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      <FootnoteTextInd>X</FootnoteTextInd>
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        <FormAndLineReferenceDesc>PART X, LINE 2:</FormAndLineReferenceDesc>
        <ExplanationTxt>THE FOUNDATION HAS RECEIVED A DETERMINATION LETTER FROM THE INTERNAL REVENUE SERVICE INDICATING THAT IT IS EXEMPT FROM INCOME TAXES UNDER SECTION 501(C)(3) OF INTERNAL REVENUE CODE AND IS CLASSIFIED AS AN ORGANIZATION THAT IS NOT A PRIVATE FOUNDATION. ACCORDINGLY, NO PROVISION FOR INCOME TAXES IS INCLUDED IN THE FINANCIAL STATEMENTS. THE FOUNDATION RECOGNIZES UNCERTAIN INCOME TAX POSITIONS USING THE "MORE-LIKELY-THAN-NOT" APPROACH AS DEFINED IN THE ASC. NO LIABILITY FOR UNCERTAIN TAX POSITIONS HAS BEEN RECORDED IN THE ACCOMPANYING FINANCIAL STATEMENTS.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>PART XI, LINE 4B - OTHER ADJUSTMENTS:</FormAndLineReferenceDesc>
        <ExplanationTxt>LOSS ON SALE OF SECURITIES -11,171.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>PART XII, LINE 2D - OTHER ADJUSTMENTS:</FormAndLineReferenceDesc>
        <ExplanationTxt>LOSS ON SALE OF SECURITIES 11,171. RETURNED GRANT -50,000.</ExplanationTxt>
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    <IRS990ScheduleI documentId="RetDoc1041900001">
      <GrantRecordsMaintainedInd>1</GrantRecordsMaintainedInd>
      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>KENTUCKY SCIENCE AND TECHNOLOGY CORPORATION</BusinessNameLine1Txt>
        </RecipientBusinessName>
        <USAddress>
          <AddressLine1Txt>200 W VINE ST</AddressLine1Txt>
          <CityNm>LEXINGTON</CityNm>
          <StateAbbreviationCd>KY</StateAbbreviationCd>
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        <PurposeOfGrantTxt>SEE PART IV SUPPLEMENTAL INFORMATION</PurposeOfGrantTxt>
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      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>NORTHWESTERN MEMORIAL HEALTHCARE</BusinessNameLine1Txt>
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        <USAddress>
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          <CityNm>CHICAGO</CityNm>
          <StateAbbreviationCd>IL</StateAbbreviationCd>
          <ZIPCd>60611</ZIPCd>
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        <IRCSectionDesc>501(C)(3)</IRCSectionDesc>
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        <PurposeOfGrantTxt>SEE PART IV SUPPLEMENTAL INFORMATION</PurposeOfGrantTxt>
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      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>DUKE UNIVERSITY HEALTH SYSTEM FOR PBMT PROGRAM</BusinessNameLine1Txt>
        </RecipientBusinessName>
        <USAddress>
          <AddressLine1Txt>2301 ERWIN RD</AddressLine1Txt>
          <CityNm>DURHAM</CityNm>
          <StateAbbreviationCd>NC</StateAbbreviationCd>
          <ZIPCd>27710</ZIPCd>
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        <RecipientEIN>562070036</RecipientEIN>
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        <PurposeOfGrantTxt>SEE PART IV SUPPLEMENTAL INFORMATION</PurposeOfGrantTxt>
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      <RecipientTable>
        <RecipientBusinessName>
          <BusinessNameLine1Txt>OREF</BusinessNameLine1Txt>
