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        <TitleTxt>CHIEF SCIENTIST</TitleTxt>
        <AverageHoursPerWeekRt>33.00</AverageHoursPerWeekRt>
        <HighestCompensatedEmployeeInd>X</HighestCompensatedEmployeeInd>
        <ReportableCompFromOrgAmt>129000</ReportableCompFromOrgAmt>
        <ReportableCompFromRltdOrgAmt>0</ReportableCompFromRltdOrgAmt>
        <OtherCompensationAmt>19047</OtherCompensationAmt>
      </Form990PartVIISectionAGrp>
      <TotalReportableCompFromOrgAmt>431344</TotalReportableCompFromOrgAmt>
      <TotReportableCompRltdOrgAmt>0</TotReportableCompRltdOrgAmt>
      <TotalOtherCompensationAmt>94159</TotalOtherCompensationAmt>
      <IndivRcvdGreaterThan100KCnt>2</IndivRcvdGreaterThan100KCnt>
      <FormerOfcrEmployeesListedInd>0</FormerOfcrEmployeesListedInd>
      <TotalCompGreaterThan150KInd>1</TotalCompGreaterThan150KInd>
      <CompensationFromOtherSrcsInd>0</CompensationFromOtherSrcsInd>
      <CntrctRcvdGreaterThan100KCnt>0</CntrctRcvdGreaterThan100KCnt>
      <AllOtherContributionsAmt>1802646</AllOtherContributionsAmt>
      <NoncashContributionsAmt>250</NoncashContributionsAmt>
      <TotalContributionsAmt>1802646</TotalContributionsAmt>
      <OtherRevenueMiscGrp>
        <Desc>MISCELLANEOUS INCOME</Desc>
        <BusinessCd>900099</BusinessCd>
        <TotalRevenueColumnAmt>2500</TotalRevenueColumnAmt>
        <ExclusionAmt>2500</ExclusionAmt>
      </OtherRevenueMiscGrp>
      <OtherRevenueTotalAmt>2500</OtherRevenueTotalAmt>
      <TotalRevenueGrp>
        <TotalRevenueColumnAmt>1805146</TotalRevenueColumnAmt>
        <RelatedOrExemptFuncIncomeAmt>0</RelatedOrExemptFuncIncomeAmt>
        <UnrelatedBusinessRevenueAmt>0</UnrelatedBusinessRevenueAmt>
        <ExclusionAmt>2500</ExclusionAmt>
      </TotalRevenueGrp>
      <InfoInScheduleOPartIXInd>X</InfoInScheduleOPartIXInd>
      <CompCurrentOfcrDirectorsGrp>
        <TotalAmt>290314</TotalAmt>
        <ProgramServicesAmt>161675</ProgramServicesAmt>
        <ManagementAndGeneralAmt>70828</ManagementAndGeneralAmt>
        <FundraisingAmt>57811</FundraisingAmt>
      </CompCurrentOfcrDirectorsGrp>
      <OtherSalariesAndWagesGrp>
        <TotalAmt>417174</TotalAmt>
        <ProgramServicesAmt>405107</ProgramServicesAmt>
        <ManagementAndGeneralAmt>3017</ManagementAndGeneralAmt>
        <FundraisingAmt>9050</FundraisingAmt>
      </OtherSalariesAndWagesGrp>
      <OtherEmployeeBenefitsGrp>
        <TotalAmt>29578</TotalAmt>
        <ProgramServicesAmt>23142</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1609</ManagementAndGeneralAmt>
        <FundraisingAmt>4827</FundraisingAmt>
      </OtherEmployeeBenefitsGrp>
      <PayrollTaxesGrp>
        <TotalAmt>49430</TotalAmt>
        <ProgramServicesAmt>40976</ProgramServicesAmt>
        <ManagementAndGeneralAmt>3409</ManagementAndGeneralAmt>
