2017-11-14T11:44:39-06:00 2016-12-31 720398470 HEARD MCELROY & VESTAL LLC 333 TEXAS STREET SUITE 1525 SHREVEPORT LA 71101 990 2016-01-01 760497352 INSTITUTE OF ORTHOPEDIC RESEARCH AND EDUCATION INST 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 JIM BOCELL MD PRESIDENT 7136104270 2017-11-10 1 ROY E PRESTWOOD P00419967 3184291525 2017-11-10 208.88.67.114 2017-11-10 16:17:01 CS P 6F30DD7E2ED82AC977728B4CAB9C5CE00AE8CFC1 A6425488045BD5ED90781C575FBDE9AD11156031 2016 2017-02-10 21:41:12Z JAMES BOCELL MD 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 1403216 0 X WWW.IORE.NET X 1995 TX IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 5 5 15 10 0 0 850000 930000 410328 472949 818 106 799 161 1261945 1403216 0 0 0 0 968300 896375 0 0 0 375571 389573 1343871 1285948 -81926 117268 217974 335387 15950 16095 202024 319292 X IORE'S FUNDAMENTAL RESEARCH MISSION IS TO PROVIDE THE STAFF AND FACILITIES REQUIRED TO ENABLE ORTHOPEDIC FACULTY, RESIDENTS AND FELLOWS TO ACHIEVE NATIONAL AND INTERNATIONAL PROMINENCE THROUGH APPLIED RESEARCH OF THE VERY HIGHEST STANDARD. 1 0 39433 1. METHODIST HOSPITAL POST-GRADUATE TRAINING PROJECTS.DURING 2016, IORE SUPPORTED ACADEMIC RESEARCH PROJECTS COMPLETED BY TRAINEES WITHIN THE HOUSTON METHODIST ORTHOPEDIC FELLOWSHIP PROGRAM UNDERGOING TRAINING IN JOINT REPLACEMENT. THESE PROJECTS WERE PERFORMED IN COLLABORATION WITH FACULTY OF THE ORTHOPEDIC DEPARTMENT OF HOUSTON METHODIST HOSPITAL IN HOUSTON. THESE PROJECTS INCLUDED:1.1 TIBIAL RESECTION AND CORONAL ALIGNMENT IN TOTAL KNEE ARTHROPLASTYONE OF THE FACTORS COMPROMISING THE FUNCTION AND LONGEVITY OF TOTAL KNEE REPLACEMENTS IS MALALIGNMENT OF THE IMPLANT WITH RESPECT TO THE AXIS OF THE KNEE JOINT. ONE FACTOR CONTRIBUTING TO THIS ERROR IS MALROTATION OF THE TOOLS ATTACHED TO THE BONES AT SURGERY TO DIRECT CUTTING OF THE BONY SURFACES SUPPORTING THE PROSTHETIC COMPONENTS. THIS SOURCE OF ERROR WAS EXPLORED IN AN EXPERIMENT IN WHICH WE SIMULATED CUTTING OF THE TIBIA WITH A GUIDE ORIENTED IN DIFFERENT ROTATIONAL POSITIONS ON THE SURFACE OF THE BONE. RESEARCH ASSOCIATES AND ORTHOPEDIC TRAINEES RECONSTRUCTED THREE-DIMENSIONAL DIGITAL MODELS OF 15 CADAVERIC LOWER LIMBS USING HIGH DEFINITION COMPUTED TOMOGRAPHY. UPON INCORPORATING THE IMAGES INTO A CUSTOM SIMULATION SOFTWARE, VARIOUS KINEMATIC MEASURES WERE DEFINED WITH RESPECT TO POST-TKA CORONAL PLANE ALIGNMENT. STATISTICAL ANALYSIS OF MEASUREMENTS ALLOWED US TO DELINEATE VARIATION OF THESE KINEMATIC MEASURES AMONG SPECIMENS POST-TKA, PARTICULARLY EFFECTS OF MALROTATION OF THE CUTTING GUIDE IN ALTERING THE FINAL CORONAL PLANE ALIGNMENT. THIS WORK HAS BEEN SUBMITTED FOR PUBLICATION AND CONFERENCE PRESENTATIONS. 