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          <CityNm>ROSEMONT</CityNm>
          <StateAbbreviationCd>IL</StateAbbreviationCd>
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        <ExplanationTxt>THE ORGANIZATION MEETS REGULARLY WITH REPRESENTATIVES FROM THE GRANT RECIPIENT(S) AND RECEIVES UPDATES AND REPORTS REGARDING EXPENDITURE OF THE FUNDS.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>PART II, LINE 1, COLUMN (H):</FormAndLineReferenceDesc>
        <ExplanationTxt>NAME OF ORGANIZATION OR GOVERNMENT: KENTUCKY SCIENCE AND TECHNOLOGY CORPORATION (H)FUND A RESEARCH PROJECT TO THE INTERNATIONAL SPACE STATION (ISS) IN COLLABORATION WITH RESEARCHERS AT THE SCRIPPS RESEARCH INSTITUTE AND THE NEW YORK STEM CELL RESEARCH FOUNDATION. NAME OF ORGANIZATION OR GOVERNMENT: NORTHWESTERN MEMORIAL HEALTHCARE (H)SUPPORT IMMUNE MONITORING OF RENAL TRANSPLANT PATIENTS TREATED IN A CLINICAL TRIAL AT NORTHWESTERN MEMORIAL HOSPITAL. NAME OF ORGANIZATION OR GOVERNMENT: DUKE UNIVERSITY HEALTH SYSTEM (H)UNDERWRITE INSURANCE DEDUCTIBLES AND CO-PAYS FOR THE FAMILIES OF CHILDREN ELIGIBLE BUT FINANCIALLY UNABLE TO PARTICIPATE IN CLINICAL TRIALS FOR RARE DISEASES AT DUKE UNIVERSITY'S PEDIATRIC BLOOD AND MARROW TRANSPLANT PROGRAM. NAME OF ORGANIZATION OR GOVERNMENT: OREF (H)FUND A MULTI-YEAR PEER-REVIEWED GRANT SUPPORTING ADULT STEM CELL RESEARCH IN A CLINICAL TRIAL TO ADVANCE THERAPIES IN ORTHOPEDIC MEDICINE.</ExplanationTxt>
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      <CompensationSurveyInd>X</CompensationSurveyInd>
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        <TotalCompensationFilingOrgAmt>202165</TotalCompensationFilingOrgAmt>
        <TotalCompensationRltdOrgsAmt>0</TotalCompensationRltdOrgsAmt>
        <CompReportPrior990FilingOrgAmt>0</CompReportPrior990FilingOrgAmt>
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        <NoncashContributionsRptF990Amt>552106</NoncashContributionsRptF990Amt>
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        <FormAndLineReferenceDesc>FORM 990, PART III, LINE 2</FormAndLineReferenceDesc>
        <ExplanationTxt>THE FOUNDATION BEGAN TWO NEW PROGRAM SERVICES DURING THE YEAR: A PATIENT ADVOCACY PROGRAM THAT HELPS FAMILIES OF LIMITED MEANS PARTICIPATE IN CLINICAL TRIALS FOR THE TREATMENT OF CURRENTLY INCURABLE RARE DISEASES. COLLABORATIONS BETWEEN FUNDED RESEARCHERS FOR STUDIES IN ZERO GRAVITY TO ADVANCE SCIENCE IN THE NATIONAL STEM CELL FOUNDATION'S FUNDED AREAS.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION A, LINE 2</FormAndLineReferenceDesc>
        <ExplanationTxt>PAULA GRISANTI, CHAIRMAN OF THE BOARD, AND MICHAEL GRISANTI, DIRECTOR, HAVE A FAMILY RELATIONSHIP.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION A, LINE 3</FormAndLineReferenceDesc>
        <ExplanationTxt>THE ORGANIZATION HAS CONTRACTED ITS FINANCIAL MANAGEMENT OVERSIGHT TO AN OUTSIDE CHIEF FINANCIAL OFFICER AND ITS DAY TO DAY FINANCIAL DUTIES TO A CONTROLLER.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>FORM 990 WAS PREPARED BY AN OUTSIDE ACCOUNTING FIRM AND REVIEWED IN DETAIL BY THE CONTRACT CFO, CONTRACT CONTROLLER, BOARD CHAIR AND FINANCE COMMITTEE. A COPY WAS THEN SENT TO EACH BOARD MEMBER FOR THEIR REVIEW BEFORE THE FORM 990 WAS FILED.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 12C</FormAndLineReferenceDesc>
