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        <PersonNm>William R Hearst III</PersonNm>
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        <PersonNm>Sherry Lansing start 50718</PersonNm>
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        <PersonNm>Ge Li</PersonNm>
        <TitleTxt>Director</TitleTxt>
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        <PersonNm>Claudia S Luttrell</PersonNm>
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        <PersonNm>Joel S Marcus</PersonNm>
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        <PersonNm>John Martin start 50718</PersonNm>
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        <PersonNm>Mark Pearson</PersonNm>
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        <PersonNm>Bernard Saint-Donat PhD</PersonNm>
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        <PersonNm>Paul R Schimmel end 92818</PersonNm>
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        <PersonNm>Jeffery Kelly start 92818</PersonNm>
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        <PersonNm>Christopher T Walsh</PersonNm>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Douglas A Bingham</PersonNm>
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        <PersonNm>Jared M Machado</PersonNm>
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        <PersonNm>Tamara L Barnas</PersonNm>
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        <PersonNm>James R Williamson</PersonNm>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Kaye I Wynne</PersonNm>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Cary E Thomas</PersonNm>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Matthew S Tremblay</PersonNm>
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        <PersonNm>Demetrios I Andrikos</PersonNm>
        <TitleTxt>VP Legal &amp; General Counsel</TitleTxt>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Eric Topol MD</PersonNm>
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      <Form990PartVIISectionAGrp>
        <PersonNm>Ronald L Davis</PersonNm>
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        <PersonNm>Richard A Lerner</PersonNm>
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        <PersonNm>Edward Roberts</PersonNm>
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        <PersonNm>Karl B Sharpless</PersonNm>
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        <PersonNm>Jim C Paulson</PersonNm>
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        <FormAndLineReferenceDesc>Part I, Line 1a</FormAndLineReferenceDesc>
        <ExplanationTxt>Business travel and first class travel. The Scripps Research Institute allows for business travel for certain key employees for long haul flights. In certain circumstances, business class service is not available on smaller aircraft. In those circumstances, TSRI allows first class travel. At times TSRI will relocate employees between campuses and will provide a housing allowance for a limited duration to assist with the transition, which was provided to Douglas A. Bingham, Executive Vice President of Scripps Florida.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Part I, Line 4b</FormAndLineReferenceDesc>
        <ExplanationTxt>Richard Lerner, M.D. participated in a non-qualified deferred compensation plan. Plan terminated 8/31/17 and payment was issued for $6,494,597.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Other Information Related to Form 990, Part VII, Line 5:</FormAndLineReferenceDesc>
        <ExplanationTxt>Eric Topol, M.D., received compensation from an unrelated organization, Scripps Clinic Medical Group, for services provided to The Scripps Research Institute. In 2017, in exchange for these services, The Scripps Research Institute reimbursed the Scripps Medical Group $375,000.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Schedule K, Part I, Bond Issues:</FormAndLineReferenceDesc>
        <ExplanationTxt>(a) Issue Name: California Infrastructure &amp; Economic Development Bank (f) Description on Purpose: Refund and defease bonds previously issued for the benefit of the Institute on 6/29/2000 and 2/23/2005. Schedule K, Part IV, Line 6: This question is being answered without regard to a yield-restricted advance refunding escrow financed with proceeds of the bonds.</ExplanationTxt>
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        <TransactionDesc>The Scripps Research Institute (TSRI) leases office and laboratory space building from Alexandria Real Estate (ARE). Joel S. Marcus is the Executive Chairman &amp; Founder of ARE. Mr. Marcus was appointed to TSRI'S Board as of May 2017. Lease commenced in November 1997, at which time, the property was not owned by ARE and Mr. Marcus was not a member of TSRI'S Board.</TransactionDesc>
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        <FormAndLineReferenceDesc>Part I, Column (b):</FormAndLineReferenceDesc>