1.2 TOTAL KNEE ARTHROPLASTY IN THE OSTEOPOROTIC TIBIA: A BIOMECHANICAL EVALUATION IN THE ROLE OF STEM EXTENSIONS AND CEMENTING TECHNIQUESIN THIS PROJECT, IORE STAFF ASSISTED AN ORTHOPEDIC TRAINEE IN EVALUATING THE IMPACT OF EXTENDING THE LENGTH OF JOINT REPLACEMENT IMPLANTS INSERTED IN THE TIBIAL BONE ON THE STABILITY OF ITS FIXATION UNDER LOADING IN PATIENTS WITH OSTEOPOROSIS. THIS WAS DONE BY IMPLANTING A STANDARD TIBIAL TRAY IN A MODIFIED REPLICA OF THE MALE OSTEOPOROTIC TIBIA. 24 SUBSEQUENT IMPLANTATION PROCEDURES WERE PERFORMED USING 3 VARIATIONS OF IMPLANT LENGTH AND CEMENTING TECHNIQUE. UPON SUBJECTING EACH IMPLANT TO THE LOADING CONDITIONS THAT OCCUR DURING WALKING, THE MICRO-MOTION OF THE IMPLANT WITHIN THE BONE WAS MEASURED BY DIGITAL IMAGE CORRELATION (DIC) ANALYSIS. THE RESULTS SHOWED SIGNIFICANT DIFFERENCES IN THE RIGIDITY OF IMPLANT FIXATION AS A FUNCTION OF IMPLANT SELECTION AND METHOD OF FIXATION. THIS WORK HAS BEEN SUBMITTED FOR PUBLICATION AND CONFERENCE PRESENTATIONS. 83884 2. FACTORS CONTRIBUTING TO HIP ARTHRITIS- THE LAXITY OF THE HIP JOINT CAPSULE.IORE HAS FUNDED AN ONGOING RESEARCH PROGRAM INVESTIGATING THE FUNDAMENTAL ROLE OF ANATOMIC STRUCTURES CONTROLLING THE MOTION OF THE HIP JOINT. THIS WORK IS MOTIVATED BY OUR INTEREST IN THE CAUSES OF HIP ARTHRITIS AND WAYS OF PREVENTING THIS CRIPPLING CONDITION. PREVIOUSLY, IT HAS BEEN HYPOTHESIZED THAT CHANGES IN THE SOFT-TISSUES OF THE HIP THAT OCCUR WITH DISEASE OR INJURY LEAD TO CHANGES IN THE CENTERING OF THE HEAD OF THE FEMUR IN THE HIP SOCKET LEADING TO AREAS OF OVERLOAD AND, EVENTUALLY, ARTHRITIS. IN CONTINUATION OF A RESEARCH PROJECT STARTED IN 2015, 8 CADAVERIC SPECIMENS WERE MOUNTED IN A MECHANICAL TESTING FRAME THAT CONTROLLED THE POSTURE AND LOADING OF THE HIP. EACH SPECIMEN WAS PLACED IN A BATTERY OF POSITIONS ASSOCIATED WITH COMMON FUNCTIONAL ACTIVITIES. DURING THESE PROCEDURES, THE RELATIVE MOTION OF THE FEMORAL HEAD WITHIN THE ACETABULUM WAS MEASURED USING INFRA-RED REFLECTORS MOUNTED ON BOTH BONES. THESE EXPERIMENTAL PROCEDURES WERE REPEATED BEFORE AND AFTER MODIFICATIONS TO THE HIP CAPSULE, THE CONTINUOUS LIGAMENTOUS STRUCTURE ENCLOSING THE HIP JOINT. BY CALCULATING THE INCREASED SHIFT OF THE BONES WITHIN THE HIP JOINT IT WAS DEMONSTRATED THAT INCREASED MOTION AND "LOOSENESS" OF THE HIP ALSO LEADS TO INCREASED INSTABILITY AND MAL-TRACKING OF THE CARTILAGE SURFACES. THE RESULTS SUPPORTED THE HYPOTHESIS THAT THE STIFFNESS OF THE HIP CAPSULE, IF REDUCED BY REPETITIVE STRETCHING OR PATHOLOGIC LAXITY, ALLOWS ABNORMAL MOTION OF THE FEMORAL HEAD WITHIN THE ACETABULAR SOCKET. THIS CHANGE IS ASSOCIATED WITH OVERLOAD OF THE CARTILAGE AND LOSS OF LUBRICATION OF THE JOINT, CONDITIONS LEADING TO ARTHRITIC CHANGES OVER TIME. THIS WORK HAS BEEN SUBMITTED FOR PUBLICATION AND CONFERENCE PRESENTATIONS. 