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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Part X : FIN48 Footnote</FormAndLineReferenceDesc>
        <ExplanationTxt>The Institute is a public charity and is exempt from income taxes under Section 501(c)(3) of the Internal Revenue Code and Section 23701(d) of the California Revenue and Taxation Code. The Institute believes that it has appropriate support for any tax positions taken, and as such, does not have any uncertain tax positions that are material to the financial statements. The Institute is not a private foundation.</ExplanationTxt>
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      <SupplementalInformationDetail>
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        <TitleTxt>President</TitleTxt>
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        <RelationshipDescriptionTxt>Owned by family mbrs</RelationshipDescriptionTxt>
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        <FormAndLineReferenceDesc>Schedule L, Part V Supplemental Information</FormAndLineReferenceDesc>
        <ExplanationTxt>3DT HOLDINGS, LLC:ON APRIL 29, 2015, THE INSTITUTE ADOPTED A MODIFICATION TO THE LOAN AGREEMENT PREVIOUSLY ENTERED INTO WITH 3DT HOLDINGS, LLC, AN ENTITY OWNED IN PART BY DR. KASSAB. IN 2014, 3DT HOLDINGS, LLC LOANED $600,000 TO THE INSTITUTE TO ADDRESS THE CASH FLOW SHORTAGE THAT THE INSTITUTE FACED AS A RESULT OF ITS SUBSTANTIAL START-UP COSTS. THE INITIAL LOAN WAS APPROVED BY THE DISINTERESTED MEMBERS OF THE BOARD OF DIRECTORS. IN 2015, THE INSTITUTE REQUIRED ADDITIONAL FUNDS TO COVER ITS OPERATING COSTS AND 3DT HOLDINGS, LLC AGREED TO MODIFY THE LOAN AGREEMENT TO INCREASE THE MAXIMUM AMOUNT BORROWABLE FROM $600,000 TO $900,000. THE TERMS OF THE MODIFIED LOAN WERE REVIEWED AND APPROVED BY THE DISINTERESTED MEMBERS OF THE BOARD OF DIRECTORS. IN DETERMINING WHETHER THE TERMS OF THE MODIFIED LOAN WERE REASONABLE, THE DISINTERESTED MEMBERS OF THE BOARD REVIEWED COMPARABILITY INFORMATION AND CONSIDERED THAT THE INTEREST CHARGED ON THE LOAN IS WELL BELOW THE RATE THAT WOULD HAVE BEEN CHARGED BY A DISINTERESTED THIRD PARTY. THE DECISION OF THE BOARD OF DIRECTORS WAS DOCUMENTED IN THE MINUTES OF THE MEETING WHERE THE MODIFIED LOAN AGREEMENT WAS DISCUSSED. DR. KASSAB AND MR. ANDRIKOS BOTH LEFT THE MEETING PRIOR TO THE VOTE AND ABSTAINED FROM THE VOTE. WHILE THE ADDITIONAL $300,000 LINE OF CREDIT WAS APPROVED BY THE BOARD IN 2015, NO ADDITIONAL AMOUNTS WERE BORROWED UNDER THE EXTENDED LINE OF CREDIT DURING 2016. BECAUSE THE ADDITIONAL $300,000 LINE OF CREDIT WAS DETERMINED TO NOT BE NECESSARY, THE LOAN AMOUNT WAS REDUCED BACK TO $600,000 IN 2016.Kassab Global Biotech, LLC:The Institute has entered into a written lease agreement with Kassab Global Biotech, LLC. The terms of the lease were reviewed and approved by the disinterested members of the Board of Directors in 2015 IN ACCORDANCE WITH THE REBUTTABLE PRESUMPTION OF REASONABLENESS.</ExplanationTxt>
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    </IRS990ScheduleL>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 2: Description of Business or Family Relationship of Officers, Directors, Et</FormAndLineReferenceDesc>
        <ExplanationTxt>None of the Officers or Directors were related by family. However, one of the Directors had a business relationship with Dr. Kassab, as described below: Director Demetri Andrikos was an employee of 3DT Holdings, LLC, an organization owned in part by Dr. Kassab. The employee relationship ended August 2015. Subsequent to August 2015 Demetri Andrikos provided contract services. OUT OF AN ABUNDANCE OF CAUTION, the Institute TREATED Mr. Andrikos AS THOUGH HE WAS "INTERESTED" with respect to transactions involving Dr. Kassab. THEREFORE, MR. ANDRIKOS DID NOT PARTICIPATE IN ANY VOTES RELATING TO TRANSACTIONS INVOLVING DR. KASSAB.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 11b: Form 990 Review Process</FormAndLineReferenceDesc>
        <ExplanationTxt>The Form 990 was reviewed and discussed by senior management, the President, the Board of Directors, and outside counsel for the Institute prior to filing.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 12c: Explanation of Monitoring and Enforcement of Conflicts</FormAndLineReferenceDesc>
        <ExplanationTxt>The Board of Directors has adopted two written Conflict of Interest Policies. The first policy (the Financial Conflict of Interest Policy) is applicable to Officers and Directors of the Institute. Each Officer and each member of the Board of Directors is required to review and acknowledge their understanding of the Financial Conflict of Interest Policy upon appointment to office or to the board. Officers and Directors are routinely encouraged to bring any and all potential conflicts of interest to the attention of the disinterested board members for review.The second policy (the Research Conflict Policy) is applicable to researchers participating in any of the Institutes federally funded grants. Researchers are required to review the Research Conflict Policy and complete a training program on financial conflicts of interest in research at least every four years. The Institute takes very seriously its obligation to report any financial conflicts of interest to the National Institute of Health and encourages all researchers to fully disclose any and all potential conflicts for review by the independent members of the Board of Directors. To the extent that the independent members of the Board of Directors determine that a significant conflict exists, the following conditions and restrictions could be imposed: public disclosure of the conflict, monitoring of the research by independent reviewers, modification of the research plan or removal of the affected researcher from the research, divestiture of significant financial interests, or severance of the relationship that creates the actual or potential conflicts.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 15a: Compensation Review &amp; Approval Process - CEO, Top Management</FormAndLineReferenceDesc>
        <ExplanationTxt>The Presidents compensation was reviewed and approved by the disinterested members of the Board of Directors in 2015. In determining whether the amount of compensation was reasonable, the disinterested members of the Board reviewed and discussed the proposed compensation arrangement and carefully considered the background, education, professional experience, skills and achievements of Dr. Ghassan Kassab, the unique qualities to the Institute to fill the position of President and Chief Scientific Officer, and the reports of compensation levels paid by other similar organizations according to the Economic Institute Report. The disinterested members of the Board also reviewed and relied upon the opinion of counsel that the compensation proposed to be paid to Dr. Kassab was within the range that would be expected for an employee with Dr. Kassabs unique expertise, performing the specified duties for an organization of the size of the Institute. The decision of the Board of Directors was documented in the minutes of the meeting where the compensation was discussed. Dr. Kassab and Demetri Andrikos (who was deemed to be an interested Director with respect to Dr. Kassab), both left the meeting prior to the vote and abstained from the vote.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 18: Explanation of Other Means Forms Available For Public Inspection</FormAndLineReferenceDesc>
        <ExplanationTxt>The Institute makes its application and return available to the public upon request.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Line 19: Other Organization Documents Publicly Available</FormAndLineReferenceDesc>
        <ExplanationTxt>The Institute makes its governing documents, conflicts of interest policies, and financial statements available to the public upon request.</ExplanationTxt>
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</Return>