2016-11-15T13:59:58-06:00 2015-12-31 720398470 HEARD MCELROY & VESTAL LLC 333 TEXAS STREET SUITE 1525 SHREVEPORT LA 71101 990 2015-01-01 760497352 INSTITUTE OF ORTHOPEDIC RESEARCH AND EDUCATION INST 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 JIM BOCELL MD PRESIDENT 7136104270 2016-11-08 1 ROY E PRESTWOOD P00419967 3184291525 2016-11-08 2015 2017-02-10 21:41:12Z JAMES BOCELL MD 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 1261945 0 X WWW.IORE.NET X 1995 TX IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 5 5 25 15 0 0 850000 850000 554560 410328 108 818 678 799 1405346 1261945 0 0 0 0 860868 968300 0 0 0 457274 375571 1318142 1343871 87204 -81926 298614 217974 14664 15950 283950 202024 X IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 0 0 188283 METHODIST HOSPITAL POST-GRADUATE TRAINING PROJECTSDURING 2015, IORE SUPPORTED ACADEMIC RESEARCH PROJECTS COMPLETED BY METHODIST FELLOWS UNDERGOING TRAINING IN JOINT REPLACEMENT AND SPORTS MEDICINE, AND STUDIES PERFORMED IN COLLABORATION WITH FACULTY OF THE SPORTS MEDICINE SECTION OF THE METHODIST ORTHOPAEDIC DEPARTMENT WITH AN INTEREST IN HIP INJURIES ASSOCIATED WITH DANCE AND RECREATIONAL SPORT. THESE PROJECTS INCLUDED:1. THE ACCURACY AND REPRODUCIBILITY OF ALTERNATIVE METHODS OF MEASURING THE RANGE OF MOTION OF THE HIP, KNEE, SHOULDER AND ELBOW. CADAVER SPECIMENS WERE INSTRUMENTAL WITH ARRAS OF REFLECTIVE MARKERS WHICH ENABLED PRECISE MEASUREMENT OF THE POSITION OF THE MAJOR JOINTS IN SPACE. A TEAM OF SURGEONS, TRAINEES AND PHYSICAL THERAPISTS PERFORMED STANDARD MANEUVERS USED TO DETERMINE THE RANGE OF MOTION OF THE MAJOR JOINTS DURING STANDARD PHYSICAL EXAMINATION. THESE METHODS INCLUDED VISUAL ESTIMATION, MEASUREMENT WITH A GONIOMETER, AND PREPARATION OF PHOTOGRAPHS WHICH WERE LATER ANALYZED USING A COMPUTERIZED IMAGE-BASED MEASUREMENT TOOL. STATISTICAL ANALYSIS OF THE RESULTS ALLOWED US TO DETERMINE THE ACCURACY AND RELIABILITY OF THE 3 METHODS AND THE EFFECT OF TRAINING AND EXPERIENCE OF THE CLINICIAN PERFORMING THE MEASUREMENTS. THE RESULTS WERE SUMMARIZED IN A SERIES OF MANUSCRIPTS SUBMITTED TO PROFESSIONAL JOURNALS.2. WE COLLABORATED IN THE COLLECTION AND ANALYSIS OF CLINICAL DATA DOCUMENTING THE RESULTS OF TWO-STAGE REVISION OF INJECTED TOTAL HIP ARTHROPLASTY USING 2 ALTERNATIVE TREATMENTS: (I) IMPLANTATION OF A HEMIPROSTHESIS DURING TREATMENT OF THE INFECTION PRIOR TO IMPLANTATION OF A NEW TOTAL HIP, AND (II) IMPLANTATION OF AN ANTIBIOTIC INFUSED ARTICULATING SPACER PRIOR TO THE NEW HIP PROSTHESIS. WE DEVELOPED SPECIALIZED SOFTWARE TO COMPARE RADIOGRAPHS TAKEN AT EACH STAGE OF TREATMENT AND CALCULATED THE CHANGE IN THE POSITION OF THE IMPLANTS. THIS WORK HAS BEEN SUBMITTED FOR PUBLICATION AND WAS RECENTLY PRESENTED TO THE ANNUAL MEETING OF THE HIP SOCIETY.3. WE PERFORMED A MAJOR INVESTIGATION OF THE ROLE OF THE HIP JOINT