65901 3. THE INFLUENCE OF SURGICAL TECHNIQUE VARIABLES ON THE FIXATION OF CEMENTLESS TIBIAL TRAYSIN TOTAL KNEE REPLACEMENT, FIXATION OF IMPLANTS TO BONE IS TRADITIONALLY PERFORMED USING AN ACRYLIC CEMENT PUTTY WHICH CURES IN THE BODY. HOWEVER, PARTICLES OF THIS CEMENT OFTEN MAKE THEIR WAY INTO THE JOINT, SCRATCHING AND DEGRADING THE ARTIFICIAL BEARING SURFACES. AN ATTRACTIVE ALTERNATIVE IS TO USE METAL IMPLANTS WITH POROUS SURFACES THAT SUPPORT ATTACHMENT OF THE BONE TO THE PROSTHESIS. HOWEVER, THIS MODE OF FIXATION IS ONLY SUCCESSFUL IF THE IMPLANT-BONE INTERFACE IS IMMOBILE DURING THE INITIAL PERIOD OF BONY ATTACHMENT. IN THIS STUDY, WE EXAMINED FACTORS AFFECTING THE INITIAL STABILITY OF TWO DIFFERENT DESIGNS OF CEMENTLESS PROSTHESES BY APPLYING A SERIES OF COMPLEX LOADS TO CADAVERIC CONSTRUCTS AND MEASURING THE RESULTING MICROMOTION BETWEEN THE IMPLANT AND THE UNDERLYING TIBIAL BONE. SECTIONS TAKEN THROUGH EACH IMPLANT AFTER TESTING ALLOWED US TO CORRELATE THE MAGNITUDE OF INTERFACE MOTION WITH THE ACCURACY OF IMPLANTATION OF THE PROSTHETIC COMPONENT. THIS WORK HAS BEEN SUBMITTED FOR PUBLICATION AND CONFERENCE PRESENTATIONS. 724915 472956 OTHER ORTHOPEDIC RESEARCH PROJECTS. 724915 472956 914133 1 1 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 0 0 1 13 0 1 15 1 0 0 0 0 0 0 0 0 0 0 X 5 5 0 0 0 0 0 0 0 1 1 0 0 1 1 1 1 1 1 1 1 0 X X KIM MCCONN 7136104270 6550 FANNIN STREET SUITE 2512 HOUSTON TX 77030 X JAMES BOCELL MD PRESIDENT 1.00 X X 0 0 0 BRADLEY WEINER MD VICE PRESIDENT 1.00 X X 0 0 0 STEVEN INCAVO MD DIRECTOR 0.50 X 0 0 0 KENNETH MATHIS MD DIRECTOR 1.00 X 0 0 0 WILLIAM J BRYAN MD DIRECTOR 0.50 X 0 0 0 0 0 0 0 0 0 0 0 930000 930000 RESEARCH SERVICES 541700 472949 472949 472949 106 106 154 154 MISCELLANEOUS 900099 7 7 7 1403216 472956 0 260 702773 562218 140555 36247 28998 7249 108780 87024 21756 48575 38860 9715 42000 42000 14547 14547 2397 2397 1393 1393 2642 2642 91243 72994 18249 31414 25131 6283 31097 31097 25400 25400 SUPPLIES 105275 84220 21055 MEALS & ENTERTAINMENT 10409 8327 2082 SERVICES - COMMUNICATIO 8828 8828 SERVICES - REPAIRS 8240 8240 14688 6361 8327 1285948 914133 371815 0 74144 198022 57200 56284 602746 521665 86630 81081 217974 335387 15950 16095 15950 16095 X 0 0 0 0 202024 319292 202024 319292 217974 335387 117268 0 X 0 0 0 X 850000 738000 850000 850000 930000 4218000 422957 472084 554560 399798 472949 2322348 1272957 1210084 1404560 1249798 1402949 6540348 0 0 0 6540348 800 104004 108 1253 260 106425 800 104004 108 1253 260 106425 1091 1446 678 365 7 3587 1274848 1315534 1405346 1251416 1403216 6650360 0.98350 0.94050 0.01600 0.03440 X RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED RESTRICTED 90000 39329 50671 512746 482336 30410 81081 FORM 990, PART III, LINE 2 PLEASE SEE FORM 990, PAGE 2, PART III, SECTION 4B & 4C. 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