        <FundraisingAmt>5045</FundraisingAmt>
      </PayrollTaxesGrp>
      <FeesForServicesLegalGrp>
        <TotalAmt>5753</TotalAmt>
        <ManagementAndGeneralAmt>5753</ManagementAndGeneralAmt>
      </FeesForServicesLegalGrp>
      <FeesForServicesAccountingGrp>
        <TotalAmt>9625</TotalAmt>
        <ManagementAndGeneralAmt>9625</ManagementAndGeneralAmt>
      </FeesForServicesAccountingGrp>
      <FeesForServicesProfFundraising>
        <TotalAmt>19000</TotalAmt>
        <FundraisingAmt>19000</FundraisingAmt>
      </FeesForServicesProfFundraising>
      <FeesForServicesOtherGrp>
        <TotalAmt>153691</TotalAmt>
        <ProgramServicesAmt>118507</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1884</ManagementAndGeneralAmt>
        <FundraisingAmt>33300</FundraisingAmt>
      </FeesForServicesOtherGrp>
      <AdvertisingGrp>
        <TotalAmt>158342</TotalAmt>
        <ProgramServicesAmt>134589</ProgramServicesAmt>
        <ManagementAndGeneralAmt>23402</ManagementAndGeneralAmt>
        <FundraisingAmt>351</FundraisingAmt>
      </AdvertisingGrp>
      <OfficeExpensesGrp>
        <TotalAmt>19337</TotalAmt>
        <ProgramServicesAmt>14463</ProgramServicesAmt>
        <FundraisingAmt>4874</FundraisingAmt>
      </OfficeExpensesGrp>
      <InformationTechnologyGrp>
        <TotalAmt>96911</TotalAmt>
        <ProgramServicesAmt>78282</ProgramServicesAmt>
        <ManagementAndGeneralAmt>6149</ManagementAndGeneralAmt>
        <FundraisingAmt>12480</FundraisingAmt>
      </InformationTechnologyGrp>
      <OccupancyGrp>
        <TotalAmt>50533</TotalAmt>
        <ProgramServicesAmt>29717</ProgramServicesAmt>
        <ManagementAndGeneralAmt>14873</ManagementAndGeneralAmt>
        <FundraisingAmt>5943</FundraisingAmt>
      </OccupancyGrp>
      <TravelGrp>
        <TotalAmt>27094</TotalAmt>
        <ProgramServicesAmt>22388</ProgramServicesAmt>
        <ManagementAndGeneralAmt>1542</ManagementAndGeneralAmt>
        <FundraisingAmt>3164</FundraisingAmt>
      </TravelGrp>
      <ConferencesMeetingsGrp>
        <TotalAmt>13641</TotalAmt>
        <ProgramServicesAmt>5341</ProgramServicesAmt>
        <FundraisingAmt>8300</FundraisingAmt>
      </ConferencesMeetingsGrp>
      <InterestGrp>
        <TotalAmt>264</TotalAmt>
        <ManagementAndGeneralAmt>264</ManagementAndGeneralAmt>
      </InterestGrp>
      <DepreciationDepletionGrp>
        <TotalAmt>316</TotalAmt>
        <ManagementAndGeneralAmt>316</ManagementAndGeneralAmt>
      </DepreciationDepletionGrp>
      <InsuranceGrp>
        <TotalAmt>7135</TotalAmt>
        <ManagementAndGeneralAmt>7135</ManagementAndGeneralAmt>
      </InsuranceGrp>
      <OtherExpensesGrp>
        <Desc>SPECIAL EVENT</Desc>
        <TotalAmt>653</TotalAmt>
        <FundraisingAmt>653</FundraisingAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>RECRUITING</Desc>