        <ExplanationTxt>Securities - Publicly traded - No. of contributions Real Estate - Residential - No. of items contributed Schedule M, Part II, Line 15b: TSRI received a real estate residential contribution appraised by Philip Tolles Appraisals, and it was valued at $3,000,000.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Part I, Line 32b:</FormAndLineReferenceDesc>
        <ExplanationTxt>Shares of stock gifted to TSRI are transferred into our brokerage account at Morgan Stanley Smith and Barney and they in turn sell the shares and wire the stock proceeds to TSRI.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section A, line 4</FormAndLineReferenceDesc>
        <ExplanationTxt>Effective 3/29/18, the Bylaws were amended to facilitate TSRI's merger with The California Institute for Biomedical Research, a 501(c)(3) not-for-profit biomedical research institute incorporated in California.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 11b</FormAndLineReferenceDesc>
        <ExplanationTxt>On June 19, 2019, the Audit Committee reviewed a draft of the Form 990 (including all supplemental schedules). This review included a presentation of the statements by the Chief Financial Officer with particular emphasis on disclosures about governance and about transactions with interested persons. The 990 will be provided to the full Board of Trustees prior to filing.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 12c</FormAndLineReferenceDesc>
        <ExplanationTxt>TSRI'S Conflict of Interest Policies and Procedures apply to members of the Board of Directors, officers, key personnel, and their family members (altogether covered individuals) to protect the interests of TSRI when it is contemplating entering into a transaction or arrangement that could: 1) Benefit the private interest of a covered individual within the meaning of Treasury Regulation Section 1.501(c)(3)-1(d)(1)(ii), 2) Result in a possible excess benefit transaction within the meaning of Section 4958(c) of the Internal Revenue Code of 1986, as amended; or 3) Be a self-dealing transaction within the meaning of Section 5233 of the California Corporations Code (the "Corporations Code"). TSRI's policies and procedures are intended to supplement, but not replace, any state and federal laws governing actual, potential, or apparent conflict of interest applicable to TSRI. Disclosure documents responsive to TSRI's policies are annually submitted by covered individuals, and are reviewed by TSRI administration for pertinent relationships. Any transactions or arrangements involving covered individuals that fall within the scope of the policies are then subject to review and consideration by non-conflicted Board of Director members, with conflicted members being recused from any vote to approve or disapprove.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section B, line 15</FormAndLineReferenceDesc>
        <ExplanationTxt>The compensation of the CEO and certain other key executives was reviewed and approved by the Board of Directors. This review was based, in part, on analysis performed by the Human Resources department, and included data from outside consultants or internally-conducted research. On an ongoing basis, executives may participate in the normal annual salary increase program, which is based on a recommendation from the Human Resources department based on market research. Any unusual or potentially non-qualified compensation would be reviewed by outside counsel for any tax compliance issues.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VI, Section C, line 19</FormAndLineReferenceDesc>
        <ExplanationTxt>Governing documents and Conflict of Interest Policies are not available to the public at this time. The financial statements are filed with the State of Florida by The Scripps Florida Funding Corporation. The statements are provided to bond holders through TSRI's dissemination agent. The annual information return is provided upon request.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part VII, Section B:</FormAndLineReferenceDesc>
        <ExplanationTxt>TSRI patents many of its discoveries. For most of those discoveries, the cost of these patents is recovered from third parties pursuant to the terms of the underlying license.</ExplanationTxt>
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        <FormAndLineReferenceDesc>Form 990, Part IX, line 11g</FormAndLineReferenceDesc>
        <ExplanationTxt>Purchase Services and Maintenance: Program service expenses 79,310,161. Management and general expenses 2,613,095. Fundraising expenses 321,675. Total expenses 82,244,931.</ExplanationTxt>
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      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>Form 990, Part XI, line 9:</FormAndLineReferenceDesc>
        <ExplanationTxt>Rounding 7.</ExplanationTxt>
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          <AddressLine1Txt>10550 North Torrey Pins Rd</AddressLine1Txt>
          <CityNm>La Jolla</CityNm>
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