        <ExplanationTxt>INTERESTED PERSONS WILL ANNUALLY DISCLOSE OR UPDATE TO THE CHAIRMAN OF THE BOARD OF DIRECTORS ON A FORM PROVIDED BY THE ORGANIZATION THEIR INTERESTS THAT COULD GIVE RISE TO CONFLICTS OF INTEREST, SUCH AS A LIST OF FAMILY MEMBERS, SUBSTANTIAL BUSINESS OR INVESTMENT HOLDINGS AND OTHER TRANSACTIONS OR AFFILIATION WITH BUSINESSES AND OTHER ORGANIZATIONS OR THOSE OF FAMILY MEMBERS. FOR EACH INTEREST DISCLOSED TO THE CHAIRMAN OF THE BOARD OF DIRECTORS, THE CHAIRMAN WILL DETERMINE WHETHER TO: (A) TAKE NO ACTION; (B) ASSURE FULL DISCLOSURE TO THE BOARD OF DIRECTORS AND OTHER INDIVIDUALS COVERED BY THE POLICY; (C) ASK THE PERSON TO RECUSE FROM PARTICIPATION IN RELATED DISCUSSIONS OR DECISION WITHIN THE ORGANIZATION; OR (D) ASK THE PERSON TO RESIGN FROM HIS OR HER POSITION IN THE ORGANIZATION OR, IF THE PERSON REFUSES TO RESIGN, BECOME SUBJECT TO POSSIBLE REMOVAL IN ACCORDANCE WITH THE ORGANIZATION'S REMOVAL PROCEDURES. THE ORGANIZATION'S CHIEF EMPLOYED EXECUTIVE AND CHIEF EMPLOYED FINANCE EXECUTIVE WILL MONITOR PROPOSED OR ONGOING TRANSACTIONS FOR CONFLICTS OF INTEREST AND DISCLOSE THEM TO THE CHAIRMAN OF THE BOARD OF DIRECTORS IN ORDER TO DEAL WITH POTENTIAL OR ACTUAL CONFLICTS, WHETHER DISCOVERED BEFORE OR AFTER THE TRANSACTION HAS OCCURRED. TO DATE NO POTENTIAL CONFLICTS HAVE BEEN IDENTIFIED.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 15</FormAndLineReferenceDesc>
        <ExplanationTxt>IN 2015 THE BOARD ENGAGED AN OUTSIDE CONSULTING FIRM TO DETERMINED AN APPROPRIATE SALARY RANGE FOR THE CHAIR/CEO POSITION. A BOARD APPROVED SALARY WAS ESTABLISHED BASED ON THEIR GUIDANCE AND NO SALARY ADJUSTMENT HAS BEEN MADE SINCE THAT TIME. CONTRACTED CFO AND CONTRACTED CONTROLLER ARE PAID ON AN HOURLY BASIS.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION C, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>THE ORGANIZATION MAKES ITS GOVERNING DOCUMENTS, CONFLICT OF INTEREST POLICY AND FINANCIAL STATEMENTS AVAILABLE TO THE PUBLIC UPON REQUEST.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART XII, LINE 2C:</FormAndLineReferenceDesc>
        <ExplanationTxt>THE PROCESS HAS NOT CHANGED FROM THE PRIOR YEAR. THE ORGANIZATION'S BOARD OF DIRECTORS CONTINUE TO SELECT THE INDEPENDENT ACCOUNTANT. THE COMMITTEE CONTINUES TO MEET WITH THE INDEPENDENT AUDITOR AT THE CONCLUSION OF THE ANNUAL AUDIT.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>PART XI, LINE 8, PRIOR PERIOD ADJUSTMENT</FormAndLineReferenceDesc>
        <ExplanationTxt>DURING 2016, MANAGEMENT WAS NOTIFIED THAT THE DONOR OF A $100,000 IRREVOCABLE SECOND-TO-DIE LIFE INSURANCE POLICY HAD CHANGED THE TERMS OF THE DONATION AND REMOVED THE FOUNDATION AS A BENEFICIARY. AN ADJUSTMENT OF $37,970 TO TEMPORARILY RESTRICTED NET ASSETS AS OF JANUARY 1, 2015 IS REFLECTED IN A DECREASE OF NET ASSETS FROM $3,311,450 TO $3,273,480. THE 2015 AUDITED FINANCIAL STATEMENTS HAVE BEEN REVISED TO REFLECT THE CHANGES IN THE TERMS. ADDITIONALLY, A $50,000 GRANT WAS RETURNED DURING 2016. THE CHANGE TO NET ASSETS AS A RESULT OF THESE PRIOR PERIOD ADJUSTMENTS IS A NET INCREASE OF $12,030.</ExplanationTxt>
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    </IRS990ScheduleO>
  </ReturnData>
</Return>