        <TotalAmt>552</TotalAmt>
        <ProgramServicesAmt>552</ProgramServicesAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>TAXES AND LICENSES</Desc>
        <TotalAmt>245</TotalAmt>
        <ManagementAndGeneralAmt>245</ManagementAndGeneralAmt>
      </OtherExpensesGrp>
      <OtherExpensesGrp>
        <Desc>MISC</Desc>
        <TotalAmt>100</TotalAmt>
        <ProgramServicesAmt>100</ProgramServicesAmt>
      </OtherExpensesGrp>
      <AllOtherExpensesGrp>
        <TotalAmt>75</TotalAmt>
        <ManagementAndGeneralAmt>75</ManagementAndGeneralAmt>
      </AllOtherExpensesGrp>
      <TotalFunctionalExpensesGrp>
        <TotalAmt>1349763</TotalAmt>
        <ProgramServicesAmt>1034839</ProgramServicesAmt>
        <ManagementAndGeneralAmt>150126</ManagementAndGeneralAmt>
        <FundraisingAmt>164798</FundraisingAmt>
      </TotalFunctionalExpensesGrp>
      <CashNonInterestBearingGrp>
        <BOYAmt>89042</BOYAmt>
        <EOYAmt>557450</EOYAmt>
      </CashNonInterestBearingGrp>
      <PledgesAndGrantsReceivableGrp>
        <BOYAmt>189164</BOYAmt>
        <EOYAmt>155000</EOYAmt>
      </PledgesAndGrantsReceivableGrp>
      <AccountsReceivableGrp>
        <BOYAmt>0</BOYAmt>
        <EOYAmt>30554</EOYAmt>
      </AccountsReceivableGrp>
      <PrepaidExpensesDefrdChargesGrp>
        <BOYAmt>11185</BOYAmt>
        <EOYAmt>19265</EOYAmt>
      </PrepaidExpensesDefrdChargesGrp>
      <LandBldgEquipCostOrOtherBssAmt>7416</LandBldgEquipCostOrOtherBssAmt>
      <LandBldgEquipAccumDeprecAmt>3462</LandBldgEquipAccumDeprecAmt>
      <LandBldgEquipBasisNetGrp>
        <BOYAmt>0</BOYAmt>
        <EOYAmt>3954</EOYAmt>
      </LandBldgEquipBasisNetGrp>
      <InvestmentsOtherSecuritiesGrp>
        <BOYAmt>0</BOYAmt>
        <EOYAmt>2000</EOYAmt>
      </InvestmentsOtherSecuritiesGrp>
      <OtherAssetsTotalGrp>
        <BOYAmt>6912</BOYAmt>
        <EOYAmt>6912</EOYAmt>
      </OtherAssetsTotalGrp>
      <TotalAssetsGrp>
        <BOYAmt>296303</BOYAmt>
        <EOYAmt>775135</EOYAmt>
      </TotalAssetsGrp>
      <AccountsPayableAccrExpnssGrp>
        <BOYAmt>198793</BOYAmt>
        <EOYAmt>108581</EOYAmt>
      </AccountsPayableAccrExpnssGrp>
      <OtherLiabilitiesGrp>
        <BOYAmt>18000</BOYAmt>
        <EOYAmt>131661</EOYAmt>
      </OtherLiabilitiesGrp>
      <TotalLiabilitiesGrp>
        <BOYAmt>216793</BOYAmt>
        <EOYAmt>240242</EOYAmt>
      </TotalLiabilitiesGrp>
      <OrganizationFollowsSFAS117Ind>X</OrganizationFollowsSFAS117Ind>
      <UnrestrictedNetAssetsGrp>
        <BOYAmt>-27996</BOYAmt>
        <EOYAmt>14432</EOYAmt>
      </UnrestrictedNetAssetsGrp>
      <TemporarilyRstrNetAssetsGrp>
        <BOYAmt>107506</BOYAmt>
        <EOYAmt>520461</EOYAmt>
      </TemporarilyRstrNetAssetsGrp>
      <TotalNetAssetsFundBalanceGrp>
        <BOYAmt>79510</BOYAmt>
        <EOYAmt>534893</EOYAmt>