CAPSULE IN STABILIZING THE HIP JOINT DURING FUNCTIONAL ACTIVITIES AND IDENTIFIED PARAMETERS THAT MAY BE USED TO DETECT ABNORMAL HIP MOTION THAT IS BELIEVED TO LEAD TO ARTHRITIC DEGENERATION OVER TIME. CADAVERIC SPECIMENS WERE MOUNTED IN A MECHANICAL TESTING FRAME THAT CONTROLLED THE POSTURE AND LOADING OF THE HIP. EACH SPECIMEN WAS PLACED IN A BATTERY OF POSITIONS ASSOCIATED WITH COMMON FUNCTIONAL ACTIVITIES. DURING THESE PROCEDURES, THE RELATIVE MOTION OF THE FEMORAL HEAD WITHIN THE ACETABULUM WAS MEASURED USING INFRA-RED REFLECTORS MOUNTED ON BOTH BONES. THESE EXPERIMENTAL PROCEDURES WERE REPEATED BEFORE AND AFTER MODIFICATIONS TO THE HIP CAPSULE, THE CONTINUOUS LIGAMENTOUS STRUCTURE ENCLOSING THE HIP JOINT. BY CALCULATING THE INCREASED SHIFT OF THE BONES WITHIN THE HIP JOINT IT WAS DEMONSTRATED THAT INCREASED MOTION AND "LOOSENESS" OF THE HIP ALSO LEADS TO INCREASED INSTABILITY AND MALTRACKING OF THE CARTILAGE SURFACES. THIS CHANGE IS ASSOCIATED WITH OVERLOAD OF THE CARTILAGE AND LOSS OF LUBRICATION OF THE JOINT, CONDITIONS LEADING TO ARTHRITIC CHANGES OVER TIME. 62758 STABILITY OF TIBIAL METAPHYSEAL SLEEVE IMPLANTS IN A MODEL FOR REVISION TOTAL KNEE ANTHROPLASTY WHEN TOTAL KNEE REPLACEMENTS FAIL, THE OPTIMAL STRATEGY FOR STABILIZATION OF COMPONENTS WITH THE COMPROMISED BONES OF THE KNEE IS SUBJECT OF SIGNIFICANT SPECULATION. TO RESOLVE SOME OF THE CONFOUNDING ISSUES, WE PERFORMED A BIOMECHANICAL STUDY USING POLYMERIC MODELS OF THE TIBIAL BONE THAT HAD BEEN PREPARED WITH CORTICAL DEFECTS THAT SIMULATED CONDITIONS SEEN IN SURGERY. COMMERCIAL IMPLANTS WERE IMPLANTED IN EACH MODEL IN A MANNER THAT CREATED 3 DIFFERENT LEVELS OF ENGAGEMENT OF THE METAPHYSEAL SLEEVE WITH THE PROXIMAL TIBIA IN COMBINATION WITH 3 DIFFERENT LENGTHS OF ENGAGEMENT OF THE DISTAL STEM WITH THE TIBIAL CANAL.EACH IMPLANT-MODEL CONSTRUCT WAS LOADED UNDER CONDITIONS SIMULATING THE LOADING CONDITION EXPERIENCED DURING THE STANCE PHASE OF GAIT. MOTION OCCURRING BETWEEN THE BONE MODEL AND THE IMPLANT WERE MEASURED OVER 100 CYCLES OF LOADING USING PHOTO REFLECTIVE MARKERS WITH AN OPTICAL MEASUREMENT SYSTEM. THIS WORK ALLOWED IDENTIFICATION OF THE PARAMETERS DETERMINING THE STABILITY OF REVISION PROSTHESES UNDER CONDITIONS OF INCREASING SEVERITY AND THE THRESHOLD FOR MODIFYING IMPLANT SELECTION TO MAINTAIN STABILITY OF FIXATION TO BONE. 69214 VALIDATION OF A BIOREACTOR FOR LABORATORY SIMULATION OF BONY ATTACHMENT TO METALLIC IMPLANTSIN 2013, IORE DEVELOPED A LABORATORY SPECIALIZING IN THE EXPERIMENTAL SIMULATION OF INTERFACES BETWEEN ARTIFICIAL AND BIOLOGICAL TISSUES. THROUGH THE ADDITION OF INCUBATORS AND A STERILE WORK AREA TO THIS LABORATORY, IT HAS BEEN POSSIBLE TO CONSTRUCT A PNEUMATICALLY-DRIVEN BIOREACTOR FOR LOADING LIVE CANCELLOUS BONE SPECIMENS IN CONTACT WITH POROUS METAL SURFACES DESIGNED TO SUPPORT DIRECT TISSUE ANCHORAGE OF