARD. THE BOARD ENSURES THAT COMPENSATION OF THE INSTITUTE DIRECTOR SHALL BE REVIEWED NO LESS THAN ONCE IN THREE YEARS BY DISINTERESTED MEMBERS OF THE BOARD. CALIBR'S PRESIDENT IS ELIGIBLE FOR A BASE SALARY FOR PERFORMANCE OF SERVICES IN ANY GIVEN ONE YEAR PERIOD AND SHALL AUTOMATICALLY BE DUE THE BOARD'S PREDETERMINED AND CONTEMPORANEOUSLY APPROVED FAIR AND REASONABLE BASE SALARY, SUBJECT TO AN EXECUTIVE CAP OF $1.05 M PER YEAR. ADDITIONALLY, THE PRESIDENT IS ELIGIBLE TO RECEIVE BONUS INCENTIVE PAY SEPARATE FROM COMPENSATION PAYMENTS IN AMOUNTS DETERMINED BY THE BOARD AT ITS SOLE REASONABLE DISCRETION, PROVIDED THAT SUCH BONUS SHALL NOT CAUSE THE TOTAL COMPENSATION OF EXECUTIVE TO EXCEED THE EXECUTIVE CAP. AT EXECUTIVE'S SOLE DISCRETION, EXECUTIVE MAY WAIVE THE RIGHT TO RECEIVE ALL OR PART OF THE PAYMENTS DUE BEFORE RECEIPT, PROVIDED THAT THE EXECUTIVE GIVES WRITTEN NOTICE TO INSTITUTE OF THE AMOUNT OF PAYMENT(S) WAIVED. IT IS EXPRESSLY UNDERSTOOD BY CALIBR AND EXECUTIVE THAT WAIVER OF PAYMENT(S) SHALL IN NO WAY ALTER OR INFLUENCE INSTITUTE'S FUTURE PAYMENT OBLIGATIONS TO EXECUTIVE OR THE DETERMINATION OR IMPLEMENTATION OF THE EXECUTIVE CAP. THE PRESIDENT HAS WAIVED ANY OTHER FORMS OF COMPENSATION INCLUDING BONUSES AND NON-MONETARY BENEFITS AND PREREQUISITES FOR THE FISCAL YEAR ENDING 08/31/2015. OTHER OFFICER SALARIES ARE DETERMINED BY CALIBR'S PRESIDENT BASED ON COMPARABLE SALARIES FOR INDIVIDUALS HAVING SIMILAR ROLES AND RESPONSIBILITIES AT SIMILAR NON-PROFITS AND BIOTECH COMPANIES.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990 Part VI Line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS ARE AVAILABLE UPON REQUEST.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>