      </TotalNetAssetsFundBalanceGrp>
      <TotLiabNetAssetsFundBalanceGrp>
        <BOYAmt>296303</BOYAmt>
        <EOYAmt>775135</EOYAmt>
      </TotLiabNetAssetsFundBalanceGrp>
      <ReconcilationRevenueExpnssAmt>455383</ReconcilationRevenueExpnssAmt>
      <OtherChangesInNetAssetsAmt>0</OtherChangesInNetAssetsAmt>
      <MethodOfAccountingAccrualInd>X</MethodOfAccountingAccrualInd>
      <AccountantCompileOrReviewInd>0</AccountantCompileOrReviewInd>
      <FSAuditedInd>0</FSAuditedInd>
      <FederalGrantAuditRequiredInd>0</FederalGrantAuditRequiredInd>
    </IRS990>
    <IRS990ScheduleA documentId="RetDoc1039100001">
      <PublicOrganization170Ind>X</PublicOrganization170Ind>
      <GiftsGrantsContriRcvd170Grp>
        <CurrentTaxYearMinus4YearsAmt>1352290</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>810884</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>1410505</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>1622936</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>1802396</CurrentTaxYearAmt>
        <TotalAmt>6999011</TotalAmt>
      </GiftsGrantsContriRcvd170Grp>
      <TotalCalendarYear170Grp>
        <CurrentTaxYearMinus4YearsAmt>1352290</CurrentTaxYearMinus4YearsAmt>
        <CurrentTaxYearMinus3YearsAmt>810884</CurrentTaxYearMinus3YearsAmt>
        <CurrentTaxYearMinus2YearsAmt>1410505</CurrentTaxYearMinus2YearsAmt>
        <CurrentTaxYearMinus1YearAmt>1622936</CurrentTaxYearMinus1YearAmt>
        <CurrentTaxYearAmt>1802396</CurrentTaxYearAmt>
        <TotalAmt>6999011</TotalAmt>
      </TotalCalendarYear170Grp>
      <SubstantialContributorsTotAmt>4117934</SubstantialContributorsTotAmt>
      <PublicSupportTotal170Amt>2881077</PublicSupportTotal170Amt>
      <OtherIncome170Grp>
        <CurrentTaxYearAmt>2500</CurrentTaxYearAmt>
        <TotalAmt>2500</TotalAmt>
      </OtherIncome170Grp>
      <TotalSupportAmt>7001511</TotalSupportAmt>
      <PublicSupportCY170Pct>0.41150</PublicSupportCY170Pct>
      <PublicSupportPY170Pct>0.44240</PublicSupportPY170Pct>
      <ThirtyThrPctSuprtTestsCY170Ind>X</ThirtyThrPctSuprtTestsCY170Ind>
      <Form990ScheduleAPartVIGrp>
        <FormAndLineReferenceDesc>PART II, SECTION C, LINE 14:</FormAndLineReferenceDesc>
        <ExplanationTxt>PUBLIC SUPPORT PERCENTAGE FOR 2017 WAS RESTATED.</ExplanationTxt>
      </Form990ScheduleAPartVIGrp>
    </IRS990ScheduleA>
    <IRS990ScheduleB documentId="RetDoc1234500001">
      <ContributorInformationGrp>
        <ContributorNum>RESTRICTED</ContributorNum>
        <ContributorBusinessName>
          <BusinessNameLine1>RESTRICTED</BusinessNameLine1>
        </ContributorBusinessName>
        <ContributorUSAddress>
          <AddressLine1>RESTRICTED</AddressLine1>
          <AddressLine2>RESTRICTED</AddressLine2>
          <City>RESTRICTED</City>
          <State>RESTRICTED</State>