LOAD-BEARING CEMENTLESS IMPLANTS. DURING 2015, WE CONVERTED OUR ORIGINAL SINGLE-STATION PROTOTYPE BIOREACTOR TO AN 8-STATION SYSTEM WHICH WAS USED TO PERFORM BONY INGROWTH STUDIES FOR UP TO 7 WEEKS USING FIXATION SURFACES OBTAINED FROM HIP PROSTHESES. THESE EXPERIMENTS WERE SUCCESSFUL WITHOUT LOSS OF THE ASEPTIC CONDITIONS WITHIN THE BIOREACTOR. ADDITIONAL EXPERIMENTS WERE PERFORMED EVALUATING THE RATE OF PROLIFERATION OF BONE CELLS ON IMPLANT-GRADE TITANIUM ALLOY SPECIMENTS FABRICATED BY 3D PRINTING. 719145 410693 OTHER ORTHOPEDIC RESEARCH PROJECTS. 719145 410693 1039400 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 14 0 1 25 1 0 0 0 0 0 0 0 0 0 0 X 5 5 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 X X KIM MCCONN 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 X JAMES BOCELL MD PRESIDENT 1.00 X X 0 0 0 BRADLEY WEINER MD VICE PRESIDENT 1.00 X X 0 0 0 STEVEN INCAVO MD DIRECTOR 0.50 X 0 0 0 KENNETH MATHIS MD DIRECTOR 1.00 X 0 0 0 WILLIAM J BRYAN MD DIRECTOR 0.50 X 0 0 0 0 0 0 0 0 0 0 0 850000 850000 RESEARCH SERVICES 541700 410328 410328 410328 818 818 434 434 MISCELLANEOUS 900099 365 365 365 1261945 410693 0 1252 774628 619702 154926 35523 28418 7105 103471 82777 20694 54678 43742 10936 42000 42000 3991 3991 341 341 1362 1362 2047 2047 89762 86455 3307 37551 29718 7833 24742 16734 8008 29339 29339 SUPPLIES 113408 109694 3714 MEALS & ENTERTAINMENT 9759 8682 1077 SERVICES - COMMUNICATIO 9077 8743 334 DUES/MEMBERSHIP 3625 3625 8567 1110 7457 1343871 1039400 304471 0 130042 74144 57200 57200 577198 490568 111372 86630 298614 217974 14664 15950 14664 15950 X 0 0 0 0 283950 202024 283950 202024 298614 217974 -81926 0 X 0 0 0 X 600000 850000 738000 850000 850000 3888000 307577 422957 472084 554560 399798 2156976 907577 1272957 1210084 1404560 1249798 6044976 0 151626 151626 151626 151626 5893350 109603 800 104004 108 1253 215768 109603 800 104004 108 1253 215768 1800 1091 1446 678 365 5380 1018980 1274848 1315534 1405346 1251416 6266124 0.94050 0.88770 0.03440 0.05150 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 90000 37021 52979 487198 453547 33651 86630 FORM 990, PART VI, SECTION B, LINE 11 A COPY OF THE 990 IS PROVIDED TO THE ORGANIZATION'S GOVERNING BODY BEFORE IT IS FILED. FORM 990, PART VI, SECTION B, LINE 12C THE BOARD REGULARLY AND CONSISTENTLY MONITORS AND ENFORCES THE COMPLIANCE WITH THE CONFLICT OF INTEREST POLICY BY OVERSEEING THE OPERATIONS OF THE ORGANIZATION. FORM 990, PART VI, SECTION B, LINE 15 THE PROCESS FOR DETERMINING COMPENSATION INCLUDES A REVIEW AND APPROVAL OF THE BOARD, COMPARABILITY DATA, AND CONTEMPORANEOUS SUBSTANTIATION. FORM 990, PART VI, SECTION C, LINE 19 THE ORGANIZATION MAKES ITS GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY, AND FINANCIAL STATEMENTS AVAILABLE TO THE PUBLIC UPON REQUEST. 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