          <ZIPCode>RESTRICTED</ZIPCode>
        </ContributorUSAddress>
        <TotalContributionsAmt>RESTRICTED</TotalContributionsAmt>
      </ContributorInformationGrp>
    </IRS990ScheduleB>
    <IRS990ScheduleD documentId="RetDoc1040000001">
      <EquipmentGrp>
        <OtherCostOrOtherBasisAmt>7416</OtherCostOrOtherBasisAmt>
        <DepreciationAmt>3462</DepreciationAmt>
        <BookValueAmt>3954</BookValueAmt>
      </EquipmentGrp>
      <TotalBookValueLandBuildingsAmt>3954</TotalBookValueLandBuildingsAmt>
      <OtherLiabilitiesOrgGrp>
        <Desc>ACCRUED LIABILITIES</Desc>
        <Amt>6750</Amt>
      </OtherLiabilitiesOrgGrp>
      <OtherLiabilitiesOrgGrp>
        <Desc>XCURES STOCK ADJUSTMENT</Desc>
        <Amt>124911</Amt>
      </OtherLiabilitiesOrgGrp>
      <TotalLiabilityAmt>131661</TotalLiabilityAmt>
    </IRS990ScheduleD>
    <IRS990ScheduleG documentId="RetDoc1041200001">
      <EmailSolicitationsInd>X</EmailSolicitationsInd>
      <PhoneSolicitationsInd>X</PhoneSolicitationsInd>
      <InPersonSolicitationsInd>X</InPersonSolicitationsInd>
      <SpecialFundraisingEventsInd>X</SpecialFundraisingEventsInd>
      <AgrmtProfFundraisingActyInd>1</AgrmtProfFundraisingActyInd>
      <FundraiserActivityInfoGrp>
        <PersonNm>THERESE QUINLAN</PersonNm>
        <USAddress>
          <AddressLine1Txt>1529 SEAPORT BLVD</AddressLine1Txt>
          <CityNm>REDWOOD CITY</CityNm>
          <StateAbbreviationCd>CA</StateAbbreviationCd>
          <ZIPCd>94063</ZIPCd>
        </USAddress>
        <ActivityTxt>IN CHARGE OF STRATEGY, ADVISE/STRATEGIZE</ActivityTxt>
        <FundraiserControlOfFundsInd>0</FundraiserControlOfFundsInd>
        <GrossReceiptsAmt>0</GrossReceiptsAmt>
        <RetainedByContractorAmt>19000</RetainedByContractorAmt>
        <NetToOrganizationAmt>-19000</NetToOrganizationAmt>
      </FundraiserActivityInfoGrp>
      <TotalRetainedByContractorsAmt>19000</TotalRetainedByContractorsAmt>
      <TotalNetToOrganizationAmt>-19000</TotalNetToOrganizationAmt>
      <LicensedStatesCd>CA</LicensedStatesCd>
    </IRS990ScheduleG>
    <IRS990ScheduleJ documentId="RetDoc1042400001">
      <BoardOrCommitteeApprovalInd>X</BoardOrCommitteeApprovalInd>
      <SeverancePaymentInd>0</SeverancePaymentInd>
      <SupplementalNonqualRtrPlanInd>0</SupplementalNonqualRtrPlanInd>
      <EquityBasedCompArrngmInd>0</EquityBasedCompArrngmInd>
      <CompBasedOnRevenueOfFlngOrgInd>0</CompBasedOnRevenueOfFlngOrgInd>
      <CompBsdOnRevRelatedOrgsInd>0</CompBsdOnRevRelatedOrgsInd>
      <CompBsdNetEarnsFlngOrgInd>0</CompBsdNetEarnsFlngOrgInd>
      <CompBsdNetEarnsRltdOrgsInd>0</CompBsdNetEarnsRltdOrgsInd>
      <AnyNonFixedPaymentsInd>0</AnyNonFixedPaymentsInd>
      <InitialContractExceptionInd>0</InitialContractExceptionInd>
      <RltdOrgOfficerTrstKeyEmplGrp>
        <PersonNm>ERIKA MONTEVERDI</PersonNm>
        <TitleTxt>EXECUTIVE DIRECTOR</TitleTxt>
        <BaseCompensationFilingOrgAmt>172576</BaseCompensationFilingOrgAmt>
        <CompensationBasedOnRltdOrgsAmt>0</CompensationBasedOnRltdOrgsAmt>
        <BonusFilingOrganizationAmount>0</BonusFilingOrganizationAmount>
        <BonusRelatedOrganizationsAmt>0</BonusRelatedOrganizationsAmt>
        <OtherCompensationFilingOrgAmt>0</OtherCompensationFilingOrgAmt>
        <OtherCompensationRltdOrgsAmt>0</OtherCompensationRltdOrgsAmt>
        <DeferredCompensationFlngOrgAmt>0</DeferredCompensationFlngOrgAmt>
        <DeferredCompRltdOrgsAmt>0</DeferredCompRltdOrgsAmt>
        <NontaxableBenefitsFilingOrgAmt>22336</NontaxableBenefitsFilingOrgAmt>
        <NontaxableBenefitsRltdOrgsAmt>0</NontaxableBenefitsRltdOrgsAmt>
        <TotalCompensationFilingOrgAmt>194912</TotalCompensationFilingOrgAmt>
        <TotalCompensationRltdOrgsAmt>0</TotalCompensationRltdOrgsAmt>
        <CompReportPrior990FilingOrgAmt>0</CompReportPrior990FilingOrgAmt>
        <CompReportPrior990RltdOrgsAmt>0</CompReportPrior990RltdOrgsAmt>
      </RltdOrgOfficerTrstKeyEmplGrp>
    </IRS990ScheduleJ>
    <IRS990ScheduleO documentId="RetDoc1044400001">
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 11B</FormAndLineReferenceDesc>
        <ExplanationTxt>THE FORM 990 IS GIVEN TO THE GOVERNING BODY BEFORE THE RETURN IS FILED. THEY REVIEW AND CAN REQUEST CHANGES AT THIS TIME.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 12C</FormAndLineReferenceDesc>
        <ExplanationTxt>THE OFFICERS, DIRECTORS AND KEY EMPLOYEES ARE REQUIRED TO REVIEW AND SIGN THE WRITTEN CONFLICT OF INTEREST POLICY ANNUALLY.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION B, LINE 15</FormAndLineReferenceDesc>
        <ExplanationTxt>THE GOVERNANCE COMMITTEE PERFORMS ALL INTERVIEWS SPECIFIC TO TOP KEY POSITIONS WHICH IS THEN FORWARDED TO THE FULL BOARD OF DIRECTORS FOR REVIEW AND APPROVAL.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART VI, SECTION C, LINE 19</FormAndLineReferenceDesc>
        <ExplanationTxt>MADE AVAILABLE UPON REQUEST.</ExplanationTxt>
      </SupplementalInformationDetail>
      <SupplementalInformationDetail>
        <FormAndLineReferenceDesc>FORM 990, PART IX, LINE 11G</FormAndLineReferenceDesc>
        <ExplanationTxt>PAYROLL SERVICES RELATED: PROGRAM SERVICE EXPENSES 0. MANAGEMENT AND GENERAL EXPENSES 1,884. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 1,884. OUTSIDE CONTRACT SERVICES: PROGRAM SERVICE EXPENSES 118,507. MANAGEMENT AND GENERAL EXPENSES 0. FUNDRAISING EXPENSES 0. TOTAL EXPENSES 118,507. DEVELOPMENT DEPARTMENT ASSISTANTS: PROGRAM SERVICE EXPENSES 0. MANAGEMENT AND GENERAL EXPENSES 0. FUNDRAISING EXPENSES 33,300. TOTAL EXPENSES 33,300.</ExplanationTxt>
      </SupplementalInformationDetail>
    </IRS990ScheduleO>
  </ReturnData>
</Return>